J Hypertens 2021 Apr 14. Epub 2021 Apr 14.
Department of Pediatric and Adolescents Medicine, Akershus University Hospital, Lørenskog, Norway MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK Institute of Clinical Medicine, University of Oslo, Campus AHUS, Lørenskog, Norway NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton Vascular Physiology Unit, Institute of Cardiovascular Science, University College London, London Institute of Developmental Sciences, University of Southampton, Southampton, UK.
Objective: In children aged 8--9 years, we examined the associations of linear and abdominal circumference growth during critical stages of prenatal and postnatal development with six vascular measurements commonly used as early markers of atherosclerosis and later cardiovascular disease (CVD) risk.
Methods: In 724 children from the UK Southampton Women's Survey mother--offspring cohort, offspring length/height and abdominal circumference measurements were collected at 10 ages between 11 weeks' gestation and age 8--9 years. Using residual growth modelling and linear regression, we examined the independent associations between growth and detailed vascular measures made at 8--9 years. Read More