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Application of a new serratus anterior plane block in modified radical mastectomy under ultrasound guidance: A prospective, randomized controlled trial.

J Clin Anesth 2021 Jun 9;74:110377. Epub 2021 Jun 9.

Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Electronic address:

Study Objectives: Post-operative pain is a significant concern following modified radical mastectomy in breast cancer patients. The serratus anterior plane block has recently been described as an effective technique for post-operative analgesia of modified radical mastectomy. The purpose of this study was to evaluate the analgesic efficacy and safety of a new serratus anterior plane (SAP) block for post-operative pain of mastectomy. Read More

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Ultrasound contrast agents: microbubbles made simple for the pediatric radiologist.

Pediatr Radiol 2021 Jun 12. Epub 2021 Jun 12.

Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.

The ability to provide prompt, real-time, easily accessible and radiation-free diagnostic assessments makes ultrasound (US) one of the most versatile imaging modalities. The introduction and development of stable microbubble-based ultrasound contrast agents (UCAs) in the early 1990s improved visualization of complex vascular structures, overcoming some of the limitations of B-mode and Doppler imaging. UCAs have been used extensively in the adult population to visualize vasculature and to evaluate perfusion and blood flow dynamics in organs and lesions. Read More

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Adiponectin and cardiometabolic trait and mortality: where do we go?

Cardiovasc Res 2021 Jun 12. Epub 2021 Jun 12.

Division of Cardiovascular Disease, Gachon University Gil Hospital, Incheon, Korea, Gachon Cardiovascular Research Institute, Incheon, Korea.

Adiponectin is an adipocyte-derived cytokine known for its cardioprotective effects in preclinical studies. Early epidemiologic studies replicated these findings and drew great interest. Subsequent large-scale prospective cohorts, however, showed that adiponectin levels seemed not to relate to incident coronary artery disease (CAD). Read More

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Impact of Wuhan lockdown on the spread of COVID-19 in China: a study based on the data of population mobility.

Zhejiang Da Xue Xue Bao Yi Xue Ban 2021 Feb;50(1):61-67

Department of Surgical Oncology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China.

This study aimed to quantitatively assess the effectiveness of the Wuhan lockdown measure on controlling the spread of coronavirus diesase 2019 (COVID-19). : Firstly,estimate the daily new infection rate in Wuhan before January 23,2020 when the city went into lockdown by consulting the data of Wuhan population mobility and the number of cases imported from Wuhan in 217 cities of Mainland China. Then estimate what the daily new infection rate would have been in Wuhan from January 24 to January 30th if the lockdown measure had been delayed for 7 days,assuming that the daily new infection in Wuhan after January 23 increased in a high,moderate and low trend respectively (using exponential, linear and logarithm growth models). Read More

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February 2021

Obesity in early onset breast cancer in African American patients.

Breast J 2021 Jun 11. Epub 2021 Jun 11.

Department of Medical Oncology, Thomas Jefferson University, Sidney Kimmel Cancer Center at Jefferson Health, Philadelphia, Pennsylvania, USA.

Obesity is a modifiable risk factor in breast cancer patients and is predictive of disease outcomes in early-onset breast cancer survivors. The purpose of this review is to summarize the current evidence in the association between early-onset breast cancer and obesity, specifically in African-American women. Reviewing the molecular mechanisms and social determinants of disease in this population can provide a foundation for future interventions in prevention, detection, and treatment aiming at improving outcomes for young breast cancer patients. Read More

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Adapting the listening time for micro-electrode recordings in deep brain stimulation interventions.

Int J Comput Assist Radiol Surg 2021 Jun 11. Epub 2021 Jun 11.

Laboratoire Traitement du Signal et de l'Image (LTSI - INSERM UMR 1099), Université de Rennes 1, Rennes, France.

Purpose: Deep brain stimulation (DBS) is a common treatment for a variety of neurological disorders which involves the precise placement of electrodes at particular subcortical locations such as the subthalamic nucleus. This placement is often guided by auditory analysis of micro-electrode recordings (MERs) which informs the clinical team as to the anatomic region in which the electrode is currently positioned. Recent automation attempts have lacked flexibility in terms of the amount of signal recorded, not allowing them to collect more signal when higher certainty is needed or less when the anatomy is unambiguous. Read More

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Non-invasive electrophysiology in glaucoma, structure and function-a review.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Faculty of Medicine, Eye Center, Medical Center-University of Freiburg, Freiburg im Breisgau, Germany.

Glaucoma, its early diagnosis, and monitoring of interventions remain an ongoing challenge. We here review developments in functional assessment and its relation to morphology, evaluating recent insights in electrophysiology in glaucoma and highlighting how glaucoma research and diagnostics benefit from combined approaches of OCT and electrophysiological investigations. After concise overviews of OCT and non-invasive electrophysiology in glaucoma, we evaluate commonalities and complementarities of OCT and electrophysiology for our understanding of glaucoma. Read More

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Effect of Emerging Major Infectious Diseases on Sleep Quality of Medical Workers: Findings from Medical Workers Providing Support During the COVID-19 Pandemic.

Med Sci Monit 2021 Jun 12;27:e931881. Epub 2021 Jun 12.

Department of Health Services Management, School of Health Services Management, Anhui Medical University, Hefei, Anhui, China (mainland).

BACKGROUND The coronavirus disease 2019 (COVID-19) outbreak has exerted immense pressure on medical systems in China and abroad. This study aimed to compare the sleep quality of medical personnel conscripted to the Wuhan Union Cancer Centre to offer support during the early stages of the COVID-19 pandemic to the sleep quality of those who remained at Anhui Medical University Hospital and to determine the role of interventions in improving sleep quality. MATERIAL AND METHODS Questionnaires were completed by 369 individuals who were conscripted to support Wuhan (N=137) and others who were not (the control group; N=232). Read More

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Muscle Deteriorations Become Prominent within 24 Hours after Admission in Severely Burned Adults.

J Trauma Acute Care Surg 2021 May 18. Epub 2021 May 18.

US Army Institute of Surgical Research, Ft Sam Houston, TX 78234 Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 Uniformed Services University of the Health Sciences, Bethesda, MD 20814.

Background: Severe burn injury results in profound catabolic deterioration. Although burn related catabolism have been well stated, it is unclear when the catabolic response begins. This study characterized acute changes of muscle protein breakdown at the admission and the day after in severely burned adults. Read More

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Warwick-India-Canada (WIC) global mental health group: rationale, design and protocol.

BMJ Open 2021 Jun 11;11(6):e046362. Epub 2021 Jun 11.

Division of Mental Health & Wellbeing, Warwick Medical School, University of Warwick, Coventry, UK.

Introduction: The primary aim of the National Institute of Health Research-funded global health research group, Warwick-India-Canada (WIC), is to reduce the burden of psychotic disorders in India. India has a large pool of undetected and untreated patients with psychosis and a treatment gap exceeding 75%. Evidence-based packages of care have been piloted, but delivery of treatments still remains a challenge. Read More

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Effect of bowel preparation on intestinal permeability and inflammatory response during postoperative ileus in mice.

Surgery 2021 Jun 8. Epub 2021 Jun 8.

Medical Department of General and Visceral Surgery, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Germany. Electronic address:

Background: Postoperative ileus entails pathophysiological changes in mucosal permeability and an intestinal inflammatory immune response. We hypothesized that preoperative selective decontamination of the digestive tract combined with preoperative mechanical bowel preparation might be advantageous to prevent or reduce permeability changes and immune response in postoperative ileus.

Methods: Postoperative ileus was induced in mice by standardized small bowel manipulation. Read More

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Route map for machine learning in psychiatry: Absence of bias, reproducibility, and utility.

Eur Neuropsychopharmacol 2021 Jun 8;50:115-117. Epub 2021 Jun 8.

IMPACT (Innovation in Mental and Physical Health and Clinical Treatment) Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia.

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Improving phonological awareness with Talking Tables in at-risk kindergarten readers.

Res Dev Disabil 2021 Jun 8;115:103996. Epub 2021 Jun 8.

Department of Educational Psychology and Leadership Studies, University of Victoria, Canada. Electronic address:

Background: For young children experiencing phonological awareness (PA) difficulties, the need for early and targeted intervention to prevent reading disability is unequivocal. There are very few studies, however, on the efficacy of PA interventions delivered at school.

Aims: This study examined the impact of an early PA intervention embedded within an oral language program designed for at-risk kindergartners. Read More

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COVID-19 treatment combinations and associations with mortality in a large multi-site healthcare system.

PLoS One 2021 11;16(6):e0252591. Epub 2021 Jun 11.

Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, Sidney Kimmel Medical College, Philadelphia, PA, United States of America.

Introduction: During the early months of the COVID-19 pandemic, mortality associated with the disease declined in the United States. The standard of care for pharmacological interventions evolved during this period as new and repurposed treatments were used alone and in combination. Though these medications have been studied individually, data are limited regarding the relative impact of different medication combinations. Read More

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Temperature, traveling, slums, and housing drive dengue transmission in a non-endemic metropolis.

PLoS Negl Trop Dis 2021 Jun 11;15(6):e0009465. Epub 2021 Jun 11.

Instituto de Investigaciones en Biodiversidad y Medioambiente (INIBIOMA), Universidad Nacional del Comahue-CONICET, S.C. de Bariloche, Río Negro, Argentina.

Dengue is steadily increasing worldwide and expanding into higher latitudes. Current non-endemic areas are prone to become endemic soon. To improve understanding of dengue transmission in these settings, we assessed the spatiotemporal dynamics of the hitherto largest outbreak in the non-endemic metropolis of Buenos Aires, Argentina, based on detailed information on the 5,104 georeferenced cases registered during summer-autumn of 2016. Read More

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GABAA receptor encephalitis associated with human parvovirus B19 virus infection: Case report.

Medicine (Baltimore) 2021 Jun;100(23):e26324

Faculdades Pequeno Principe.

Rationale: Human parvovirus B19 (B19) infection can produce a spectrum of clinical syndromes, including neurological manifestations, most notably encephalitis. Although symptoms suggestive of autoimmune disease in patients with B19 infection have been previously described, a clear association of autoimmune encephalitis with B19 infection has yet to be established.

Patient Concerns: We describe the case of a 6-year-old boy who was hospitalized due to status epilepticus, which evolved to super-refractory status epilepticus that was only mildly responsive to anticonvulsant drugs. Read More

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Philadelphia chromosome-positive B-lymphoblastic lymphoma successfully treated with chemotherapy regimen containing imatinib: A rare case report and literature review.

Medicine (Baltimore) 2021 Jun;100(23):e26323

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Rationale: B-lymphoblastic lymphoma (B-LBL) with BCR/ABL mutation (Ph+ B-LBL) is a rare type of cancer in both childhood and adults. Its clinical manifestations are similar to those of other types lymphoma. However, the targeted therapy can substantially improve the outcome of Ph+ B-LBL. Read More

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Delayed pneumocephalus induced by repeated percutaneous aspiration after spinal surgery: A case report and literature review.

Medicine (Baltimore) 2021 Jun;100(23):e26322

Department of Internal Medicine, People's Hospital of Xilin County, Baise, China.

Rationale: Severe tension pneumocephalus can lead to drowsiness, coma, and even brain hernia and death. The occurrence of delayed pneumocephalus after spinal surgery is rarely reported and often ignored. Herein, we report a case of delayed pneumocephalus after repeated percutaneous aspiration following spinal surgery. Read More

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Ovarian dysgerminoma with pseudo-Meigs syndrome: A case report.

Medicine (Baltimore) 2021 Jun;100(23):e26319

Forensic and Pathology Laboratory, Jiaxing University Medical College, Jiaxing, ZJ, China.

Rationale: Dysgerminoma is a rare malignant tumor of the ovary, more frequently occurring in young women. The main signs of pseudo-Meigs syndrome (PMS) are ascites and hydrothorax accompanying benign or malignant ovarian tumors (no fibroma or fibroma-like tumor).

Patient Concerns: A 19-year-old woman with fever and chest tightness for 2 days. Read More

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Efficacy of thromboelastography in the management of anticoagulation for veno-venous extracorporeal membrane oxygenation in a coronavirus disease 2019 patient: A case report.

Medicine (Baltimore) 2021 Jun;100(23):e26313

Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

Rationale: In coronavirus disease 2019 (COVID-19) patients with acute respiratory distress syndrome refractory to optimal conventional management, we should consider the indication for veno-venous extracorporeal membrane oxygenation (V-V ECMO). Growing evidence indicates that COVID-19 frequently causes coagulopathy, presenting as hypercoagulation and incidental thrombosis. For these reasons, a multifactorial approach with several anticoagulant markers should be considered in the management of anticoagulation using heparin in COVID-19 patients on V-V ECMO. Read More

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Transesophageal echocardiography detection of air embolism during endoscopic surgery and validity of hyperbaric oxygen therapy: Case report.

Medicine (Baltimore) 2021 Jun;100(23):e26304

Department of Information, The First People's Hospital of Foshan, North of Ling Nan Road No. 81, Foshan, Guangdong, China.

Introduction: Air embolism has the potential to be serious and fatal. In this paper, we report 3 cases of air embolism associated with endoscopic medical procedures in which the patients were treated with hyperbaric oxygen immediately after diagnosis by transesophageal echocardiography. In addition, we systematically review the risk factors for air embolism, clinical presentation, treatment, and the importance of early hyperbaric oxygen therapy efficacy after recognition of air embolism. Read More

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A case report on severe nivolumab-induced adverse events similar to primary sclerosing cholangitis refractory to immunosuppressive therapy.

Medicine (Baltimore) 2021 Jun;100(23):e25774

Division of Medical Oncology, Department of Medicine, Showa University School of Medicine.

Introduction: Immune checkpoint inhibitors (ICIs), particularly anti-PD-1 antibody, have dramatically changed cancer treatment; however, fatal immune-related adverse events (irAEs) can develop. Here, we describe a severe case of sclerosing cholangitis-like irAE. We report the use of 3 immunosuppressive agents that resulted in the death of the patient due to treatment inefficacy. Read More

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The impact of non-pharmaceutical interventions on COVID-19 epidemic growth in the 37 OECD member states.

Eur J Epidemiol 2021 Jun 10. Epub 2021 Jun 10.

Evidence-Based Public Health Unit, Centre for International Health Protection, Robert Koch Institute, Nordufer 20, 13353, Berlin, Germany.

We estimated the impact of a comprehensive set of non-pharmeceutical interventions on the COVID-19 epidemic growth rate across the 37 member states of the Organisation for Economic Co-operation and Development during the early phase of the COVID-19 pandemic and between October and December 2020. For this task, we conducted a data-driven, longitudinal analysis using a multilevel modelling approach with both maximum likelihood and Bayesian estimation. We found that during the early phase of the epidemic: implementing restrictions on gatherings of more than 100 people, between 11 and 100 people, and 10 people or less was associated with a respective average reduction of 2. Read More

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Telehealth and Autism Prior to and in the Age of COVID-19: A Systematic and Critical Review of the Last Decade.

Clin Child Fam Psychol Rev 2021 Jun 10. Epub 2021 Jun 10.

Department of Psychology, Louisiana State University, 236 Audubon Hall, Baton Rouge, LA, 70803, USA.

There has been growing interest in the use of telehealth; however, the COVID-19 pandemic and the subsequent isolation and restrictions placed on in-person services have fast-tracked implementation needs for these services. Individuals with autism spectrum disorder (ASD) have been particularly affected due to the often-intensive service needs required by this population. As a result, the aim of this review was to examine the evidence base, methodology, and outcomes of studies that have used telehealth for assessment and/or intervention with children and adolescents with ASD as well as their families over the last decade. Read More

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Nursing Management of a Patient With COVID-19 Receiving ECMO: A Case Report.

Crit Care Nurse 2021 Jun 11:e1-e10. Epub 2021 Jun 11.

Taline Marcarian is a clinical nurse in the cardiothoracic intensive care unit, Ronald Reagan UCLA Medical Center.

Introduction: Venovenous extracorporeal membrane oxygenation has been recommended as an effective rescue therapy for select critically ill patients with COVID-19. This case report describes a first experience caring for a patient with COVID-19 who received venovenous extracorporeal membrane oxygenation and expands the literature by discussing relevant nursing management and operational considerations.

Clinical Findings: A 46-year-old man presented to a hospital emergency department with pleuritic chest pain, dyspnea, anorexia, and chills. Read More

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Adverse Pregnancy Outcomes in Endometriosis - Myths and Realities.

Curr Obstet Gynecol Rep 2020 Mar 30;9(1):27-35. Epub 2020 Jan 30.

Department of Epidemiology, Harvard T.H. Chan School of Public Health.

Purpose Of Review: There is increasing interest in the long-term health and comorbid conditions associated with endometriosis for both women and neonates. The purpose of this review was to synthesize and discuss the current state of the literature investigating endometriosis and risk of adverse pregnancy outcomes.

Recent Findings: Methodologic considerations for studying endometriosis and adverse pregnancy outcomes include complexities regarding the comparison population, endometriosis definition, sample size, residual confounding, and interactions. Read More

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Screening for Sarcopenia (Physical Frailty) in the COVID-19 Era.

Int J Endocrinol 2021 21;2021:5563960. Epub 2021 May 21.

Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.

Although the numbers of aged populations have risen considerably in the last few decades, the current coronavirus disease 2019 (COVID-19) has revealed an extensive vulnerability among these populations. Sarcopenia is an age-related disorder that increases hospitalization, dependencies, and mortality in older adults. It starts to develop in midlife or even earlier as a result of unbalanced diet/poor nutrition and low levels of physical activity, in addition to chronic disorders such as obesity and diabetes mellitus. Read More

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Gene Therapy for Overactive Bladder: A Review of BK-Channel α-Subunit Gene Transfer.

Ther Clin Risk Manag 2021 4;17:589-599. Epub 2021 Jun 4.

Department of Urology, Albert Einstein College of Medicine, Ardsley, NY, USA.

A need exists for local (ie, bladder-specific) interventions to treat overactive bladder (OAB) with low risk of unwanted postprocedural outcomes. Gene therapy targeted to leverage endogenous physiology in bladder cells may assist in restoring normal cell and organ function. Herein, we review the potential promise of gene therapy for treating OAB, focusing on gene transfer of URO-902, a non-viral naked plasmid DNA expressing the big potassium (BK) channel. Read More

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