496,377 results match your criteria early detection


Surgical Outcome of Spinal Subdural Abscesses: A Report of Four Consecutive Patients and Brief Review of the Literature.

J Neurol Surg A Cent Eur Neurosurg 2022 Jan 18. Epub 2022 Jan 18.

Department of Neurosurgery, Aile Hospital, Istanbul, Turkey.

Background And Study Aims:  Spinal subdural abscesses (SSAs) are rare and have a poor prognosis, especially when they are diagnosed late. In the literature, most cases of SSAs have been reported as case reports and small case series. In this study, we aimed to evaluate the surgical outcomes of four consecutive SSA patients. Read More

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January 2022

Diagnostic challenges in patients with alcohol-related liver disease.

Z Gastroenterol 2022 Jan 18;60(1):45-57. Epub 2022 Jan 18.

Centre of Alcohol Research, University of Heidelberg, Heidelberg, Germany.

Alcohol is globally the leading risk factor for cirrhosis and is subsumed under the term alcohol-related liver disease (ALD). However, only ca. 10% of people with harmful alcohol consumption (>40 gram alcohol per day) develop cirrhosis, while 15% have normal liver histology. Read More

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January 2022

Liver specific, systemic and genetic contributors to alcohol-related liver disease progression.

Z Gastroenterol 2022 Jan 18;60(1):36-44. Epub 2022 Jan 18.

Department of Medicine, Columbia University, New York, United States.

Alcohol-related liver disease (ALD) impacts millions of patients worldwide each year and the numbers are increasing. Disease stages range from steatosis via steatohepatitis and fibrosis to cirrhosis, severe alcohol-associated hepatitis and liver cancer. ALD is usually diagnosed at an advanced stage of progression with no effective therapies. Read More

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January 2022

Benefits of Newborn Screening and Hematopoietic Cell Transplant in Infantile Krabbe Disease.

Blood Adv 2022 Jan 18. Epub 2022 Jan 18.

Duke University Medical Center, Durham, North Carolina, United States.

Infantile Krabbe Disease (IKD) can be treated with hematopoietic cell transplantation (HCT) if done during the first weeks of life before symptoms develop. To facilitate this, newborn screening (NBS) has been instituted in eight U.S. Read More

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January 2022

Development of Sensitization to Multiple Allergen Molecules from Preschool to School Age Is Related to Asthma.

Int Arch Allergy Immunol 2022 Jan 18:1-12. Epub 2022 Jan 18.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Introduction: Allergic sensitization in early life has been identified as a strong risk factor for subsequent asthma in childhood. It is still unclear why only a part of sensitized children develop asthma, and the role of specific allergen molecules in asthma pathogenesis is ambiguous [Pharmacol Ther. 2009 Feb;121(2):174-84]. Read More

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January 2022

Executive functioning skills in early childhood children with autism, intellectual disability, and co-occurring autism and intellectual disability.

Res Dev Disabil 2022 Jan 15;122:104169. Epub 2022 Jan 15.

Department of Psychiatry, University of Tennessee Health Science Center, 853 Jefferson Avenue, Memphis, TN, USA. Electronic address:

Background: Many children with autism and intellectual disability (ID) experience executive functioning (EF) difficulties. However, there is minimal research on EF skills in children with autism, ID, and co-occurring autism/ID in early childhood.

Aims: To address this gap in the research, we evaluated EF profiles using the BRIEF-P among early childhood children (2-5 years of age) with autism, ID, and co-occurring autism/ID. Read More

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January 2022

Adult Wilms tumor: An unusual case report with dedicated literature review.

Clin Imaging 2022 Jan 13;83:138-143. Epub 2022 Jan 13.

Department of Radiology, Columbia University at Bassett Healthcare, 1 Atwell Road, Cooperstown, NY 13326, USA.

Wilms tumor is the most common primary renal malignancy in pediatric age group, however, is rare in adults accounting for 0.5% of all adult renal malignancies. The histopathology is similar in both age groups, however the prognosis in adults is poor with tumor being at advanced stage at presentation with increased incidence of metastasis. Read More

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January 2022

Diagnosis and treatment for primary Candida parapsilosis infection of the native knee joint: A case report.

Int J Surg Case Rep 2021 Dec 27;91:106730. Epub 2021 Dec 27.

Department of Orthopedic Surgery, Daegu Fatima Hospital, Daegu, Republic of Korea.

Introduction And Importance: Candida arthritis is a very rare disease and Candida parapsilosis infection of the native knee joint is extremely rare. It is challenging to diagnose and treat because the clinical manifestations, laboratory and radiologic findings are not specific and not well defined. We report the rare case of C. Read More

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December 2021

The effect of apnea length on vital parameters in apnea of prematurity - Hybrid observations from clinical data and simulation in a mathematical model.

Early Hum Dev 2022 Jan 11;165:105536. Epub 2022 Jan 11.

Applied Physics, Eindhoven University of Technology, Eindhoven, the Netherlands; Clinical Physics, Máxima Medical Center, Veldhoven, the Netherlands.

Apnea of prematurity (AOP) is a critical condition for preterm infants which can lead to several adverse outcomes. Despite its relevance, mechanisms underlying AOP are still unclear. In this work we aimed at improving the understanding of AOP and its physiologic responses by analyzing and comparing characteristics of real infant data and model-based simulations of AOP. Read More

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January 2022

Detecting early osteoarthritis through changes in biomechanical properties - A review of recent advances in indentation technologies in a clinical arthroscopic setup.

J Biomech 2022 Jan 11;132:110955. Epub 2022 Jan 11.

Laboratory of Cell Biology, Department of Orthopaedic Surgery, University Hospital of Tübingen, D-72072 Tübingen, Germany; Department of Orthopaedic, Trauma, and Reconstructive Surgery, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address:

Osteoarthritis (OA) is a degenerative joint disease currently affecting half of all women and one-third of all men aged over 65 and it is predicted to even increase in the next decades. In the variety of causes leading to OA, the first common denominator are changes in the extracellular matrix of the cartilage. In later stages, OA affects the whole joint spreading to higher levels of tissue architecture causing irreversible functional and structural damage. Read More

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January 2022

Sensitivity of wastewater-based epidemiology for detection of SARS-CoV-2 RNA in a low prevalence setting.

Water Res 2022 Jan 2;211:118032. Epub 2022 Jan 2.

Institute of Environmental Science and Research Ltd, 27 Creyke Road, Ilam, Christchurch 8041, New Zealand.

To assist public health responses to COVID-19, wastewater-based epidemiology (WBE) is being utilised internationally to monitor SARS-CoV-2 infections at the community level. However, questions remain regarding the sensitivity of WBE and its use in low prevalence settings. In this study, we estimated the total number of COVID-19 cases required for detection of SARS-CoV-2 RNA in wastewater. Read More

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January 2022

Primary results of STRONG: An open-label, multicenter, phase 3b study of fixed-dose durvalumab monotherapy in previously treated patients with urinary tract carcinoma.

Eur J Cancer 2022 Jan 15;163:55-65. Epub 2022 Jan 15.

Department of Oncology, Juravinski Cancer Centre (JCC), Hamilton Health Sciences 699 Concession Street, Hamilton, ON, Canada. Electronic address:

Background: Prior durvalumab (anti-PD-L1 agent) studies in platinum-refractory metastatic urothelial carcinoma evaluated a dose of 10 mg/kg administered every two weeks. The nonrandomised phase 3b STRONG study (NCT03084471) evaluated the safety and efficacy of fixed-dose durvalumab at a more convenient dosing schedule in a previously treated patient population, more similar to a real-world clinical setting.

Patients And Methods: 867 patients with urothelial or nonurothelial urinary tract carcinoma (UTC) who progressed on or after platinum or nonplatinum chemotherapy were treated with durvalumab 1500 mg every four weeks; 87% had an Eastern Cooperative Oncology Group performance status (ECOG PS) of 0-1, and 13% had an ECOG PS of 2. Read More

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January 2022

The best protection is early detection.

Biomed J 2022 Jan 15. Epub 2022 Jan 15.

Berlin, Germany. Electronic address:

This current special issue of the Biomedical Journal provides insights in various cancer forms, and possible ways of prognostic and predictive screening. In detail we learn about lung cancer and tissue samples from ground glass opacifications, liquid biopsy through circulating tumor cells in colon cancer, transcription factor analysis in cervical cancer, and long non-coding RNAs in breast and lung cancer. A prognosis factor in individuals with acute myeloid leukemia and a rare fungal infection are determined. Read More

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January 2022

Deep learning of early brain imaging to predict post-arrest electroencephalography.

Resuscitation 2022 Jan 15. Epub 2022 Jan 15.

Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA; Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA; Intelligent Systems Program, University of Pittsburgh, Pittsburgh, PA, USA.

Introduction: Guidelines recommend use of computerized tomography (CT) and electroencephalography (EEG) in post-arrest prognostication. Strong associations between CT and EEG might obviate the need to acquire both modalities. We quantified these associations via deep learning. Read More

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January 2022

Kinase inhibitor-induced cardiotoxicity assessed in vitro with human pluripotent stem cell derived cardiomyocytes.

Toxicol Appl Pharmacol 2022 Jan 15:115886. Epub 2022 Jan 15.

VistaGen Therapeutics, Inc., 343 Allerton Ave., South San Francisco, CA, 94080, United States of America. Electronic address:

Many small molecule kinase inhibitors (SMKIs), used predominately in cancer therapy, have been implicated in serious clinical cardiac adverse events, which means that traditional preclinical drug development assays were not sufficient for identifying these cardiac liabilities. To improve clinical cardiac safety predictions, the effects of SMKIs targeting many different signaling pathways were studied using human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) in combined assays designed for the detection of both electrophysiological (proarrhythmic) and non-electrophysiological (non-proarrhythmic) drug-induced cardiotoxicity. Several microplate-based assays were used to quantitate cell death, apoptosis, mitochondrial damage, energy depletion, and oxidative stress as mechanism-based non-electrophysiological cardiomyocyte toxicities. Read More

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January 2022

Sustained Release In Situ Thermogelling Hydrogel of Cerebrolysin for Treatment of Facial Nerve Axotomy in Rats.

J Oral Maxillofac Surg 2021 Dec 23. Epub 2021 Dec 23.

Assistant Professor, Oral Biology Department, Faculty of Dentistry, Mansoura University, Egypt. Electronic address:

Purpose: The most essential principle in managing facial nerve (FN) injury is proper diagnosis and early treatment. This study evaluated local application of different concentrations and injection intervals of cerebrolysin hydrogel (CBL) for facial nerve axotomy (FNA) treatment.

Hypothesis: We hypothesized that local application of CBL may provide a sustained release of CBL and enhance neural regeneration. Read More

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December 2021

Does Evoked Electromyography Detect the Injured Facial Nerve Recovery Earlier Than Clinical Assessments?

J Oral Maxillofac Surg 2021 Dec 22. Epub 2021 Dec 22.

Scientist - I, Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.

Purpose: The key element in managing postoperative facial nerve (FN) injuries is timely diagnosis and intervention as indicated. The purpose of this study was to measure and compare evoked electromyography (EEMG) and clinical assessment in terms of the recovery of the injured FN in operated temporomandibular joint ankylosis (TMJA) cases.

Methods: The investigators designed a prospective cohort study in the primary operated TMJA patients. Read More

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December 2021

Development of the gut microbiome in early life.

Exp Physiol 2022 Jan 18. Epub 2022 Jan 18.

Clinical and Translational Research Institute, Newcastle University, Newcastle, NE2 4HH, UK.

New Findings: What is the topic of this review? This symposium report discusses the importance of the early life gut microbiome, with a focus on preterm infants and microbially-related diseases. Current techniques to study the preterm gut microbiome are appraised, and the potential of recent methodological advancements is discussed. What advances does it highlight? Recent findings in the field achieved by the application of advanced technologies are acknowledged. Read More

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January 2022

A clinical update on Gestational Diabetes Mellitus.

Endocr Rev 2022 Jan 18. Epub 2022 Jan 18.

Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.

Gestational diabetes mellitus (GDM) traditionally refers to abnormal glucose tolerance with onset or first recognition during pregnancy (1). GDM has long been associated with obstetric and neonatal complications primarily relating to higher infant birthweight and is increasingly recognised as a risk factor for future maternal and offspring cardiometabolic disease. The prevalence of GDM continues to rise internationally due to epidemiological factors including the increase in background rates of obesity in women of reproductive age and rising maternal age, and the implementation of the revised International Association of the Diabetes and Pregnancy Study Groups' (IADPSG) criteria and diagnostic procedures for GDM (2). Read More

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January 2022

Prediction model of acute kidney injury induced by cisplatin in older adults using a machine learning algorithm.

PLoS One 2022 18;17(1):e0262021. Epub 2022 Jan 18.

Department of Information Engineering, Meijo University, Nagoya, Japan.

Background: Early detection and prediction of cisplatin-induced acute kidney injury (Cis-AKI) are essential for the management of patients on chemotherapy with cisplatin. This study aimed to evaluate the performance of a prediction model for Cis-AKI.

Methods: Japanese patients, who received cisplatin as the first-line chemotherapy at Fujita Health University Hospital, were enrolled in the study. Read More

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January 2022

NPCNet: Jointly Segment Primary Nasopharyngeal Carcinoma Tumors and Metastatic Lymph Nodes in MR Images.

IEEE Trans Med Imaging 2022 Jan 18;PP. Epub 2022 Jan 18.

Nasopharyngeal carcinoma (NPC) is a malignant tumor whose survivability is greatly improved if early diagnosis and timely treatment are provided. Accurate segmentation of both the primary NPC tumors and metastatic lymph nodes (MLNs) is crucial for patient staging and radiotherapy scheduling. However, existing studies mainly focus on the segmentation of primary tumors, eliding the recognition of MLNs, and thus fail to comprehensively provide a landscape for tumor identification. Read More

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January 2022

Association of State Medicaid Expansion Status With Hypertensive Disorders of Pregnancy in a Singleton First Live Birth.

Circ Cardiovasc Qual Outcomes 2022 Jan 18;15(1):e008249. Epub 2022 Jan 18.

Division of Cardiology, Department of Medicine (P.M.F., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL.

Background: Incidence of hypertensive disorders of pregnancy is increasing in the United States. Early detection is important to prevent adverse maternal and offspring outcomes. This ecological study evaluated changes in rates of hypertensive disorders of pregnancy among states that expanded Medicaid compared with states that did not expand Medicaid. Read More

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January 2022

Patterns of Early Coronary Artery Changes in Pediatric Heart Transplant Recipients Detected Using Optical Coherence Tomography.

Circ Cardiovasc Imaging 2022 Jan 18;15(1):e012486. Epub 2022 Jan 18.

Division of Cardiology, Department of Pediatrics, British Columbia Children's Hospital, Vancouver, Canada (S.L.L., R.S., C.V., M.C.K.H., K.C.H.).

Background: Cardiac allograft vasculopathy, the leading cause of graft failure in pediatric heart transplant recipients, is characterized by diffuse and concentric coronary intimal thickening. Early treatment yields better outcomes. While coronary angiography is the standard for cardiac allograft vasculopathy screening and diagnosis, it only identifies luminal narrowing, which occurs in more severe disease. Read More

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January 2022

Dual-Emission GFP Chromophore-Based Derivative for Imaging and Discriminating Aβ Oligomers and Aggregates.

Anal Chem 2022 Jan 18. Epub 2022 Jan 18.

MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, P. R. China.

β-Amyloid deposition is one of the main pathological features of Alzheimer's disease (AD). The development of fluorescent probes targeting specific β-amyloid species has recently become an attractive strategy to achieve the early diagnosis of AD. In this work, a dual-channel fluorescent protein chromophore derivative was rationally designed and synthesized for the detection and discrimination of Aβ aggregates and oligomers. Read More

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January 2022

Metabolomics of Synovial Fluid and Infrapatellar Fat Pad in Patients with Osteoarthritis or Rheumatoid Arthritis.

Inflammation 2022 Jan 18. Epub 2022 Jan 18.

Institute of Biomedicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.

Osteoarthritis (OA) and autoimmune-driven rheumatoid arthritis (RA) are inflammatory joint diseases with complex and insufficiently understood pathogeneses. Our objective was to characterize the metabolic fingerprints of synovial fluid (SF) and its adjacent infrapatellar fat pad (IFP) obtained during the same surgical operation from OA and RA knees. Non-targeted metabolite profiling was performed for 5 non-inflammatory trauma controls, 10 primary OA (pOA) patients, and 10 seropositive RA patients with high-resolution mass spectrometry-based techniques, and metabolites were matched with known metabolite identities. Read More

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January 2022

Sarcopenia: how to measure, when and why.

Radiol Med 2022 Jan 18. Epub 2022 Jan 18.

Department of Surgery, University of Pisa, Pisa, Italy.

Sarcopenia indicates a loss of skeletal muscle mass, a condition that leads to a decline in physical performance. In 2018, the European Working Group on Sarcopenia in Older People met to update the original definition of sarcopenia: New scientific and clinical insights were introduced to emphasize the importance of muscle strength loss as a prime indicator of probable sarcopenia. In addition, the skeletal muscle is not only the organ related to mobility, but it is recognized as a secondary secretory organ too, with endocrine functions influencing several systems and preserving health. Read More

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January 2022

The big five model in bipolar disorder: a latent profile analysis and its impact on longterm illness severity.

Int J Bipolar Disord 2022 Jan 18;10(1). Epub 2022 Jan 18.

Department of Psychology, Brandenburg Medical School Theodor Fontane, Fehrbelliner Straße 38, 16816, Neuruppin, Germany.

Background: Using a personality typing approach, we investigated the relationship between personality profiles and the prediction of longterm illness severity in patients with bipolar disorder (BD). While previous research suggests associations between BD and traits from the NEO-FFI profiles, the current study firstly aimed to identify latent classes of NEO-FFI profiles, and, secondly, to examine their impact on the longterm prognosis of BD.

Methods: Based on the NEO-FFI profiles of 134 euthymic patients diagnosed with BD (64. Read More

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January 2022

Thrombotic microangiopathy in children.

Pediatr Nephrol 2022 Jan 18. Epub 2022 Jan 18.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

The syndrome of thrombotic microangiopathy (TMA) is a clinical-pathological entity characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end organ involvement. It comprises a spectrum of underlying etiologies that may differ in children and adults. In children, apart from ruling out shigatoxin-associated hemolytic uremic syndrome (HUS) and other infection-associated TMA like Streptococcus pneumoniae-HUS, rare inherited causes including complement-associated HUS, cobalamin defects, and mutations in diacylglycerol kinase epsilon gene must be investigated. Read More

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January 2022

Feasibility of Training Community Health Workers in the Detection of Oral Cancer.

JAMA Netw Open 2022 Jan 4;5(1):e2144022. Epub 2022 Jan 4.

Division of Health Sciences, University of Warwick, Coventry, United Kingdom.

Importance: Visual screening for oral cancer has been found to be useful in a large randomized clinical trial in Kerala, India, showing substantial reduction in mortality. To address the shortage of medical personnel in resource-deficient regions, using the services of community health workers has been proposed as a strategy to fill the gap in human resources in health care.

Objective: To assess the feasibility of community health workers in screening and early detection of oral cancer using a mobile application capturing system. Read More

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January 2022

Association of Computed Tomographic Screening Promotion With Lung Cancer Overdiagnosis Among Asian Women.

JAMA Intern Med 2022 Jan 18. Epub 2022 Jan 18.

Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts.

Importance: As smoking continues to decline in many developed countries, the proportion of lung cancers in nonsmokers will rise. This shift may create substantial pressure to further expand lung cancer screening to lower-risk groups.

Objective: To determine the association of lung cancer incidence with the promotion of screening in a largely nonsmoking population. Read More

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January 2022