489 results match your criteria ebc observed


Adjuvant CDK4/6 inhibitors combined with endocrine therapy in HR-positive, HER2-negative early breast cancer: A meta-analysis of randomized clinical trials.

Breast 2021 Jul 6;59:165-175. Epub 2021 Jul 6.

Department of Breast Cancer, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No.123 Huifu West, Yuexiu District, Guangzhou, 510080, Guangdong, China; Shantou University Medical College, Shantou, 515041, Guangdong, China. Electronic address:

Background: The benefit of adjuvant cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors with endocrine therapy (ET) in hormone receptor-positive, human epidermal growth factor 2 receptor-negative (HR+/HER2-) early breast cancer (EBC) is uncertain. Hence, we performed a meta-analysis to determine the efficacy and safety of adjuvant CDK4/6 inhibitors plus ET and to identify potential preferred subpopulations for this regimen.

Methods: A literature search was conducted in PubMed, Embase, Cochrane databases up to Jan 15, 2021. Read More

View Article and Full-Text PDF

Impact of Anti-HER2 Treatments Combined With Atezolizumab on the Tumor Immune Microenvironment in Early or Metastatic Breast Cancer: Results From a Phase Ib Study.

Clin Breast Cancer 2021 May 15. Epub 2021 May 15.

Department of Medicine, University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA, USA.

Background: Despite advances, there continues to be unmet need in breast cancer. Combining anti-programmed death-ligand 1 (PD-L1) cancer immunotherapy atezolizumab with other targeted therapies may enhance T-cell-dependent cytolytic antitumor activity.

Methods: This open-label, phase Ib study evaluated the safety of atezolizumab-based combinations with antibody-dependent cellular cytotoxicity or antibody-drug conjugate (ADC) agents. Read More

View Article and Full-Text PDF

Prognostic Impact of Ki-67 Change in Locally Advanced and Early Breast Cancer after Neoadjuvant Chemotherapy: A Single Institution Experience.

J Oncol 2021 4;2021:5548252. Epub 2021 May 4.

Clinica Oncologica e Centro Regionale di Genetica Oncologica, Università Politecnica delle Marche, AOU Ospedali Riuniti, Ancona (AN) 60126, Marche, Italy.

Systemic neoadjuvant chemotherapy (NCT) is a standard treatment for locally advanced breast cancer (LABC) and for selected early breast cancer (EBC). In these settings, the prognostic and predictive role of Ki-67 before and after NCT is unclear. The aim of our study was to investigate the prognostic role of Ki-67 change in patients not achieving pathological complete response (pCR). Read More

View Article and Full-Text PDF

Genome of Peştera Muierii skull shows high diversity and low mutational load in pre-glacial Europe.

Curr Biol 2021 Jul 18;31(14):2973-2983.e9. Epub 2021 May 18.

Human Evolution, Department of Organismal Biology, Uppsala University, 752 36 Uppsala, Sweden. Electronic address:

Few complete human genomes from the European Early Upper Palaeolithic (EUP) have been sequenced. Using novel sampling and DNA extraction approaches, we sequenced the genome of a woman from "Peştera Muierii," Romania who lived ∼34,000 years ago to 13.5× coverage. Read More

View Article and Full-Text PDF

First detection of mobilized colistin resistance gene in isolated from livestock and sewage in Iran.

New Microbes New Infect 2021 May 18;41:100862. Epub 2021 Mar 18.

Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Currently, few studies have investigated the mechanisms of resistance to colistin in Iran. The aim of this study was to investigate -harbouring dissemination in livestock and sewage in Iran. A total of 115 samples from cows ( = 38), chickens ( = 47) and urban sewage samples ( = 30) were collected. Read More

View Article and Full-Text PDF

Luminal Breast Cancer: Risk of Recurrence and Tumor-Associated Immune Suppression.

Mol Diagn Ther 2021 Jul 11;25(4):409-424. Epub 2021 May 11.

Azienda Tutela della Salute Sardegna, Ospedale A. Segni, Ozieri, Italy.

Hormone-receptor positive (HR+) breast cancer (BC) (including the luminal A and the luminal B subtypes) is the most common type of tumor in women diagnosed with early-stage BC (EBC). It represents a highly heterogeneous subgroup that is characterized by different risks of relapse. The aim of this review is to discuss the possible role played by the immune response in predicting this risk, along with the most common clinical and pathological factors and molecular tools that have been developed and are already in use. Read More

View Article and Full-Text PDF

Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer.

Br J Cancer 2021 Jul 10;125(2):209-219. Epub 2021 May 10.

Pinderfields Hospital, Mid Yorkshire NHS Foundation Trust, Wakefield, UK.

Background: Chemotherapy improves outcomes for high risk early breast cancer (EBC) patients but is infrequently offered to older individuals. This study determined if there are fit older patients with high-risk disease who may benefit from chemotherapy.

Methods: A multicentre, prospective, observational study was performed to determine chemotherapy (±trastuzumab) usage and survival and quality-of-life outcomes in EBC patients aged ≥70 years. Read More

View Article and Full-Text PDF

Success and risks of pregnancy after breast cancer.

Breast Cancer Res Treat 2021 Aug 21;188(3):593-600. Epub 2021 Apr 21.

Medical Gynecology, Institut de Cancérologie de l'Ouest Pays de Loire, 15 rue André Boquel, 49055 Cedex 02, Angers, France.

Introduction: Breast cancer is the most common cancer in women worldwide. The number of childbearing-age women diagnosed with early breast cancer (eBC) is increasing, raising questions over their subsequent fertility.

Purpose: The main objective of this study was therefore to assess, in a cohort of eBC patients with pregnancy desire, the rate of live births achieved spontaneously or by assisted reproductive technology. Read More

View Article and Full-Text PDF

CDK4/6 inhibitors as adjuvant treatment for hormone receptor-positive, HER2-negative early breast cancer: a systematic review and meta-analysis.

ESMO Open 2021 Apr 18;6(2):100091. Epub 2021 Mar 18.

Academic Trials Promoting Team, Institut Jules Bordet and l'Université Libre de Bruxelles (ULB), Brussels, Belgium.

Background: The combination of cyclin-dependent kinases 4/6 inhibitors (CDK4/6is) and endocrine therapy (ET) is standard of care for patients with hormone receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer (BC). However, studies evaluating adjuvant CDK4/6is provided contradictory results thus far.

Materials And Methods: We conducted a systematic review and meta-analysis to assess if the addition of CDK4/6is to adjuvant ET impacts on survival's outcomes and safety of patients with HR+/HER2- early BC (EBC). Read More

View Article and Full-Text PDF

Carbon Dots Detect Water-to-Ice Phase Transition and Act as Alcohol Sensors Fluorescence Turn-Off/On Mechanism.

ACS Nano 2021 04 16;15(4):6582-6593. Epub 2021 Mar 16.

Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University Olomouc, Šlechtitelů 27, Olomouc 783 71, Czech Republic.

Highly fluorescent carbon nanoparticles called carbon dots (CDs) have been the focus of intense research due to their simple chemical synthesis, nontoxic nature, and broad application potential including optoelectronics, photocatalysis, biomedicine, and energy-related technologies. Although a detailed elucidation of the mechanism of their photoluminescence (PL) remains an unmet challenge, the CDs exhibit robust, reproducible, and environment-sensitive PL signals, enabling us to monitor selected chemical phenomena including phase transitions or detection of ultralow concentrations of molecular species in solution. Herein, we report the PL turn-off/on behavior of aqueous CDs allowing the reversible monitoring of the water-ice phase transition. Read More

View Article and Full-Text PDF

Clinical Utility of microRNAs in Exhaled Breath Condensate as Biomarkers for Lung Cancer.

J Pers Med 2021 Feb 9;11(2). Epub 2021 Feb 9.

Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Córdoba, Spain.

This study represents a novel proof of concept of the clinical utility of miRNAs from exhaled breath condensate (EBC) as biomarkers of lung cancer (LC). Genome-wide miRNA profiling and machine learning analysis were performed on EBC from 21 healthy volunteers and 21 LC patients. The levels of 12 miRNAs were significantly altered in EBC from LC patients where a specific signature of miR-4507, miR-6777-5p and miR-451a distinguished these patients with high accuracy. Read More

View Article and Full-Text PDF
February 2021

Lipid peroxidation metabolites associated with biomarkers of inflammation and oxidation stress in workers handling carbon nanotubes and metal oxide nanoparticles.

Nanotoxicology 2021 Jun 11;15(5):577-587. Epub 2021 Feb 11.

Department of Chemistry, Fu Jen Catholic University, New Taipei City, Taiwan.

The purpose of this study was to assess the effects of lipid peroxidation with occupational exposure to different types of nanomaterials (NMs). In this cross-sectional study, urine and exhaled breath condensate (EBC) samples were collected from 80 NM-handling workers [30 workers handling nano-titanium oxide (nano-TiO), 28 handling nano-silicon dioxide (nano-SiO), 22 handling carbon nanotubes (CNTs)], and 69 controls (office workers) from 2010 to 2012. Urinary 8-isoPGF, 2,3 dinor-8-isoPGF, PGF, and EBC 8-iso PGF were measured as lipid peroxidation biomarkers in 2013. Read More

View Article and Full-Text PDF

Endoscopic radiofrequency ablation plus plastic stent placement versus stent placement alone for unresectable extrahepatic biliary cancer: a multicenter randomized controlled trial.

Gastrointest Endosc 2021 07 24;94(1):91-100.e2. Epub 2020 Dec 24.

Department of Gastroenterology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Yangpu District, Shanghai, China; Department of Gastroenterology, Third Affiliated Hospital, Second Military Medical University, Jiading District, Shanghai, China.

Background And Aims: We sought to compare the efficacy and safety between endoscopic radiofrequency ablation (RFA) and stent placement alone in patients with unresectable extrahepatic biliary cancer (EBC).

Methods: In this randomized controlled trial, patients with locally advanced or metastatic cholangiocarcinoma (CCA) or ampullary cancer who were unsuitable for surgery were recruited from 3 tertiary centers. Eligible patients were randomly assigned to RFA plus plastic stent placement (RFA group) or plastic stent placement alone (stent placement alone group) in a 1:1 ratio. Read More

View Article and Full-Text PDF

Meningococcal disease epidemiology in Brazil (2005-2018) and impact of MenC vaccination.

Vaccine 2021 01 24;39(3):605-616. Epub 2020 Dec 24.

GSK, Rio de Janeiro, RJ, Brazil.

Background: Meningococcal disease (MD) presents a substantial public health problem in Brazil. Meningococcal C conjugate (MenC) vaccination was introduced into the routine infant immunization program in 2010, followed by adolescent vaccination in 2017. We evaluated changes in national and regional MD incidence and mortality between 2005 and 2018, serogroup distribution and vaccine coverage. Read More

View Article and Full-Text PDF
January 2021

[Thermal heliox proteome. High-temperature heliox does not cause destruction of human respiratory system cells].

Ter Arkh 2020 Jul 9;92(6):69-72. Epub 2020 Jul 9.

Pirogov Russian National Research Medical University.

Aim: Conducting a pilot study to assess the effect of thermal heliox on the state of the respiratory tract by studying of the exhaled breath condensate protein composition before the thermal heliox procedure, immediately after and after three hours of relaxation Materials and methods. A comparative study of the exhaled breath condensates (EBC) protein composition of five non-smoking healthy donors was carried out. The EBC was taken before the respiratory procedure, immediately after a 20-minute inhalation by mixture of He/O2 gases (70/30) heated to 70C and 3 hours later. Read More

View Article and Full-Text PDF

Soluble interleukin-2 receptor in exhaled breath condensate in pulmonary sarcoidosis: a cross-sectional pilot study.

J Breath Res 2020 12 18;15(1):016016. Epub 2020 Dec 18.

Norwich Medical School, The University of East Anglia, Norwich, United Kingdom. Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, United Kingdom.

Introduction: Sarcoidosis is a chronic granulomatous disease of unknown aetiology with a variable clinical course and prognosis. There is an urgent need to identify new and novel biomarkers to help differentiate between clinical phenotypes and guide clinical decisions with respect to commencing and monitoring treatment. Across the spectrum of respiratory disease there has been a growing interest in the role of breath-based biomarkers given their non-invasive nature and ability to repeat sampling with ease for serial monitoring. Read More

View Article and Full-Text PDF
December 2020

The allylic oxidation of tigliane esters.

Fitoterapia 2021 Jan 9;148:104802. Epub 2020 Dec 9.

University of Naples Federico II, Department of Pharmacy, School of Medicine and Surgery, Via D. Montesano 49, 80131 Naples, Italy. Electronic address:

As part of a study on the structure-activity relationships of the anticancer agent tigilanol tiglate (EBC-46, 2), the allylic oxidation of phorbol triacetate (1c) and of the acetonide of its 3αH-dihydroderivative (5) was investigated. The aim was to introduce an oxygen function at C-5 en route to point-like analogues of 2, but functionalization of C-10 was instead observed. This was followed by oxidative fragmentation of ring B to the 9,10-secotigliane derivative 6 and oxidation of the endocyclic Δ double bond to the C-6/C-10 oxygen bridged 7-oxotigliane 7. Read More

View Article and Full-Text PDF
January 2021

Epidemiological aspects of Ancylostoma spp. infection in naturally infected dogs from São Paulo state, Brazil.

Vet Parasitol Reg Stud Reports 2020 12 24;22:100452. Epub 2020 Aug 24.

Department of Veterinary Clinics, São Paulo State University (UNESP), School of Veterinary Medicine and Animal Science, Botucatu, São Paulo, Brazil. Electronic address:

Ancylostoma spp. are the most prevalent canine nematode parasites in Brazil. Despite their widespread parasitism in juvenile dogs, infections may occur regardless of host age. Read More

View Article and Full-Text PDF
December 2020

Naming the untouchable - environmental sequences and niche partitioning as taxonomical evidence in fungi.

IMA Fungus 2020 Nov 3;11(1):23. Epub 2020 Nov 3.

Department of Ecology and Genetics, Evolutionary Biology, Uppsala University, Norbyvägen 18D, 752 36, Uppsala, Sweden.

Due to their submerged and cryptic lifestyle, the vast majority of fungal species are difficult to observe and describe morphologically, and many remain known to science only from sequences detected in environmental samples. The lack of practices to delimit and name most fungal species is a staggering limitation to communication and interpretation of ecology and evolution in kingdom Fungi. Here, we use environmental sequence data as taxonomical evidence and combine phylogenetic and ecological data to generate and test species hypotheses in the class Archaeorhizomycetes (Taphrinomycotina, Ascomycota). Read More

View Article and Full-Text PDF
November 2020

Spatiotemporal Characteristics and Driving Factors of Black Carbon in Augsburg, Germany: Combination of Mobile Monitoring and Street View Images.

Environ Sci Technol 2021 01 8;55(1):160-168. Epub 2020 Dec 8.

Joint Mass Spectrometry Center, Cooperation Group Comprehensive Molecular Analytics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg 85764, Germany.

The study investigates the spatial pattern of black carbon (BC) at a high spatial resolution in Augsburg, Germany. Sixty two walks were performed to assess the concentrations of equivalent black carbon (eBC), ultraviolet particulate matter (UVPM), and equivalent brown carbon (eBrC) in different seasons and at different times of the day with a mobile platform (i.e. Read More

View Article and Full-Text PDF
January 2021

Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years.

Nanomaterials (Basel) 2020 Dec 6;10(12). Epub 2020 Dec 6.

J. Heyrovský Institute of Physical Chemistry CAS, Dolejškova 3, 182 23 Prague 8, Czech Republic.

Human data concerning exposure to nanoparticles are very limited, and biomarkers for monitoring exposure are urgently needed. In a follow-up of a 2016 study in a nanocomposites plant, in which only exhaled breath condensate (EBC) was examined, eight markers of oxidative stress were analyzed in three bodily fluids, i.e. Read More

View Article and Full-Text PDF
December 2020

Source Apportionment of Ambient Black Carbon During the COVID-19 Lockdown.

Int J Environ Res Public Health 2020 12 3;17(23). Epub 2020 Dec 3.

Environmental Engineering Department, College of Engineering, Imam Abdulrahman Bin Faisal University, East Campus, P.O. Box 1982, Dammam 34212, Saudi Arabia.

Black carbon (BC) particles being emitted from mobile and stationary emission sources as a result of combustion activities have significant impacts on human health and climate change. A lot of social activities have been halted during the COVID-19 lockdowns, which has evidently enhanced the ambient and indoor air quality. This paper investigates the possible emission sources and evaluates the meteorological conditions that may affect the dispersion and transport of BC locally and regionally. Read More

View Article and Full-Text PDF
December 2020

Urodynamics in Posterior Urethral Valve: Pursuit of prognostication or optimisation.

J Pediatr Urol 2021 Feb 6;17(1):111.e1-111.e8. Epub 2020 Nov 6.

Calcutta Medical Research Institute, 7, 2, Diamond Harbour Rd, New Alipore, Kolkata, West Bengal 700027, India. Electronic address:

Introduction: Detrusor dysfunction is known to persist in several patients of Posterior Urethral Valve (PUV) after successful fulguration leading to progressive deterioration of renal function. Persistent bladder outlet obstruction (BOO) in the form of bladder neck hypertrophy, residual valves or strictures may contribute to progressive detrusor dysfunction. These are assessed radiologically or cystoscopically and are managed variedly by anticholinergics, alpha-adrenergic blockers or even bladder neck incision. Read More

View Article and Full-Text PDF
February 2021

A comprehensive assessment of potential hazard caused by organic compounds in biochar for agricultural use.

J Hazard Mater 2021 02 9;403:123644. Epub 2020 Aug 9.

Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale Università degli Studi di Napoli Federico II, Italy.

Great attention has been paid to using biochar as soil conditioner and bio-accumulator. Nevertheless, biochar application in agriculture might cause a potential hazard to ecosystems, considering that toxic organic pollutants present in biochar may enter the environment. European Biochar Certificate (EBC) set certain criteria for biochar production. Read More

View Article and Full-Text PDF
February 2021

NMR Profiling of Exhaled Breath Condensate Defines Different Metabolic Phenotypes of Non-Cystic Fibrosis Bronchiectasis.

Int J Mol Sci 2020 Nov 14;21(22). Epub 2020 Nov 14.

Institute of Biomolecular Chemistry, National Research Council, 80078 Pozzuoli, Naples, Italy.

Nuclear-magnetic-resonance (NMR) profiling of exhaled breath condensate (EBC) provides insights into the pathophysiology of bronchiectasis by identifying specific biomarkers. We evaluated whether NMR-based metabolomics discriminates the EBC-derived metabolic phenotypes ("metabotypes") of 41 patients with non-cystic fibrosis (nCF) bronchiectasis of various etiology [24 subjects with Primary Ciliary Dyskinesia (PCD); 17 patients with bronchiectasis not associated with PCD (nCF/nPCD)], who were compared to 17 healthy subjects (HS). NMR was used for EBC profiling, and Orthogonal Projections to Latent Structures with partial least-squares discriminant analysis (OPLS-DA) was used as a classifier. Read More

View Article and Full-Text PDF
November 2020

Final Efficacy Results of Neratinib in HER2-positive Hormone Receptor-positive Early-stage Breast Cancer From the Phase III ExteNET Trial.

Clin Breast Cancer 2021 02 6;21(1):80-91.e7. Epub 2020 Oct 6.

Puma Biotechnology Inc., Los Angeles, CA.

Background: The ExteNET trial demonstrated improved invasive disease-free survival (iDFS) with neratinib, an irreversible pan-HER tyrosine kinase inhibitor, versus placebo in patients with human epidermal growth factor receptor 2-positive (HER2)/hormone receptor-positive (HR) early-stage breast cancer (eBC).

Patients And Methods: ExteNET was a multicenter, randomized, double-blind, phase III trial of 2840 patients with HER2 eBC after neoadjuvant/adjuvant trastuzumab-based therapy. Patients were stratified by HR status and randomly assigned 1-year oral neratinib 240 mg/day or placebo. Read More

View Article and Full-Text PDF
February 2021

Measurements and simulations of energy fluxes over a high-rise and compact urban area in Hong Kong.

Sci Total Environ 2021 Apr 6;765:142718. Epub 2020 Oct 6.

Department of Civil Engineering, The University of Hong Kong, Pokfulam, Hong Kong. Electronic address:

Measuring energy fluxes in a dense and high-rise urban area is extremely challenging, thus our knowledge in such area remains limited. This study assessed the surface energy fluxes and investigated the energy balance closure (EBC) over such complex urban surface in Hong Kong. Net radiation (Q), sensible (Q) and latent (Q) heat fluxes were measured using an eddy covariance system from September 2018 to August 2019. Read More

View Article and Full-Text PDF

Seasonal Prevalence of Shiga Toxin-Producing Escherichia coli on Pork Carcasses for Three Steps of the Harvest Process at Two Commercial Processing Plants in the United States.

Appl Environ Microbiol 2020 12 17;87(1). Epub 2020 Dec 17.

USDA ARS, U.S. Meat Animal Research Center, Clay Center, Nebraska, USA

Shiga toxin-producing (STEC) is a foodborne pathogen that has a significant impact on public health, with strains possessing the attachment factor intimin referred to as enterohemorrhagic (EHEC) and associated with life-threatening illnesses. Cattle and beef are considered typical sources of STEC, but their presence in pork products is a growing concern. Therefore, carcasses ( = 1,536) at two U. Read More

View Article and Full-Text PDF
December 2020

Increased Expression of Y-Encoded Demethylases During Differentiation of Human Male Neural Stem Cells.

Stem Cells Dev 2020 12 5;29(23):1497-1509. Epub 2020 Nov 5.

Department of Organismal Biology, EBC, Uppsala University, Uppsala, Sweden.

Human neural stem cells (hNSCs) have long been used as an in vitro model to study neurogenesis and as candidates for nervous system therapy. Many parameters have been considered when evaluating the success of transplantation, but sex of donor and recipients is often not discussed. We investigated two commercial NSC lines, the female hNSC-H9 and male hNSC-H14, and we observed faster growth rates in the male cells. Read More

View Article and Full-Text PDF
December 2020

Abemaciclib Combined With Endocrine Therapy for the Adjuvant Treatment of HR+, HER2-, Node-Positive, High-Risk, Early Breast Cancer (monarchE).

J Clin Oncol 2020 12 20;38(34):3987-3998. Epub 2020 Sep 20.

University of Pittsburgh, NSABP Foundation, Pittsburgh, PA.

Purpose: Many patients with HR+, HER2- early breast cancer (EBC) will not experience recurrence or have distant recurrence with currently available standard therapies. However, up to 30% of patients with high-risk clinical and/or pathologic features may experience distant recurrence, many in the first few years. Superior treatment options are needed to prevent early recurrence and development of metastases for this group of patients. Read More

View Article and Full-Text PDF
December 2020