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Nitrogen fertilizer affects rhizosphere Cd re-mobilization by mediating gene AmALM2 and AmALMT7 expression in edible amaranth roots.

J Hazard Mater 2021 Jun 6;418:126310. Epub 2021 Jun 6.

Key Laboratory of Environmental Pollution and Health of Guangdong Province, School of Environment, Jinan University, Guangzhou 510632, China. Electronic address:

In-situ stabilization of Cd-contaminated farmland is a commonly used remediation technology. Yet, rhizosphere metabolites (e.g. Read More

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Nutritional Risk at intensive care unit admission and outcomes in survivors of critical illness.

Clin Nutr 2021 May 11;40(6):3868-3874. Epub 2021 May 11.

Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Nashville, TN, USA; Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University College of Medicine, Columbus OH, USA; Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

Background And Aims: Risk factors for poor outcomes after critical illness are incompletely understood. While nutritional risk is associated with mortality in critically ill patients, its association with disability, cognitive, and health-related quality of life is unclear in survivors of critical illness. This study's objective was to determine whether greater nutritional risk at ICU admission is associated with greater disability, worse cognition, and worse HRQOL at 3 and 12-month follow-up. Read More

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Methodology for altering omega-3 EPA+DHA and omega-6 linoleic acid as controlled variables in a dietary trial.

Clin Nutr 2021 May 12;40(6):3859-3867. Epub 2021 May 12.

Department of Neurology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background & Aims: Increasing dietary intake of n-3 EPA+DHA and lowering dietary n-6 LA is under investigation as a therapeutic diet for improving chronic pain syndromes as well as other health outcomes. Herein we describe the diet methodology used to modulate intake of n-3 and n-6 PUFA in a free living migraine headache population and report on nutrient intake, BMI and diet acceptability achieved at week 16 of the intensive diet intervention and week 22 follow-up time-point.

Methods: A total of 178 participants were randomized and began one of three diet interventions: 1) a high n-3 PUFA, average n-6 PUFA (H3) diet targeting 1500 mg EPA+DHA/day and 7% of energy (en%) from n-6 linoleic acid (LA), 2) a high-n-3 PUFA, low-n-6 PUFA (H3L6) targeting 1500 mg EPA+DHA/day and <1. Read More

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The outer membrane protein Amuc_1100 of Akkermansia muciniphila alleviates the depression-like behavior of depressed mice induced by chronic stress.

Biochem Biophys Res Commun 2021 Jun 11;566:170-176. Epub 2021 Jun 11.

School of Life Sciences, Anhui University, Hefei, Anhui, 230601, China; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institutes, Anhui University, Hefei, Anhui, 230601, China. Electronic address:

Akkermansia muciniphila is a symbiotic intestinal bacterium with a high medicinal value. Amuc_1100 is the outer membrane protein of A. muciniphila and plays an important role in the interaction between A. Read More

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Global Reach 2018: nitric oxide-mediated cutaneous vasodilation is reduced in chronic, but not acute, hypoxia independently of enzymatic superoxide formation.

Free Radic Biol Med 2021 Jun 12. Epub 2021 Jun 12.

Department of Kinesiology, University of Texas at Arlington, Arlington, TX, USA. Electronic address:

We tested the hypotheses that 1) cutaneous microvascular function is impaired by acute normobaric and chronic hypobaric hypoxia and 2) that the superoxide free radical (via NADPH oxidase or xanthine oxidase) contributes to this impairment via nitric oxide (NO) scavenging. Local heating-induced cutaneous hyperemia (39°C) was measured in the forearm of 11 male lowlanders at sea level (SL) and following 14-18 days at high altitude (HA; 4340 m in Cerro de Pasco, Peru), and compared to 11 highlanders residing permanently at this elevation. Cutaneous vascular conductance (CVC; laser-Doppler flux/mean arterial pressure) was not different during 39°C [control site: 73 (19) vs. Read More

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Lipoproteins and cancer: The role of HDL-C, LDL-C, and cholesterol-lowering drugs.

Biochem Pharmacol 2021 Jun 12:114654. Epub 2021 Jun 12.

Department of Molecular, Cellular, and Biomedical Sciences, Sophie Davis School of Biomedical Education, City University of New York School of Medicine, New York, NY, USA; Graduate Program in Biology, City University of New York Graduate Center, New York, USA. Electronic address:

Cholesterol is an amphipathic sterol molecule that is vital for maintaining normal physiological homeostasis. It is a relatively complicated molecule with 27 carbons whose synthesis starts with 2-carbon units. This in itself signifies the importance of this molecule. Read More

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Assessing university guidance and tutoring in higher education: Validating a questionnaire on Ecuadorian students.

PLoS One 2021 15;16(6):e0253400. Epub 2021 Jun 15.

Department of Psychology, University of Cordoba, Cordoba, Spain.

This study was intended to explore and confirm the factorial structure and to analyze the psychometric properties of an instrument for university guidance and tutoring, apply it, and detect differences between sociodemographic variables. A total of 1,048 students from five universities in the province of Manabi (Ecuador) participated. The study was divided into two phases with differentiated samples. Read More

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The associations between smart device use and psychological distress among secondary and high school students in Kuwait.

PLoS One 2021 15;16(6):e0251479. Epub 2021 Jun 15.

Department of Physical Education, College of Basic Education, The Public Authority for Applied Education and Training, Kuwait.

Background: Smart devices (SDs) are widely used among adolescents. Numerous studies have recommended further research on this topic to find out the prevalence of SD overuse among school students and to what extent this is associated with psychological distress. The present study aimed to investigate the pattern of SD use among secondary and high school students in the state of Kuwait, as well as the possible associations with psychological problems, weight, physical activity, and school performance. Read More

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Coproducing clinical curricula in undergraduate medical education: Student and faculty experiences in longitudinal integrated clerkships.

Med Teach 2021 Jun 15:1-11. Epub 2021 Jun 15.

Department of Medicine, Cambridge Health Alliance, Cambridge, MA, USA.

Purpose: Educational coproduction, in which learners partner with educators to create and improve their educational experiences, can facilitate student-centered medical education. Empirical descriptions of best practices for involving students in clinical curricular coproduction are needed. We aimed to understand faculty and student perspectives on methods, perceived benefits, and common barriers and solutions to clinical curricular coproduction. Read More

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The Use of Aerosolized Medications in Adult Intensive Care Unit Patients: A Prospective, Multicenter, Observational, Cohort Study.

J Aerosol Med Pulm Drug Deliv 2021 Jun 14. Epub 2021 Jun 14.

Department of Respiratory and Critical Care Medicine, West China Medical Center, Sichuan University, Chengdu, China.

Only limited data are available on the real-life clinical utilization of aerosolized medications in intensive care unit (ICU) patients. Exploring the utilization of aerosolized medications in the ICU may contribute to develop appropriate education and improve the quality of aerosol therapy. A 2-week, prospective, multicenter, observational, cohort study was conducted to record how the aerosolized medications were utilized in the Chinese ICUs, including indications, medications used in solo or combination, dosage, and side-effects in adult patients. Read More

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Genetic Diversity for Accelerating Microbial Adaptive Laboratory Evolution.

ACS Synth Biol 2021 Jun 15. Epub 2021 Jun 15.

Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.

Adaptive laboratory evolution (ALE) is a widely used and highly effective tool for improving microbial phenotypes and investigating the evolutionary roots of biological phenomena. Serving as the raw materials of evolution, mutations have been extensively utilized to increase the chances of engineering molecules or microbes with tailor-made functions. The generation of genetic diversity is therefore a core technology for accelerating ALE, and a high-quality mutant library is crucial to its success. Read More

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Satisfaction and stress levels of dentistry students relating to distance education.

Dent Med Probl 2021 Jun 15. Epub 2021 Jun 15.

Department of Pediatric Dentistry, Faculty of Dentistry, Nuh Naci Yazgan University, Kayseri, Turkey.

Background: It is not known whether the coronavirus disease 2019 (COVID-19) pandemic has affected dentistry education.

Objectives: This study aimed to determine the satisfaction and stress levels of dentistry students in Turkey regarding distance education during the COVID-19 pandemic, and to evaluate their opinions on this matter.

Material And Methods: This cross-sectional research study was conducted from October to November 2020 with the use of a web-based questionnaire consisting of 3 sections. Read More

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Elevated Anti-Müllerian Hormone Levels in Newborns of Women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis Based on Observational Studies.

Reprod Sci 2021 Jun 15. Epub 2021 Jun 15.

Department of Obstetrics and Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, China.

We performed this updated systematic review and meta-analysis to evaluate anti-Müllerian hormone levels (AMH) in newborns of mothers with polycystic ovary syndrome (PCOS) compared with healthy controls. A search of the literature was conducted in the PubMed, MEDLINE, EMBASE, Cochrane Library, CBM, CNKI, WANFANG, and VIP for articles to assess AMH levels in offspring of PCOS and non-PCOS mothers irrespective of language. These databases were searched from their inception to December 7, 2020. Read More

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Losartan Protects Podocytes against High Glucose-induced Injury by Inhibiting B7-1 Expression.

Curr Med Sci 2021 Jun 15. Epub 2021 Jun 15.

Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.

The role of B7-1 in podocyte injury has received increasing attention. The aim of this study was to investigate whether losartan protects podocytes of patients with diabetic kidney disease (DKD) by regulating B7-1 and the underlying mechanisms. Rats with streptozotocin-induced DKD were treated with losartan for 8 weeks. Read More

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Investigation of high correlation with carcass traits of SNPs of the PLCB1, C/EBPα, and TDRKH genes and the combinations of SNPs using the MDR method in the Hanwoo.

Genes Genomics 2021 Jun 15. Epub 2021 Jun 15.

Center for Bio-Medical Engineering Core Facility, Dankook University, Cheonan-si, 31116, Republic of Korea.

Background: Recently, many researchers focus on the best way to produce high-quality meat, as the trend in food consumption today is to focus on quality. In general, consumers' preferences in beef differ depending on taste and meatiness. Therefore, researchers are interested in how the marbling score affects the flavors of meat or the various factors that make up the meatiness to captivate the consumers' tastes. Read More

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Improving rice eating and cooking quality by coordinated expression of the major starch synthesis-related genes, SSII and Wx, in endosperm.

Plant Mol Biol 2021 Jun 15. Epub 2021 Jun 15.

Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding, State Key Laboratory of Hybrid Rice, Key Laboratory of Plant Functional Genomics of the Ministry of Education, College of Agriculture, Yangzhou University, Yangzhou, 225009, China.

Key Message: Coordinated regulation of amylose and amylopectin synthesis via manipulation of SSII-2, SSII-3 and Wx expression in endosperm can improve rice eating and cooking quality. With increasing rice consumption worldwide, many researchers are working to increase the yield and improve grain quality, especially eating and cooking quality (ECQ). The rice ECQ is mainly controlled by the expression of starch synthesis-related genes (SSRGs) in endosperm. Read More

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LRH-1 high expression in the ovarian granulosa cells of PCOS patients.

Endocrine 2021 Jun 15. Epub 2021 Jun 15.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.

Purpose: Polycystic ovary syndrome (PCOS) is considered one of the most common endocrine disorders with heterogeneity. There are also reports that liver receptor homolog 1 [LRH-1 or nuclear receptor subfamily 5 group A member 2] plays an important role in the reproductive system. But up to now, there are no reports related to the link with PCOS and LRH-1. Read More

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The AGE Presents Introduction to Geroscience video lecture series.

Geroscience 2021 Jun 15. Epub 2021 Jun 15.

Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195-7470, USA.

The AGE Presents Introduction to Geroscience video lecture series is a collection of high-quality didactic video lectures and associated teaching materials focused on foundational topics in aging biology. The videos are made freely available on YouTube and are targeted toward an audience familiar with concepts learned in the first year of a college undergraduate biology/biomedical major. Members of the American Aging Association also receive the original lecture slides and lecture notes, with additional course materials to be developed in the future. Read More

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Increased TIGIT expressing NK cells with dysfunctional phenotype in AML patients correlated with poor prognosis.

Cancer Immunol Immunother 2021 Jun 15. Epub 2021 Jun 15.

The Second Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology; Sino-French Hoffmann Institute, School of Basic Sciences, Guangzhou Medical University, Guangzhou, China.

AML is the most common blood cancer in adults with a high relapse and an overall poor survival rate. NK cells have been demonstrated to have the capacity to eradicate AML blast, and an impaired NK cell function is involved in AML development and progression. Immune checkpoints are involved in immune escape in various cancers. Read More

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HBI Transcription Factor-Mediated ROS Homeostasis Regulates Nitrate Signal Transduction.

Plant Cell 2021 Jun 15. Epub 2021 Jun 15.

The Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao, 266237, China.

Nitrate is both an important nutrient and a critical signaling molecule that regulates plant metabolism, growth, and development. Although several components of the nitrate signaling pathway have been identified, the molecular mechanism of nitrate signaling remains unclear. Here, we showed that the growth-related transcription factors HOMOLOG OF BRASSINOSTEROID ENHANCED EXPRESSION2 INTERACTING WITH IBH1 (HBI1) and its three closest homologs (HBIs) positively regulate nitrate signaling in Arabidopsis thaliana. Read More

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Patterns and prevalence of daily tobacco smoking in Australia by industry and occupation: 2007-2016.

Nicotine Tob Res 2021 Jun 15. Epub 2021 Jun 15.

National Centre for Education and Training on Addiction, Flinders University.

Introduction: Australian workers' daily tobacco smoking over time was examined by industry, and occupation, to identify factors associated with high/low prevalence.

Methods: Secondary analyses of 2007, 2010, 2013 and 2016 National Drug Strategy Household Surveys were undertaken (pooled n=49,395). Frequency analyses informed subsequent modelling of select industries and occupations. Read More

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Association of a Sweetened Beverage Tax With Purchases of Beverages and High-Sugar Foods at Independent Stores in Philadelphia.

JAMA Netw Open 2021 Jun 1;4(6):e2113527. Epub 2021 Jun 1.

Department of Medical Ethics and Health Policy, University of Pennsylvania Perelman School of Medicine, Philadelphia.

Importance: The relationship between a sweetened beverage tax and changes in the prices and purchases of beverages and high-sugar food is understudied in the long term and in small independent food retail stores where sugar-sweetened beverages are among the most commonly purchased items.

Objective: To examine whether a 1.5 cent-per-fluid-ounce excise tax on sugar- and artificially sweetened beverages Philadelphia, Pennsylvania, was associated with sustained changes in beverage prices and purchases, as well as calories purchased from beverages and high-sugar foods, over 2 years at small independent stores. Read More

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The effect of remote peer support on stigma in patients after breast cancer surgery during the COVID-19 pandemic: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26332

Institute of Business, School of Business, Henan University, Jinming Avenue, Kaifeng, Henan, China.

Background: Patients after breast cancer surgery have a high sense of stigma due to the formation of surgical scars, loss of breast shape or other reasons, leading to anxiety, depression, and other adverse mental health problems, thus reducing their quality of life. Remote peer support intervention based on telephone, internet or email is low-cost and easy to spread, and protects patients' privacy, solves the barriers to access that many patients face when attending face-to-face programs. Therefore, remote peer support may be an effective way to reduce stigma and improve mental health in patients after breast cancer surgery during the coronavirus disease 2019 (COVID-19) pandemic. Read More

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High-fidelity simulation is associated with good discriminability in emergency medicine residents' in-training examinations.

Medicine (Baltimore) 2021 Jun;100(24):e26328

Department of Emergency Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan.

Abstract: In-training examinations (ITEs), arranged during residency training, evaluate the residents' performances periodically. There is limited literature focusing on the effectiveness of resident ITEs in the format of simulation-based examinations, as compared to traditional oral or written tests. Our primary objective is to investigate the effectiveness and discriminative ability of high-fidelity simulation compared with other measurement formats in emergency medicine (EM) residency training program. Read More

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Web-Based Delivery of the Caregiving Essentials Course for Informal Caregivers of Older Adults in Ontario: Mixed Methods Evaluation Study.

JMIR Aging 2021 Jun 15;4(2):e25671. Epub 2021 Jun 15.

School of Earth, Environment & Society, McMaster University, Hamilton, ON, Canada.

Background: Many informal caregivers of older adults have limited time because of the number of responsibilities that their caregiving role entails. This population often experiences high levels of burden due to the stressful nature of their work and are vulnerable to developing negative psychological health outcomes. Easily accessible and flexible knowledge interventions are needed to alleviate the burden and stress experienced by this group. Read More

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Preferences in digital smartphone mental health applications among adolescents: a qualitative study.

JMIR Form Res 2021 May 6. Epub 2021 May 6.

Health Service and Population Research Department, IOPPN, Kings' College London, UK, Centre for Research in Individual Differences, Department of Psychology, London, GB.

Background: Mental health digital applications (apps) hold promise to provide scalable solutions to individual self-care, education, and illness prevention. However, a problem with these apps is that they lack engaging user interfaces and experiences, potentially resulting in high attrition. While guidelines for new digital interventions in adults have begun to examine engagement, there is a paucity of evidence on how to best address digital interventions in adolescents. Read More

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Implementation of iPads to Increase Compliance With Delivery of New Parent Education in the Mother-Baby Unit: Retrospective Study.

JMIR Pediatr Parent 2021 Jun 15;4(2):e18830. Epub 2021 Jun 15.

University of South Carolina School of Medicine Greenville, Greenville, SC, United States.

Background: Abusive head trauma (AHT) is a serious health problem affecting more than 3000 infants annually in the United States. The American Academy of Pediatrics and the Centers for Disease Control and Prevention (CDC) recommend that health care providers counsel new parents about the dangers of AHT. Previous studies demonstrate that parental education is effective at reducing AHT events. Read More

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Adherence to and patient's knowledge of self-management of subcutaneous biologic therapy in chronic inflammatory rheumatic diseases: results of a multicentre cross-sectional study.

Clin Exp Rheumatol 2021 May 28. Epub 2021 May 28.

Department of Rheumatology - Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, and INSERM (UMR1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France.

Objectives: Non-adherence to biologic therapy is an issue in chronic inflammatory rheumatic diseases (CIRDs) and might be related to poor patient knowledge of the risk of these therapies. Our aim here was to evaluate the level of patient adherence to and knowledge of self-care safety skills for biologic therapy.

Methods: This was a multicentre, cross-sectional study in which out-patients visited an office- or hospital-based rheumatologist. Read More

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Characteristics of Effective Auditory Training: Implications From Two Training Programs That Successfully Trained Nonnative Cantonese Tone Identification in Monolingual Mandarin and Bilingual Mandarin-Taiwanese Tone Speakers.

J Speech Lang Hear Res 2021 Jun 15:1-23. Epub 2021 Jun 15.

Division of Speech and Hearing Sciences, Faculty of Education, The University of Hong Kong, Pokfulam.

Purpose Auditory training is important in pedagogical and clinical settings. In search of a more effective perceptual program for training new suprasegmental categories, this study examined the effect of two auditory programs that incorporated five elements that have previously been identified to be effective for training nonnative segmental and suprasegmental speech sounds on the identification of a complex foreign lexical tone system (Cantonese) that contrasts both pitch shapes and pitch heights. To investigate the training outcomes in learners with different tonal systems, monolingual Mandarin-speaking learners who have a smaller native tonal system that contrasts pitch shapes only and bilingual Mandarin-Taiwanese-speaking learners who have a larger native tonal system that contrasts both pitch shapes and pitch heights were recruited for training. Read More

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