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Inhibitors of Protein Convertase Subtilisin/Kexin 9 (PCSK9) and Acute Coronary Syndrome (ACS): The State-of-the-Art.

J Clin Med 2021 Apr 5;10(7). Epub 2021 Apr 5.

Department of Translational Medical Sciences, "Federico II" University of Naples, Via S. Pansini 5, 80131 Naples, Italy.

Acute Coronary Syndrome (ACS) remains one of the most frequent causes of morbidity and mortality in the world. Although the age- and gender-adjusted incidence of ACS is decreasing, the mortality associated with this condition remains high, especially 1-year after the acute event. Several studies demonstrated that PCSK9 inhibitors therapy determine a significant reduction of major adverse cardiovascular events (MACE) in post-ACS patients, through a process of plaque modification, by intervening in lipid metabolism and platelet aggregation and finally determining an improvement in endothelial function. Read More

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Cushing's Syndrome With Nocardiosis: A Case Report and a Systematic Review of the Literature.

Front Endocrinol (Lausanne) 2021 29;12:640998. Epub 2021 Mar 29.

Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China.

Objective: To analyze and summarize the clinical characteristics, treatments, and prognosis of Cushing's syndrome (CS) with nocardiosis.

Methods: A patient in our hospital and additional 17 patients of CS with nocardiosis in the English literature were included in this study. Clinical characteristics, laboratory data, imaging studies, treatments, and prognosis were evaluated. Read More

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A rare case of ectopic ACTH syndrome caused by primary renal neuroendocrine tumor.

Endocrinol Diabetes Metab Case Rep 2021 Apr 12;2021. Epub 2021 Apr 12.

Division of Endocrinology and Metabolism, Department of Medicine.

Summary: Ectopic adrenocorticotropic hormone (ACTH) secretion is responsible for 5-15% of Cushing's syndrome (CS). Neuroendocrine tumor (NET) is a common cause of ectopic ACTH syndrome (EAS). However, primary renal NET is exceedingly rare. Read More

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An inventory of 44 qPCR assays using hydrolysis probes operating with a unique amplification condition for the detection and quantification of antibiotic resistance genes.

Diagn Microbiol Infect Dis 2021 Jan 30;100(3):115328. Epub 2021 Jan 30.

ANSES - Université de Lyon, Unité Antibiorésistance et Virulence Bactériennes (AVB), Lyon, France. Electronic address:

Early antibiotic resistance determinants (ARDs) detection in humans or animals is crucial to counteract their propagation. The ARDs quantification is fundamental to understand the perturbation caused by disruptors, such as antibiotics, during therapies. Forty-three qPCRs on the most diffused ARDs and integrons among human and animal Enterobacterales, and one on the 16S rDNA for bacteria quantification, were developed. Read More

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January 2021

Translational research around five categories of CI.

Acta Otolaryngol 2021 Mar;141(sup1):178-184

MED-EL Elektromedizinische Geraete Gesellschaft m.b.H., Innsbruck, Austria.

Five categories of cochlear implants are introduced: The 'classic CI', the 'combined CI' - which can be combining a CI based on electric stimulation with acoustic stimulation (EAS) or with mechanical stimulation (EMS) or with electrical stimulation of the vestibular system (VICI) -, the 'individualised CI', the 'augmented CI' and the 'totally implantable CI'. The translational research activities leading to and within these categories have been, are and will be numerous and are the subject of the compendium for which this paper is the concluding chapter. Early translational research has resulted in the 'classic CI' in 1994. Read More

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Associations Between Variations in Accumulated Workload and Physiological Variables in Young Male Soccer Players Over the Course of a Season.

Front Physiol 2021 18;12:638180. Epub 2021 Mar 18.

Movement, Sport, Health and Sciences Laboratory (M2S), University of Rennes 2, Rennes, France.

This study sought to analyze the relationship between in-season training workload with changes in aerobic power (VO ), maximum and resting heart rate (HR and HR ), linear sprint medium (LSM), and short test (LSS), in soccer players younger than 16 years (under-16 soccer players). We additionally aimed to explain changes in fitness levels during the in-season through regression models, considering accumulated load, baseline levels, and peak height velocity (PHV) as predictors. Twenty-three male sub-elite soccer players aged 15. Read More

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New Materials for Orthodontic Interceptive Treatment in Primary to Late Mixed Dentition. A Retrospective Study Using Elastodontic Devices.

Materials (Basel) 2021 Mar 30;14(7). Epub 2021 Mar 30.

Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, Via S. Sofia 78, 95124 Catania, Italy.

The aim of this study was to assess the skeletal and dentoalveolar changes obtained after 1 year of treatment with elastodontic appliances (EA) in a retrospective cohort of children reporting early signs of malocclusion. Also, a detailed description of the tested EAs was reported. The study sample included 20 subjects, 8 males and 12 females, with a mean age of 8. Read More

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Effect of oral steroids on olfactory function in chronic rhinosinusitis with nasal polyps.

Eur Ann Otorhinolaryngol Head Neck Dis 2021 Mar 3. Epub 2021 Mar 3.

ENT Department, Chania General Hospital, Chania, Crete, Greece. Electronic address:

Aims: The present study aimed to investigate the effects of oral steroids on olfactory disturbances in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).

Material And Methods: This is a prospective randomized non-blinded study. Selected CRSwNP patients (n=140), with hyposmia, were devided into two groups; group A received a 7-day course of oral steroids with a 12-weeks course of nasal steroids and douching; group B received a 12-weeks course of nasal steroids and douching. Read More

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Steering clear: Traffic violations among emerging adults who engage in habitual or casual cannabis use.

Accid Anal Prev 2021 Apr 1;153:106059. Epub 2021 Mar 1.

School of Public Health and Health Systems, University of Waterloo, Waterloo, Canada. Electronic address:

While some research has shown that cannabis use can impair driving ability, evidence to the degree and impact of impairment are lacking. This study examined the association between habitual or casual cannabis use and past-year traffic violations among emerging adults (EAs). Data come from the 2012 Canadian Community Health Survey-Mental Health. Read More

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Efficacy of parent-infant psychotherapy compared to care as usual in children with regulatory disorders in clinical and outpatient settings: study protocol of a randomised controlled trial as part of the SKKIPPI project.

BMC Psychiatry 2021 02 27;21(1):118. Epub 2021 Feb 27.

Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, Liebigstrasse 20a, 04103, Leipzig, Germany.

Background: The first years of life are a significant period for child development, when children are particularly sensitive and prone to crises. This early phase lays the foundation for healthy growth. Clinical assessment of psychological symptoms in early infancy and adequate treatment are both important in improving the diagnostic outcome and preventing later long-term developmental consequences. Read More

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February 2021

The effectiveness of adapted schema therapy for cluster C personality disorders in older adults - integrating positive schemas.

Contemp Clin Trials Commun 2021 Mar 30;21:100715. Epub 2021 Jan 30.

PersonaCura, Clinical Centre of Excellence for Personality Disorders and Autism in Older Adults, GGz Breburg, Tilburg, the Netherlands.

Introduction: Schema therapy (ST) is an efficacious psychotherapy for personality disorders (PDs) in adults. The first empirical support for the effectiveness of ST in older adults with cluster C PDs was provided recently. ST partly focusses on the positive, but there is an increasing awareness of imbalance in the ST community because of the emphasis on negative schemas versus attention to positive schemas. Read More

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The challenges of insecurity on implementing vaccination campaign and its effect on measles elimination and control efforts: A case study of 2017/18 measles campaign in Borno state, Nigeria.

Vaccine 2021 Feb 2. Epub 2021 Feb 2.

National Primary Health Care Development Agency, Nigeria.

Conflict has a negative effect on immunization outcomes leading to epidemics of measles and other vaccine preventable diseases. Borno state, located in the North-Eastern parts of the country, started experiencing insurgency since 2009 by a militant group commonly referred to as "Boko Haram", leading to displacement of numerous persons from their homes. The state government created internally displaced persons (IDPs) camps with an estimated 600,000 persons and over 100,000 children aged 9 - 59 months. Read More

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February 2021

Clinical Heterogeneity of Ectopic ACTH Syndrome: A Long-Term Follow-Up Study.

Endocr Pract 2020 Dec;26(12):1435-1441

From the Endocrine Service and the Research Unit in Endocrine Diseases, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.. Electronic address:

Objective: Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a heterogeneous condition caused by neuroendocrine neoplasms (NENs) located in the lungs, thymus, or pancreas. Our purpose was to evaluate the long-term outcome of these patients.

Methods: Retrospective study at a referral center. Read More

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December 2020

[Function of Pudendal Motor Nerve in Patients with or Without Fecal Incontinence after Low Anterior Resection for Lower Rectal Cancer].

Gan To Kagaku Ryoho 2020 Dec;47(13):1756-1758

Dept. of Surgery, School of Life Dentistry, Nippon Dental University.

To clarify the pudendal motor nerve(PMN)play in preventing fecal incontinence(FI)after low anterior resection(LAR) for lower rectal cancer, the PMN function was studied at early postoperative period after LAR. A total of 30 patients aged 43 to 78 years (21 men and 9 women with a mean age of 62.4 years) who underwent LAR for LRC were enrolled in the present study. Read More

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December 2020

How much should LDL cholesterol be lowered in secondary prevention? Clinical efficacy and safety in the era of PCSK9 inhibitors.

Prog Cardiovasc Dis 2020 Dec 28. Epub 2020 Dec 28.

Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Department of Hypertension, Medical University of Lodz (MUL), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland. Electronic address:

There is a strong evidence that more marked lowering of low-density lipoprotein cholesterol (LDL-C) leads to progressively lower risk of cardiovascular disease (CVD) events. The evidence on validity of this hypothesis comes from epidemiological, genetic and clinical studies. The hypothesis "the lower the better" has been recently strongly supported by the results of secondary prevention trials with PCSK9 inhibitors. Read More

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December 2020

Regulation of glial size by eicosapentaenoic acid through a novel Golgi apparatus mechanism.

PLoS Biol 2020 12 28;18(12):e3001051. Epub 2020 Dec 28.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

Coordination of cell growth is essential for the development of the brain, but the molecular mechanisms underlying the regulation of glial and neuronal size are poorly understood. To investigate the mechanisms involved in glial size regulation, we used Caenorhabditis elegans amphid sheath (AMsh) glia as a model and show that a conserved cis-Golgi membrane protein eas-1/GOLT1B negatively regulates glial growth. We found that eas-1 inhibits a conserved E3 ubiquitin ligase rnf-145/RNF145, which, in turn, promotes nuclear activation of sbp-1/ SREBP, a key regulator of sterol and fatty acid synthesis, to restrict cell growth. Read More

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December 2020

Cytoreductive nephrectomy for metastatic renal cell carcinoma, the ultimate urologic 'Choosing Wisely' campaign: a narrative review.

Transl Cancer Res 2020 Nov;9(11):7337-7349

Section of Urologic Oncology, Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA.

In the early 2000s, cytoreductive nephrectomy in addition to systemic cytokines became standard of care for treating metastatic renal cell carcinoma. Since that time, the development of novel systemic targeted therapies and immuno-oncologic agents have challenged the utility of cytoreductive nephrectomy in clinical practice. In 2019, the controversial CARMENA study was published, providing the first level one evidence suggesting that cytoreductive nephrectomy combined with targeted therapy yielded no survival advantage over targeted therapy alone in intermediate and poor risk metastatic renal cell carcinoma patients. Read More

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November 2020

Predictive and Incremental Validity of Parental Representations During Pregnancy on Child Attachment.

Front Public Health 2020 2;8:439449. Epub 2020 Dec 2.

Department of Dynamic and Clinical Psychology, "Sapienza" University of Rome, Rome, Italy.

Parental pre-natal representations predict the interactive patterns that parents will put in place after childbirth. Early interactions defined by high parental emotional availability (EA) influence the development of security in children. To date, research on the predictive role of parental pre-natal representations on child attachment is still poor. Read More

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December 2020

Clinical Forms and Genotype of Severe End of Epileptic-Aphasia Spectrum Disorder.

Front Pediatr 2020 6;8:574803. Epub 2020 Nov 6.

Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing, China.

This study aims to analyze the electroclinical characteristics and gene test results of children on the severe end of the epilepsy aphasia spectrum (EAS) and also the correlation of EAS-related GRIN2A genes to explore the genotype-phenotype relationships, as well as potential pathogenic mechanism of EAS. A retrospective study was conducted on the participants diagnosed with Landau-Kleffner syndrome (LKS), epileptic encephalopathy with continuous spike-and-wave during sleep (CSWS), and atypical benign partial epilepsy (ABPE) at the Children's Hospital of Chongqing Medical University from January 2013 to June 2019. Whole-exome sequencing was performed in six patients, and epileptic panel was carried out in two. Read More

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November 2020

The initiation, standardization and proficiency (ISP) phases of the learning curve for minimally invasive liver resection: comparison of a fellowship-trained surgeon with the pioneers and early adopters.

Surg Endosc 2020 Nov 10. Epub 2020 Nov 10.

Department of Surgery, Hôpital du Sacre Coeur, Montreal, QC, H4J 1C5, Canada.

Background: Using the Ideal Development Exploration Assessment and Long-term study (IDEAL) paradigm, Halls et al. created risk-adjusted cumulative sum (RA-CUSUM) curves concluding that Pioneers (P) and Early Adopters (EA) of minimally invasive (MI) liver resection obtained similar results after fewer cases. In this study, we applied this framework to a MI Hepatic-Pancreatic and Biliary fellowship-trained surgeon (FT) in order to assess where along the curves this generation fell. Read More

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November 2020

Application of bulbocavernosus reflex combined with anal sphincter electromyography in the diagnosis of MSA and PD.

Int J Neurosci 2020 Nov 17:1-6. Epub 2020 Nov 17.

Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Background: Multiple system atrophy (MSA) and Parkinson's disease (PD) are characterized by abnormal changes in the extrapyramidal system and autonomic nervous system. The two diseases are consistent in some clinical manifestations and few objective indicators for preclinical prediction.

Method: The value of anal sphincter electromyography (EAS-EMG) in the diagnosis of MSA has been recognized by researchers, while the bulbocavernosus reflex (BCR) has been found to be of great significance in the diagnosis of PD and MSA. Read More

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November 2020

Differential value of external anal- and urethral-sphincter electromyography in multiple system atrophy cerebellar type and spinocerebellar ataxias.

J Clin Neurosci 2020 Oct 15;80:16-22. Epub 2020 Aug 15.

Department of Neurology, Sixth Medical Center of Chinese PLA General Hospital, Beijing, China. Electronic address:

Objective: Clinically differentiating multiple system atrophy cerebellar type (MSA-C) and spinocerebellar ataxias (SCAs) is challenging, especially at early disease stages, because of their similarities in clinical manifestation and imaging results. The purpose of this study was to explore the value of external anal-sphincter electromyography (EAS-EMG) and urethral-sphincter electromyography (US-EMG) for distinguishing between MSA-C and SCAs.

Methods: A total of 51 subjects, including 33 MSA-C and 18 SCAs, were recruited. Read More

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October 2020

Investigating the role of attachment orientation during emotional face recognition: An event-related potential study.

Biol Psychol 2020 10 28;156:107953. Epub 2020 Sep 28.

Bahcesehir University, Department of Psychology Brain and Cognition Research Laboratory, Ciragan Cad. No. 4 Besiktas, 34353 İstanbul, Turkey. Electronic address:

We recorded event-related potentials (ERPs) while anxious and avoidant participants performed an emotional face recognition task featuring happy and angry faces. The avoidant attachment individuals were more accurate on angry trials, whereas anxious attachment individuals were more accurate on happy trials. FN400 amplitude was larger in the anxious attachment group than in the avoidant attachment group. Read More

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October 2020

Euvascor - early intervention of hypertension and dyslipidaemia (dual combination of atorvastatin and perindopril).

Vnitr Lek 2020 ;66(3):190-195

Over the last 30 years, the number of cardiovascular causes of death has decreased, but Cardi-ovascular Disease has been the leading cause of mortality and morbidity in the Czech Republic. In spite of a clear decline, this still persisting primacy is due to the failure to achieve the target recommended values and the late initiation of pharmacotherapy. We know that lifetime LDL cholesterol exposure reduced by 1 mmol/l is associated with a 54% reduction in the incidence of coronary events. Read More

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November 2020

Extracurricular Activities and Chinese Children's School Readiness: Who Benefits More?

Child Dev 2020 Aug 25. Epub 2020 Aug 25.

East China Normal University.

Organized extracurricular activities (EAs) are prevalent among Chinese preschoolers, yet their role in children's development is poorly understood. This study investigated the relations between EA participation and Chinese preschoolers' school readiness (N = 343; M  = 55.14 months) among a predominantly middle-class sample. Read More

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Unusual ectopic ACTH syndrome in a patient with orbital neuroendocrine tumor, resulted false-positive outcome of BIPSS:a case report.

BMC Endocr Disord 2020 Jul 31;20(1):116. Epub 2020 Jul 31.

Division of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.

Background: Cushing's syndrome has been described as a complex endocrine disorder characterized with high cortisol concentration. Correct and early diagnosis of Cushing's syndrome is challenging. According to the latest guideline, bilateral inferior petrosal sinus sampling (BIPSS) is considered to be the gold standard for the differential diagnosis. Read More

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Endocr Pract 2020 Jul 13. Epub 2020 Jul 13.

From the Endocrine Service and the Research Unit in Endocrine Diseases, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, Mexico City.

: The ectopic ACTH syndrome (EAS) is a heterogeneous condition, caused by neuroendocrine neoplasms (NEN) located in the lungs, thymus or pancreas. Our purpose was to evaluate the long-term outcome of these patients. : Retrospective study at a referral center. Read More

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Efficacy of Parent-Infant-Psychotherapy with mothers with postpartum mental disorder: study protocol of the randomized controlled trial as part of the SKKIPPI project.

Trials 2020 Jun 5;21(1):490. Epub 2020 Jun 5.

Department of Psychiatry, Psychosomatics and Psychotherapy, Diakonissenkrankenhaus Flensburg, Flensburg, Germany.

Background: After the birth of a child, many mothers and fathers experience postpartum mental disorders like depression, anxiety, obsessive-compulsive disorder, stress or other illnesses. This endangers the establishment of a secure attachment between the children and their primary caregivers. Early problems in parent-child interaction can have adverse long-term effects on the family and the child's well-being. Read More

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Pilot implementation of elder-friendly care practices in acute care setting: a mixed methods study.

BMC Health Serv Res 2020 Apr 24;20(1):347. Epub 2020 Apr 24.

Alberta Health Services, Seniors Health Strategic Clinical Networks, Calgary, AB, Canada.

Background: Frail older patients are at risk of experiencing a decline in physical and cognitive function unrelated to the reason for admission. The Elder-Friendly Care (EFC) program was designed to improve the care, experiences, and outcomes of frail older adults. The project supported 8 Early Adoption Sites (EAS) in a large Canadian healthcare organization by providing multiple strategies, educational opportunities, and resources. Read More

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