J Am Acad Orthop Surg Glob Res Rev 2020 05;4(5):e1900155
From the IGEA, Clinical Biophysics, Carpi, Italy (Dr. Cadossi), the Department of Biomedical and Specialty Surgical Sciences, Azienda Ospedaliero-Universitaria di Ferrara, Arcispedale Sant'Anna, University of Ferrara, Ferrara, Italy (Dr. Massari), and the Department of Orthopaedics, Warren Alpert Medical School, Brown University, Providence, RI (Ms. Racine-Avila and Dr. Aaron).
The US FDA has approved pulsed electromagnetic fields (PEMFs) as a safe and effective treatment for nonunions of bone. Despite its clinical use, the mechanisms of action of electromagnetic stimulation of the skeleton have been elusive. Recently, cell membrane receptors have been identified as the site of action of PEMF and provide a mechanistic rationale for clinical use. Read More