47 results match your criteria ecc dcc


Comparison of Three Different Cord Clamping Techniques Regarding Oxidative-antioxidative Capacity in Term Newborns.

Am J Perinatol 2022 Jan 13. Epub 2022 Jan 13.

Biochemistry, Gaziantep University, Gaziantep, Turkey.

Objective As newborns are exposed to oxidative stress during delivery, cord clamping techniques play significant role on antioxidant status. In this study, we aimed to show the relationship between early cord clamping (ECC), delayed cord clamping (DCC) and cut umblical cord milking (C-UCM) techniques with total oxidant capacity (TOC), total antioxidant capacity (TAC) and peroxynitrite levels. Study Design Sixty-nine term infants were selected with APGAR score of 7 and above in the first and fifth minutes. Read More

View Article and Full-Text PDF
January 2022

Impact of Deferred Cord Clamping on Mortality and Severe Neurologic Injury in Twins Born at <30 Weeks of Gestation.

J Pediatr 2021 Nov 30;238:118-123.e3. Epub 2021 Jul 30.

Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada; Division of Maternal Fetal Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Department of Radiology, McMaster University, Hamilton, Ontario, Canada.

Objective: To determine whether deferred cord clamping (DCC) compared with early cord clamping (ECC) was associated with reduction in death and/or severe neurologic injury among twins born at <30 weeks of gestation.

Study Design: We performed a retrospective cohort study including all liveborn twins of <30 weeks admitted to a tertiary-level neonatal intensive care unit (NICU) in Canada between 2015 and 2018 using the Canadian Neonatal/Preterm Birth Network database. We compared DCC ≥30 seconds vs ECC <30 seconds. Read More

View Article and Full-Text PDF
November 2021

Autophagy activity in cholangiocarcinoma is associated with anatomical localization of the tumor.

PLoS One 2021 15;16(6):e0253065. Epub 2021 Jun 15.

2nd Department of Pathology, Semmelweis University, Budapest, Hungary.

The presence of autophagy has been indicated in cholangiocarcinoma (CC), which disease has poor prognosis and limited treatment options. Recently, CC has been classified by anatomical localization as intrahepatic (iCC), perihilar (pCC) and distal (dCC), showing different clinical and molecular characteristics. Thus, our aim was to compare autophagy activity in CC samples resected from different anatomical locations. Read More

View Article and Full-Text PDF
November 2021

Timing of umbilical cord clamping among infants with congenital heart disease.

Prog Pediatr Cardiol 2020 Dec 28;59. Epub 2020 Oct 28.

Center for Perinatal Research, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH.

The optimal timing of clamping and cutting the umbilical cord at birth among infants with congenital heart disease (CHD) remains a subject of controversy and debate. The benefits of delayed umbilical cord clamping (DCC) among term infants without CHD are well described, but the evidence base for DCC among infants with CHD has not been characterized adequately. The goals of the present review are to: 1) compare outcomes of DCC versus early cord clamping (ECC) in term (≥37 weeks of gestation) infants; 2) discuss potential risk/benefit profiles in applying DCC among term infants with CHD; 3) use rigorous systematic review methodology to assess the quality and quantity of published reports on cord clamping practices among term infants with CHD; 4) identify needs and opportunities for future research and interdisciplinary collaboration. Read More

View Article and Full-Text PDF
December 2020

Sustained Inflation Reduces Pulmonary Blood Flow during Resuscitation with an Intact Cord.

Children (Basel) 2021 Apr 29;8(5). Epub 2021 Apr 29.

Department of Pediatrics, University of California at Davis, Davis, CA 95616, USA.

The optimal timing of cord clamping in asphyxia is not known. Our aims were to determine the effect of ventilation (sustained inflation-SI vs. positive pressure ventilation-V) with early (ECC) or delayed cord clamping (DCC) in asphyxiated near-term lambs. Read More

View Article and Full-Text PDF

Does Delayed Cord Clamping Improve Long-Term (≥4 Months) Neurodevelopment in Term Babies? A Systematic Review and a Meta-Analysis of Randomized Clinical Trials.

Front Pediatr 2021 12;9:651410. Epub 2021 Apr 12.

Clinic of Obstetrics and Gynecology, University Hospital of Udine, Udine, Italy.

Recently, the literature suggested that placental transfusion facilitated by delayed cord clamping (DCC), besides having benefits on hematological parameters, might improve the infants' brain development. The present review primarily evaluates the Ages and Stages Questionnaire (ASQ) total score mean difference (MD) at long-term follow-up (≥4 months) comparing DCC (>90 or >180 s) to early cord clamping (ECC). Secondary aims consisted of evaluating the ASQ domains' MD and the results obtained from other methods adopted to evaluate the infants' neurodevelopment. Read More

View Article and Full-Text PDF

Umbilical Cord Management at Term and Late Preterm Birth: A Meta-analysis.

Pediatrics 2021 03;147(3)

Department of Pediatrics, The Robert Larner College of Medicine, The University of Vermont, Burlington, Vermont.

Context: The International Liaison Committee on Resuscitation prioritized scientific review of umbilical cord management at term and late preterm birth.

Objective: To assess effects of umbilical cord management strategies (clamping timing and cord milking) in infants ≥34 weeks' gestational age.

Data Sources: Cochrane Central Register of Controlled Trials, Medline, PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, and trial registries searched July 2019. Read More

View Article and Full-Text PDF

Effect of delayed cord clamping on jaundice and hypoglycemia in the neonates of mothers with gestational diabetes mellitus.

Int J Gynaecol Obstet 2022 Jan 17;156(1):77-81. Epub 2021 Feb 17.

Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Objective: To study the effect of delayed cord clamping (DCC) on the bilirubin levels and hypoglycemia in neonates with diabetic mothers (NDMs).

Methods: This is a comparison between a prospective cohort and a historical control cohort. Women with gestational diabetes mellitus who performed DCC were enrolled into the prospective cohort (n = 156), and those who performed early cord clamping (ECC) were enrolled into the historical control cohort (n = 161). Read More

View Article and Full-Text PDF
January 2022

Effects of delayed cord clamping in intrauterine growth-restricted neonates: a randomized controlled trial.

Eur J Pediatr 2021 Jun 21;180(6):1701-1710. Epub 2021 Jan 21.

Department of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India.

The time of cord clamping in intrauterine growth-restricted (IUGR) neonates remains an area of uncertainty. This assessor-blinded randomized controlled trial compared the effects of delayed cord clamping (DCC) with early cord clamping (ECC) on the systemic blood flow (SBF) and cerebral hemodynamics in IUGR neonates of gestational age ≥28 weeks, not requiring resuscitation. Eligible newborns were randomized to DCC (cord clamping after 60 s; n=55) or ECC (cord clamping within 30 s; n=55) group immediately after delivery. Read More

View Article and Full-Text PDF

Effects of timing of umbilical cord clamping on preventing early infancy anemia in low-risk Japanese term infants with planned breastfeeding: a randomized controlled trial.

Matern Health Neonatol Perinatol 2021 Jan 19;7(1). Epub 2021 Jan 19.

Division of Epidemiology and Statistics, Graduate School of Nursing Science, St. Luke's International University, 10-1 Akashi-cho, Chuo-ku, Tokyo, 104-0044, Japan.

Background: Japanese infants have relatively higher risk of anemia and neonatal jaundice. This study aimed to assess the effects of delayed cord clamping (DCC) on the incidence of anemia during early infancy in low-risk Japanese term infants with planned exclusive breastfeeding for 4 months. This study also aimed to explore the effects of DCC on neonatal jaundice. Read More

View Article and Full-Text PDF
January 2021

Umbilical cord clamping and skin-to-skin contact in deliveries from women positive for SARS-CoV-2: a prospective observational study.

BJOG 2021 04 30;128(5):908-915. Epub 2020 Nov 30.

Obstetrics and Gynaecology Service, Hospital Universitario Puerta de Hierro, Majadahonda, Universidad Autónoma de Madrid, Madrid, Spain.

Objective: To demonstrate that delayed cord clamping (DCC) is safe in mothers with confirmed SARS-CoV-2 infection.

Design, Setting And Participants: Prospective observational study involving epidemiological information from 403 pregnant women with SARS-CoV-2 between 1 March and 31 May 2020. Data were collected from 70 centres that participate in the Spanish Registry of COVID-19. Read More

View Article and Full-Text PDF

The risk of hyperbilirubinemia in term neonates after placental transfusion - a randomized-blinded controlled trial.

Ginekol Pol 2020;91(10):613-619

Department of Neonatology and Intensive Care Unit, Faculty of Medicine, Medical University of Warsaw, Poland.

Objective: We aimed to demonstrate non-inferiority of delayed cord clamping (DCC) and cord milking (CM) in comparison to early cord clamping (ECC) in the incidence of hyperbilirubinemia requiring phototherapy.

Material And Methods: 467 of maternal-foetal dyads were screened for eligibility. 389 term infants, of breastfeeding, non-smoking mothers were randomized to receive ECC ( < 40 s), DCC (1-2 min) or CM (4 times towards the neonate). Read More

View Article and Full-Text PDF

Effect of Delayed Versus Early Cord Clamping on Improving Anemia in Term Infants Aged Two Months or Older - A Meta-analysis.

Indian Pediatr 2020 09;57(9):815-819

Department of Neonatology, The First Hospital of Jilin University, Changchun 130021, China. Correspondence to: Dr Hui Wu, Department of Neonatology, The First Hospital of Jilin University,NO.71 Xinmin Street, Changchun, China 130 021.

Objective: To assess the effects of delayed cord clamping (DCC) on hemoglobin (Hb), mean corpuscular volume (MCV) and ferritin level in infants 2 months or older.

Evidence Acquisition: Meta-analysis of randomized control trials searched systematically from PubMed, Cochrane and Web of science. Trials published from Jan 1,1975 to Mar 12, 2018, no language and country restrictions. Read More

View Article and Full-Text PDF
September 2020

A Comparison of Strategies for Managing the Umbilical Cord at Birth in Preterm Infants.

J Pediatr 2020 10 20;225:58-64.e4. Epub 2020 May 20.

Maternal-Infant Care (MiCare) Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Pediatrics, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.

Objective: To evaluate the rates of practice, and the associations between different cord management strategies at birth (delayed cord clamping [DCC], umbilical cord milking [UCM], and early cord clamping [ECC]) and mortality or major morbidity, rates of blood transfusion, and peak serum bilirubin in a large national cohort of very preterm infants.

Study Design: We retrospectively studied preterm infants <33 weeks of gestation admitted to the Canadian Neonatal Network between January 2015 and December 2017. Patients who received ECC (<30 seconds), UCM, or DCC (≥30 seconds) were compared. Read More

View Article and Full-Text PDF
October 2020

Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.

Cochrane Database Syst Rev 2019 09 17;9:CD003248. Epub 2019 Sep 17.

BSMS Academic Department of Paediatrics, Brighton and Sussex University Hospitals, Royal Sussex Country Hospital, Eastern Road, Brighton, UK, BN2 5BE.

Background: Infants born preterm (before 37 weeks' gestation) have poorer outcomes than infants at term, particularly if born before 32 weeks. Early cord clamping has been standard practice over many years, and enables quick transfer of the infant to neonatal care. Delayed clamping allows blood flow between the placenta, umbilical cord and baby to continue, and may aid transition. Read More

View Article and Full-Text PDF
September 2019

Delayed Cord Clamping versus Early Cord Clamping in Elective Cesarean Section: A Randomized Controlled Trial.

Neonatology 2019 2;116(3):252-259. Epub 2019 Jul 2.

Department of Women's and Children's Health, University of Padua, Padua, Italy,

Background: Delaying cord clamping is recommended in order to assure placental transfusion. However, the evidence on cord management in elective cesarean section (CS) is limited.

Objective: To compare delayed cord clamping (DCC) with early cord clamping (ECC) with regard to postnatal adaptation in neonates born through elective CS. Read More

View Article and Full-Text PDF

Early versus delayed umbilical cord clamping on maternal and neonatal outcomes.

Arch Gynecol Obstet 2019 09 15;300(3):531-543. Epub 2019 Jun 15.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No. 109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, China.

Purpose: Policies for timing of cord clamping varied from early cord clamping (ECC) in the first 30 s after birth, to delayed cord clamping (DCC) in more than 30 s after birth or when cord pulsation has ceased. DCC, an inexpensive method allowed physiological placental transfusion. The aim of this article is to review the benefits and the potential harms of early versus delayed cord clamping. Read More

View Article and Full-Text PDF
September 2019

Effect of early versus delayed cord clamping in neonate on heart rate, breathing and oxygen saturation during first 10 minutes of birth - randomized clinical trial.

Matern Health Neonatol Perinatol 2019 30;5. Epub 2019 May 30.

Department of Clinical Sciences Lund, Pediatrics/Neonatology, Skane University Hospital, Lund University, Lund, Sweden.

Background: Delayed cord clamping (DCC) after 180 s reduces iron deficiency up to 8 months of infancy compared to babies who received Early Cord Clamping (ECC) at less than 60 s. Experimentally DCC has shown to improve cardio-vascular stability. To evaluate the effect of delayed (≥180 s) group versus early (≤60 s) cord clamping group on peripheral blood oxygenation and heart rate up to 10 min after birth on term and late preterm infants. Read More

View Article and Full-Text PDF

Is Delaying Cord Clamping until Placenta Delivery Beneficial? Oxygen Saturation and Heart Rate Transition during the Initial 5 Minutes after Delivery in Indian Healthy Newborns.

Am J Perinatol 2020 06 30;37(7):738-744. Epub 2019 May 30.

Rashtriya Bal Swasthya Karyakram, Ministry of Health & Family Welfare, Government of India, New Delhi, India.

Objective: This study aimed to compare the preductal oxygen saturation (SpO) and heart rate (HR) in newborns during the initial 5 minutes after birth with delayed cord clamping (DCC) and early cord clamping (ECC) practices at sea level.

Study Design: This prospective observational study included newborns born at >34 weeks vaginally (Dharampur, Gujarat) or through caesarean section (CS) (Kolkata, West Bengal). In Dharampur, the newborns received ECC practice (8 weeks) followed by DCC practice (10 weeks). Read More

View Article and Full-Text PDF

Delayed cord clamping does not affect umbilical cord blood gas analysis.

Arch Gynecol Obstet 2019 03 17;299(3):719-724. Epub 2019 Jan 17.

Department of Laboratory Medicine, Dr. Everett Chalmers Regional Hospital, Horizon Health Network, Fredericton, NB, E3B 5N5, Canada.

Background: Although delayed umbilical cord clamping has been shown to have significant benefits for both term and preterm infants, currently, data on its impact on blood gas analysis have been scant and conflicting.

Methods: In a retrospective review, we compared the demographic characteristics and blood gas parameters of 114 delayed cord clamping (DCC-births between 45 and 90 s in length; 109 being for 60 s) versus 407 early cord clamping births (ECC-immediately after delivery) collected over a 1-year period. Intrapartum care and timing of cord clamping for individual cases were performed at the discretion of obstetricians. Read More

View Article and Full-Text PDF

Safety of delayed umbilical cord clamping in preterm neonates of less than 34 weeks of gestation: a randomized controlled trial.

Obstet Gynecol Sci 2018 Nov 29;61(6):655-661. Epub 2018 Oct 29.

Department of Obstetrics and Gynecology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.

Objective: There is concern regarding the safety of delayed cord clamping (DCC) in babies born at less than 34 weeks' gestation. Therefore, the primary objective of this study was to compare the rates of hyperbilirubinemia and polycythemia during initial 7 days in infants born at less than 34 weeks' gestation and randomized to receive DCC by 120 seconds or early cord clamping (ECC) within less than 30 seconds.

Methods: One hundred pregnant women were randomly subjected to DCC or ECC at the time of birth in a tertiary referral hospital setting. Read More

View Article and Full-Text PDF
November 2018

Delayed cord clamping in term large-for-gestational age infants: A prospective randomised study.

J Paediatr Child Health 2019 May 4;55(5):555-560. Epub 2018 Oct 4.

Division of Neonatology, Department of Pediatrics, Marmara University Faculty of Medicine, Istanbul, Turkey.

Aim: To compare the post-natal effects of delayed cord clamping (DCC) and early cord clamping (ECC) in term large-for-gestational age (LGA) infants.

Methods: This prospective randomised study included 51 term LGA infants. The umbilical cords of these infants were clamped at 15 s in group 1 (ECC group (n = 26)) and at 60 s in group 2 (DCC group (n = 25)). Read More

View Article and Full-Text PDF

Effect of Delayed Cord Clamping of Term Babies on Neurodevelopment at 12 Months: A Randomized Controlled Trial.

Neonatology 2019 2;115(1):36-42. Epub 2018 Oct 2.

Department of Women's and Children's Health, Uppsala University, Uppsala,

Background: Delayed cord clamping (DCC) is associated with an improved iron status at 8 months, a reduction of anemia at 12 months, and an improved development at 4 years. Assessment of the development after DCC has not been performed earlier in a setting with a high prevalence of iron deficiency.

Objective: The aim of this paper was to investigate the effects of DCC compared to early cord clamping (ECC) on the development evaluated with the Ages and Stages Questionnaire (ASQ) at 12 months of age. Read More

View Article and Full-Text PDF
December 2019

Early versus delayed cord clamping in small for gestational age infants and iron stores at 3 months of age - a randomized controlled trial.

BMC Pediatr 2018 07 18;18(1):234. Epub 2018 Jul 18.

Department of Obstetrics and Gynecology, Sir Ganga Ram Hospital, New Delhi, India.

Background: Delayed cord clamping is the standard of care in infants not requiring resuscitation; however effects of cord clamping strategies have not been evaluated systematically in small for gestational age (SGA) infants. The primary objective was to compare effects of delayed cord clamping (DCC) and early cord clamping (ECC) on serum ferritin at 3 months in SGA infants born at ≥35 weeks. The secondary objectives were to compare hematological parameters, clinical outcomes in neonatal period and growth at 3 months of age. Read More

View Article and Full-Text PDF

Maternal bleeding complications following early versus delayed umbilical cord clamping in multiple pregnancies.

BMC Pregnancy Childbirth 2018 May 4;18(1):131. Epub 2018 May 4.

Neonatal Research Institute at Sharp Mary Birch Hospital for Women and Newborns, 8555 Aero Dr., Suite 104, San Diego, CA, 92123, USA.

Background: In 2015, the American Academy of Pediatrics recommended delayed umbilical cord clamping for at least 30-60 s for all infants. However, there is limited data regarding the maternal safety of delayed cord clamping in multiple pregnancies. We aimed to compare the maternal bleeding complications following early cord clamping (ECC) versus of delayed cord clamping (DCC) in multiple pregnancies. Read More

View Article and Full-Text PDF

Placental transfusion in preterm neonates of 30-33 weeks' gestation: a randomized controlled trial.

J Perinatol 2018 05 6;38(5):496-504. Epub 2018 Feb 6.

Division of Neonatology, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Objectives: To compare effect of placental transfusion by delayed cord clamping (DCC) or cord milking (CM) with early cord clamping (ECC) on a composite of mortality or abnormal neurological status at 40 weeks' post-menstrual age (PMA) and 24-30 months' chronological age in neonates of 30-33 weeks' gestation.

Study Design: Randomized, controlled trial.

Outcomes: A composite of mortality or abnormal neurological status at 40 weeks PMA and survival free of neurodevelopmental abnormalities at 24-30 months' chronological age. Read More

View Article and Full-Text PDF

The dynamic pattern of PLIN3 in pig oocytes and cumulus cells during in vitro maturation.

Zygote 2018 Feb 13;26(1):40-49. Epub 2017 Dec 13.

College of Animal Science and Technology,Nanjing Agricultural University,Nanjing Weigang No. 1,Jiangsu Province 210095,People's Republic of China.

Lipid droplets (LDs) are the main energy resource for porcine preimplantation embryonic development. PLIN3 has been implicated in LD formation and regulation. Therefore, this study aimed to detect the dynamic pattern of PLIN3 in pig oocytes and cumulus cells (CC) during in vitro maturation (IVM), and to determine the relationship between PLIN3 and LD content. Read More

View Article and Full-Text PDF
February 2018

Association between oxidative stress and cord serum lipids in relation to delayed cord clamping in term neonates.

Lipids Health Dis 2017 Nov 9;16(1):210. Epub 2017 Nov 9.

Department of Clinical Pathology, Minia University Hospital, Al-Minya, Egypt.

Background: Although delayed cord clamping (DCC) is a recent WHO recommendation, early cord clamping (ECC) is still a routine practice in many countries. Limited researches studied the effect of delayed cord clamping on oxidative stress in term neonates; In this study we aim to assess the influence of cord clamping either early or late on oxidative stress in term neonates and to evaluate the association of oxidative stress and cord blood lipids.

Methods: One-hundred mothers and their term neonates were included in the present study. Read More

View Article and Full-Text PDF
November 2017

Effect of Placental Transfusion on Iron Stores in Moderately Preterm Neonates of 30-33 weeks Gestation.

Indian J Pediatr 2018 03 4;85(3):172-178. Epub 2017 Nov 4.

Neonatal Unit, Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Objective: To assess the effect of placental transfusion by delayed cord clamping (DCC) of 60 s or cord milking (CM) on serum ferritin levels at hospital discharge and 3 mo of postmenstrual age (PMA) in preterm neonates of 30 to 33 wk gestation in comparison to early cord clamping (ECC) within 10 s.

Methods: This mixed longitudinal study was conducted in moderately preterm neonates of 30 to 33 wk gestation born in a level III unit in Northern India with the study sample nested within a randomized controlled trial on placental transfusion. Intervention was delayed cord clamping for 60 s or cord milking compared with early cord clamping (within 10 s). Read More

View Article and Full-Text PDF

Effects and safety of delayed versus early umbilical cord clamping in newborns of HIV-infected mothers.

J Matern Fetal Neonatal Med 2019 Feb 16;32(4):646-649. Epub 2017 Oct 16.

a Department of Pediatrics , ASST-FBF-Sacco, Sacco Hospital, University of Milan , Milan , Italy.

Objective: To investigate the effect of a 2 minutes-delayed cord clamp (DCC) versus early cord clamp (ECC) on neonate haemoglobin concentration 24 hours and 1 month after birth, and assess the safety of DCC concerning the risk of HIV infection.

Design: Sixty-four mother-infant peers were enrolled. All mothers were on stable ARV therapy. Read More

View Article and Full-Text PDF
February 2019