71,130 results match your criteria early identification

The antenatal risk questionnaire-revised: Development, use and test-retest reliability in a community sample of pregnant women in Australia.

J Affect Disord 2021 Jun 5;293:43-50. Epub 2021 Jun 5.

School of Nursing and Midwifery, University of Newcastle, NSW, Australia; Black Dog Institute, NSW, Australia; Royal Hospital for Women, NSW, Australia.

Background: Routine psychosocial assessment during pregnancy and the first postnatal year is a public health strategy that prioritises early identification of known risk factors for poor perinatal mental health. We aimed to report on the development and use of the Antenatal Risk Questionnaire-Revised (ANRQ-R), contribute normative data for a community sample of pregnant women and examine its test-retest reliability.

Methods: The ANRQ-R was developed in consultation with an expert advisory group. Read More

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The Future of Newborn Screening for Lysosomal Disorders.

Neurosci Lett 2021 Jun 21:136080. Epub 2021 Jun 21.

Department of Chemistry, University of Washington, Seattle, WA.

The goal of newborn screening is to enhance the outcome of individuals with serious, treatable disorders through early, pre-symptomatic detection. The lysosomal storage disorders (LSDs) comprise a group of more than 50 diseases with a combined frequency of approximately 1:7000. With the availability of existing and new enzyme replacement therapies, small molecule treatments and gene therapies, there is increasing interest in screening newborns for LSDs with the goal of reducing disease-related morbidity and mortality through early detection. Read More

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Impact of early nutrition route in patients on extracorporeal membrane oxygenation: A retrospective cohort study.

JPEN J Parenter Enteral Nutr 2021 Jun 24. Epub 2021 Jun 24.

Intensive Care Unit of Cardiothoracic Surgery, Anesthesia and Critical Care Department, Hôpital Nord Laennec, Centre Hospitalier Universitaire de Nantes, Nantes, France.

Background: Early nutritional management in patients on extracorporeal membrane oxygenation (ECMO) remains controversial. Despite its potentially beneficial effect, enteral nutrition (EN) could be associated with gastrointestinal (GI) complications. Total daily energy (TDE) requirements remain difficult to achieve with ECMO support. Read More

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Spatial organization and transitions of spontaneous neuronal activities in the developing sensory cortex.

Dev Growth Differ 2021 Jun 24. Epub 2021 Jun 24.

Laboratory of Mammalian Neural Circuits, National Institute of Genetics, Mishima, Shizuoka, Japan.

The sensory cortex underlies our ability to perceive and interact with the external world. Sensory perceptions are controlled by specialized neuronal circuits established through fine-tuning, which relies largely on neuronal activity during the development. Spontaneous neuronal activity is an essential driving force of neuronal circuit refinement. Read More

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Identification of Carbazole Alkaloid Derivatives with Acylhydrazone as Novel Anti-TMV Agents with the Guidance of a Digital Fluorescence Visual Screening.

J Agric Food Chem 2021 Jun 24. Epub 2021 Jun 24.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, P. R. China.

Difficulty in preventing crops from plant viruses urges to discover novel efficient antiviral chemicals, which is sped up by precise screening methods. Fluorescence-based methods have recently been applied as innovative and rapid tools for visually monitoring the replication of viruses and screening of antivirals, whereas the quantification of fluorescence signals mainly depends on manually calculating the fluorescent spots, which is time-consuming and imprecise. In the present work, the fluorescence spots were automatically identified, and the fluorescence area was directly quantified by a program developed in our group, which avoided subjective errors from the operators. Read More

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Comparing different markers of tubular dysfunction in transfusion-dependent thalassemia patients.

Int Urol Nephrol 2021 Jun 24. Epub 2021 Jun 24.

Pediatric Department, Cairo University, Cairo, Egypt.

Background: Renal tubular dysfunction was reported in transfusion-dependent thalassemia (TDT) patients and ranges from mild to severe. The objectives of our study were identification of the best marker of early renal tubular dysfunction in TDT patients among the three most commonly used urinary biomarkers, named neutrophil gelatinase-associated lipocalin (NGAL), retinol-binding protein (RBP) and N-acetyl-D-glucosaminidase (NAG) and correlation of these biomarkers with different patient variables.

Methodology: Sixty-one TDT patients and another 62 healthy children were enrolled in a cross-sectional study. Read More

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Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip.

Mol Med Rep 2021 Aug 24;24(2). Epub 2021 Jun 24.

Department of Plastic and Reconstructive Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China.

In early pregnancy, fetal skin wounds can heal quickly and undergo a transition period from scarless healing to scar formation. The aim of the present study was to identify potential biomarkers associated with scarless repair of cleft lips, in order to determine the intrinsic factors leading to scar formation in embryonic tissue. A stable model of cleft lip was established using microsurgery by constructing a wedge‑shaped cleft lip‑like defect in fetal rats at gestational age (GA) 16. Read More

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Knowledge, attitude and practice on usage and toxicity of local anaesthetic agents (LA) amongst health care professionals in obstetrics and gynaecology.

J Obstet Gynaecol 2021 Jun 24:1-4. Epub 2021 Jun 24.

Department of Obstetrics and Gynaecology, Worcestershire Acute Hospitals NHS Trust, Worcester, UK.

A sound knowledge of LA and their dosage is essential for effective anaesthesia and patient safety as LA toxicity could be potentially life-threatening and clinicians undertaking LA procedures must be competent in early recognition of toxicity and instigating remedial measures timely. This is a prospective national-level survey using self-administered questionnaires among health care professionals in Obstetrics and Gynaecology primarily based in Worcestershire Acute Hospital NHS Trust and further extended to other regions of the United Kingdom. The survey was focussed on evaluating the knowledge, attitude and practice (KAP) of the common local anaesthetic agents, their dosage, early recognition and management of LA systemic toxicity(LAST). Read More

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Community involvement facilitating the discussion of alcohol use in primary care: A nominal group study.

Eur J Gen Pract 2021 Dec;27(1):130-139

Department for Public Health and Primary Care, KU Leuven, Leuven, Belgium.

Background: Hazardous alcohol use significantly affects health and wellbeing in society. General practitioners (GPs) are uniquely positioned to address this problem by integrating early identification and brief intervention (EIBI) in daily practice. Unfortunately, EIBI implementation remains low. Read More

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December 2021

The Monographs Programme of the International Agency for Research on Cancer. A brief history of its Preamble.

ALTEX 2021 Jun 16. Epub 2021 Jun 16.

The IARC Monographs Programme, International Agency for Research on Cancer, Lyon, France (retired).

Since the early 1970s, the Monographs published by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards. The Preamble to the IARC Monographs describes the objective and scope of the Programme, the scientific principles and procedures used in developing a Monograph, the types of evidence considered, and the scientific criteria that guide the evaluations. This article presents an overview of the historical development of the Preamble from the time it began to take shape in the late 1970s up to and including the most recent update in 2019. Read More

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MRI detected synovitis of the small joints predicts rheumatoid arthritis development in large joint undifferentiated inflammatory arthritis.

Rheumatology (Oxford) 2021 Jun 23. Epub 2021 Jun 23.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: New onset undifferentiated large joint inflammatory arthritis can be diagnostically challenging. It is unknown how often these patients progress to rheumatoid arthritis (RA), and how they can be identified at first presentation. We assessed clinical and serological features associated with RA-development in patients with an undifferentiated mono- or oligo-articular large joint arthritis, and with keen interest if an MRI of the small joints of the hand and foot would aid diagnosis. Read More

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A Novel Hierarchical Deep Learning Framework for Diagnosing Multiple Visual Impairment Diseases in the Clinical Environment.

Front Med (Lausanne) 2021 7;8:654696. Epub 2021 Jun 7.

Complete Genomics Inc., San Jose, CA, United States.

Early detection and treatment of visual impairment diseases are critical and integral to combating avoidable blindness. To enable this, artificial intelligence-based disease identification approaches are vital for visual impairment diseases, especially for people living in areas with a few ophthalmologists. In this study, we demonstrated the identification of a large variety of visual impairment diseases using a coarse-to-fine approach. Read More

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Gasless transaxillary endoscopic thyroidectomy for unilateral low-risk thyroid cancer: Li's six-step method.

Gland Surg 2021 May;10(5):1756-1766

Department of Head and Neck Surgery, Sichuan Cancer Hospital, Sichuan Cancer Institute, Sichuan Cancer Prevention and Treatment Center, Cancer Hospital of University of Electronic Science and Technology School of Medicine, Chengdu, China.

The past decade has witnessed rapid advances in gasless transaxillary endoscopic thyroidectomy (GTET) for thyroid cancer, which has become a reliable procedure with good therapeutic effectiveness, aesthetic benefits, and safety. This procedure has been widely promoted in some Asian countries; however, few studies have described the specific surgical steps for unilateral low-risk thyroid cancer. Based on a review of the literature and our own clinical experience, we introduce in detail the surgical procedure of GTET for the unilateral low-risk thyroid cancer, briefly summarized into Li's 6 steps: surgical position and incision design; creation of surgical cavities; dissection of the superior pole of the thyroid and its vessels, and identification and protection of superior laryngeal nerve; identification and protection of the superior parathyroid gland, and identification of the inferior parathyroid gland; identification and protection of the recurrent laryngeal nerve and the inferior parathyroid gland, and central neck dissection; and processing of the suspensory ligaments of thyroid gland and resection of the tumor. Read More

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Establishment of a model for predicting sentinel lymph node metastasis in early breast cancer based on contrast-enhanced ultrasound and clinicopathological features.

Gland Surg 2021 May;10(5):1701-1712

Department of Breast Surgery, Affiliated Cancer Hospital of Zhengzhou University (Henan Cancer Hospital), Zhengzhou, China.

Background: Sentinel lymph node (SLN) biopsy (SLNB) is the standard procedure for axillary staging in clinically node-negative (cN0) breast cancer patients. However, the positive rate of SLNs among cN0 stage patients is 26-35%. The identification of appropriate candidates for SLNB is quite challenging. Read More

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Comparative study of two contrast agents for intraoperative identification of sentinel lymph nodes in patients with early breast cancer.

Gland Surg 2021 May;10(5):1638-1645

Department of General Surgery, Peking University Third Hospital, Beijing, China.

Background: The use of contrast-enhanced ultrasound (CEUS) to locate sentinel lymph nodes (SLNs) in breast cancer has been studied more and more in recent years. This prospective study aimed to compare periareolar injection of two different contrast agents, SonoVue (SNV) and Sonazoid (SNZ), followed by CEUS to identify SLNs in breast cancer patients with clinically negative nodes.

Methods: A total of 205 patients with T1-2N0M0 breast cancer were divided into the SNV group and SNZ group. Read More

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Screen-detected solid nodules: from detection of nodule to structured reporting.

Transl Lung Cancer Res 2021 May;10(5):2335-2346

Scienze Radiologiche, Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy.

Lung cancer screening (LCS) is gaining some interest worldwide after positive results from International trials. Unlike other screening practices, LCS is performed by an extremely sensitive test, namely low-dose computed tomography (LDCT) that can detect the smallest nodules in lung parenchyma. Up-to-date detection approaches, such as computer aided detection systems, have been increasingly employed for lung nodule automatic identification and are largely used in most LCS programs as a complementary tool to visual reading. Read More

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Differences in Expression in Pancreatic Cancers and Pancreatic Cysts in Egypt.

J Carcinog Mutagen 2018 26;9(1). Epub 2018 Mar 26.

Department of Environmental, Occupational, and Geospatial Health Sciences, Graduate School of Public Health and Health Policy, City University of New York, New York, USA.

Pancreatic cancer is the fourth cause of cancer deaths in the U.S. with most patients diagnosed at advanced stages followed by short survival. Read More

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Xenogeneic materials for the surgical treatment of aortic infections.

J Thorac Dis 2021 May;13(5):3021-3032

European Vascular Center Aachen-Maastricht, Department of Vascular Surgery, RWTH University Hospital Aachen, Aachen, Germany.

Background: The surgical treatment of aortic infections (AIs) is challenging. In situ aortic reconstructions represent nowadays the favored therapy for fit patients and xenogeneic materials are used increasingly. The aim of this study was to present our experience with xenogeneic reconstructions for AI using self-made bovine pericardium tubes and/or the biosynthetic Omniflow II graft. Read More

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Automated Facial Recognition for Noonan Syndrome Using Novel Deep Convolutional Neural Network With Additive Angular Margin Loss.

Front Genet 2021 7;12:669841. Epub 2021 Jun 7.

Department of Pediatric Cardiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Structural Heart Disease, Guangzhou, China.

Background: Noonan syndrome (NS), a genetically heterogeneous disorder, presents with hypertelorism, ptosis, dysplastic pulmonary valve stenosis, hypertrophic cardiomyopathy, and small stature. Early detection and assessment of NS are crucial to formulating an individualized treatment protocol. However, the diagnostic rate of pediatricians and pediatric cardiologists is limited. Read More

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Computed Tomography Based Score of Early Ischemic Changes Predicts Malignant Infarction.

Front Neurol 2021 7;12:669828. Epub 2021 Jun 7.

Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Identification of ischemic stroke patients at high risk of developing life-threatening malignant infarction at an early stage is critical to consider more rigorous monitoring and further therapeutic measures. We hypothesized that a score consisting of simple measurements of visually evident ischemic changes in non-enhanced CT (NEMMI score) predicts malignant middle cerebral artery (MCA) infarctions (MMI) with similar diagnostic power compared to other baseline clinical and imaging parameters. One hundred and nine patients with acute proximal MCA occlusion were included. Read More

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A novel computer-aided diagnostic system for accurate detection and grading of liver tumors.

Sci Rep 2021 Jun 23;11(1):13148. Epub 2021 Jun 23.

BioImaging Lab, Department of Bioengineering, University of Louisville, Louisville, KY, 40292, USA.

Liver cancer is a major cause of morbidity and mortality in the world. The primary goals of this manuscript are the identification of novel imaging markers (morphological, functional, and anatomical/textural), and development of a computer-aided diagnostic (CAD) system to accurately detect and grade liver tumors non-invasively. A total of 95 patients with liver tumors (M = 65, F = 30, age range = 34-82 years) were enrolled in the study after consents were obtained. Read More

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Capecitabine induced Steven-Johnson syndrome: A rare case report.

J Oncol Pharm Pract 2021 Jun 24:10781552211027945. Epub 2021 Jun 24.

Department of Oncology, Lourdes Hospital, Kochi, India.

Introduction: Steven-Johnson syndrome (SJS) is a serious mucocutaneous reaction, characterized by fever, influenza-like symptoms and followed by dermatological manifestations. Capecitabine is an oral fluoropyrimidine carbamate analogue of 5-Fluorouracil (5-FU). It is widely accepted for many malignancies because of its better safety profile and tolerability. Read More

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DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.

Cell Rep 2021 Jun;35(12):109281

Shanghai Key Laboratory of Metabolic Remodeling and Disease, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, and Shanghai Qi Zhi Institute, Shanghai, China; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China. Electronic address:

Obesity has become a global pandemic. Identification of key factors in adipogenesis helps to tackle obesity and related metabolic diseases. Here, we show that DDB1 binds the histone reader BRWD3 to promote adipogenesis and diet-induced obesity. Read More

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First report of causing spring dead spot of hybrid bermudagrass in China.

Plant Dis 2021 Jun 23. Epub 2021 Jun 23.

Nanjing Agricultural University, 70578, Agro-grassland Science, Nanjing, Jiangsu, China;

Hybrid bermudagrass (Cynodon dactylon×C. transvaalensis) is widely used as turf in transition zone of China. Spring dead spot (SDS) is one of the most damaging diseases of hybrid bermudagrass. Read More

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Dual-Targeting Nanoprobe for Early Diagnosis of Pheochromocytoma Though Coinstantaneous Identification of Circulating Tumor Cells.

Anal Chem 2021 Jun 23. Epub 2021 Jun 23.

Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.

Circulating tumor cells (CTCs) play a pivotal role in the early diagnosis of pheochromocytoma (PCC). Herein, we fabricated a new dual-targeting nanoprobe for coinstantaneous identification of rare PCC-CTCs from peripheral blood via targeting the norepinephrine transporter (NET) and somatostatin receptor SSTR2 overexpressed on the surface of PCC cells. Meta-iodobenzylguanidine (MIBG) functionalized magnetic FeO and octreotide (DOTA) decorated signal amplification [email protected] nanosphere were used to capture and detect PCC-CTCs by binding to NET and SSTR2. Read More

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Retinal arteriolar tortuosity and fractal dimension are associated with long-term cardiovascular outcomes in people with type 2 diabetes.

Diabetologia 2021 Jun 23. Epub 2021 Jun 23.

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.

Aims/hypothesis: Our aim was to determine whether quantitative retinal traits in people with type 2 diabetes are independently associated with incident major cardiovascular events including CHD and stroke.

Methods: A total of 1066 men and women with type 2 diabetes, aged 65-74 years, were followed up over 8 years in the population-based Edinburgh Type 2 Diabetes Study. Using retinal photographs taken at baseline and specialist software, a number of quantitative retinal traits were measured, including arteriolar and venular widths and tortuosity as well as fractal dimension (a measure of the branching pattern complexity of the retinal vasculature network). Read More

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Next-generation sequencing diagnostics of bacteremia in pediatric sepsis.

Medicine (Baltimore) 2021 Jun;100(25):e26403

Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen.

Introduction: Sepsis and septic shock are the most severe forms of infection affecting predominantly elderly people, preterm and term neonates, and young infants. Even in high-income countries sepsis causes about 8% of admissions to pediatric intensive care units (PICUs). Early diagnosis, rapid anti-infective treatment, and prompt hemodynamic stabilization are crucial for patient survival. Read More

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Synthesis of Fluorescent Probes Targeting Tumor-Suppressor Protein FHIT and Identification of Apoptosis-Inducing FHIT Inhibitors.

J Med Chem 2021 Jun 23. Epub 2021 Jun 23.

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

For the early diagnosis of cancer, leading to a better chance of full recovery, marker genes whose expression is already altered in precancerous lesions are desirable, and the tumor-suppressor gene is one candidate. The gene product, FHIT protein, has a unique dinucleoside triphosphate hydrolase (APAase) activity, and in this study, we designed and synthesized a series of FHIT fluorescent probes utilizing this activity. We optimized the probe structure for high and specific reactivity with FHIT and applied the optimized probe in a screening assay for FHIT inhibitors. Read More

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