Bioorg Chem 2021 Jun 13;111:104972. Epub 2021 May 13.
Department of Chemistry, School of Physical & Decision Sciences (SPDS), Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow 226025, UP, India; Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Brig. S. K. Mazumdar Road, Delhi 110054, India. Electronic address:
Quantitative changes in expression level of 5HT are somewhere related to common neurological disorders such as anxiety, major depression and schizophrenia. We have designed EDTA conjugated SPECT imaging probe for localization of 5HT receptor in brain. For designing SPECT probe we have employed the concept of bivalent approach and a homodimeric system with desirable pharmacokinetics of 5HT imaging. Read More