181,539 results match your criteria edema]

Developmental alterations, teratogenic effects, and oxidative disruption induced by ibuprofen, aluminum, and their binary mixture on Danio rerio.

Environ Pollut 2021 Sep 9;291:118078. Epub 2021 Sep 9.

Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA, CSIC), Jordi Girona 18, 08017, Barcelona, Spain.

Several studies highlighted the ubiquitous presence of ibuprofen and aluminum in the aquatic environment around the world and demonstrated their potential to induce embryotoxic and teratogenic defects on aquatic species individually. Although studies that evaluate developmental alterations induced by mixtures of these pollutants are scarce; and, since environmental contamination presented in the form of a mixture of toxicants with different chemical properties and toxicity mechanisms capable of generating interactions; the objective of this study was to evaluate the developmental defects, teratogenic alterations, and oxidative stress induced by individual forms and the mixture of ibuprofen (IBU) and aluminum (Al) on zebrafish embryos. Oocytes exposed to environmentally relevant concentrations of IBU (0. Read More

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September 2021

Subclinical myocardial injury and the phenotype of clinical congestion in patients with heart failure and reduced left ventrcular ejection fraction.

J Card Fail 2021 Sep 14. Epub 2021 Sep 14.

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

Background: Clinical congestion is associated with adverse outcomes in patients with heart failure. The pathophysiological mediators of this association remain uncertain.

Methods: We prospectively enrolled a cohort of patients with heart failure and reduced left ventricular ejection fraction (LVEF) and performed a detailed clinical examination followed on the same day by an invasive right heart catheterization and blood sampling for biomarkers. Read More

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September 2021

MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice.

Brain Res Bull 2021 Sep 14. Epub 2021 Sep 14.

Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, Anhui Province, China; Department of Psychiatry, Anhui Psychiatric Center, Anhui Medical University, Hefei, Anhui Province, China. Electronic address:

Background: The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6. TRAF6 interacted with NLRP3 to promote the activation of NLRP3 inflammasome. However, the role of MST4 on neuroinflammation after intracerebral hemorrhage (ICH), and how it interacts with NLRP3 inflammasome, remains unclear. Read More

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September 2021

Lenvatinib exposure induces hepatotoxicity in zebrafish via inhibiting Wnt signaling.

Toxicology 2021 Sep 14:152951. Epub 2021 Sep 14.

Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Ji'an, Jiangxi, China; Jiangxi Key Laboratory of Developmental Biology of Organs, College of Life Sciences, Jinggangshan University, Ji'an, 343009, Jiangxi, China. Electronic address:

Lenvatinib is a multi-kinase inhibitor for widely treating thyroid cancer. However, little studies have been done about it or its toxicity on embryonic development of vertebrate. In this study, we used zebrafish to assess the effect of lenvatinib on early embryonic development. Read More

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September 2021

Effect of dexamethasone on experimental enteritis produced by Giardia lamblia in a Meriones unguiculatus model.

Exp Parasitol 2021 Sep 14:108158. Epub 2021 Sep 14.

Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:

Our aim was to evaluate the impact of immunosuppression on the development of giardiasis. Thirty-six gerbils (4-6 weeks old) were distributed in four groups containing nine animals each: Control (CT); Control-Infected by Giardia lamblia (CTIn), Immunosuppressed (IS), and Immunosuppressed-Infected by G. lamblia (ISIn). Read More

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September 2021

Impairments of cerebral blood flow microcirculation in rats brought on by cardiac cessation and respiratory arrest.

J Biophotonics 2021 Sep 17:e202100216. Epub 2021 Sep 17.

Histology, Cytology and Embryology Department, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

The impairments of cerebral blood flow microcirculation brought on by cardiac and respiratory arrest were assessed with multi-modal diagnostic facilities, utilising laser speckle contrast imaging, fluorescence spectroscopy and diffuse reflectance spectroscopy. The results of laser speckle contrast imaging show a notable reduction of cerebral blood flow in small and medium size vessels during a few minutes of respiratory arrest, while the same effect was observed in large sinuses and their branches during the circulatory cessation. Concurrently, the redox ratio assessed with fluorescence spectroscopy indicates progressing hypoxia, NADH accumulation and increase of FAD consumption. Read More

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September 2021

Activation of vagovagal reflex prevents hepatic ischemia/reperfusion-induced lung injury via anti-inflammatory and antioxidant effects.

Exp Physiol 2021 Sep 17. Epub 2021 Sep 17.

Department of Cardiology, The First People's Hospital of Jingmen, Jingmen, 448000, China.

New Findings: What is the central question of this study? Does VNS have protective effects against both direct liver damage and distant lung injury in a hepatic ischemia/reperfusion rat model? What is the main finding and its importance? VNS provides the protective effects through anti-inflammation and anti-oxidative stress possibly achieved by the vagovagal reflex.

Abstract: Hepatic ischemia reperfusion (I/R) is not an isolated event; instead, it can result in remote organ dysfunction. The aim of this study was to investigate whether vagal nerve stimulation (VNS) can alleviate hepatic I/R-induced lung injury and to explore the underlying mechanism. Read More

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September 2021

Closed incision Negative Pressure Therapy (ciNPT): does depression affect underlying tissues?

Eur Rev Med Pharmacol Sci 2021 Sep;25(17):5458-5462

Department of Emergency and Trauma Surgery, Policlinico Gemelli, Catholic University of Sacred Heart, Rome, Italy.

Objective: Closed incision Negative Pressure Therapy (ciNPT) has become a widespread practice in recent years. Described benefits concern the rate of wound infection, based on the assumption that negative pressure spreads inside the wound removing collections and edema. The study aims to clarify this technical point, on which experimental scientific evidence is lacking in literature. Read More

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September 2021

Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy.

Invest Ophthalmol Vis Sci 2021 Sep;62(12):15

Vision Science Program, School of Optometry, Indiana University, Bloomington, Indiana, United States.

Purpose: The Slc4a11 knock out (KO) mouse model recapitulates the human disease phenotype associated with congenital hereditary endothelial dystrophy (CHED). Increased mitochondrial reactive oxygen species (ROS) in the Slc4a11 KO mouse model is a major cause of edema and endothelial cell loss. Here, we asked if autophagy was activated by ROS in the KO mice. Read More

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September 2021

[Progress in the relationship between NLRP3 inflammasome and lung injury in COVID-19].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Sep;37(9):844-850

Department of Microbiology, Shandong Traditional Chinese Medicine University, Jinan 250000, China. *Corresponding author, E-mail:

Severe inflammatory responses are considered responsible for acute lung damage in COVID-19. SARS-CoV-2 enters lung cells via ACE2, and the NLR family pyrin domain containing 3 (NLRP3) inflammasome and the pro-caspase-1 are then activated, followed by release of mature IL-1β and IL-18 and other inflammatory cytokines, thereby leading to inflammation and apoptosis. This inflammatory process induces syndromes such as inflammatory cell infiltration, congestion, and edema in the lungs of COVID-19 patients. Read More

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September 2021

[Bradykinin and angiotensin-converting enzyme in serum of patients with diabetic retinopathy and the prognosis of diabetic macular edema development (pilot study)].

Probl Endokrinol (Mosk) 2021 Aug 19;67(4):13-19. Epub 2021 Aug 19.

Helmholtz National Medical center of Eye Diseases.

Background: Diabetic macular edema (DME) is a microvascular complication of diabetic retinopathy. One of the key roles in the pathogenesis of DME may belong to the components of rennin-angiotensin and kallikrein-kinin systems: bradykinin (Bk) and angiotensin-converting enzyme (ACE).

Purpose: To determine the Bk and ACE concentration and ACE activity in serum of patients with proliferative diabetic retinopathy (PDR) and to estimate the significance of these parameters for the early diagnostic and prognosis of DMO. Read More

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Efficacy of Naoxueshu in acute spontaneous intracerebral hemorrhage: a multicenter observational study.

Neurol Sci 2021 Sep 16. Epub 2021 Sep 16.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.

Objective: To evaluate the efficacy and safety outcome and related risk factors of Naoxueshu in the treatment of acute SICH.

Methods: Two hundred twenty patients were enrolled in this study. Diagnosis of SICH was based on neuroimaging. Read More

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September 2021

Application of contrast-enhanced ultrasound in the diagnosis of burn depth.

Ann Transl Med 2021 Aug;9(16):1315

Grand Life Science & Technology, Ltd., Beijing, China.

Background: The diagnosis of burn depth often relies on the subjective judgment of plastic surgeons. Contrast-enhanced ultrasound (CEUS) can visualize the microcirculation well and has potential value in diagnosing the depth of burn wounds. We assessed the depth of the burn wounds by CEUS, and compared the results with histological examination. Read More

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Animal models of corneal endothelial dysfunction to facilitate development of novel therapies.

Ann Transl Med 2021 Aug;9(15):1271

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.

Progressive corneal endothelial disease eventually leads to corneal edema and vision loss due to the limited regenerative capacity of the corneal endothelium in vivo and is a major indication for corneal transplantation. Despite the relatively high success rate of corneal transplantation, there remains a pressing global clinical need to identify improved therapeutic strategies to address this debilitating condition. To evaluate the safety and efficacy of novel therapeutics, there is a growing demand for pre-clinical animal models of corneal endothelial dysfunction. Read More

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Synovial Fluid of Patient With Rheumatoid Arthritis Enhanced Osmotic Sensitivity Through the Cytotoxic Edema Module in Synoviocytes.

Front Cell Dev Biol 2021 31;9:700879. Epub 2021 Aug 31.

Department of Physiology, College of Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, South Korea.

Rheumatoid arthritis (RA) is an autoimmune disease that causes inflammation of the synovial membrane ultimately leading to permanent damage in the affected joints. For this study, synovial fluids from 16 patients diagnosed with either RA or osteoarthritis (OA) were used to examine volume regulation and cooperative water channels, both of which are involved in the cytotoxic edema identified in RA-fibroblast-like synoviocytes (FLS). The osmolarity and inflammatory cytokine interleukin (IL)-6 of synovial fluids from RA patients were mildly enhanced compared to that from OA patients. Read More

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Testicular rupture following rubber bullet trauma case report.

Transl Androl Urol 2021 Aug;10(8):3529-3531

Department of Urology, University of Minnesota Medical School, Minneapolis, MN, USA.

Following civil unrest during 2020, physicians began to notice a variety of injuries resulting from crowd control weapons. While prior research emphasized ocular trauma, genitourinary complications of injuries have yet to be investigated. A previously healthy 27-year-old male presented to the emergency department due to sudden onset of severe left testicular pain following rubber bullet trauma. Read More

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The Prognostic Effect of Dexamethasone on Patients With Glioblastoma: A Systematic Review and Meta-Analysis.

Front Pharmacol 2021 31;12:727707. Epub 2021 Aug 31.

Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, China.

Dexamethasone (DEX) is widely adopted to reduce tumor-associated edema in glioblastoma (GBM) patients despite its side effects. However, the benefits of using DEX in GBM patients remains elusive. In this study, we performed a comprehensive meta-analysis to address this concern. Read More

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Toxicity of amantadine hydrochloride on cultured bovine cornea endothelial cells.

Sci Rep 2021 Sep 16;11(1):18514. Epub 2021 Sep 16.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.

Amantadine hydrochloride (HCl) is commonly prescribed for treating influenza A virus infection and Parkinson's disease. Recently, several studies have indicated that the use of amantadine HCl is associated with corneal edema; however, the cytotoxic effect of amantadine HCl has not been investigated. In the present study, the effects of amantadine HCl on cell growth, proliferation, and apoptosis in bovine cornea endothelial cells, and in vitro endothelial permeability were examined. Read More

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September 2021

Interactions of brain, blood, and CSF: a novel mathematical model of cerebral edema.

Fluids Barriers CNS 2021 Sep 16;18(1):42. Epub 2021 Sep 16.

Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Kiryat Hadassah, 91120, Jerusalem, Israel.

Background: Previous models of intracranial pressure (ICP) dynamics have not included flow of cerebral interstitial fluid (ISF) and changes in resistance to its flow when brain swelling occurs. We sought to develop a mathematical model that incorporates resistance to the bulk flow of cerebral ISF to better simulate the physiological changes that occur in pathologies in which brain swelling predominates and to assess the model's ability to depict changes in cerebral physiology associated with cerebral edema.

Methods: We developed a lumped parameter model which includes a representation of cerebral ISF flow within brain tissue and its interactions with CSF flow and cerebral blood flow (CBF). Read More

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September 2021

Re-expansion pulmonary edema following a pneumothorax drainage in a patient with COVID-19.

BMC Pulm Med 2021 Sep 16;21(1):293. Epub 2021 Sep 16.

Respiratory Medicine and Infectious Diseases, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan.

Background: Re-expansion pulmonary edema is an uncommon complication following drainage of a pneumothorax or pleural effusion. While pneumothorax is noted to complicate COVID-19 patients, no case of COVID-19 developing re-expansion pulmonary edema has been reported.

Case Representation: A man in his early 40 s without a smoking history and underlying pulmonary diseases suddenly complained of left chest pain with dyspnea 1 day after being diagnosed with COVID-19. Read More

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September 2021

Myocardial protein aggregates in pet guinea pigs.

Vet Pathol 2021 Sep 16:3009858211042586. Epub 2021 Sep 16.

University of California, Davis, CA, USA.

A retrospective study of guinea pigs submitted for necropsy revealed intracytoplasmic inclusions in the cardiomyocytes of 26 of 30 animals. The inclusions were found with approximately the same frequency in male and female guinea pigs and were slightly more common in older animals. In most cases, the animals did not have clinical signs or necropsy findings suggestive of heart failure, and the cause of death or reason for euthanasia was attributed to concurrent disease processes. Read More

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September 2021

[Adherence to adjuvant with therapy imatinib in patients with gastrointestinal stromal tumor: a national multi-center cross-sectional study].

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Sep;24(9):775-782

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

To analyze the current adherence to imatinib in patients with gastrointestinal stromal tumors (GIST) in China and its influencing factors. A cross-sectional survey was conducted. Study period: from October 1, 2020 to November 31, 2020. Read More

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September 2021

COVID-19-related Posterior Reversible Encephalopathy Syndrome in an Adult ICU Patient in Ireland.

J Coll Physicians Surg Pak 2021 Jan;31(1):S87-S89

Department of Respiratory Medicine, Our Lady of Lourdes Hospital, Ireland.

Radiologically confirmed, novel coronavirus disease 2019 (COVID-19)-related neurological manifestations are being reported with increasing frequency since the outbreak of the disease. We describe a 54-year-old male with COVID-19, who demonstrated radiological and clinical findings of posterior reversible encephalopathy syndrome(PRES). The proposed mechanism suggested for COVID-19-related PRES is a disease induced inflammatory storm, which causes endothelial injury, resulting in endothelialdysfunction (ED), interstitial fluid extravasation and cerebral edema. Read More

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January 2021

Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury.

Int Immunopharmacol 2021 Sep 13;100:108106. Epub 2021 Sep 13.

Department of Emergency, Longhua Hospital Affiliated to Shanghai University of Chinese Medicine, China. Electronic address:

Background: NOD-like receptor protein 3 (NLRP3) inflammasome activation has emerged as a crucial contributor to sepsis-induced lung injury. Geranylgeranyl diphosphate synthase 1 (GGPPS1) reportedly exerts the pro-inflammatory capability via activation of NLRP3 inflammasome. However, little is known about the role and mechanism of GGPPS1 in sepsis-induced lung injury. Read More

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September 2021

β-Hydroxybutyrate, One of the Three Main Ketone Bodies, Ameliorates Acute Pancreatitis in Rats by Suppressing the NLRP3 Inflammasome Pathway.

Turk J Gastroenterol 2021 Aug;32(8):702-711

Department of Histology and Embryology, Eskisehir Osmangazi University School of Medicine, Eskişehir, Turkey.

Background: Acute pancreatitis (AP) is a widespread disease resulting from the inflammation of acinar cells in the pancreas. β-hydroxybutyrate (BHB) is a water-soluble main ketone body synthesized in the human liver. The purpose of this study was to examine the possible therapeutic effects of BHB in the experimentally-induced AP model in rats. Read More

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Assessment of Imaging Features of Crohn's Disease with MR Enterography.

Turk J Gastroenterol 2021 Aug;32(8):631-639

Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey.

Background: To evaluate the frequency of pathological findings determined on magnetic resonance (MR) enterography (MRE) in patients with Crohn's Disease.

Methods: A retrospective analysis of the MRE images was made in 34 female and 41 male patients (mean age 41 years) with Crohn's disease. The prevalence of bowel wall (mural thickening, mural edema, mural fat deposits, mucosal enhancement, ulceration, cobblestone appearance, pseudopolyps) and mesenteric fatty tissue alterations (fatty tissue proliferation, mesenteric hypervascularity, enlarged lymph nodes, peri-enteric inflammation, reactive fluid), complications due to penetrating (fistula, sinus tract, abscess) and stenosing processes (fibrotic and inflammatory stenosis, obstruction, dilatation), and involvement of the colon were determined. Read More

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Maternal LiCl exposure disrupts thyroid-cerebral axis in neonatal albino rats.

Int J Dev Neurosci 2021 Sep 16. Epub 2021 Sep 16.

Division of Anatomy and Embryology, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.

This work aimed to elucidate whether maternal lithium chloride (LiCl) exposure disturbs the thyroid-cerebral axis in neonatal albino rats. 50 mg of LiCl/kg. b. Read More

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September 2021

[Comparative efficacy of various methods of treatment of chronic venous oedema in real clinical practice].

Angiol Sosud Khir 2021 ;27(3):77-83

Chair of Faculty Surgery #2 of Therapeutic Department, Pirogov Russian National Research Medical University of the RF Ministry of Public Health, Moscow, Russia.

Aim: The study was aimed at assessing efficacy and safety of micronized purified flavonoid fraction (MPFF, Detralex) in comprehensive treatment of chronic venous oedema induced by lower limb varicose veins.

Patients And Methods: We performed a post hoc analysis of the results of treatment of 708 patients included into the observational programme VAP-PRO-C3 (ClinicalTrials.gov. Read More

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September 2021

The inducing of caspase and Bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats.

Environ Sci Pollut Res Int 2021 Sep 15. Epub 2021 Sep 15.

Department of Pathology, Medical School, Firat University, Elazig, Turkey.

In this study, 42 Wistar albino male rats (n = 42, 8 weeks old) were used. Rats were divided into 6 groups and 7 rats included each group. Groups: (i) Control group: Standard diet; (ii) RJ (royal jelly) group: Standard diet + royal jelly; (iii) F50 group: Standard diet + 50 mg/kg fluoride; (iv): F100 group: Standard diet + 100 mg/kg fluoride; (v) F50+RJ group: Standard diet + 50 mg/kg fluoride + royal jelly; (vi): F100+RJ group: Standard diet + 100 mg/kg fluoride + royal jelly. Read More

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September 2021