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Severity of Aortic Stenosis: A Moving Target.

Authors:
Jae K Oh Saki Ito

J Am Coll Cardiol 2022 Aug;80(7):677-680

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.

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Incidence and clinical impact of tachyarrhythmic events following transcatheter aortic valve replacement: A review.

Heart Rhythm 2022 Aug 8. Epub 2022 Aug 8.

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada. Electronic address:

Transcatheter aortic valve replacement (TAVR) is well-established for treating severe symptomatic aortic stenosis. Whereas broad information exists about the epidemiology, clinical implications and management of bradyarrhythmias after TAVR, data about tachyarrhythmic events remains scarce. Despite the progressively lower risk profile of TAVR patients and the improvement in device characteristics and operators' skills, approximately 10% of patients develop new-onset atrial fibrillation (NOAF) after TAVR. Read More

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Optimizing atrial sensing parameters in leadless pacemakers: atrioventricular synchrony achievement in real world.

Heart Rhythm 2022 Aug 8. Epub 2022 Aug 8.

Cardiology Department. Infanta Leonor Hospital. Gran Vía del Este, 28030, Madrid, Spain; Complutense University, Av. Séneca, 2, 28040, Madrid, Spain.

Background: Performance of the leadless pacemaker capable of atrioventricular (AV) synchronous pacing on de novo patients warrants further investigation.

Objective: To assess what programming changes are needed to achieve proper atrial tracking and to study the percentage of AV synchrony (AVS) the device can provide under real-world conditions.

Methods: Consecutive patients undergoing Micra AV implant between June 2020 and November 2021 were studied. Read More

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Incidence of persistent left bundle branch block after rapid-deployment aortic valve replacement.

Ann Thorac Surg 2022 Aug 8. Epub 2022 Aug 8.

Department of Cardiac Surgery, La Timone Hospital, Marseille, France. Electronic address:

Background: We aimed to evaluate the incidence, prognosis and predictive factors of new onset of persistent left bundle branch block(NOP-LBBB) after rapid-deployment aortic valve replacement(RD-AVR).

Methods: This study was an observational, retrospective, single-center study of 274 consecutive patients with no baseline ventricular conduction disorder and no previous permanent pacemaker implantation(PPI) who underwent RD-AVR with an INTUITY valve(n=55) and INTUITY Elite Valve(n=219). Twelve-lead electrocardiography and transthoracic echocardiography were performed preoperatively, upon discharge, at 1-month and 1-year intervals. Read More

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A case of primary mediastinal seminoma with superior vena cava syndrome and large intracardiac thrombus.

Int J Surg Case Rep 2022 Aug 3;97:107478. Epub 2022 Aug 3.

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Electronic address:

Background: Primary mediastinal seminoma is rare, especially with complications of superior vena cava syndrome (VCSS) and large thrombus.

Case Presentation: A 23-years-old Indonesian male complained of dyspnea, phlegm cough, chest pain, and body weight loss. The patient experienced swelling in the face and neck 1 week ago, accompanied by increased jugular venous pressure. Read More

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Mobile health vs. standard care after cardiac surgery: results of The Box 2.0 study.

Europace 2022 Aug 11. Epub 2022 Aug 11.

Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

Aims: Postoperative atrial fibrillation (POAF) is a common complication of cardiac surgery, yet difficult to detect in ambulatory patients. The primary aim of this study is to investigate the effect of a mobile health (mHealth) intervention on POAF detection after cardiac surgery.

Methods And Results: We performed an observational cohort study among 730 adult patients who underwent cardiac surgery at a tertiary care hospital in The Netherlands. Read More

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Association between the reflection magnitude and blood pressure in a multiethnic cohort: the Healthy Life in an Urban Setting study.

J Hypertens 2022 Aug 9. Epub 2022 Aug 9.

Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam.

Aims: Reflection magnitude (RM), the ratio of the amplitudes of the backward and forward central arterial pressure waves, has been shown to predict cardiovascular events. However, the association with blood pressure (BP) and hypertension is unclear.

Methods: We assessed RM in 10 195 individuals of Dutch, South-Asian Surinamese, African Surinamese, Ghanaian, Turkish and Moroccan origin aged between 18 and 70 years (54. Read More

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Subclinical Arrhythmias and Conduction Disturbances in Children with Myopericarditis: A 24-hour Holter Monitorization Study.

Eurasian J Med 2022 Aug 11. Epub 2022 Aug 11.

Division of Pediatric Cardiology, Department of Pediatrics, Atatürk University Faculty of Medicine, Erzurum, Turkey.

Objective: Myopericarditis is reported as a benign clinical entity in children and adolescents. However, there is no study investigating specifically the arrhythmias in these children. In the present study, we aimed to investigate the frequency of arrhythmias and conduction disturbances from surface electrocardiography and 24-hour Holter monitor, in children with myopericarditis. Read More

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Common Supraventricular and Ventricular Arrhythmias in Children.

Turk Arch Pediatr 2022 Aug 11. Epub 2022 Aug 11.

Department of Pediatric Cardiology, Pediatric Cardiac Electrophysiologist, University of Health Sciences, İstanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul, Turkey.

The most common pediatric arrhythmias are tachycardias, and the most common type is supraventricular tachycardia, originating from or above the atrioventricular node and HIS bundle. Ventricular tachycardias are less common but more dangerous. Supraventricular tachycardias usually cause a narrow complex tachycardia unless there is a basal bundle branch block or rate-dependent aberration. Read More

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Spatial uniformity of action potentials indicates base-to-apex depolarization and repolarization of rainbow trout (Oncorhynchus mykiss) ventricle.

J Exp Biol 2022 Aug 11. Epub 2022 Aug 11.

University of Eastern Finland, Department of Environmental and Biological Sciences, P.O. Box 111, 80101 Joensuu, Finland.

The spatial pattern of electrical activation is crucial for a full understanding of fish heart function. However, it remains unclear whether there is regional variation in action potential (AP) morphologies and underlying ion currents. Because the direction of depolarization and spatial differences in the durations of ventricular APs set limits to potential patterns of ventricular repolarization, we determined AP morphologies, underlying ion currents, and ion channel expression in 4 different regions (spongy myocardium; and apex, base, and middle of the compact myocardium), and correlated them with in vivo electrocardiogram (ECG) in rainbow trout (Oncorhynchus mykiss). Read More

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Reverse Takotsubo Cardiomyopathy after Orthotopic Liver Transplantation. A Case Report.

J Crit Care Med (Targu Mures) 2022 Apr 12;8(2):117-122. Epub 2022 May 12.

Department of Anesthesiology and Intensive Care I, Fundeni Clinical Institute, Bucharest, Romania.

Introduction: Takotsubo cardiomyopathy is a rare reversible type of heart failure, often precipitated by emotional stress; other risk factors include intracranial bleeding, ischemic stroke, sepsis, major surgery, pheochromocytoma. The clinical, electrical and blood sample analysis features resemble those of a myocardial infarction- however, they occur in the absence of angiographic coronary filling defects.

Case Presentation: A 61-year-old male patient, 71 kg, 175 cm, underwent liver transplantation for Child-Pugh B cirrhosis secondary to mixed viral hepatitis (B and D). Read More

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Atrial Flutter Masquerading as an ST-segment-elevation Myocardial Infarction in a Patient with Dextrocardia.

J Innov Card Rhythm Manag 2022 Jul 15;13(7):5083-5086. Epub 2022 Jul 15.

Department of Electrophysiology, Ascension Sacred Heart, Pensacola, FL, USA.

Electrocardiogram (ECG) findings suggestive of an ST-segment-elevation myocardial infarction (STEMI) often lead to emergent left heart catheterization. Occasionally, non-coronary conditions mimic ECG findings of STEMI, resulting in an increased risk and expenses from emergent transportation and procedures. In this report, we describe diagnostic and management strategies for a case of 1:1 atrial flutter in a patient with dextrocardia presenting as a STEMI. Read More

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Open-chest Pulsed Electric Field Ablation of Cardiac Ganglionated Plexi in Acute Canine Models.

J Innov Card Rhythm Manag 2022 Jul 15;13(7):5061-5069. Epub 2022 Jul 15.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

This study aimed to evaluate the safety and acute effect on markers of cardiac autonomic tone following pulsed electric fields (PEFs) delivered to epicardial ganglionated plexi (GP) during a cardiac surgical procedure. Ablation of GP as a treatment for atrial fibrillation (AF) has shown promise, but thermal ablation energy sources are limited by the risk of inadvertent collateral tissue injury. In acute canine experiments, median sternotomy was performed to facilitate the identification of 5 epicardial GP regions using an anatomy-guided approach. Read More

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Exacerbation of heart failure due to total pacemaker extrusion.

J Cardiol Cases 2022 Aug 28;26(2):144-147. Epub 2022 Apr 28.

Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan.

Total extrusion of a pacemaker is rare and may result from skin and/or pocket infection or skin erosion because of fragility caused by actions such as scratching an itch. Total extrusion of a pacemaker may cause fatal arrhythmias, exacerbation of heart failure, and infection. We report the case of a 37-year-old man with a pacemaker implanted for complete atrioventricular block who presented with exacerbation of advanced heart failure due to complete extrusion of the pacemaker from the left groin and pacing failure. Read More

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Atresia of the right coronary arterial ostium with a left ventricular fistula: A case report.

J Cardiol Cases 2022 Aug 7;26(2):88-91. Epub 2022 Apr 7.

Department of Pediatric Cardiology, Aichi Children's Health and Medical Center, Aichi, Japan.

We describe the case of a young patient with atresia of the right coronary arterial ostium with left ventricular fistula. This was suspected from the abnormality detected on a 12‑lead electrocardiogram (ECG) during a school examination at the time of admission to junior high school and echocardiography findings. This disease may occur due to abnormalities in several molecules that are essential for coronary artery development. Read More

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Prevalence and determinants of silent myocardial ischemia in patients with type 2 diabetes in Cameroon: a cross-sectional study.

Pan Afr Med J 2022 16;42:41. Epub 2022 May 16.

Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Introduction: diabetes mellitus is a major health problem worldwide. It is associated with high cardiovascular morbi-mortality especially coronary artery disease. Myocardial ischemia is often asymptomatic (silent myocardial ischemia) in people with type 2 diabetes mellitus thus making early diagnosis difficult. Read More

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An inline deep learning based free-breathing ECG-free cine for exercise cardiovascular magnetic resonance.

J Cardiovasc Magn Reson 2022 Aug 11;24(1):47. Epub 2022 Aug 11.

Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave., Boston, MA, 02215, USA.

Background: Exercise cardiovascular magnetic resonance (Ex-CMR) is a promising stress imaging test for coronary artery disease (CAD). However, Ex-CMR requires accelerated imaging techniques that result in significant aliasing artifacts. Our goal was to develop and evaluate a free-breathing and electrocardiogram (ECG)-free real-time cine with deep learning (DL)-based radial acceleration for Ex-CMR. Read More

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The effect of progesterone length in timed AI in ewes.

Trop Anim Health Prod 2022 Aug 11;54(5):258. Epub 2022 Aug 11.

Faculdade de Ciências Agrárias, Universidade Federal do Amazonas, Manaus, AM, 69067-005, Brasil.

This study aimed to evaluate the reproductive performance of ewes submitted to timed AI protocol with 7 (D7) or 9 (D9) days of progesterone. A total of 220 crossbred ewes (Doper × Santa Ines) were distributed in the treatments according to body weight (52.67 ± 11. Read More

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Novel insights into the substrate involved in maintenance of ventricular fibrillation: results from continuous multipolar mapping in a canine model.

J Interv Card Electrophysiol 2022 Aug 10. Epub 2022 Aug 10.

Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Background: While the triggers for ventricular fibrillation (VF) are well-known, the substrate required for its maintenance remains elusive. We have previously demonstrated dynamic spatiotemporal changes across VF from electrical induction of VF to asystole. Those data suggested that VF drivers seemed to reside in the distal RV and LV. Read More

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Prolonged QT interval in athletes: Distinguishing between pathology and physiology.

Cardiology 2022 Aug 10. Epub 2022 Aug 10.

Background: The physiological QT prolongation in athletes is expected to widen the grey zone between physiology and pathology of QT, increasing the diagnostic challenges encountered in athletes with QT prolongation.

Summary: According to International recommendations for electrocardiogram (ECG) in athletes, further evaluation for long QT syndrome (LQTS) is indicated in male athletes with corrected QTc≥470 ms and in female athletes with QTc≥480 ms. Apart from corrected QT (QTc)≥500 ms, diagnostic challenges arise in borderline cases of QTc prolongation, where further clinical investigations are needed to be performed to clarify whether LQTS exists. Read More

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Short-term acute constipation and not short-term acute diarrhea altered cardiovascular variables in male Wistar rats.

Niger J Physiol Sci 2022 Jun 30;37(1):43-48. Epub 2022 Jun 30.

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Gastrointestinal dysmotility is a substantial public health challenge globally. Based on previous findings in developed countries, it has been observed that there is an association between diarrhea, constipation, and some cardiovascular variables. This study investigated the effects of experimentally-induced short-term acute constipation and short-term acute diarrhea on certain cardiovascular variables in rats. Read More

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Use of Electrocardiogram Monitoring in Adult Patients Taking High-Risk QT Interval Prolonging Medicines in Clinical Practice: Systematic Review and Meta-analysis.

Drug Saf 2022 Aug 10. Epub 2022 Aug 10.

Clinical and Health Sciences, University of South Australia, Adelaide, Australia.

Introduction: Electrocardiogram (ECG) monitoring is an important tool to detect and mitigate the risk of potentially fatal drug-induced QT prolongation and remains fundamental in supporting the quality use of high-risk QT interval prolonging medicines.

Objective: The aim of this systematic review was to determine the prevalence of baseline and/or follow-up ECG use in adult patients taking high-risk QT interval prolonging medicines in clinical practice.

Methods: CINAHL, Cochrane Library, Embase, PubMed, EThOS, OpenGrey and Proquest were searched for studies in adults that reported ECG use at baseline and/or at follow-up in relation to the initiation of a high-risk QT interval prolonging medicine in any clinical setting; either hospital or non-hospital. Read More

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Simple electrocardiography algorithm for localizing accessory pathway in patients with Wolff-Parkinson-White syndrome.

Acta Cardiol 2022 Aug 10:1-5. Epub 2022 Aug 10.

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.

Background: Existing algorithms to predict the location of an accessory pathway (AP) in Wolff-Parkinson-White Syndrome (WPW) have good sensitivity and specificity but complex with various accuracy and inter-observer agreement rates. A simple algorithm with high accuracy and inter-observer agreement rates is needed.

Methods: This was a cross-sectional and retrospective diagnostic study. Read More

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At-home ECG monitoring with a real-time outpatient cardiac telemetry system during the COVID-19 pandemic.

J Osteopath Med 2022 Aug 10. Epub 2022 Aug 10.

Department of Clinical Specialties, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA.

Context: During the COVID-19 pandemic, essential in-person electrocardiogram (ECG) recordings became unfeasible, while patients continued to suffer from cardiac conditions. To circumvent these challenges, the cardiology clinic (Long Island Heart Rhythm Center [LIHRC]) at the New York Institute of Technology College of Osteopathic Medicine (NYITCOM) transitioned to a remote real-time outpatient cardiac telemetry (ROCT) service.

Objectives: The goal of this study is to test the hypothesis that at-home ROCT, provided by the LIHRC, is an effective method of providing ECG monitoring to symptomatic patients during the COVID-19 pandemic. Read More

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Prognostic Value of T-wave Positivity in Lead aVR in COVID-19 Pneumonia.

Rev Assoc Med Bras (1992) 2022 Jul;68(7):882-887

Dörtyol State Hospıtal - Hatay, Turkey.

Objective: T-wave positivity in the lead aVR is a marker of ventricular repolarization abnormality and provides information on short- and long-term cardiovascular mortality in heart failure patients, those with anterior myocardial infarction, and patients who underwent hemodialysis for various reasons. The aim of this study was to investigate the relationship between T-wave positivity in the lead aVR on superficial electrocardiogram and mortality from COVID-19 pneumonia.

Methods: This study retrospectively included 130 patients who were diagnosed with COVID-19 and treated as an outpatient or in the thoracic diseases ward in a single center between January 2021 and June 2021. Read More

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Risk of Dementia Associated With Atrial Cardiopathy: The ARIC Study.

J Am Heart Assoc 2022 Aug 10:e025646. Epub 2022 Aug 10.

Cardiovascular Division, Department of Medicine University of Minnesota Medical School Minneapolis MN.

Background The contribution of atrial cardiopathy to dementia risk is uncharacterized. We aimed to evaluate the association of atrial cardiopathy with incident dementia and potential mediation by atrial fibrillation (AF) and stroke. Methods and Results We conducted a prospective cohort analysis of participants in the ARIC (Atherosclerosis Risk in Communities) study attending visit 5 (2011-2013). Read More

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Electric catfish hearts are not intrinsically immune to electric shocks.

J Exp Biol 2022 Aug 10;225(15). Epub 2022 Aug 10.

Department of Animal Physiology, University of Bayreuth, Universitätsstrasse 30, 95447 Bayreuth, Germany.

High voltage electric shocks cause life threatening cardiac injuries such as sudden cardiac standstill or severe myocardial injury. Here, we analysed the physiology of the heart of the strongly electric catfish (Malapterurus beninensis) that stuns prey with high-voltage shocks but is immune to its own, as well as external, high-voltage shocks. Neither a detailed analysis of the electrocardiogram nor the structure of the heart indicated a specialized cardiac conduction system. Read More

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Effect of Intravenous Calcium Gluconate on Prevention of Post Spinal Hypotension during Spinal Anaesthesia for Caesarean Section: A Randomized Double-Blind Controlled Study.

J Nepal Health Res Counc 2022 Jun 2;20(1):89-95. Epub 2022 Jun 2.

UCMS and associated GTB Hospital, Shahdara, Delhi, India.

Background: Calcium, a physiological ion, causes vasoconstriction and has a positive ionotropic action on heart. Its use to prevent post-spinal hypotension has been suggested but never formally evaluated for patients undergoing caesarean section. This study investigated the hemodynamic effects of calcium administration in parturients with the primary aim of comparing the incidence of post-spinal hypotension. Read More

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Surface ECG-based complexity parameters for predicting outcomes of catheter ablation for nonparoxysmal atrial fibrillation: efficacy of fibrillatory wave amplitude.

Medicine (Baltimore) 2022 Aug;101(31):e29949

Yeungnam University College of Medicine, Daegu, Korea.

Catheter ablation (CA) is a well-established therapy for rhythm control in atrial fibrillation (AF). However, CA outcomes for persistent AF remain unsatisfactory because of the high recurrence rate despite time-consuming efforts and the latest ablation technology. Therefore, the selection of good responders to CA is necessary. Read More

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