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Diagnostic KASP Markers of Wheat Broad-spectrum Powdery Mildew Resistance Genes Pm21, PmV and Pm12 Developed for High Throughput Marker-assisted Selection.

Plant Dis 2021 Apr 21. Epub 2021 Apr 21.

Yantai University, No.30, Qingquan Road, Yantai, Shandong, China, 264005;

Wheat powdery mildew is a devastating disease that seriously threatens yield worldwide. Utilization of host resistance is considered an effective strategy to minimize powdery mildew damage. Pm21, PmV, and Pm12 confer broad-spectrum resistance to wheat powdery mildew in China, of which Pm21 and PmV are allelic genes derived from the 6VS chromosome of Dasypyrum villosum, and Pm12 is derived from the 6SS chromosome of Aegilops speltoides and most likely orthologous to the former two genes. Read More

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Phases of procedural learning and memory: characterisation with perceptual-motor sequence tasks.

J Cogn Psychol (Hove) 2019 14;31(5-6):543-558. Epub 2019 Jul 14.

Neuroscience Program, Biosciences Division, Center for Health Sciences, SRI International, Menlo Park, CA, USA.

Procedural learning and memory has been conceptualised as consisting of cognitive and autonomous phases. Although the Serial Reaction Time Task (SRTT) is a popular task used to study procedural memory (PM), it has not been used to explore the different phases of PM. The present study employed a modified SRTT and investigated whether it can distinguish phases of PM. Read More

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Leaf spot disease of Orychophragmus violaceus caused by Alternaria tenuissima in China.

Plant Dis 2021 Apr 5. Epub 2021 Apr 5.

Northeast Agricultural University, 12430, No. 59, Mucai street, harbin, China, 150030;

Orychophragmus violaceus (L.) O. E. Read More

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Risk factors for in-hospital mortality and acute kidney injury in neonatal-pediatric patients receiving extracorporeal membrane oxygenation.

J Formos Med Assoc 2021 Mar 31. Epub 2021 Mar 31.

Division of Nephrology, Department of Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan.

Background: Acute kidney injury (AKI) is the most frequent complication in critically ill neonatal and pediatric patients receiving extracorporeal membrane oxygenation (ECMO) support. This study analyzed risk factors for in-hospital mortality and the incidence of AKI in neonatal and pediatric patients received ECMO support.

Methods: We reviewed the medical records of 105 neonatal and 171 pediatric patients who received ECMO support at the intensive care unit (ICU) of a tertiary care university hospital between January 2008 and December 2015. Read More

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Characteristic Features of Infrared Thermographic Imaging in Primary Raynaud's Phenomenon.

Diagnostics (Basel) 2021 Mar 20;11(3). Epub 2021 Mar 20.

Department of Nuclear Medicine, Copenhagen University Hospital, Herlev Hospital, Borgmester Ib Juuls Vej 1, 2730 Herlev, Denmark.

Raynaud's phenomenon (RP) is characterized by the episodic whitening of the fingers upon exposure to cold. Verification of the condition is crucial in vibration-exposed patients. The current verification method is outdated, but thermographic imaging seems promising as a diagnostic replacement. Read More

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HCV core antigen plays an important role in the fight against HCV as an alternative to HCV-RNA detection.

J Clin Lab Anal 2021 Mar 31:e23755. Epub 2021 Mar 31.

Department of Transfusion, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Objective: To discuss the clinical significance of HCV-cAg testing in the diagnosis, activity determination, and monitoring of therapeutic effectiveness of HCV infection and its advantages compared with HCV-RNA and anti-HCV antibodies detection.

Methods: By summarizing the published literature, the advantages and significance of HCV core antigen detection were sought.

Results: The expression of HCV-cAg is highly consistent with that of HCV-RNA, but compared with HCV-RNA, detection of HCV-cAg is easy to operate, time saving, and low cost. Read More

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Prediction of Function Determining and Buried Residues Through Analysis of Saturation Mutagenesis Datasets.

Front Mol Biosci 2021 11;8:635425. Epub 2021 Mar 11.

Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India.

Mutational scanning can be used to probe effects of large numbers of point mutations on protein function. Positions affected by mutation are primarily at either buried or at exposed residues directly involved in function, hereafter designated as active-site residues. In the absence of prior structural information, it has not been easy to distinguish between these two categories of residues. Read More

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A new species of genus Hexacentrus Serville, 1831 from Taiwan (Orthoptera: Tettigoniidae: Hexacentrinae).

Zootaxa 2021 Feb 23;4933(4):zootaxa.4933.4.5. Epub 2021 Feb 23.

Formosa Natural History Information Ltd., New Taipei City 231, Taiwan..

There are 29 species or subspecies in genus Hexacentrus occurring in Asia, Africa and Australia. Because of its similar appearance, it is not easy to distinguish them by traditional methods. In this study, we collected samples and sequenced COI genes from wide range. Read More

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February 2021

Pigeons acquire the 1-back task: Implications for implicit versus explicit learning?

Learn Behav 2021 Mar 16. Epub 2021 Mar 16.

Department of Psychology, University of Kentucky, Lexington, KY, 40506-0044, USA.

In humans, a distinction can be made between implicit or procedural learning (involving stimulus-response associations) and explicit or declarative learning (involving verbalizable rules) that is relatively easy to make in verbal humans. According to several investigators, it is also possible to make such a distinction in nonverbal animals. One way is by training them on a conditional discrimination task (e. Read More

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The STAR/HOP system: a newly proposed abbreviated descriptive clinical coding system for craniopharyngiomas.

Childs Nerv Syst 2021 Mar 11. Epub 2021 Mar 11.

Pediatric Neurosurgery, Children's Cancer Hospital Egypt (CCHE-57357), 24, Faisal City, Miami, Alexandria, Egypt.

Craniopharyngiomas are complex and challenging tumors of the central nervous system (CNS) which require multidisciplinary and tailored management plans. An extensive variety of clinical presentations, treatment options, and patient outcomes exists. It is crucial to accurately and effectively distinguish the clinical status and the patient's specific roadmap to ensure proper disease status identification, patient-tailored care, follow-up, doctor-doctor and doctor-patient communication, and research. Read More

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Towards Easy-to-Use Bacteria Sensing: Modeling and Simulation of a New Environmental Impedimetric Biosensor in Fluids.

Sensors (Basel) 2021 Feb 21;21(4). Epub 2021 Feb 21.

Department of Electrical and Computer Engineering, Technical University of Munich, 80333 Munich, Germany.

Conventional pathogenic bacteria-detection methods are lab-bound, time-consuming and need trained personnel. Microelectrodes can be used to recognize harmful microorganisms by dielectric impedance spectroscopy. However, crucial for this spectroscopy method are the spatial dimensions and layout of the electrodes, as the corresponding distribution of the electric field defines the sensor system parameters such as sensitivity, SNR, and dynamic range. Read More

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February 2021

Sex identification in embryos and adults of Darwin's finches.

PLoS One 2021 5;16(3):e0237687. Epub 2021 Mar 5.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America.

Darwin's finches are an iconic example of adaptive radiation and evolution under natural selection. Comparative genetic studies using embryos of Darwin's finches have shed light on the possible evolutionary processes underlying the speciation of this clade. Molecular identification of the sex of embryonic samples is important for such studies, where this information often cannot be inferred otherwise. Read More

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Non-predatory mortality of planktonic microcrustaceans (Cladocera and Copepoda) in neotropical semiarid reservoirs.

An Acad Bras Cienc 2021 26;93(2):e20190991. Epub 2021 Feb 26.

Universidade Federal Rural de Pernambuco (UFRPE), Departamento de Biologia, Laboratório de Ecologia do Plâncton (LEPLANC), Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, 52171-900 Recife, PE, Brazil.

The accuracy of traditional methods to sample planktonic microcrustaceans depends on two assumptions: that organisms are alive during sampling and that all carcasses can be identified despite their degradation state, but fresh carcasses are not easy to distinguish by traditional methods. Previous studies about mortality have shown that neglecting dead organisms can provide biased ecological information. Thus, our objective was to determine the mortality rate and the proportion of dead microcrustacean in three tropical reservoirs. Read More

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A New Approach to Assessing Children's Interpretation of Severity Qualifiers in a Multi-Attribute Utility Instrument-The EQ-5D-Y-5L: Development and Testing.

Patient 2021 Mar 2. Epub 2021 Mar 2.

The EuroQol Group, Version Management Committee, Rotterdam, Netherlands.

Introduction: The beta EQ-5D-Y-5L is a new patient-reported outcome measure (PROM) for children aged 8-15 years that is currently under development by the EuroQol Group. The EQ-5D-Y-5L is similar to the EQ-5D-Y but has five levels of severity per dimension rather than three. The increased number of levels increases the granularity of the responses but possibly has also increased the difficulty of distinguishing between levels. Read More

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Recognizing lung cancer and stages using a self-developed electronic nose system.

Comput Biol Med 2021 Apr 23;131:104294. Epub 2021 Feb 23.

Key Laboratory of Biotechnology Science and Technology, Ministry of Education, College of Bioengineering,Chongqing University, Chongqing, PR China. Electronic address:

Exhaled breath contains thousands of gaseous volatile organic compounds (VOCs) that could be used as non-invasive biomarkers of lung cancer. Breath-based lung cancer screening has attracted wide attention on account of its convenience, low cost and easy popularization. In this paper, the research of lung cancer detection and staging is conducted by the self-developed electronic nose (e-nose) system. Read More

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Separation and Elevated Residential Mobility: A Cross-Country Comparison.

Eur J Popul 2021 Mar 29;37(1):121-150. Epub 2020 May 29.

Population Research Centre, Faculty of Spatial Sciences, University of Groningen, Groningen, The Netherlands.

This study investigates the magnitude and persistence of elevated post-separation residential mobility (i.e. residential instability) in five countries (Australia, Belgium, Germany, the Netherlands, and the UK) with similar levels of economic development, but different welfare provisions and housing markets. Read More

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Liq_ccRCC: Identification of Clear Cell Renal Cell Carcinoma Based on the Integration of Clinical Liquid Indices.

Front Oncol 2020 6;10:605769. Epub 2021 Jan 6.

Institute of Urology, Lanzhou University Second Hospital, Key Laboratory of Gansu Province for Urological Diseases, Clinical Center of Gansu Province for Nephrourology, Lanzhou, China.

Currently, preoperative diagnosis and differentiation of renal clear cell carcinoma and other subtypes remain a serious challenge for doctors. The liquid biopsy technique and artificial intelligence have inspired the pursuit of distinguishing clear cell renal cell carcinoma using clinically available test data. In this work, a method called liq_ccRCC based on the integration of clinical blood and urine indices through machine learning approaches was successfully designed to achieve this goal. Read More

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January 2021

Establishment and Application of a Dual TaqMan Real-Time PCR Method for and .

Pol J Microbiol 2020 Sep 25;69(3):293-300. Epub 2020 Aug 25.

Chongqing Academy of Animal Science, Chongqing, China.

species are common opportunistic bacteria and foodborne pathogens. The proper detection of can effectively reduce the occurrence of food-borne public health events. and are the two most important pathogens in the genus. Read More

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September 2020

Synovial fluid analysis with leukocyte esterase reagent strip test.

Clin Rheumatol 2021 Feb 1. Epub 2021 Feb 1.

Rheumatology Department, DHU FIRE, Pôle infection immunité, Bichat Hospital (APHP), 46 rue Henri Huchard, 75018, Paris, France.

To determine whether leukocyte esterase reagent strip test (LERST) analysis could help distinguish inflammatory arthritis from mechanical joint effusion. We analyzed synovial fluid (SF) from consecutive patients with a non-traumatic joint effusion during a 6-month period. Inflammatory SF was defined by white blood cell (WBC) count ≥ 2000/mm. Read More

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February 2021

Plasmonic nanobowtiefluidic device for sensitive detection of glioma extracellular vesicles by Raman spectrometry.

Lab Chip 2021 03 29;21(5):855-866. Epub 2021 Jan 29.

Department of Bioengineering, McGill University, Montreal, QC H3A 0E9, Canada.

Cancer cells shed into biofluids extracellular vesicles (EVs) - nanoscale membrane particles carrying diagnostic information. EVs shed by heterogeneous populations of tumor cells offer a unique opportunity to access biologically important aspects of disease complexity. Glioblastoma (GBM) exemplifies cancers that are incurable, because their temporal dynamics and molecular complexity evade standard diagnostic methods and confound therapeutic efforts. Read More

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Genetic circuits combined with machine learning provides fast responding living sensors.

Biosens Bioelectron 2021 Apr 23;178:113028. Epub 2021 Jan 23.

UNAM - Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center, Bilkent University, 06800, Bilkent-Ankara, Turkey. Electronic address:

Whole cell biosensors (WCBs) have become prominent in many fields from environmental analysis to biomedical diagnostics thanks to advanced genetic circuit design principles. Despite increasing demand on cost effective and easy-to-use assessment methods, a considerable amount of WCBs retains certain drawbacks such as long response time, low precision and accuracy. Here, we utilized a neural network-based architecture to improve the features of WCBs and engineered a gold sensing WCB which has a long response time (18 h). Read More

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Comparison of Canine and Feline Meningiomas Using the Apparent Diffusion Coefficient and Fractional Anisotropy.

Front Vet Sci 2020 11;7:614026. Epub 2021 Jan 11.

Laboratory of Veterinary Radiology, Nippon Veterinary and Life Science University, Musashino, Japan.

Meningiomas are the most common intracranial tumor in dogs and cats, and their surgical resection is often performed because they are present on the brain surface. Typical meningiomas show comparatively characteristic magnetic resonance imaging findings that lead to clinical diagnosis; however, it is necessary to capture not only macroscopic changes but also microstructural changes to devise a strategy for surgical resection and/or quality of removal. To visualize such microstructural changes, diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) have been used in human medicine. Read More

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January 2021

Oral microbiome and pancreatic cancer.

World J Gastroenterol 2020 Dec;26(48):7679-7692

Boston College William F. Connell School of Nursing, Boston College William F. Connell School, MA, 02467, United States.

Background: Microbiota profiles differ between patients with pancreatic cancer and healthy people, and understanding these differences may help in early detection of pancreatic cancer. Saliva sampling is an easy and cost-effective way to determine microbiota profiles compared to fecal and tissue sample collection.

Aim: To investigate the saliva microbiome distribution in patients with pancreatic adenocarcinoma (PDAC) and the role of oral microbiota profiles in detection and risk prediction of pancreatic cancer. Read More

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December 2020

[Comparative analysis of immunofluorescence double staining for foamy macrophages and in paraffin-embedded tissue of clinical tuberculous wound].

Zhonghua Shao Shang Za Zhi 2021 Feb;37(2):157-163

Xiamen Center for Disease Control and Prevention, Xiamen 361021, China.

To observe the effect of immunofluorescence double staining for foamy macrophages and (MTB) in paraffin-embedded tissue of clinical tuberculous wound, in comparison with three routine staining methods. The experimental method was used. From April 2019 to May 2020, 10 patients with tuberculous wound (5 males and 5 females, aged 28-77 years) meeting the inclusion criteria were treated in the Department of Burns and Plastic & Wound Repair Surgery of Xiang'an Hospital of Xiamen University. Read More

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February 2021

An Efficient and Easy-to-Use Network-Based Integrative Method of Multi-Omics Data for Cancer Genes Discovery.

Front Genet 2020 8;11:613033. Epub 2021 Jan 8.

Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

Identifying personalized driver genes is essential for discovering critical biomarkers and developing effective personalized therapies of cancers. However, few methods consider weights for different types of mutations and efficiently distinguish driver genes over a larger number of passenger genes. We propose MinNetRank (Minimum used for Network-based Ranking), a new method for prioritizing cancer genes that sets weights for different types of mutations, considers the incoming and outgoing degree of interaction network simultaneously, and uses minimum strategy to integrate multi-omics data. Read More

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January 2021

Leiomyosarcoma of the vulva: a case report.

Prz Menopauzalny 2020 Dec 7;19(4):184-187. Epub 2021 Jan 7.

Saint Marina University Hospital, Medical University Pleven, Pleven, Bulgaria.

Introduction: Leiomyosarcoma of the vulva is a rare disease accounting for about 1% of all primary vulvar neoplasia but it is the most common type of vulvar sarcomas. Usually it arises from the smooth muscles, blood vessels, rough ligaments, and erector-pili muscles. No treatment algorithms have been established yet. Read More

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December 2020

COVID-19 diagnosis from chest X-ray images using transfer learning: Enhanced performance by debiasing dataloader.

J Xray Sci Technol 2021 ;29(1):19-36

Department of Medical Laboratory Techniques, Akdeniz University, Vocational School of Health Services, Antalya, Turkey.

Background: Chest X-ray imaging has been proved as a powerful diagnostic method to detect and diagnose COVID-19 cases due to its easy accessibility, lower cost and rapid imaging time.

Objective: This study aims to improve efficacy of screening COVID-19 infected patients using chest X-ray images with the help of a developed deep convolutional neural network model (CNN) entitled nCoV-NET.

Methods: To train and to evaluate the performance of the developed model, three datasets were collected from resources of "ChestX-ray14", "COVID-19 image data collection", and "Chest X-ray collection from Indiana University," respectively. Read More

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Profiling and analysis of chemical compounds using pointwise mutual information.

J Cheminform 2021 Jan 10;13(1). Epub 2021 Jan 10.

CZ-OPENSCREEN National Infrastructure for Chemical Biology, Department of Informatics and Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague, Czech Republic.

Pointwise mutual information (PMI) is a measure of association used in information theory. In this paper, PMI is used to characterize several publicly available databases (DrugBank, ChEMBL, PubChem and ZINC) in terms of association strength between compound structural features resulting in database PMI interrelation profiles. As structural features, substructure fragments obtained by coding individual compounds as MACCS, PubChemKey and ECFP fingerprints are used. Read More

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January 2021

Genomic Insights into Methicillin-Resistant Staphylococcus aureus Type t899 Isolates Belonging to Different Sequence Types.

Appl Environ Microbiol 2021 02 26;87(6). Epub 2021 Feb 26.

Department of Bacteriology, Veterinary Research Institute, Brno, Czech Republic.

Methicillin-resistant (MRSA) presenting type t899 is commonly associated with sequence type 9 (ST9) but is also increasingly linked to ST398. This study provides genomic insight into the diversity of t899 isolates using core genome multilocus sequence typing (cgMLST), single nucleotide polymorphism (SNP)-based phylogeny, and the description of selected antimicrobial resistance and virulence markers. The SNP-based phylogenic tree showed that isolates sharing the same type (t899) but different STs highly diverged in their core and accessory genomes, revealing discriminant antimicrobial resistance (AMR) and virulence markers. Read More

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February 2021

Comparison of Alzheimer's disease patients and healthy controls in the easy Z-score imaging system with differential image reconstruction methods using SPECT/CT: verification using normal database of our institution.

Ann Nucl Med 2021 Mar 4;35(3):307-313. Epub 2021 Jan 4.

Department of Radiology, Yamagata University Hospital, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.

Objective: The easy Z-score imaging system (eZIS) analysis is used for the diagnosis of dementia by cerebral blood flow on single photon emission computed tomography (SPECT). Differences in the acquisition and reconstruction conditions in SPECT may affect the eZIS analysis results. The present study aimed to construct our institutional normal database (NDB) and Alzheimer's disease (AD)-specific volumes of interest (VOIs) in eZIS analysis, and to compare the differential diagnostic ability between healthy controls (HC) and patients with AD in the image reconstruction filtered back projection (FBP) and ordered subset expectation maximization (OSEM) methods. Read More

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