19,440 results match your criteria eastern north

The European multistakeholder PanCareFollowUp project: novel, person-centred survivorship care to improve care quality, effectiveness, cost-effectiveness and accessibility for cancer survivors and caregivers.

Eur J Cancer 2021 Jun 18;153:74-85. Epub 2021 Jun 18.

Princess Máxima Centre for Paediatric Oncology, Heidelberglaan 25, Utrecht, 3584 CS, the Netherlands.

Background: The majority of childhood cancer survivors are at risk of treatment-related adverse health outcomes. Survivorship care to mitigate these late effects is endorsed, but it is not available for many adult survivors of childhood cancer in Europe. The PanCareFollowUp project was initiated to improve their health and quality of life (QoL) by facilitating person-centred survivorship care. Read More

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Fatal Human Infection with Evidence of Intrahost Variation of Eastern Equine Encephalitis Virus, Alabama, USA, 2019.

Emerg Infect Dis 2021 Jul;27(7):1886-1892

Eastern equine encephalitis virus (EEEV) is an arbovirus in the family Togaviridae, genus Alphavirus, found in North America and associated with freshwater/hardwood swamps in the Atlantic, Gulf Coast, and Great Lakes regions. EEEV disease in humans is rare but causes substantial illness and death. To investigate the molecular epidemiology and microevolution of EEEV from a fatal case in Alabama, USA, in 2019, we used next-generation sequencing of serum and cerebrospinal fluid (CSF). Read More

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Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk.

J Alzheimers Dis 2021 Jun 17. Epub 2021 Jun 17.

Karolinska Institutet, NVS, Division of Clinical Geriatrics, Solna, Stockholm, Sweden.

We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60-77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0. Read More

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Genetic diversity, virulence and distribution of antimicrobial resistance among isolated from milk, beef, and bovine farm environment.

Iran J Vet Res 2021 ;22(1):1-8

Department of Veterinary Public Health and Epidemiology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai-600 007, Tamil Nadu, India.

Background: is an opportunistic intracellular foodborne pathogen and is ubiquitous in nature. The occurrence of in animal production units coupled with their presence in milk, faeces, feed, water, sewage, and soil is a contributory factor for foodborne listeriosis in humans and animals.

Aims: The study was aimed to characterize genotype and serogroup of recovered from different types of samples and also to study antimicrobial patterns by phenotypic and genotypic methods. Read More

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January 2021

Implementation of a patient centred medical home (PCMH) initiative in general practices in New South Wales, Australia.

BMC Fam Pract 2021 Jun 21;22(1):120. Epub 2021 Jun 21.

General Practice Academic Unit, School of Medicine, University of Wollongong, Wollongong, Australia.

Background: With an ageing population and an increase in chronic disease burden in Australia, Patient Centred Medical Home (PCMH) models of care have been identified as potential options for primary care reform and improving health care outcomes. Adoption of PCMH models are not well described outside of North America. We examined the experiences of seven general practices in an Australian setting that implemented projects aligned with PCMH values and goals supported by their local Primary Health Network (PHN). Read More

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The influence of dusts on radiation and temperature over the eastern Asia with a regional climate model.

Sci Total Environ 2021 Jun 8;792:148351. Epub 2021 Jun 8.

Institute of Desert Meteorology China Meteorological Administration, Urumqi 830001, PR China.

In order to investigate the climate effects of dusts, a regional climate model (RegCM 4.6) with the dust scheme was used to simulate the direct radiative forcing and air temperature response at 2 m near surface of dusts over the eastern Asia. Two sets of experiments were conducted, one with and one without dust aerosols. Read More

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Temporal trends in the spatial-scale contributions to black carbon in a Middle Eastern megacity.

Sci Total Environ 2021 Jun 9;792:148364. Epub 2021 Jun 9.

Civil and Environmental Engineering Department, University of Wisconsin-Madison, WI, USA.

The analysis of high-resolution changes in black carbon (BC) concentrations was examined to distinguish and quantify various spatial-scale contributions to BC concentrations from nearby sources within 1 km distance to ranges of emission sources distributed over a larger city scale spanning tens of kilometers. Our analysis illustrated that BC emissions on the neighborhood scale only contribute a minor fraction (~15%) to total BC concentrations in the megacity of Tehran. Approximately 62% of the total black carbon is part of the city emissions, and around 23% is transported into the city from local nearby surroundings. Read More

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Electrospun gold nanorods/graphene oxide loaded-core-shell nanofibers for local delivery of paclitaxel against lung cancer during photo-chemotherapy method.

Eur J Pharm Sci 2021 Jun 16:105914. Epub 2021 Jun 16.

Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran. Electronic address:

The combinations of photothermal therapy (PTT) and chemotherapy (CHT) have attracted increasing attention for cancer therapy. In the present study, paclitaxel as an anticancer drug and graphene oxide/gold nanorods (GO/Au NRs) were simultaneously loaded into the poly (tetramethylene ether) glycol based-polyurethane (PTMG-PU) (core)/chitosan (shell) nanofibers prepared by the coaxial electrospinning method. The potential of the synthesized nanofiber as a pH/temperature dual responsive carrier was investigated for the controlled release of paclitaxel against A549 lung cancer during PTT/CHT combined method. Read More

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Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element.

Am J Hum Genet 2021 Jun 16. Epub 2021 Jun 16.

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.

A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. A recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 (signal 2), and 42 (signal 3) credible causal variants at these loci. We used publicly available in silico DNase I and ChIP-seq data with in vitro reporter gene and CRISPR assays to annotate signals 2 and 3. Read More

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Outcomes after ultramassive transfusion in the modern era: An Eastern Association for the Surgery of Trauma multicenter study.

J Trauma Acute Care Surg 2021 Jul;91(1):24-33

From the Department of Surgery at Zuckerberg San Francisco General Hospital, University of California San Francisco (Z.A.M., Z.J.H., R.A.C., B.N.-G., L.Z.K., E.E.R., J.J.P., B.R., M.K.A., A.T.F.), San Francisco, California; Department of Epidemiology and Biostatistics, University of California San Francisco (E.C.M), San Francisco, California; Department of Laboratory Medicine, University of California, San Francisco (J.H.E., A.N., J.M.), San Francisco, California; Department of Surgery, University of California Irvine (W.D., J.N.), Irvine, Orange, California; Department of Surgery, Ohio Health Grant Medical Center (A.K.L., M.C.S.), Columbus, Ohio; Department of Surgery, University of Kentucky (S.S.D., J.K.R.), Lexington, Kentucky; Department of Surgery, Miami Valley Hospital (H.L., Y.W., C.H.), Dayton, Ohio; Department of Surgery, R Adams Cowley Shock Trauma Center (A.M.C., R.A.K., P.T.), University of Maryland School of Medicine, Baltimore, Maryland; Department of Surgery, Loma Linda Medical Center (L.P., K.M., X.L.-O.), Loma Linda, California; Department of Surgery, University of Kansas Medical Center (K.T., C.A.G.), Kansas City, Kansas; Department of Surgery, Crozer-Chester Medical Center (S.S.S., A.R.), Upland, Pennsylvania; Department of Surgery, WakeMed Health and Hospitals (A.M., P.U., A.S., B.P., K.T.), Raleigh, North Carolina; Department of Surgery, University of New Mexico School of Medicine (K.M., S.A.M.), Albuquerque, New Mexico; Department of Surgery, Wellspan York Hospital (J.G.), York, Pennsylvania; Department of Surgery, Ascension Via Christi Hospitals St. Francis (J.K., J.H., K.L.), Wichita, Kansas; Department of Surgery, Maine Medical Center (J.B.O., D.C.C.), Portland, Maine; Department of Surgery, South Shore Hospital/Brigham and Women's Hospital (S.A.S., J.C.K.), Boston, Massachusetts; Department of Surgery, Penn State Hershey Medical Center (J.G., J.P.H.), Hershey, Pennsylvania; Department of Surgery, Northwestern University Feinberg School of Medicine (A.Z.B., J.A.P.), Chicago, Illinois; Department of Surgery, University of California (R.A.C.), UC Davis, Sacramento, California; Department of Surgery, Ryder Trauma Center (K.A.J., G.R.), University of Miami Miller School of Medicine, Miami, Florida; and Washington University School of Medicine St. Louis (J.K.), Missouri.

Background: Despite the widespread institution of modern massive transfusion protocols with balanced blood product ratios, survival for patients with traumatic hemorrhage receiving ultramassive transfusion (UMT) (defined as ≥20 U of packed red blood cells [RBCs]) in 24 hours) remains low and resource consumption remains high. Therefore, we aimed to identify factors associated with mortality in trauma patients receiving UMT in the modern resuscitation era.

Methods: An Eastern Association for the Surgery of Trauma multicenter retrospective study of 461 trauma patients from 17 trauma centers who received ≥20 U of RBCs in 24 hours was performed (2014-2019). Read More

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Support and attitudes of Qatar mental health professionals to a proposed mental health inpatient smoking ban: results of a cross-sectional survey.

J Psychiatr Ment Health Nurs 2021 Jun 18. Epub 2021 Jun 18.

Senior Consultant Psychiatrist, Mental Health Services, Hamad Medical Corporation, Doha, Qatar.

Introduction: Despite the fact that patients with severe mental illness (SMI) have high rates of smoking and an increased standardised mortality, there is virtually no information about attitudes to smoking bans in mental health units from countries in the Middle East and North Africa region.

Aim: To assess support for, and attitudes towards, a proposed total smoking ban in psychiatric wards among mental health clinicians in Qatar.

Method: Cross-sectional survey of mental health professionals working in Qatar's primary mental health service. Read More

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spp. as Models for Studying the Ecology and Evolution of Species Interactions across Environmental Gradients.

Am Nat 2021 Jul 1;198(1):158-176. Epub 2021 Jun 1.

AbstractA central challenge in ecology and evolutionary biology is to understand how variation in abiotic and biotic factors combine to shape the distribution, abundance, and diversity of focal species. Environmental gradients, whether natural (e.g. Read More

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Letter to Editor A Clinical 'PIC- Perspectives, issues & Concerns" on Idiopathic Transient Osteoporosis during Pregnancy with alarm bells on its Idiopathic nature - Response.

Sharat Agarwal

J Orthop Case Rep 2021 ;11(1):118-120

Department of Orthopaedics & Trauma, North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences (NEIGRIHMS), Shillong (India).

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January 2021

Pleistocene climate fluctuations as the major driver of genetic diversity and distribution patterns of the Caspian green lizard, Eichwald, 1831.

Ecol Evol 2021 Jun 2;11(11):6927-6940. Epub 2021 May 2.

CIBIO Research Centre in Biodiversity and Genetic Resources InBIO Universidade do Porto Porto Portugal.

Green lizards of the genus have served as excellent models for studying the impact of Pleistocene climatic oscillations on genetic structures. The Caspian green lizard, , occupies various habitats across the Caucasus and the South Caspian Sea, with the Hyrcanian Forests and north of the Alborz Mountains forming the core of the range. This study aimed to re-examine the phylogenetic relationships of with other congeneric members and to assess the genetic structure and historical demography of the species. Read More

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Diel patterns of predation and fledging at nests of four species of grassland songbirds.

Ecol Evol 2021 Jun 1;11(11):6913-6926. Epub 2021 May 1.

U.S. Geological Survey (emeritus) Northern Prairie Wildlife Research Center Jamestown ND USA.

Although it is common for nestlings to exhibit a strong bias for fledging in the morning, the mechanisms underlying this behavior are not well understood. Avoiding predation risk has been proposed as a likely mechanism by a number of researchers. We used video surveillance records from studies of grassland birds nesting in North Dakota, Minnesota, and Wisconsin to determine the diel pattern of nest predation and fledging patterns of four ground-nesting obligate grassland passerines (Grasshopper Sparrow (), Savannah Sparrow (), Bobolink (), and Eastern Meadowlark ()). Read More

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Demographic and ecogeographic factors limit wild grapevine spread at the southern edge of its distribution range.

Ecol Evol 2021 Jun 8;11(11):6657-6671. Epub 2021 May 8.

Department of Chemical Engineering Ariel University Ariel Israel.

The spatial distribution of plants is constrained by demographic and ecogeographic factors that determine the range and abundance of the species. Wild grapevine ( ssp. ) is distributed from Switzerland in the north to Israel in the south. Read More

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Integrative taxonomy of Nearctic and Palaearctic Aleocharinae: new species, synonymies, and records (Coleoptera, Staphylinidae).

Zookeys 2021 31;1041:27-99. Epub 2021 May 31.

Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, 1055 du PEPS, PO Box 10380, Stn. Sainte-Foy, Québec, QC, G1V 4C7, Canada Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Quebec Sainte-Foy, Québec Canada.

A long tradition of separate Nearctic and Palaearctic taxonomic studies of the diverse aleocharine rove beetles (Coleoptera: Staphylinidae) has obscured the recognition of Holarctic species and detection of adventive species in both regions. Recently, integrated study of the two regions through detailed morphological comparisons and development of an authoritatively identified DNA barcode reference library has revealed the degree to which these two aleocharine faunas are interconnected, both naturally and through human activity. Here this approach is adopted to recognize new species, reveal Holarctic species, and recognize adventive species in both North America and Europe. Read More

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An Oligocene giant rhino provides insights into Paraceratherium evolution.

Commun Biol 2021 Jun 17;4(1):639. Epub 2021 Jun 17.

Hezheng Paleozoological Museum, Hezheng, Gansu, China.

As one of the largest land mammals, the origin and evolution of the giant rhino Paraceratherium bugtiense in Pakistan have been unclear. We report a new species Paraceratherium linxiaense sp. nov. Read More

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Effectiveness of Group Problem Management Plus, a brief psychological intervention for adults affected by humanitarian disasters in Nepal: A cluster randomized controlled trial.

PLoS Med 2021 Jun 17;18(6):e1003621. Epub 2021 Jun 17.

World Health Organization, Geneva, Switzerland.

Background: Globally, 235 million people are impacted by humanitarian emergencies worldwide, presenting increased risk of experiencing a mental disorder. Our objective was to test the effectiveness of a brief group psychological treatment delivered by trained facilitators without prior professional mental health training in a disaster-prone setting.

Methods And Findings: We conducted a cluster randomized controlled trial (cRCT) from November 25, 2018 through September 30, 2019. Read More

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The utilization of advance telemetry to investigate critical physiological parameters including electroencephalography in cynomolgus macaques following aerosol challenge with eastern equine encephalitis virus.

PLoS Negl Trop Dis 2021 Jun 17;15(6):e0009424. Epub 2021 Jun 17.

Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America.

Most alphaviruses are mosquito-borne and can cause severe disease in humans and domesticated animals. In North America, eastern equine encephalitis virus (EEEV) is an important human pathogen with case fatality rates of 30-90%. Currently, there are no therapeutics or vaccines to treat and/or prevent human infection. Read More

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Host utilization by the pepper weevil (Anthonomus eugenii): suitability, preference and offspring performance.

Pest Manag Sci 2021 Jun 17. Epub 2021 Jun 17.

Agriculture and Agri-Food Canada, Harrow Research and Development Centre, 2585 Essex County Rd 20, Harrow, Ontario, N0R 1G0.

Background: Host plant selection is a key factor affecting the survival, population establishment, and spread of herbivorous insect pests. The pepper weevil is one of the most important pests of cultivated pepper in North America with a capacity to rapidly expand its geographic range, in part through its ability to switch between cultivated and wild Solanaceous host plants. Towards better managing this pest, this study examined metrics of pepper weevil host use including oviposition preference, development time, and successful offspring emergence on wild Solanaceous species and cultivated pepper cultivars. Read More

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Association of Modifiable Risk Factors With Early Discontinuation of Adjuvant Endocrine Therapy: A Post Hoc Analysis of a Randomized Clinical Trial.

JAMA Oncol 2021 Jun 17. Epub 2021 Jun 17.

Department of Social Sciences and Health Policy, Wake Forest University Health Sciences, Winston Salem, North Carolina.

Importance: Early discontinuation of adjuvant endocrine therapy (ET) is problematic among breast cancer survivors, with previous studies suggesting that up to 50% of women do not adhere to the recommended full 5 years of ET treatment.

Objective: To identify the association between early discontinuation of ET in the Trial Assigning Individualized Options for Treatment (TAILORx) and modifiable risk factors, polypharmacy, and types of additional medications such as antidepressants and opioids.

Design, Setting, And Participants: This post hoc analysis includes a subgroup of 954 patients with breast cancer in TAILORx, a randomized clinical trial conducted from April 7, 2006, to October 6, 2010. Read More

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Dizziness is a predictor factor for the risk of falls in institutionalised older adults in Brazil.

Health Soc Care Community 2021 Jun 17. Epub 2021 Jun 17.

Physiology Department, Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, Aracaju, Brazil.

Considering the small number of studies aimed at evaluating outcomes related to dizziness and falls in the older adults who live in long-term care facilities, especially in north-eastern Brazil, and considering the negative impact of these events on the quality of life of these individuals, this study purpose was to evaluate dizziness as a predictor of risk of falls in institutionalised older adults. This cross-sectional analysis of data on falls and dizziness of 187 institutionalised older adults carried out between the years 2014 and 2016. The data collection instruments used were a socioeconomic and demographic questionnaire and questionnaires for assessing variables related to falls. Read More

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Timing of iceberg scours and massive ice-rafting events in the subtropical North Atlantic.

Nat Commun 2021 06 16;12(1):3668. Epub 2021 Jun 16.

United States Geological Survey, Pacific Coastal & Marine Science Center, Santa Cruz, CA, USA.

High resolution seafloor mapping shows extraordinary evidence that massive (>300 m thick) icebergs once drifted >5,000 km south along the eastern United States, with >700 iceberg scours now identified south of Cape Hatteras. Here we report on sediment cores collected from several buried scours that show multiple plow marks align with Heinrich Event 3 (H3), ~31,000 years ago. Numerical glacial iceberg simulations indicate that the transport of icebergs to these sites occurs during massive, but short-lived, periods of elevated meltwater discharge. Read More

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Genetic diversity of two populations of the tufted puffin Fratercula cirrhata (Pallas, 1769).

Genes Genet Syst 2021 Jun 17. Epub 2021 Jun 17.

Graduate School of Science and Engineering, Ibaraki University.

The tufted puffin Fratercula cirrhata (Charadriiformes: Alcidae) is distributed throughout the boreal and low Arctic areas of the North Pacific, from California, USA to Hokkaido, Japan. Few studies have investigated the genetic diversity of this species. Therefore, we analyzed the genetic diversity of two captive populations using nucleotide sequences of two mitochondrial loci (COX1 and D-loop) and one nuclear locus (RHBG). Read More

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Discrete breathers in a triangular β-Fermi-Pasta-Ulam-Tsingou lattice.

Phys Rev E 2021 May;103(5-1):052202

Institute for Metals Superplasticity Problems of RAS, Khalturin St. 39, Ufa 450000, Russia.

A practical approach to the search for (quasi-) discrete breathers (DBs) in a triangular β-FPUT lattice (after Fermi, Pasta, Ulam, and Tsingou) is proposed. DBs are obtained by superimposing localizing functions on delocalized nonlinear vibrational modes (DNVMs) having frequencies above the phonon spectrum of the lattice. Zero-dimensional and one-dimensional DBs are obtained. Read More

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Burden and determinants of multimorbidity among women in reproductive age group: a cross-sectional study based in India.

Wellcome Open Res 2020 18;5:275. Epub 2021 Feb 18.

ICMR Regional Medical Research Centre, Indian Council of Medical Research, Department of Health Research, Bhubaneswar, Odisha, 751023, India.

India's government is currently running several programs with a sole focus on women's health during their child-bearing years. However, none of these programs incorporate the management of chronic health conditions during the reproductive span. This issue is an emerging public health concern; therefore, the present study aims to identify the patterns and correlates of multimorbidity among women in reproductive age groups in India. Read More

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February 2021

Adjoint traveltime tomography unravels a scenario of horizontal mantle flow beneath the North China craton.

Sci Rep 2021 Jun 15;11(1):12523. Epub 2021 Jun 15.

Division of Mathematical Sciences, School of Physical and Mathematical Sciences and Asian School of the Environment, Nanyang Technological University, Singapore, Singapore.

The North China craton (NCC) was dominated by tectonic extension from late Cretaceous to Cenozoic, yet seismic studies on the relationship between crust extension and lithospheric mantle deformation are scarce. Here we present a three dimensional radially anisotropic model of NCC derived from adjoint traveltime tomography to address this issue. We find a prominent low S-wave velocity anomaly at lithospheric mantle depths beneath the Taihang Mountains, which extends eastward with a gradually decreasing amplitude. Read More

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Informatics Methods and Infrastructure Needed to Study Factors Associated with High Incidence of Pediatric Brain and Central Nervous System Tumors in Kentucky.

J Registry Manag 2020 ;47(3):127-134

Pediatric brain and central nervous system tumors (PBCNSTs) are the most common solid tumors and are the leading cause of disease-related death in US children. PBCNST incidence rates in Kentucky are significantly higher than in the United States as a whole, and are even higher among Kentucky's Appalachian children. To understand and eventually eliminate such disparities, population-based research is needed to gain a thorough understanding of the epidemiology and etiology of the disease. Read More

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