101,579 results match your criteria early loss

Exercise alleviates symptoms of CNS lupus.

Brain Res 2021 Apr 11:147478. Epub 2021 Apr 11.

Department of Medicine, University at Buffalo, Buffalo, NY 14086. Electronic address:

Systemic lupus erythematosus (lupus) is a global health problem where 20-80% patients display cognitive problems and central nervous system (CNS) dysfunction. Early diagnosis and treatment of lupus remains a clinical challenge. Exercise improves experimental lupus nephritis. Read More

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UTX promotes CD8 T cell-mediated antiviral defenses but reduces T cell durability.

Cell Rep 2021 Apr;35(2):108966

Department of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Microbiology & Immunology, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. Electronic address:

Persistent virus infections can cause pathogenesis that is debilitating or lethal. During these infections, virus-specific T cells fail to protect due to weakened antiviral activity or failure to persist. These outcomes are governed by histone modifications, although it is unknown which enzymes contribute to T cell loss or impaired function over time. Read More

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Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.

Cell Rep 2021 Apr;35(2):108991

Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA; Laboratory for Translational Cell Biology, Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

Transcriptional silencing of the FMR1 gene in fragile X syndrome (FXS) leads to the loss of the RNA-binding protein FMRP. In addition to regulating mRNA translation and protein synthesis, emerging evidence suggests that FMRP acts to coordinate proliferation and differentiation during early neural development. However, whether loss of FMRP-mediated translational control is related to impaired cell fate specification in the developing human brain remains unknown. Read More

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Koala cathelicidin PhciCath5 has antimicrobial activity, including against Chlamydia pecorum.

PLoS One 2021 14;16(4):e0249658. Epub 2021 Apr 14.

School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia.

Devastating fires in Australia over 2019-20 decimated native fauna and flora, including koalas. The resulting population bottleneck, combined with significant loss of habitat, increases the vulnerability of remaining koala populations to threats which include disease. Chlamydia is one disease which causes significant morbidity and mortality in koalas. Read More

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Case Report: Idiopathic Sclerosing Orbital Inflammation.

Optom Vis Sci 2021 Apr;98(4):409-417

Eye Institute, Medical College of Wisconsin, Milwaukee, Wisconsin.

Significance: Idiopathic sclerosing orbital inflammation (ISOI) is characterized by insidious, chronic, progressive inflammation and fibrosis that damage ocular structures and produce a mass effect. This case highlights the challenges in diagnosis and management of ISOI, as well as the associated ocular morbidities, including potential vision loss.

Purpose: The purpose of this study was to provide education regarding a rare condition that exhibits variable presentation and has an unpredictable success rate with regard to treatment paradigm. Read More

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Evaluation of licofelone as an adjunct anti-inflammatory therapy to biologic scaffolds in the treatment of volumetric muscle loss.

Cell Tissue Res 2021 Apr 14. Epub 2021 Apr 14.

DoD-VA Extremity Trauma and Amputation Center of Excellence, Bethesda, MD, USA.

Biologic scaffolds (BS) are the most widely studied therapeutics for the treatment of volumetric muscle loss (VML) owing to their purported effects on cell proliferation, chemotaxis, migration, and differentiation. Despite these claims, variability in reports on the nature of the immune response to their implantation suggests that BS-associated inflammation may be limiting their regenerative efficacy. To address this shortcoming, this study sought to evaluate licofelone (ML3000), a dual 5-LOX/COX inhibitor, as an anti-inflammatory adjunct therapy to a BS in the treatment of VML. Read More

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A huge ureteric stone in a functionally, metabolically and anatomically normal kidney: an alliance of rarity.

Ann R Coll Surg Engl 2021 Apr 14. Epub 2021 Apr 14.

Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Urinary stones are a common health problem, necessitating frequent outpatient visits and hospital admissions. Ureteric stones demand special attention, given their propensity for upstream hydroureteronephrosis and loss of renal function. They are usually predisposed by diverse anatomical, functional or metabolic abnormalities of the urinary tract and have an early symptomatic presentation. Read More

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Effects of Perfusion Pressures on Podocyte Loss in the Isolated Perfused Mouse Kidney.

Cell Physiol Biochem 2021 Apr;55(S4):1-12

Division of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany,

Background/aims: Podocytes are lost in most glomerular diseases, leading to glomerulosclerosis and progressive kidney disease. It is generally assumed, that podocytes are exposed to the filtration flow and thus to significant shear forces driving their detachment from the glomerular basement membrane (GBM). In this context, foot process effacement has been proposed as potential adaptive response to increase adhesion of podocytes to the GBM. Read More

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Early Outcomes of Simultaneous Translabyrinthine Resection and Cochlear Implantation.

Laryngoscope 2021 Apr 14. Epub 2021 Apr 14.

Michigan Ear Institute, Farmington Hills, Michigan, USA.

Objectives/hypothesis: Hearing rehabilitation after translabyrinthine resection of a vestibular schwannoma (VS) has largely been based on the transfer of acoustic stimulus to the contralateral ear, typically through a contralateral routing of signal hearing aid or bone-anchored hearing aid (BAHA). Cochlear implant, either as a subsequent surgery or simultaneously, has become a more common treatment option; however, there is still relatively limited data available on its success. The purpose of this study is to evaluate the early outcomes of simultaneous cochlear implantation in patients with sporadic VS undergoing translabyrinthine resection. Read More

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Our newborn hearing screening results.

Suleyman Erdogdu

North Clin Istanb 2021 12;8(2):167-171. Epub 2021 Mar 12.

Department of Otorhinolaryngology, University of Health Sciences, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.

Objective: The aim of the study was to evaluate the results of neonatal hearing screening in our hospital with the help of literature and to question and reveal the risk factors to gain healthy individuals and to raise awareness for all health workers and the public who are interested in this subject.

Methods: A total of 16,388 newborn infants were evaluated between October 2009 and January 2018. All newborns were screened with transient evoked otoacoustic emissions (TEOAEs) test. Read More

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Effect of hormone replacement therapy on bone formation quality and mineralization regulation mechanisms in early postmenopausal women.

Bone Rep 2021 Jun 23;14:101055. Epub 2021 Mar 23.

Ludwig Boltzmann Institute for Osteology, at the Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria.

Post-menopausal osteoporosis is characterized by a negative imbalance between bone formation and bone resorption resulting in a net bone loss, increasing the risk of fracture. One of the earliest interventions to protect against this was hormonal replacement therapy (HRT). Bone strength depends on both the amount and quality of bone, the latter including compositional / material and structural properties. Read More

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Clinical course in two children with Juvenile Paget's disease during long-term treatment with intravenous bisphosphonates.

Bone Rep 2021 Jun 9;14:100762. Epub 2021 Mar 9.

Department of Pediatrics, Division of Rare Diseases, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.

Juvenile Paget disease (JPD) is an ultra-rare disease, characterized by loss of function of osteoprotegerin. Osteoprotegerin inhibits osteoclast activation via the receptor activator of nuclear factor κB (RANK) pathway. Severely affected children suffer from bone deformities and pain and require long term anti-resorptive treatment. Read More

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Burden of Care and Perceived Psycho-Social Outcomes among Family Caregivers of Patients Living with Cancer.

Asia Pac J Oncol Nurs 2021 May-Jun;8(3):330-336. Epub 2021 Feb 4.

College of Nursing, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE.

Objective: Caring for patients living with cancer requires the support of family caregivers. Literature reports experiences of diverse burdens and health effects among caregivers. This study examined the burden, physical, psycho-social, and financial outcomes of caregiving among caregivers of patients living with cancer. Read More

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February 2021

Early rehabilitation after lung transplantation with extracorporeal membrane oxygenation (ECMO) of COVID-19 patient: a case report.

Ann Transl Med 2021 Mar;9(6):512

Department of Rehabilitation Medicine, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.

Even when severe acute respiratory syndrome coronavirus 2-related coronavirus disease 2019 (COVID-19) is treated with first-line drugs, it progresses and leads to irreversible loss of lung function in some critically ill patients, and lung transplantation is an effective treatment for end-stage chronic pulmonary disease. This case report mainly describes the rehabilitation of a 66-year-old female patient with severe COVID-19 after bilateral lung transplantation. The old patient had a body mass index of 31. Read More

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Advances in The Diagnosis and Treatment of Achalasia of The Cardia: a Review.

J Transl Int Med 2021 Mar 31;9(1):24-31. Epub 2021 Mar 31.

Department of Gastroenterology, ShengJing Hospital of China Medical University, Shenyang, Liaoning Province, China.

Idiopathic achalasia is an esophageal motor disorder characterized by the loss of the lower esophageal sphincter ganglion, resulting in impaired lower esophageal relaxation and absence of esophageal peristalsis. Patients commonly present with progressive dysphagia accompanied by reflux, heartburn, retrosternal pain, and severe weight loss. Diagnosis is primarily based on the patient's chief complaints, barium esophagography, and the most recent high-resolution manometry. Read More

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The effects of Y chromosome microdeletions on fertilization outcomes, health abnormalities in offspring and recurrent pregnancy loss.

Transl Androl Urol 2021 Mar;10(3):1457-1466

Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

Male factor infertility accounts for approximately 50% of all infertility evaluations. A common cause of severe oligozoospermia and azoospermia is Y chromosome microdeletions (YCMs). Men with these genetic microdeletions must typically undergo assisted reproductive technology (ART) procedures to obtain paternity. Read More

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Orbit and sinonasal metastasis as presenting sign of renal cell carcinoma.

BMJ Case Rep 2021 Apr 13;14(4). Epub 2021 Apr 13.

Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA

Orbit and sinonasal metastases are rare. Renal cell carcinoma (RCC) can metastasise to this region. We present the case of a 49-year-old woman with weight loss, diplopia and a rapidly growing facial mass. Read More

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Feasibility, acceptability, and potential efficacy of an innovative postnatal home-based breastfeeding peer support programme in Hong Kong: a feasibility and pilot randomised controlled trial.

Int Breastfeed J 2021 Apr 13;16(1):34. Epub 2021 Apr 13.

Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, James Clerk Maxwell Building, 57 Waterloo Road, London, SE1 8WA, UK.

Background: As suggested by the World Health Organization, breastfeeding peer support is being introduced worldwide to support women's breastfeeding needs. Evidence has shown that when such support is offered to women, the duration and exclusivity of breastfeeding is increased. We developed an innovative home-based intervention to sustain exclusive breastfeeding in Hong Kong. Read More

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The potential impact of salivary peptides in periodontitis.

Crit Rev Clin Lab Sci 2021 Apr 13:1-14. Epub 2021 Apr 13.

Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.

Periodontitis is a complex immune-inflammatory condition characterized by the disruption of the periodontal ligament and subsequent formation of periodontal pockets, and by alveolar bone loss, often resulting in tooth loss. A myriad of factors, namely, genetic, metabolic, immunological, and inflammatory, is associated with progression of periodontitis. Periodontitis is also associated with systemic conditions such as neoplastic disorders, obesity, and diabetes. Read More

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Deep CNN-Based CAD System for COVID-19 Detection Using Multiple Lung CT Scans.

J Med Internet Res 2021 Apr 3. Epub 2021 Apr 3.

Department of Computer Engineering, Faculty of Electrical and Computer Engineering, Shiraz University, Shiraz, IR.

Background: Due to the COVID-19 pandemic and the imminent collapse of healthcare systems following the excessive consumption of financial, hospital, and medicinal resources, the WHO changed the alert level on the COVID-19 pandemic from high to very high. Meanwhile, the world began to favor less expensive and more precise COVID-19 detection methods.

Objective: Machine vision-based COVID-19 detection methods especially Deep learning as a diagnostic technique in the early stages of the disease have found great importance during the pandemic. Read More

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The Lanata trichome mutation increases stomatal conductance and reduces leaf temperature in tomato.

J Plant Physiol 2021 Apr 6;260:153413. Epub 2021 Apr 6.

Departamento de Biologia Vegetal, Universidade Federal de Viçosa, CEP 36570-900, Viçosa, MG, Brazil. Electronic address:

Trichomes are epidermal structures with a large variety of ecological functions and economic applications. Glandular trichomes produce a rich repertoire of secondary metabolites, whereas non-glandular trichomes create a physical barrier on the epidermis: both operate in tandem against biotic and abiotic stressors. A deeper understanding of trichome development and function would enable the breeding of more resilient crops. Read More

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Comparisons of basic Target-Mediated Drug Disposition (TMDD) and Ligand Facilitated Target Removal (LFTR).

Eur J Pharm Sci 2021 Apr 10:105835. Epub 2021 Apr 10.

Firma Biopharmacon, Engelbrektsgatan 5, Gothenburg 41127, Sweden. Electronic address:

In the well-known model for basic Target-Mediated Drug Disposition (TMDD), drug binds to the target and the resulting drug-target complex is removed by a first order process, leading to loss of both drug and target. In the present note we study what happens when, instead, drug is returned to the free drug pool so that it can a new target molecule. What results is a mechanism in which the drug, here referred to as the ligand, facilitates the removal of the target,and then returns to the free ligand pool. Read More

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Genome-wide survey of tyrosine phosphatases in thirty mammalian genomes.

Cell Signal 2021 Apr 10:110009. Epub 2021 Apr 10.

National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bellary Road, Bangalore, Karnataka, 560 065, India. Electronic address:

The age of genomics has given us a wealth of information and the tools to study whole genomes. This, in turn, has facilitated genome-wide studies among organisms that were relatively less studied in the pre-genomic era or are non-model organisms. This paves the way to the discovery of interesting evolutionary patterns, which are brought to light by genome-wide surveys of protein superfamilies. Read More

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Base editing repairs an SGCA mutation in human primary muscle stem cells.

JCI Insight 2021 Apr 13. Epub 2021 Apr 13.

Muscle Research Unit, Charité University Hospital Berlin, Berlin, Germany.

Skeletal muscle can regenerate from muscle stem cells and their myogenic precursor cell progeny, myoblasts. However, precise gene editing in human muscle stem cells for autologous cell replacement therapies of untreatable genetic muscle diseases has not yet been reported. Loss-of-function mutations in SGCA, encoding α-sarcoglycan, cause limb-girdle muscular dystrophy 2D/R3, an early onset, severe and rapidly progressive form of muscular dystrophy affecting equally girls and boys. Read More

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Cell-Based Therapies for Age-Related Macular Degeneration.

Adv Exp Med Biol 2021 ;1256:265-293

Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Age-related macular degeneration (AMD) is a leading cause of blindness worldwide. The pathogenesis of AMD involves dysfunction and loss of the retinal pigment epithelium (RPE), a monolayer of cells that provide nourishment and functional support for the overlying photoreceptors. RPE cells in mammals are not known to divide, renew or regenerate in vivo, and in advanced AMD, RPE loss leads to degeneration of the photoreceptors and impairment of vision. Read More

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January 2021

Bruch's Membrane and the Choroid in Age-Related Macular Degeneration.

Adv Exp Med Biol 2021 ;1256:89-119

Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD, USA.

A healthy choroidal vasculature is necessary to support the retinal pigment epithelium (RPE) and photoreceptors, because there is a mutualistic symbiotic relationship between the components of the photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris (CC) complex. This relationship is compromised in age-related macular degeneration (AMD) by the dysfunction or death of the choroidal vasculature. This chapter will provide a basic description of the human Bruch's membrane and choroidal anatomy and physiology and how they change in AMD. Read More

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January 2021

[Relevance of meniscus loss for the progression of osteoarthritis and treatment options for early arthritis].

Orthopade 2021 Apr 13. Epub 2021 Apr 13.

Orthopädisch Chirurgisches Centrum Tübingen, Tübingen, Deutschland.

Meniscal tears are still one of the most frequent lesions in the knee joint. The relevance of meniscus loss for the development of osteoarthritis is undisputed. Meniscus repair, replacement and transplantation play an important role in the treatment of early arthritis, especially when they are a part of a master plan including alignment correction, stabilization and cartilage surgery, if needed. Read More

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Effect of acupuncture on essential hypertension: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25572

Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.

Background: Essential hypertension is a risk factor for early cardiovascular disease and is a major preventable risk factor for premature death and disability worldwide. However, some antihypertensive drugs cannot be used for treatment because of their cost-effectiveness or side effects. Non-drug treatments for hypertension include weight loss, salt restriction, smoking cessation, alcohol withdrawal, and exercise, although these methods are difficult to maintain and to achieve. Read More

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Molecular Insights into Myocilin and Its Glaucoma-Causing Misfolded Olfactomedin Domain Variants.

Acc Chem Res 2021 Apr 13. Epub 2021 Apr 13.

School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Dr. NW, Atlanta, Georgia 30332-0400, United States.

ConspectusNumerous human disorders arise due to the inability of a particular protein to adopt its correct three-dimensional structure in the context of the cell, leading to aggregation. A new addition to the list of such protein conformational disorders is the inherited subtype of glaucoma. Different and rare coding mutations in myocilin, found in families throughout the world, are causal for early onset ocular hypertension, a key glaucoma risk factor. Read More

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A novel gene variant (c.857A>G; p.Tyr286Cys) in an extended family with non‑syndromic deafness 2A.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Department of Otolaryngology‑Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi 710032, P.R. China.

Deafness is one of the most common sensory disorders found in humans; notably, >60% of all cases of deafness have been attributed to genetic factors. Variants in potassium voltage‑gated channel subfamily Q member 4 () are etiologically linked to a type of progressive hearing loss, deafness non‑syndromic autosomal dominant 2A (DFNA2A). In the present study, whole‑exome sequencing (WES) was performed on three members of a five‑generation Chinese family with 46 members with hearing loss. Read More

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