15,477 results match your criteria ecs

The Impact on Service Collaboration of Co-location of Early Childhood Services in Tasmanian Child and Family Centres: An Ethnographic Study.

Int J Integr Care 2021 Apr 29;21(2):14. Epub 2021 Apr 29.

School of Social Sciences, University of Tasmania; Private Bag 22, Hobart, TAS 7001, Australia.

Introduction: There is a global trend towards place-based initiatives (PBIs) to break the cycle of disadvantage and promote positive child development. Co-location is a common element of these initiatives and is intended to deliver more coordinated services for families of young children. This paper examines how co-locating early childhood services (ECS) from health and education in Child and Family Centres (CFCs) has impacted collaboration between services. Read More

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Alkaline phosphatase activity during a phosphate replete dinoflagellate bloom caused by Prorocentrum obtusidens.

Harmful Algae 2021 Mar 29;103:101979. Epub 2021 Jan 29.

Research Center of Harmful Algae and Marine Biology, and Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes, Jinan University, Guangzhou, China.

Prorocentrum obtusidens Schiller (formerly P. donghaiense Lu), a harmful algal species common in the East China Sea (ECS), often thrives with the depletion of phosphate. Three cruises in the spring of 2013 sampled an entire P. Read More

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Patient outcomes and experience of a task-shared screening and brief intervention service for problem substance use in South African emergency centres: a mixed methods study.

Addict Sci Clin Pract 2021 May 12;16(1):31. Epub 2021 May 12.

Alan J Flisher Centre for Public Mental Health, Department of Psychiatry and Mental Health, University of Cape Town, 46 Sawkins Road, Rondebosch, Cape Town, 7700, South Africa.

Background: Screening, brief intervention and referral to treatment (SBIRT) programmes have resulted in generally positive outcomes in healthcare settings, particularly for problem alcohol use, yet implementation is hampered by barriers such as concerns regarding the burden on healthcare professionals. In low-resourced settings, task-sharing approaches can reduce this burden by using non-professional healthcare workers, yet data are scarce regarding the outcomes and acceptability to patients within a SBIRT service. This study aims to evaluate patient-reported outcomes, patient acceptability, perceived benefits and recommendations for improving a task-shared SBIRT service in South African emergency centres (ECs). Read More

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Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells.

FASEB Bioadv 2021 May 18;3(5):334-355. Epub 2021 Feb 18.

Department of Medicine University of California San Diego La Jolla CA USA.

The transmembrane protein heart of glass1 (HEG1) directly binds to and recruits Krev interaction trapped protein 1 (KRIT1) to endothelial junctions to form the HEG1-KRIT1 protein complex that establishes and maintains junctional integrity. Genetic inactivation or knockdown of endothelial HEG1 or KRIT1 leads to the upregulation of transcription factors Krüppel-like factors 4 and 2 (KLF4 and KLF2), which are implicated in endothelial vascular homeostasis; however, the effect of acute inhibition of the HEG1-KRIT1 interaction remains incompletely understood. Here, we report a high-throughput screening assay and molecular design of a small-molecule HEG1-KRIT1 inhibitor to uncover acute changes in signaling pathways downstream of the HEG1-KRIT1 protein complex disruption. Read More

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Endothelial Exosome Plays a Functional Role during Rickettsial Infection.

mBio 2021 May 11;12(3). Epub 2021 May 11.

Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA

Spotted fever group rickettsioses (SFRs) are devastating human infections. Vascular endothelial cells (ECs) are the primary targets of rickettsial infection. Edema resulting from EC barrier dysfunction occurs in the brain and lungs in most cases of lethal SFR, but the underlying mechanisms remain unclear. Read More

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Maternal Anti-HPA-1a Antibodies Increase Endothelial Cell Apoptosis and Permeability.

J Vasc Res 2021 May 11:1-9. Epub 2021 May 11.

Thrombosis Unit, Sheba Medical Center, Tel Hashomer, Israel.

Intracranial hemorrhage (ICH) associated with fetal/neonatal alloimmune thrombocytopenia (FNAIT) is attributed mainly to endothelial damage caused by binding of maternal anti-HPA-1a antibodies to the αvβ3 integrin on endothelial cells (ECs). We examined the effect of anti-HPA-1a antibodies on EC function using 2 EC lines from different vascular beds, HMVEC of dermal origin and hCMEC/D3 of cerebral origin. Anti-HPA-1a sera significantly increased apoptosis in both HMVEC and hCMEC/D3 cells and permeability in hCMEC/D3 cells only. Read More

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Targeting RNA Editing of Antizyme Inhibitor 1: a Potential Oligonucleotide-Based Antisense Therapy for Cancer.

Mol Ther 2021 May 8. Epub 2021 May 8.

Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore 117599; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 4 Medical Drive, Singapore 117594. Electronic address:

Dysregulated adenosine-to-inosine (A-to-I) RNA editing is implicated in various cancers. However, no available RNA editing inhibitors have so far been developed to inhibit cancer-associated RNA editing events. Here we decipher the RNA secondary structure of antizyme inhibitor 1 (AZIN1), one of the best-studied A-to-I editing targets in cancer, by locating its editing site complementary sequence (ECS) at the 3'end of exon 12. Read More

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HBCD, TBECH, and BTBPE exhibit cytotoxic effects in human vascular endothelial cells by regulating mitochondria function and ROS production.

Environ Toxicol 2021 May 11. Epub 2021 May 11.

Division of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Brominated flame retardants (BFRs), such as, 1,2,5,6-tetrabromocyclooctane (HBCD), 1,2-dibromo-4-(1,2-dibromopropyl)cyclohexane (TBECH), and 1 1,2-bis-(2,4,6-tribromophenoxy)ethane (BTBPE), have garnered increasing attention due to their potent biological effects. In the present study, the toxicity of HBCD, TBECH, and BTBPE in human vascular endothelial cells (ECs) was explored. The data showed that HBCD, TBECH, and BTBPE induced cytotoxicity, namely dose-dependent cell viability reduction, cell membrane permeability and apoptosis increase, migration, and lumen formation inhibition. Read More

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Primary cilia control endothelial permeability by regulating expression and location of junction proteins.

Cardiovasc Res 2021 May 11. Epub 2021 May 11.

Department of Pathology and Immunology.

Aims: Wall shear stress (WSS) determines intracranial aneurysm (IA) development. Polycystic kidney disease (PKD) patients have a high IA incidence and risk of rupture. Dysfunction/absence of primary cilia in PKD endothelial cells (ECs) may impair mechano-transduction of WSS and favour vascular disorders. Read More

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Efficient and effective removal of emerging contaminants through the parallel coupling of rapid adsorption and photocatalytic degradation: A case study of fluoroquinolones.

Chemosphere 2021 May 5;280:130770. Epub 2021 May 5.

School of Chemistry, MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou, 510006, PR China. Electronic address:

The development of efficient, effective, and large-scale treatment methods to address high-risk emerging contaminants (ECs) is a growing challenge in environmental remediation. Herein, a novel parallel coupling strategy of adsorption separation and photodegradation regeneration (parallel ASPR) is proposed; subsequently, an adsorptive photocatalyst (Zn-doped BiOI) is designed to demonstrate how to effectively eliminate fluoroquinolones (FQs) from water with the proposed ASPR scheme. Compared with pure BiOI, the addition of Zn during synthesis has a significant influence on the morphology and structure of the products, resulting in Zn-doped BiOI samples with up to 5 times the specific surface area, 32 times the adsorption capacity, and 20 times the photocurrent intensity. Read More

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Static and dynamic culture of human endothelial cells encapsulated inside alginate-gelatin microspheres.

Microvasc Res 2021 May 8;137:104174. Epub 2021 May 8.

Maragheh University of Medical Sciences, Maragheh, Iran.

This study aimed to explore the angiogenesis potential of human endothelial cells encapsulated inside alginate-gelatin microspheres under static and dynamic culture systems after 7 days. Human umbilical vein endothelial cells were encapsulated inside alginate (1%) and gelatin (1.2%) using an electrostatic encapsulation method. Read More

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Nur77 Attenuates Inflammasome Activation by Inhibiting Caspase-1 Expression in Pulmonary Vascular Endothelial Cells.

Am J Respir Cell Mol Biol 2021 May 10. Epub 2021 May 10.

Thomas Jefferson University, 6559, Philadelphia, Pennsylvania, United States;

Inflammasomes are intracellular multiprotein complexes that help trigger and maintain the inflammatory response as part of the innate immune system. Recently, it has been increasingly recognized that aberrant inflammasome activation is critically involved endothelial dysfunction in a variety of human diseases, such as atherosclerosis, acute lung injury (ALI), and type 2 diabetes. The molecular mechanisms underlying endothelial inflammasome activation, however, are not completely elucidated. Read More

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Role of TRPV4 Channel in Vasodilation and Neovascularization.

Miao Chen Xiucun Li

Microcirculation 2021 May 10:e12703. Epub 2021 May 10.

Department of Hand and Foot Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, No.247, Beiyuan Street, Jinan, Shandong Province, 250031, China.

The transient receptor potential vallinoid type 4 (TRPV4) channel, a Ca -permeable nonselective cation channel, is widely distributed in the circulatory system, particularly in vascular endothelial cells (ECs) and smooth muscle cells (SMCs). The TRPV4 channel is activated by various endogenous and exogenous stimuli, including shear stress, low intravascular pressure, and arachidonic acid. TRPV4 has a role in mediating vascular tone and arterial blood pressure. Read More

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'This won't hurt a bit!' - A descriptive review of health care professionals' pharmacological management of pain in minor trauma.

S Afr Fam Pract (2004) 2021 Apr 22;63(1):e1-e8. Epub 2021 Apr 22.

Division of Emergency Medicine, Nelson Rolihlahla Mandela School of Medicine, University of KwaZulu-Natal, Durban.

Background: Emergency Centres (ECs) have a prominent trauma burden requiring effective pain management. This study aimed to review analgesia-prescribing habits in minor trauma, reviewing the patient demographics and diagnoses, analgesia-prescribing habits of health care professionals (HCPs) managing these cases, and differences in prescribing noted by patients' age group, gender and triage code.

Methods: A prospective, cross-sectional, descriptive study was conducted in a regional EC in KwaZulu-Natal. Read More

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Myofibroblast-Derived Exosome Induce Cardiac Endothelial Cell Dysfunction.

Front Cardiovasc Med 2021 23;8:676267. Epub 2021 Apr 23.

Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.

Endothelial cells (ECs) play a critical role in the maintenance of vascular homeostasis and in heart function. It was shown that activated fibroblast-derived exosomes impair cardiomyocyte function in hypertrophic heart, but their effect on ECs is not yet clear. Thus, we hypothesized that activated cardiac fibroblast-derived exosomes (FB-Exo) mediate EC dysfunction, and therefore modulation of FB-exosomal contents may improve endothelial function. Read More

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Multi-omics analyses on the response mechanisms of 'Shine Muscat' grapevine to low degree of excess copper stress (Low-ECS).

Environ Pollut 2021 Apr 30;286:117278. Epub 2021 Apr 30.

Department of Horticulture, Nanjing Agricultural University, Nanjing, Jiangsu Province, 210095, China; Fruit Crop Genetic Improvement and Seedling Propagation Engineering Center of Jiangsu Province, Nanjing, 210095, China.

Copper stress is one of the most severe heavy metal stresses in plants. Grapevine has a relatively higher copper tolerance than other fruit crops. However, there are no reports regarding the tolerance mechanisms of the 'Shine Muscat' ('SM') grape to a low degree of excess copper stress (Low-ECS). Read More

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Acute effects of graduated and progressive compression stockings on leg vein cross-sectional area and viscoelasticity in patients with chronic venous disease.

J Vasc Surg Venous Lymphat Disord 2021 May 5. Epub 2021 May 5.

Vascular Medicine, Montpellier University Hospital, France; EA2992, Montpellier University, France.

Objective: To determine the effects of graduated and progressive elastic compression stockings (ECS) on postural diameter changes and viscoelasticity of leg veins in healthy controls and in limbs with chronic venous disease (CVD).

Methods: In 57 patients whose legs presented with C, C, or C CEAP classes of CVD and treated primarily with compression, and 54 healthy controls matched for age and body mass index, we recorded interface pressures at 9 reference leg levels. Cross-sectional areas of the small saphenous vein (SSV) and a deep calf vein (DCV) were measured with B-mode ultrasound with subjects supine and standing, recording the force (PF) applied on the ultrasound probe to collapse each vein with progressive ECS, and with and without graduated 15‒20 mmHg and 20‒36 mmHg elastic stockings. Read More

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Heated tobacco product use and its relationship to quitting combustible cigarettes in Korean adults.

PLoS One 2021 7;16(5):e0251243. Epub 2021 May 7.

Department of Family Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Objective: We assessed the prevalence of, and factors associated with, heated tobacco product (HTP) use and analysed the association between HTP use and quitting combustible cigarettes (CCs) in Korean adults.

Methods: We conducted an online survey with 7,000 adults (males, 2,300; females, 4,700; ages 20-69) out of 70,000 age-, sex- and provincial-distribution-matched individuals based on 2018 national population statistics. Females were oversampled because the prevalence of tobacco product use is very low among women in Korea. Read More

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Mechanoresponsive Smad5 Enhances MiR-487a Processing to Promote Vascular Endothelial Proliferation in Response to Disturbed Flow.

Front Cell Dev Biol 2021 20;9:647714. Epub 2021 Apr 20.

Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan.

MicroRNAs (miRs) and bone morphogenetic protein receptor-specific Smads are mechano-responsive molecules that play vital roles in modulating endothelial cell (EC) functions in response to blood flow. However, the roles of interplay between these molecules in modulating EC functions under flows remain unclear. We elucidated the regulatory roles of the interplay between miR-487a and Smad5 in EC proliferation in response to different flow patterns. Read More

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Exosomal Transfer of miR-185 Is Controlled by hnRNPA2B1 and Impairs Re-endothelialization After Vascular Injury.

Front Cell Dev Biol 2021 20;9:619444. Epub 2021 Apr 20.

Department of Vascular Surgery, Zhongshan Hospital Fudan University, Shanghai, China.

Dysfunction of endothelial cells (ECs) contributes to restenosis after vascular reconstruction for patients with coronary artery disease (CAD). The intercellular communication between ECs and vascular smooth muscle cells (VSMCs) might be critical in the development of restenosis and can be mediated by exosomes carrying functional microRNAs. miR-185 is reported to be associated with atherosclerosis, whether it plays a similar role in restenosis is unknown. Read More

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Released Myeloperoxidase Attenuates Neutrophil Migration and Accumulation in Inflamed Tissue.

Front Immunol 2021 20;12:654259. Epub 2021 Apr 20.

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

Neutrophil (PMN) recruitment to sites of insult is critical for host defense, however excessive PMN activity and tissue accumulation can lead to exacerbated inflammation and injury. Myeloperoxidase (MPO) is a PMN azurophilic granule enzyme, which together with HO, forms a powerful antimicrobial system designed to kill ingested bacteria. Intriguingly, in addition to intracellular killing of invading microorganisms and extracellular tissue damage due generation of ROS, soluble MPO has been directly implicated in modulating cellular responses and tissue homeostasis. Read More

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Cnr2 Is Important for Ribbon Synapse Maturation and Function in Hair Cells and Photoreceptors.

Front Mol Neurosci 2021 20;14:624265. Epub 2021 Apr 20.

Department of Anatomy and Neurobiology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico.

The role of the cannabinoid receptor 2 (CNR2) is still poorly described in sensory epithelia. We found strong expression in hair cells (HCs) of the inner ear and the lateral line (LL), a superficial sensory structure in fish. Next, we demonstrated that sensory synapses in HCs were severely perturbed in larvae lacking cnr2. Read More

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Cannabis alters epigenetic integrity and endocannabinoid signalling in the human follicular niche.

Hum Reprod 2021 May 5. Epub 2021 May 5.

CReATe Fertility Centre, Toronto, ON, Canada.

Study Question: Do phytocannabinoids (PCs) affect follicular endocannabinoid signalling and the epigenome in the surrounding granulosa cells (GCs)?

Summary Answer: Exposure to PCs increases the expression of endocannabinoid receptors and reduces DNA methylation enzyme expression and global DNA methylation in naïve GCs.

What Is Known Already: Cannabis plant derivatives, known as PCs, are used for medicinal and recreational purposes. The main PC, tetrahydrocannabinol (THC), is the third most commonly used substance by women of childbearing age, hence knowledge of the effect it has on reproduction is of utmost importance. Read More

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Polymer-Modified Carbon Fiber Microelectrodes for Neurochemical Detection of Dopamine and Metabolites.

ECS Trans 2020 May;97(7):901-927

Department of Chemistry, Center for Behavioral Neuroscience, American University, Washington, District of Columbia 20016, USA.

Carbon-fiber microelectrodes (CFMEs) are considered to be the standard electrodes for neurotransmitter detection. Fast-scan cyclic voltammetry (FSCV), an electro analytical method, has the ability to follow neurochemical dynamics in real time using CFMEs. Improvements in neurochemical detection with CFMEs were previously made through the coating of polymers onto the surface of the carbon-fiber. Read More

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Lung Marginated and Splenic Murine Resident Neutrophils Constitute Pioneers in Tissue-Defense During Systemic Challenge.

Front Immunol 2021 19;12:597595. Epub 2021 Apr 19.

National Heart and Lung Institute (NHLI), Imperial College London, London, United Kingdom.

The rapid response of neutrophils throughout the body to a systemic challenge is a critical first step in resolution of bacterial infection such as (). Here we delineated the dynamics of this response, revealing novel insights into the molecular mechanisms using lung and spleen intravital microscopy and 3D culture of living precision cut splenic slices in combination with fluorescent labelling of endogenous leukocytes. Within seconds after challenge, intravascular marginated neutrophils and lung endothelial cells (ECs) work cooperatively to capture pathogens. Read More

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Diagnostic Role of PET/CT Tracers in the Detection and Localization of Tumours Responsible for Ectopic Cushing's Syndrome.

Anticancer Res 2021 May;41(5):2477-2484

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.

Background/aim: Positron emission tomography/computed tomography (PET/CT) plays an important role in cancer localization in ectopic Cushing's syndrome (ECS). However, the choice of the optimal tracer for investigation of this disease is still unclear. We aimed to evaluate the diagnostic feasibility of [F]fluoro-2-deoxyglucose ([F]FDG), [F]fluoro-L-dihydroxyphenylalanine ([F] FDOPA), and [Ga]-DOTA-1-Nal3-octreotide ([Ga]-DOTANOC) in ECS. Read More

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Tumor necrosis factor-induced ArhGEF10 selectively activates RhoB contributing to human microvascular endothelial cell tight junction disruption.

FASEB J 2021 Jun;35(6):e21627

Department of Pediatrics, Yale School of Medicine, Yale University, New Haven, CT, USA.

Capillary endothelial cells (ECs) maintain a semi-permeable barrier between the blood and tissue by forming inter-EC tight junctions (TJs), regulating selective transport of fluid and solutes. Overwhelming inflammation, as occurs in sepsis, disrupts these TJs, leading to leakage of fluid, proteins, and small molecules into the tissues. Mechanistically, disruption of capillary barrier function is mediated by small Rho-GTPases, such as RhoA, -B, and -C, which are activated by guanine nucleotide exchange factors (GEFs) and disrupted by GTPase-activating factors (GAPs). Read More

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Peroxidase Enzyme Fractions as Markers of Somatic Embryogenesis Capacities in Olive ( L.).

Plants (Basel) 2021 Apr 29;10(5). Epub 2021 Apr 29.

Laboratoire d'Agroalimentaire, Biotechnologies et Valorisation des Bio-Ressources Végétales, Faculté des Sciences Semlalia, Université Cadi Ayyad, BP 2390, Marrakech 40000, Morocco.

As part of the search for biochemical markers of somatic embryogenesis in tissue cultures of olive ( L.), peroxidases (POXs) in both the soluble and ionically wall-bound fractions were studied in two reputed olive cultivars (cvs.): "Picholine Marocaine" and "Dahbia". Read More

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Sustained oxidative stress instigates differentiation of cancer stem cells into tumor endothelial cells: Pentose phosphate pathway, reactive oxygen species and autophagy crosstalk.

Biomed Pharmacother 2021 May 1;139:111643. Epub 2021 May 1.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Molecular Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Tumor angiogenesis plays a vital role in tumor growth and metastasis. It is proven that in tumor vasculature, endothelial cells (ECs) originate from a small population of cancer cells introduced as cancer stem cells (CSCs). Autophagy has a vital role in ECs differentiation from CSCs and tumor angiogenesis. Read More

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miR-25-5p regulates endothelial progenitor cell differentiation in response to shear stress through targeting ABCA1.

Cell Biol Int 2021 May 4. Epub 2021 May 4.

Department of Neurosurgery, Changhai Hospital of Shanghai affiliated to Naval Military Medical University, Shanghai, 200433, China.

The importance of flow shear stress (SS) on the differentiation of endothelial progenitor cells (EPCs) has been demonstrated in various studies. Cholesterol retention and miRNA regulation have been also proposed as relevant factors involved in this process, though evidence regarding their regulatory roles in the differentiation of EPCs is currently lacking. In the present study on high shear stress (HSS)-induced differentiation of EPCs, we investigated the importance of ABCA1, an important regulator in cholesterol efflux, and miR-25-5p, a potential regulator of endothelial reconstruction. Read More

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