174,912 results match your criteria early mortality

Bridging the Gap Between the Intensive Care Unit and the Acute Medical Care Unit.

Am J Crit Care 2021 May;30(3):193-200

Liron Sinvani is an associate professor, Division of Hospital Medicine, Department of Medicine, Zucker School of Medicine at Hofstra/Northwell, and an assistant professor, Feinstein Institutes for Medical Research, Northwell Health.

Background: Despite a growing cohort of intensive care unit (ICU) survivors, little is known about the early ICU aftercare period.

Objective: To identify gaps in early ICU aftercare and factors associated with poor hospital outcomes.

Methods: A multisite, retrospective study (January 1 to December 31, 2017) was conducted among randomly selected patients admitted to the medical ICU and subsequently transferred to acute medical care units. Read More

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Arecanut-induced fibrosis display dual phases of reorganising glycans and amides in skin extracellular matrix.

Int J Biol Macromol 2021 Jun 20. Epub 2021 Jun 20.

School of Medical Science and Technology, Indian Institute of Technology Kharagpur, West Bengal 721302, India.

The habit of chewing arecanut leads to fibrosis in the oral tissues, which can lead to cancer. Despite high mortality, fibrosis has limited clinical success owing to organ-specific variations, genetic predispositions, and slow progression. Fibrosis is a progressive condition that is unresponsive to medications in the severe phase. Read More

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Audit of empirical antibiotic therapy for sepsis and the impact of early multidisciplinary consultation on patient outcomes.

Int J Antimicrob Agents 2021 Jun 20:106379. Epub 2021 Jun 20.

Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

Objectives: To perform an audit of empirical antibiotic therapy (EAT) of sepsis at the emergency department and to analyse the impact of an antimicrobial stewardship (AMS) programme on process and patient outcomes.

Patients And Methods: A prospective single centre cohort study including patients with SOFA score ≥2 from whom blood cultures were taken, was conducted between February 2019 and April 2020. EAT assessment was done using eight applicable quality indicators for responsible antibiotic use in inpatients (IQIs). Read More

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Comparison of early and long-term follow-up results of percutaneous mitral balloon valvuloplasty and mitral valve replacement.

Rev Assoc Med Bras (1992) 2021 Jan;67(1):58-63

Florence Nightingale Şişli Hospital - Istanbul, Turkey.

Background: Percutaneous mitral balloon valvuloplasty and mitral valve replacement have been the treatment options for mitral stenosis for several years, however, studies that compare these two modalities are very rare in the literature.

Objective: In this article, we aim to investigate the comparison of clinical results of percutaneous mitral balloon valvuloplasty and mitral valve replacement.

Methods: 527 patients with rheumatic mitral stenosis, treated with percutaneous mitral balloon valvuloplasty or mitral valve replacement (276 patients with percutaneous mitral balloon valvuloplasty and 251 patients with mitral valve replacement) from 1991 to 2012 were evaluated. Read More

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January 2021

Risk Factors for Surgical Site Infection After Lower Limb Revascularization Surgery in Adults with Peripheral Artery Disease: Protocol for a Systematic Review and Meta-Analysis.

JMIR Res Protoc 2021 Jun 23. Epub 2021 Jun 23.

University of Ottawa, The Ottawa Hospital, Civic Campus, Room A-280, 1053 Carling Avenue, Ottawa, CA.

Background: Surgical site infections are common, costly, and associated with increased morbidity and potentially mortality after lower limb revascularization surgery (i.e., arterial bypass, endarterectomy, and patch angioplasty). Read More

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Neutrophil-to-lymphocyte ratio, past, present and future perspectives.

R Zahorec

Bratisl Lek Listy 2021 ;122(7):474-488

In the review we analyzed short history of the establishment of a novel hematological parameter for systemic inflammation and stress coined as a neutrophil to lymphocyte ratio (NLR). Today NLR is widely used across almost all medical disciplines as a reliable and easy available marker of immune response to various infectious and non-infectious stimuli. We analyzed the immunological and biological aspects of dynamic changes of neutrophil granulocytes and lymphocytes in circulating blood during endocrine stress, dysbalance of autonomic nervous system and systemic inflammation. Read More

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January 2021

Fluid Metabolic Pathways after Subarachnoid Hemorrhage.

J Neurochem 2021 Jun 23. Epub 2021 Jun 23.

Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating cerebrovascular disease with high mortality and morbidity. In recent years, a large number of studies have focused on the mechanism of early brain injury (EBI) and delayed cerebral ischemia (DCI), including vasospasm, neurotoxicity of hematoma and neuroinflammatory storm, after aSAH. Despite considerable efforts, no novel drugs have significantly improved the prognosis of patients in phase III clinical trials, indicating the need to further re-examine the multifactorial pathophysiological process that occurs after aSAH. Read More

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Deep neck infections with and without mediastinal involvement: treatment and outcome in 218 patients.

Eur Arch Otorhinolaryngol 2021 Jun 23. Epub 2021 Jun 23.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.

Purpose: Infections of the deep neck, although becoming scarcer due to the widespread use of antibiotics, still represent a dangerous and possibly deadly disease, especially when descending into the mediastinum. Due to the different specialities involved in the treatment and the heterogenous presentation of the disease, therapeutic standard is still controversial. This study analyzes treatment and outcome in these patients based on a large retrospective review and proposes a therapeutic algorithm. Read More

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Efficacy of Omadacycline Versus Moxifloxacin in the Treatment of Community-Acquired Bacterial Pneumonia by Disease Severity: Results From the OPTIC Study.

Open Forum Infect Dis 2021 Jun 18;8(6):ofab135. Epub 2021 Jun 18.

Paratek Pharmaceuticals, Inc., King of Prussia, Pennsylvania, USA.

Background: Severity/mortality risk scores and disease characteristics may assist in deciding whether patients with community-acquired bacterial pneumonia (CABP) require outpatient treatment or hospitalization. The phase 3 OPTIC (Omadacycline for Pneumonia Treatment In the Community) study enrolled patients with Pneumonia Outcomes Research Team (PORT) risk class II-IV. Omadacycline demonstrated noninferiority to moxifloxacin in adults with CABP, at early clinical response (ECR) and posttreatment evaluation (PTE). Read More

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Complicated pulmonary human coronavirus-NL63 infection after a second allogeneic hematopoietic stem cell transplantation for acute B-lymphocytic leukemia: A case report.

Medicine (Baltimore) 2021 Jun;100(25):e26446

Department of Bone Marrow Transplantation.

Rationale: Viruses are the most common pathogens that can cause infection-related non-recurrent death after transplantation, occurring mostly from the early stages of hematopoietic stem cell transplantation (HSCT) to within 1 year after transplantation. Human coronavirus (HCoV)-NL63 is a coronavirus that could cause mortality among patients with underlying disease complications. Serological tests are of limited diagnostic value in immunocompromised hosts and cases of latent infection reactivation. Read More

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The Cox model of predicting mortality among melioidosis patients in Northern Malaysia: A retrospective study.

Medicine (Baltimore) 2021 Jun;100(25):e26160

Clinical Research Center, Hospital Sultanah Bahiyah, Ministry of Health Malaysia, Alor Setar, Kedah, Malaysia.

Abstract: Melioidosis is an infectious disease that is initiated by a bacteria recognized as Burkholderia pseudomallei. Despite the high fatality rate from melioidosis, there is a minimal published study about the disease in Malaysia.This study aimed to identify the prognostic factors of mortality among melioidosis patients in northern Malaysia. Read More

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Treatment of Aortoiliac Occlusive Disease With the Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) Technique: Results of a UK Multicenter Study.

J Endovasc Ther 2021 Jun 23:15266028211025028. Epub 2021 Jun 23.

Department of Vascular Surgery, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.

Objective: This UK multicenter study aims to report early- and medium-term results following covered endovascular reconstruction of aortic bifurcation (CERAB) for the treatment of aortoiliac occlusive disease (AIOD) in patients with chronic limb threatening ischemia (CLTI) or intermittent claudication (IC).

Materials And Methods: Retrospective case analysis was performed of patients who underwent CERAB between November 1, 2012 and March 31, 2020 in 6 centers across the United Kingdom. Anatomical data, including degree of plaque calcification, were assessed using preoperative imaging. Read More

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Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms.

mSphere 2021 Jun 23:e0047921. Epub 2021 Jun 23.

Institute for Modeling Collaboration and Innovation, University of Idahogrid.266456.5, Moscow, Idaho, USA.

Coinfection by heterologous viruses in the respiratory tract is common and can alter disease severity compared to infection by individual virus strains. We previously found that inoculation of mice with rhinovirus (RV) 2 days before inoculation with a lethal dose of influenza A virus [A/Puerto Rico/8/34 (H1N1) (PR8)] provides complete protection against mortality. Here, we extended that finding to a second lethal respiratory virus, pneumonia virus of mice (PVM), and analyzed potential mechanisms of RV-induced protection. Read More

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Hemophagocytic lymphohistiocytosis occurring after liver transplantation: A case series and review of the literature.

Clin Transplant 2021 Jun 23. Epub 2021 Jun 23.

Recanati-Miller Transplantation Institute, The Mount Sinai Hospital, New York, New York, USA.

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease characterized by excessive inflammation and tissue destruction due to a dysregulated immune response. Its secondary form is most commonly triggered by viral infection or malignancy. There have previously been 11 cases of acquired HLH described following liver transplantation in adult transplant recipients, most occurring within the first year following transplantation. Read More

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Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain.

Genet Epidemiol 2021 Jun 22. Epub 2021 Jun 22.

Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.

SARS-CoV-2 mortality has been extensively studied in relation to host susceptibility. How sequence variations in the SARS-CoV-2 genome affect pathogenicity is poorly understood. Starting in October 2020, using the methodology of genome-wide association studies (GWAS), we looked at the association between whole-genome sequencing (WGS) data of the virus and COVID-19 mortality as a potential method of early identification of highly pathogenic strains to target for containment. Read More

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Use of ultrasound to diagnose and monitor interstitial lung disease in rheumatic diseases.

Clin Rheumatol 2021 Jun 23. Epub 2021 Jun 23.

Instituto Poal de Reumatología Barcelona, EULAR Working Group Anatomy for the Image, University of Barcelona, International University of Catalunya, Castanyer 15, Sarrià-Sant Gervasi 08022, Barcelona, Barcelona, Spain.

Interstitial lung disease (ILD) is one of the most relevant extra-articular manifestations of rheumatic diseases resulting in a substantial increase in morbidity and mortality. Early diagnosis and close monitoring to identify patients at high risk of progression are crucial to establish the need for targeted treatment with immunomodulatory and antifibrotic drugs, with potential ability to change the course of the disease. However, there are unmet needs in this field as pulmonary auscultation, chest radiography, or pulmonary function studies do not allow identification of the most incipient stages of the disease. Read More

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"Relaparoscopy" to treat early complications following colorectal surgery.

Surg Endosc 2021 Jun 22. Epub 2021 Jun 22.

Division of Colorectal Surgery, Hospital Alemán of Buenos Aires, Buenos Aires, Argentina.

Background: Laparoscopic surgery has shown clear benefits that could also be useful in the emergency setting such as early reoperations after colorectal surgery. The aim of this study was to evaluate the safety and feasibility of laparoscopic reintervention ("relaparoscopy") (RL) to manage postoperative complications after laparoscopic colorectal surgery.

Methods: We performed a retrospective study based on a prospectively collected database from 2000 to 2019. Read More

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Endocrine hypertension secondary to adrenal tumors: clinical course and predictive factors of clinical remission.

Langenbecks Arch Surg 2021 Jun 23. Epub 2021 Jun 23.

Endocrine Surgery and Advanced Laparoscopy Service, Department of Surgery, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Belisario Dominguez Sección XVI, Mexico City, 14080, México.

Purpose: Endocrinopathies constitute ~ 10% of secondary hypertension (SH) etiologies. Primary aldosteronism, pheochromocytoma (PHEO), and Cushing's syndrome are common causes. Early identification and treatment result in resolution/improvement of SH. Read More

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A visual tool inclusive of fetal ultrasound and autopsy findings to reach a balanced approach to counseling on trisomy 18 in early second trimester.

Arch Gynecol Obstet 2021 Jun 22. Epub 2021 Jun 22.

Institute of Pathology, Locarno, Switzerland.

Identified by the eponym "Edwards' Syndrome," trisomy 18 (T18) represents the second most common autosomal trisomy after T21. The pathophysiology underlying the extra chromosome 18 is a nondisjunction error, mainly linked with the advanced maternal age. More frequent in female fetuses, the syndrome portends high mortality, reaching a rate of 80% of miscarriages or stillbirths. Read More

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A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice.

bioRxiv 2021 Jun 17. Epub 2021 Jun 17.

As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urgent need for the development of effective medical countermeasures. Here, we assessed the antiviral capacity of a minimal RIG-I agonist, stem-loop RNA 14 (SLR14), in viral control, disease prevention, post-infection therapy, and cross-variant protection in mouse models of SARS-CoV-2 infection. A single dose of SLR14 prevented viral replication in the lower respiratory tract and development of severe disease in a type I interferon (IFN-I) dependent manner. Read More

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Changes in Immune Activation During Pregnancy and the Postpartum Period in Treated HIV Infection.

Open Forum Infect Dis 2021 Jun 17;8(6):ofab245. Epub 2021 May 17.

University of California San Francisco, San Francisco, California, USA.

Background: Pregnant women with HIV (PWWH) have high postpartum morbidity and mortality from infections like tuberculosis. Immunologic changes during pregnancy and postpartum periods may contribute to these risks, particularly the immunoregulatory kynurenine pathway of tryptophan catabolism, which contributes to both HIV and tuberculosis pathogenesis and increases in the early postpartum period.

Methods: Women with HIV initiating antiretroviral therapy (ART) in the Uganda AIDS Rural Treatment Outcomes (UARTO) cohort who were pregnant at enrollment or became pregnant during observation were studied (n = 54). Read More

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Severe late-onset ovarian hyperstimulation syndrome presenting with liver dysfunction after in vitro fertilization: A case report.

Case Rep Womens Health 2021 Jul 4;31:e00332. Epub 2021 Jun 4.

Division of Reproductive Endocrinology, Infertility, and Genetics, Department of Obstetrics and Gynecology, Medical College of Georgia at Augusta University, 1120 5 St, Augusta, GA, USA.

Ovarian hyperstimulation syndrome (OHSS) is a feared complication of controlled ovarian stimulation (COS) and can be associated with significant morbidity and mortality. Risk factors for OHSS include a history of OHSS, young age, low body mass index (BMI), polycystic ovary syndrome, elevated serum levels of anti-Müllerian hormone (AMH), large number of recruited follicles, elevated serum levels of estradiol, and higher gonadotropin doses during COS. However, OHSS may develop in patients with minimal risk factors. Read More

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Dengue Fever-Triggered Malignant Hyperthermia.

Cureus 2021 May 19;13(5):e15121. Epub 2021 May 19.

Internal Medicine, National Hospital of Sri Lanka, Colombo, LKA.

Malignant hyperthermia (MH) is a genetic skeletal muscle disorder characterized by hypermetabolic crisis usually triggered by anesthetic drugs. Non-anesthesia-triggered or awake MH is rare or under-reported. Other than anesthetic drugs, identified common triggers are exercise, fever, and viral infection. Read More

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Early Chest Re-Exploration for Excessive Bleeding in Post Cardiac Surgery Patients: Does It Matter?

Cureus 2021 May 18;13(5):e15091. Epub 2021 May 18.

Anesthesiology, Rehman Medical Institute, Peshawar, PAK.

Introduction Re-explorations after open-heart surgery are often required if the patient is bleeding or shows features of cardiovascular instability and does not improve with conservative measures. Our study aims to determine whether timely re-exploration of patients who are bleeding has an impact on the morbidity and mortality of the patients. Methods A retrospective analysis of 75 patients that underwent open-heart surgery and subsequently underwent chest re-exploration for excessive bleeding betweenMarch 2018 and March 2020. Read More

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Clinical Manifestations and Characterization of COVID-19 in Liver Transplant Recipients: A Systematic Review of Case Reports and Case Series.

Ethiop J Health Sci 2021 Mar;31(2):429-438

Razi Clinical Research Development Unit, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran.

Background: This systematic review is conducted to explore available information on clinical presentations, laboratory finding and outcomes of SARS-COV-2 in liver transplant patients.

Methods: We searched four databases for relevant terms related to COVID-19 and liver transplantation and collected both case reports and case series on liver transplantation published up to the end of September 2020.

Results: After initial screening of irrelevant articles, 25 studies were included and analyzed in this review. Read More

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Early Outcome of Laparotomy Wounds in Pediatric Patients in TASH, Addis Ababa, Ethiopia: A Six-Months Prospective Study.

Ethiop J Health Sci 2021 Jan;31(1):111-118

Addis Ababa University, Tikur Anbessa Specialized Hospital, Department of Surgery, Zambia St., Addis Ababa, Ethiopia.

Background: Surgical Site Infection (SSI) and wound dehiscence are two early complications of laparotomy causing significant morbidity and mortality. This study was conducted to determine the prevalence and risk factors of SSI and wound dehiscence in pediatric surgical patients.

Methods: We performed a prospective observational study of all pediatric surgical patients who underwent laparotomy at Tikur Anbessa Specialized Hospital, Ethiopia, from December 2017 to May 2018. Read More

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January 2021

Preterm Neonatal Mortality and its predictors in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: a retrospective cohort study.

Ethiop J Health Sci 2021 Jan;31(1):43-54

College of Health Science, Debre Birhan University, Debre Birhan, Ethiopia.

Background: Preterm neonatal death is a global problem. In Ethiopia, it is still high, and the trend in reduction is slower as compared to child mortality. Preterm neonatal birth is the leading cause. Read More

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January 2021

Novel therapies targeting hypoxia mechanism to treat pancreatic cancer.

Chin J Cancer Res 2021 Apr;33(2):216-231

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Pancreatic cancer (PC) is one of the deadliest malignancies. The high mortality rate of PC largely results from delayed diagnosis and early metastasis. Therefore, identifying novel treatment targets for patients with PC is urgently required to improve survival rates. Read More

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Obesity, oxidative DNA damage and vitamin D as predictors of genomic instability in children and adolescents.

Int J Obes (Lond) 2021 Jun 22. Epub 2021 Jun 22.

School of Life Sciences, University of Westminster, London, UK.

Background/objectives: Epidemiological evidence indicates obesity in childhood and adolescence to be an independent risk factor for cancer and premature mortality in adulthood. Pathological implications from excess adiposity may begin early in life. Obesity is concurrent with a state of chronic inflammation, a well-known aetiological factor for DNA damage. Read More

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Prospective validation of an 11-gene mRNA host response score for mortality risk stratification in the intensive care unit.

Sci Rep 2021 Jun 22;11(1):13062. Epub 2021 Jun 22.

Division of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Several clinical calculators predict intensive care unit (ICU) mortality, however these are cumbersome and often require 24 h of data to calculate. Retrospective studies have demonstrated the utility of whole blood transcriptomic analysis in predicting mortality. In this study, we tested prospective validation of an 11-gene messenger RNA (mRNA) score in an ICU population. Read More

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