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[Urogenital Injury in Polytrauma Patients: a Five-year Epidemiological Study].

Acta Chir Orthop Traumatol Cech 2021 ;88(4):307-312

Urologická klinika 3. lékařské fakulty Univerzity Karlovy a Fakultní nemocnice Královské Vinohrady, Praha.

INTRODUCTION The authors present an overview of polytrauma patients with urinary tract injuries managed in the Level I trauma centre. The purpose of this study was to evaluate the frequency of injuries to the urinary system, the mechanism of their injury and the method of treatment in the cohort of polytrauma patients treated in the trauma centre. MATERIAL AND METHODS Between 2012 and 2016, a total of 231 polytrauma patients were treated, of whom 47 (20. Read More

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January 2021

Characterizing human mobility patterns in rural settings of sub-Saharan Africa.

Elife 2021 Sep 17;10. Epub 2021 Sep 17.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States.

Human mobility is a core component of human behavior and its quantification is critical for understanding its impact on infectious disease transmission, traffic forecasting, access to resources and care, intervention strategies, and migratory flows. When mobility data are limited, spatial interaction models have been widely used to estimate human travel, but have not been extensively validated in low- and middle-income settings. Geographic, sociodemographic, and infrastructure differences may impact the ability for models to capture these patterns, particularly in rural settings. Read More

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September 2021

A review on production of polyhydroxyalkanoate (PHA) biopolyesters by thermophilic microbes using waste feedstocks.

Bioresour Technol 2021 Sep 8;341:125900. Epub 2021 Sep 8.

INRS Eau, Terre et Environnement, 490, rue de la Couronne, Québec G1K 9A9, Canada.

Polyhydroxyalkanoates (PHAs) are produced by numerous microbes as a subcellular energy source. Despite of their diverse applications, exorbitant production cost limits their commercial synthesis. Apart from various cost determining factors such as cost-effective feedstocks or economic recovery methods, the use of appropriate bacteria holds the key to reduce the fermentation economics. Read More

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September 2021

Editorial Comment from Dr Bertolo et al. to Partial versus radical nephrectomy in clinical T2 renal masses.

Int J Urol 2021 Sep 13. Epub 2021 Sep 13.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

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September 2021

Beneficial effect of dimethyl fumarate on experimental autoimmune uveitis is dependent of pro-inflammatory markers immunomodulation.

Inflammopharmacology 2021 Sep 13. Epub 2021 Sep 13.

Laboratory of Cellular and Molecular Biology, Team "Cytokines and NO Synthases", Department of Biology, Faculty of Biological Science, University of Sciences and Technology Houari Boumediene, BP 32, El-Alia, 16111, Algiers, Algeria.

Autoimmune uveitis is an inflammatory disease of the eye and is one of the major causes of blindness worldwide. Experimental autoimmune uveoretinitis (EAU) constitutes an animal disease model of human endogenous uveitis. In our study, we investigated the immunomodulatory effect of dimethyl fumarate (DMF) using bovine retinal extract-induced uveitis in a Female Wistar rats. Read More

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September 2021

Potential impact of 1.5, 2 and 3 °C global warming levels on heat and discomfort indices changes over Central Africa.

Sci Total Environ 2021 Sep 7;804:150099. Epub 2021 Sep 7.

Climate Change Research Laboratory (CCRL), National Institute of Cartography, P.O. Box 157, Yaounde, Cameroon; Laboratory for Environmental Modelling and Atmospheric Physics (LEMAP), Department of Physics, Faculty of Science, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon.

Investigating the effects of the increased global warming through the lens of the Paris agreements would be of particular importance for Central African countries, which are already experiencing multiple socio-political and socio-economic constraints, but are also subject to severe natural hazards that interact to limit their adaptive capacity and thus increase their vulnerability to the adverse effects of climate change. This study explores changes in heat stress and the proportion of population at risk of discomfort over Central Africa, based on an ensemble-mean of high-resolution regional climate model simulations that cover a 30-year period, under 1.5, 2 and 3 °C Global Warming Levels (GWLs). Read More

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September 2021

Differences in genetic counseling student responses to intense patient affect: A study of students in North American programs.

J Genet Couns 2021 Sep 12. Epub 2021 Sep 12.

Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA.

Research indicates genetic counseling patients often experience intense emotions. No studies, however, have investigated how genetic counseling students respond to patient affect. This survey study investigated student responses to patient emotions and select factors affecting their responses. Read More

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September 2021

The lampricide 3-trifluoromethyl-4-nitrophenol causes temporary metabolic disturbances in juvenile lake sturgeon (): implications for sea lamprey control and fish conservation.

Conserv Physiol 2021 8;9(1):coab069. Epub 2021 Sep 8.

Department of Biology and Laurier Institute for Water Science, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5, Canada.

The pesticide 3-trifluoromethyl-4-nitrophenol (TFM) is applied to rivers and streams draining into the Laurentian Great Lakes to control populations of invasive sea lamprey (), which are ongoing threats to fisheries during the lamprey's hematophagous, parasitic juvenile life stage. While TFM targets larval sea lamprey during treatments, threatened populations of juvenile lake sturgeon (), particularly young-of-the-year (<100 mm in length), may be adversely affected by TFM when their habitats overlap with larval sea lamprey. Exposure to TFM causes marked reductions in tissue glycogen and high energy phosphagens in lamprey and rainbow trout () by interfering with oxidative ATP production in the mitochondria. Read More

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September 2021

European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2021 Update on Male Infertility.

Eur Urol 2021 Sep 9. Epub 2021 Sep 9.

Division of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy.

Context: The European Association of Urology (EAU) has updated its guidelines on sexual and reproductive health for 2021.

Objective: To present a summary of the 2021 version of the EAU guidelines on sexual and reproductive health, including advances and areas of controversy in male infertility.

Evidence Acquisition: The panel performed a comprehensive literature review of novel data up to January 2021. Read More

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September 2021

European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (Ta, T1, and Carcinoma in Situ).

Eur Urol 2021 Sep 9. Epub 2021 Sep 9.

European Association of Urology, Arnhem, The Netherlands.

Context: The European Association of Urology (EAU) has released an updated version of the guidelines on non-muscle-invasive bladder cancer (NMIBC).

Objective: To present the 2021 EAU guidelines on NMIBC.

Evidence Acquisition: A broad and comprehensive scoping exercise covering all areas of the NMIBC guidelines since the 2020 version was performed. Read More

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September 2021

CD4 T-Cell Plasticity in Non-Infectious Retinal Inflammatory Disease.

Int J Mol Sci 2021 Sep 3;22(17). Epub 2021 Sep 3.

UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.

Non-infectious uveitis (NIU) is a potentially sight-threatening disease. Effector CD4 T cells, especially interferon-γ-(IFNγ) producing Th1 cells and interleukin-17-(IL-17) producing Th17 cells, are the major immunopathogenic cells, as demonstrated by adoptive transfer of disease in a model of experimental autoimmune uveitis (EAU). CD4FoxP3CD25 regulatory T cells (Tregs) were known to suppress function of effector CD4 T cells and contribute to resolution of disease. Read More

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September 2021

Making sense of diabetes medication decisions: a mixed methods cluster randomized trial using a conversation aid intervention.

Endocrine 2021 Sep 9. Epub 2021 Sep 9.

Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

Purpose: To determine the effectiveness of a shared decision-making (SDM) tool versus guideline-informed usual care in translating evidence into primary care, and to explore how use of the tool changed patient perspectives about diabetes medication decision making.

Methods: In this mixed methods multicenter cluster randomized trial, we included patients with type 2 diabetes mellitus and their primary care clinicians. We compared usual care with or without a within-encounter SDM conversation aid. Read More

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September 2021

Renal tumors ablation.

Minerva Urol Nephrol 2021 Aug;73(4):549-551

Unit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy.

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Robotic surgery for renal cell carcinoma with inferior vena cava thrombosis: balancing feasibility and safety toward individualized decision-making.

Minerva Urol Nephrol 2021 Aug;73(4):544-548

School of Medicine, Division of Urology, Department of Oncology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Turin, Italy -

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The role of MRI in the management of a prostate cancer patient with bone and lymph nodes metastases. A case report.

Acta Biomed 2021 09 2;92(4):e2021214. Epub 2021 Sep 2.

Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy. Precision Imaging and Research Unit, Department of Medical Imaging and Radiation Sciences, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy.

The use of multiparametric prostate magnetic resonance imaging (mpMRI) is recommended, in the European Association of Urology (EAU) guidelines, for local staging of patients with prostate cancer (PCa). Systemic staging is recommended only for patients with unfavourable intermediate and high-risk disease; with bone and lymph node assessments usually being performed using bone scan (BS) and computed tomography (CT), respectively. Magnetic resonance imaging (MRI) is the imaging technique with the highest sensitivity for the detection of bone metastases and has shown promising results also for lymph node assessments. Read More

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September 2021

Pharmacotherapy of patients with benign prostate enlargement and storage symptoms in everyday clinical practice.

Eur Rev Med Pharmacol Sci 2021 Aug;25(16):5248-5254

Department of Urology and Oncological Urology, Wrocław Medical University, Wrocław, Poland.

Objective: Storage symptoms significantly deteriorate the quality of life in men with benign prostate enlargement (BPE). Muscarinic receptor antagonists (MRAs) and β3-adrenergic receptors agonists alone, or in combination with selective α1-alpha-antagonists, are considered the most effective medicines relieving storage symptoms. The aim of this study was to analyze the pharmacotherapy of storage symptoms in men with BPE, and their compliance with the European Association of Urology (EAU) guidelines. Read More

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Casirivimab-Imdevimab treatment is associated with reduced rates of hospitalization among high-risk patients with mild to moderate coronavirus disease-19.

EClinicalMedicine 2021 Aug 30:101102. Epub 2021 Aug 30.

Mayo Clinic, Rochester, MN, United States.

Background: Real-world clinical data to support the use of casirivimab-imdevimab for the treatment of outpatients with mild to moderate coronavirus disease-19 (COVID-19) is needed. This study aimed to assess the outcomes of casirivimab-imdevimab treatment of mild to moderate COVID-19.

Methods: A retrospective cohort of 696 patients who received casirivimab-imdevimab between December 4, 2020 and April 9, 2021 was compared to a propensity-matched control of 696 untreated patients with mild to moderate COVID-19 at Mayo Clinic sites in Arizona, Florida, Minnesota, and Wisconsin. Read More

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Eligibility criteria according to EAU/ESTRO/SIOG guidelines for exclusive iodine-125 brachytherapy for intermediate-risk prostate adenocarcinoma patients: impact on relapse-free survival.

J Contemp Brachytherapy 2021 Aug 24;13(4):373-386. Epub 2021 Aug 24.

Department of Radiation Oncology, Centre Léon Bérard, Lyon, France.

Purpose: Iodine-125 (I) brachytherapy (BT) alone for intermediate-risk (IR) prostate adenocarcinoma (PCA) is controversial. The purpose of the study was to investigate potential predictive factors in selected IR-PCA patients treated with BT.

Material And Methods: Among 547 patients treated with I BT between 2003 and 2013, 149 IR-PCA cases were selected according to NCCN classification after an additional exclusion of patients with prostate specific antigen (PSA) > 15 ng/ml and ISUP group 3. Read More

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Prednisone Reprograms the Transcriptional Immune Cell Landscape in CNS Autoimmune Disease.

Front Immunol 2021 13;12:739605. Epub 2021 Aug 13.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Glucocorticoids (GCs) are widely used immunosuppressive drugs for autoimmune diseases, although considerable gaps exist between current knowledge of the mechanisms of GCs and their conclusive immune-regulatory effects. Here we generated a single-cell transcriptional immune cell atlas based on prednisone-treated or untreated experimental autoimmune uveitis (EAU) mice. Immune cells were globally activated in EAU, and prednisone partially reversed this effect in terms of cell composition, gene expression, transcription factor regulation, and cell-cell communication. Read More

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Attenuation of Experimental Autoimmune Uveitis in Lewis Rats by Betaine.

Exp Neurobiol 2021 Aug;30(4):308-317

College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Korea.

Experimental autoimmune uveitis (EAU) is an animal model of human autoimmune uveitis that is characterized by the infiltration of autoimmune T cells with concurrent increases in pro-inflammatory cytokines and reactive oxygen species. This study aimed to assess whether betaine regulates the progression of EAU in Lewis rats. EAU was induced via immunization with the interphotoreceptor retinoid-binding protein (IRBP) and oral administration of either a vehicle or betaine (100 mg/kg) for 9 consecutive days. Read More

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Interaction of MRI and active surveillance in prostate cancer: Time to re-evaluate the active surveillance inclusion criteria.

Urol Oncol 2021 Sep 2. Epub 2021 Sep 2.

Department of Urology, Erasmus Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.

Currently available data from long-running single- and multi-center active surveillance (AS) studies show that AS has excellent cancer-specific survival rates. For AS to be effective the 'right' patients should be selected for which up until 5-to-10 years ago systematic prostate biopsies were used. Because the systematic prostate strategy relies on sampling efficiency for the detection of prostate cancer (PCa), it is subject to sampling error. Read More

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September 2021

Energy balance assessment on chicken manure for biogas production in Rabat-Salé-Zemmour-Zaïr of Morocco.

J Environ Manage 2021 Sep 2;299:113656. Epub 2021 Sep 2.

School of Civil and Environmental Engineering, Harbin Institute of Technology, Shenzhen, Shenzhen, 518055, PR China; Guangdong Water Co., Ltd, Shenzhen, 518021, PR China.

Chicken manure management has grabbed significant attention in Morocco due to the increasing demand on chicken and eggs. Bioconversion of chicken manure to biogas could reduce the chicken manure amount as well as generate clean energy. To evaluate the feasibility of converting chicken manure to biogas in terms of energy gain, the energy balance of the chicken manure for biogas production in the region of Rabat-Salé-Zemmour-Zaïr of Morocco has been investigated. Read More

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September 2021

UBA1 and DNMT3A Mutations in VEXAS Syndrome. A Case Report and Literature Review.

Mod Rheumatol Case Rep 2021 Sep 4. Epub 2021 Sep 4.

Department of Rheumatology. Mayo Clinic Health System, Eau Claire, USA.

VEXAS syndrome is a recently described X-linked autoinflammatory condition associated with somatic mutation of the UBA1 gene. It often coexists with MDS which can occur due to DNMT3A mutation. These patients, predominantly males, present after the fifth decade of life with unique systemic inflammatory clinical features and have hematological abnormalities and vacuolated precursor cells on bone marrow pathology. Read More

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September 2021

Artificial intelligence for target prostate biopsy outcomes prediction the potential application of fuzzy logic.

Prostate Cancer Prostatic Dis 2021 Sep 3. Epub 2021 Sep 3.

Department of Oncology, Division of Urology, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Turin, Italy.

Background: In current precision prostate cancer (PCa) surgery era the identification of the best patients candidate for prostate biopsy still remains an open issue. The aim of this study was to evaluate if the prostate target biopsy (TB) outcomes could be predicted by using artificial intelligence approach based on a set of clinical pre-biopsy.

Methods: Pre-biopsy characteristics in terms of PSA, PSA density, digital rectal examination (DRE), previous prostate biopsies, number of suspicious lesions at mp-MRI, lesion volume, lesion location, and Pi-Rads score were extracted from our prospectively maintained TB database from March 2014 to December 2019. Read More

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September 2021

Hepatoprotective effect of trypsin/chymotrypsin against olanzapine-induced non-alcoholic steatohepatitis in rats.

Can J Physiol Pharmacol 2021 Sep 2:1-9. Epub 2021 Sep 2.

Departments of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Metabolic side effects of atypical antipsychotics are an important cause of deterioration of cognitive function and failure of drug adherence. The antifatty effect trypsin/chymotrypsin (T/C) and their mechanisms of action remain unclear. To investigate possible therapeutic effect of T/C in rat model of chronic olanzapine (OLZ) - induced hepatic steatosis. Read More

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September 2021

Long-term efficacy of hyperthermic intravesical chemotherapy for BCG-unresponsive non-muscle invasive bladder cancer.

Urol Oncol 2021 Aug 29. Epub 2021 Aug 29.

Department of Urology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address:

Background: The recommended treatment for patients with Bacillus Calmette-Guérin (BCG) unresponsive non-muscle invasive bladder cancer (NMIBC) is radical cystectomy (RC). However, many patients refuse, or are unfit for RC. Therefore, alternative bladder-sparing treatment modalities are needed for BCG-unresponsive NMIBC. Read More

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Percutaneous puncture during PCNL: new perspective for the future with virtual imaging guidance.

World J Urol 2021 Sep 1. Epub 2021 Sep 1.

Department of Oncology, Division of Urology, University of Turin, Turin, Italy.

Context: Large and complex renal stones are usually treated with percutaneous nephrolithotomy (PCNL). One of the crucial steps in this procedure is the access to the collecting system with the percutaneous puncture and this maneuver leads to a risk of vascular and neighboring organs' injury. In the last years, the application of virtual image-guided surgery has gained wide diffusion even in this specific field. Read More

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September 2021

Stress Suppresses Systemic Th17/Treg Imbalance in Rats with Experimental Autoimmune Uveitis.

Ocul Immunol Inflamm 2021 Sep 1:1-11. Epub 2021 Sep 1.

Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases in Universities of Shandong, Eye Institute, Shandong University of Traditional Chinese Medicine, Jinan, P. R. China.

Purpose: To explore the effect of chronic unpredictable mild stress (CUMS) on the immune response involved in rats with experimental autoimmune uveitis (EAU).

Methods: Lewis rats were randomly divided into control, EAU, CUMS, and EAU+CUMS groups and received relevant treatments. On days 7, 11, 14, 21 and 28, frequencies of Th17 and Treg cells and the related cytokines were analyzed. Read More

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September 2021