333,266 results match your criteria early age


Increased lipocalin 2 levels in adolescents with type 2 diabetes mellitus.

J Pediatr Endocrinol Metab 2021 Jun 14. Epub 2021 Jun 14.

Department of Pediatrics, Kansai Medical University, Hirakata, Osaka, Japan.

Objectives: Bone can act as an endocrine organ through the secretion of bone-specific hormones, i.e., osteokines. Read More

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Bridge clinic buprenorphine program decreases emergency department visits.

J Subst Abuse Treat 2021 Apr 17;130:108410. Epub 2021 Apr 17.

Department of Emergency Medicine, Upstate Medical University, Syracuse, NY, USA.

Introduction: Opioid withdrawal due to opioid use disorder (OUD) is an increasing health emergency and complaint in emergency departments (EDs) across the United States. As a response to the increased need for OUD treatment, a low threshold buprenorphine program, or Bridge Clinic, was established within our hospital system. Patients are primarily connected to the Bridge Clinic through the ED, and are able to complete their consultation appointment reliably within 1-3 days of referral. Read More

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Temporal transition of racial/ethnic disparities in COVID-19 outcomes in 3108 counties of the United States: Three phases from January to December 2020.

Sci Total Environ 2021 Jun 1;791:148167. Epub 2021 Jun 1.

School of the Environment, Yale University, New Haven, CT, United States of America.

Early studies reported higher risk of COVID-19 outcomes for racial/ethnic minorities in the early phase of the pandemic in the United States. While the initial surge of COVID-19 was concentrated in some areas, COVID-19 became pervasive across the entire continent with high impacts in the northern region and central region in the end of 2020. With this geographical transition, we aim to investigate patterns of these racial/ethnic disparities over time. Read More

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Co-occurring risk and protective factors and regulatory behavior of infants living in low-income homes.

Infant Behav Dev 2021 Jun 9;64:101598. Epub 2021 Jun 9.

Crane Center for Early Childhood Research and Policy, The Ohio State University, United States.

Early self-regulation is a foundation for lifelong wellness and can be shaped by the interplay among several vital exposures. In this study, we examined the emergence of reliable profiles based upon exposure to risk and protective factors in infancy, determined if sociodemographic resources predict profile membership, and determined if these profiles predict early regulatory behaviors in a sample of infants reared in low-income homes. Data were collected from a sample of primarily Black or White mother-infant dyads living in low-income homes in the Midwest (n = 222) during the infants' first year of life (mean maternal age at enrollment: 26. Read More

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Retinal thickness and microvascular pathway in Idiopathic Rapid eye movement sleep behaviour disorder and Parkinson's disease.

Parkinsonism Relat Disord 2021 Jun 6;88:40-45. Epub 2021 Jun 6.

Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, Section of Neurosciences, University of Catania, Catania, CT, Italy. Electronic address:

Introduction: Retinal impairment has previously been described in Parkinson's Disease (PD), also in early stage of disease. Idiopathic Rapid-eye-movement sleep Behavior Disorder (iRBD) is considered the strongest marker in the diagnosis of "Prodromal PD". Thus, we evaluated the thickness of retinal layers and the microvascular retinal pattern in a group of iRBD patients compared to PD and healthy subjects (HCs). Read More

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Rate of treatment success and associated factors in the program for drug susceptible tuberculosis in the Forest Region, Republic of Guinea, 2010-2017: a real-world retrospective observational cohort study.

Int J Infect Dis 2021 Jun 9. Epub 2021 Jun 9.

Centre Hospitalier Régional Spécialisé, Quartier Fassankoni, Commune urbaine Macenta, Région N'Zérékoré, Région Forestière, Guinée; Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Switzerland.

Objectives: To analyze the treatment success rate (TSR = sum of cured or treatment completed) in the tuberculosis (TB) program for drug susceptible TB (DS-TB) of the "Centre Hospitalier Régional Spécialisé" in Macenta, Forest Region, Republic of Guinea.

Methods: This cohort study included patients starting treatment for DS-TB between 2010 and 2017. Data collection was part of the documentation for the national TB program. Read More

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Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults.

Clin Immunol 2021 Jun 9:108782. Epub 2021 Jun 9.

Vaccine Development and Immunology/Vaccine Research Center, Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, FI-33520 Tampere, Finland. Electronic address:

Endemic human coronaviruses (hCoVs) are common causative agents of respiratory tract infections, affecting especially children. However, in the ongoing SARS-CoV-2 pandemic, children are the least affected age-group. The objective of this study was to investigate the magnitude of endemic hCoVs antibodies in Finnish children and adults, and pre-pandemic antibody cross-reactivity with SARS-CoV-2. Read More

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Prognostic performance of seven biomarkers compared to liver biopsy in early alcohol-related liver disease.

J Hepatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Gastroenterology and Hepatology, Odense University Hospital, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

Background & Aims: Alcohol is the most common cause of liver-related mortality and morbidity. We therefore aimed to assess and compare the prognostic performance of elastography and blood-based markers to predict time to the first liver-related event, severe infection, and all-cause mortality in patients with a history of excess drinking.

Methods: Prospective cohort study of patients with early, compensated alcohol-related liver disease. Read More

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Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG.

J Mol Cell Cardiol 2021 Jun 9. Epub 2021 Jun 9.

Department of Biomedical Engineering, Case School of Engineering, Case Western Reserve University, Cleveland, OH, USA. Electronic address:

Controlling fibrosis is an essential part of regenerating the post-ischemic heart. In the post-ischemic heart, fibroblasts differentiate to myofibroblasts that produce collagen-rich matrix to physically stabilize the infarct area. Infarct models in adult mice result in permanent scarring unlike newborn animals which fully regenerate. Read More

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Correlates of blood pressure and blood glucose screenings in Cameroon: insights from the 2018 Demographic and Health Survey.

Int Health 2021 Jun 12. Epub 2021 Jun 12.

Department of Family Health Care Nursing, School of Nursing, University of California, San Francisco, CA, USA.

Background: Hypertension and diabetes, two major risk factors for cardiometabolic diseases, are associated with high morbidity and mortality rates. Early detection through screening can initiate early treatment to reduce adverse outcomes. The current study sought to investigate the correlates of blood pressure and blood glucose screenings in Cameroon. Read More

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Evaluation of peer bullying, internet addiction, and psychological adaptation level of students aged 9-15.

J Child Adolesc Psychiatr Nurs 2021 Jun 12. Epub 2021 Jun 12.

Department of Child Health and Disease Nursing, Faculty of Health Science, University of Sivas Cumhuriyet, Sivas, Turkey.

Purpose: This study was conducted to evaluate peer bullying, internet addiction, and psychological adaptation capabilities of students in the 9-15 age group.

Design And Methods: The study was performed as cross-sectional-descriptive research with 880 students included in the research sample.

Findings: One-fourth of the students in the 9-15 age group suffered from psychological adaptation issues, one-fifth suffered from bullying issues, and 16. Read More

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Appendicular skeletal muscle mass and quality estimated by bioelectrical impedance analysis in the assessment of frailty syndrome risk in older individuals.

Aging Clin Exp Res 2021 Jun 12. Epub 2021 Jun 12.

Department of Biostructure, University School of Physical Education in Wroclaw, Al. I. J. Paderewskiego 35, 51-612, Wroclaw, Poland.

Background And Aim: The rising aging index of many populations necessitates the continuous evolution of geriatric assessment methods, especially the ones used to identify frailty and the risk of frailty. An appropriately early diagnosis of adverse changes in skeletal muscles can reduce the risk of functional limitations in elderly persons. The aim of this study was to assess the correlation between the appendicular skeletal muscle mass and quality, estimated by the bioelectrical impedance analysis method, and the risk of prevalence of the pre-frailty state in elderly persons. Read More

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Serum cartilage oligomeric matrix protein is correlated with quantitative magnetic resonance imaging and arthroscopic cartilage findings in anterior cruciate ligament deficient knees without osteoarthritic changes.

Clin Rheumatol 2021 Jun 12. Epub 2021 Jun 12.

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

Introduction/objectives: To investigate the association between serum biomarker [cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3 (MMP-3)] levels and clinical, magnetic resonance imaging (MRI), and arthroscopic findings in anterior cruciate ligament (ACL)-deficient knees without osteoarthritic changes on radiographs.

Method: Patients with ACL injury of Kellgren-Lawrence grade 0 or 1 were enrolled. Serum COMP and MMP-3 levels were measured preoperatively. Read More

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Mortality and cause of death in patients with AAV/PAN in Australia-a population-based study.

Rheumatology (Oxford) 2021 Jun 12. Epub 2021 Jun 12.

School of Medicine, University of Western Australia, Perth, Australia.

Objectives: We compared survival and causes of death in Western Australian (WA) anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and polyarteritis nodosa (PAN) patients with controls and the WA population.

Methods: In this data linkage study, we identified patients with incident AAV/PAN and age, sex and temporally matched controls 1980 - 2014 from the WA Rheumatic Disease Epidemiological Registry. Survival analyses and time-varying analyses were performed. Read More

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Q134R: Small chemical compound with NFAT inhibitory properties improves behavioral performance and synapse function in mouse models of amyloid pathology.

Aging Cell 2021 Jun 12:e13416. Epub 2021 Jun 12.

Sanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY, USA.

Inhibition of the protein phosphatase calcineurin (CN) ameliorates pathophysiologic and cognitive changes in aging rodents and mice with aging-related Alzheimer's disease (AD)-like pathology. However, concerns over adverse effects have slowed the transition of common CN-inhibiting drugs to the clinic for the treatment of AD and AD-related disorders. Targeting substrates of CN, like the nuclear factor of activated T cells (NFATs), has been suggested as an alternative, safer approach to CN inhibitors. Read More

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Development and Psychometric Properties of a Computer-Based Standardized Emotional Competence Inventory (MeKKi) for Preschoolers and School-Aged Children.

Child Psychiatry Hum Dev 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Child and Adolescent Psychology, University of Leipzig, Leipzig, Germany.

A computer-based emotional competence inventory for preschoolers and school-aged children (MeKKi) was developed to assess five components of emotional competence: emotion vocabulary, emotion identification (situational, visual, auditory), emotion understanding, emotion expression, and emotion regulation. Validity, reliability, and factor structure were examined in a community sample of 313 preschoolers and school-aged children (164 boys, 145 girls, 4 n.a. Read More

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Demography, clinical profile and surgical outcomes of paediatric giant retinal tear related retinal detachments.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Objective: To determine the demographic profile, clinical features and surgical outcomes of giant retinal tear (GRT) related retinal detachments (RD) in children.

Methods: In this retrospective study, medical records of children aged 14 years and below, who underwent surgery for RD at our centre in the last 5 years were reviewed. Among these, we selected medical records of children with RDs with GRT, and examined the coloured retinal drawings, ultrawidefield photographs and/or surgical videos. Read More

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Delayed elimination communication on the prevalence of children's bladder and bowel dysfunction.

Sci Rep 2021 Jun 11;11(1):12366. Epub 2021 Jun 11.

Pediatric Urodynamic Center and Department of Urology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

To determine the prevalence of bladder and bowel dysfunction (BBD) and its relationship with delayed elimination communication (EC) in children. A cross-sectional study was carried out in kindergartens and primary schools in mainland China. A total of 10,166 children ranging from 4 to 10 years old were included. Read More

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Family history of early onset acute lymphoblastic leukemia is suggesting genetic associations.

Sci Rep 2021 Jun 11;11(1):12370. Epub 2021 Jun 11.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

Childhood acute lymphoblastic leukemia (ALL) has an origin in the fetal period which may distinguish it from ALL diagnosed later in life. We wanted to test whether familial risks differ in ALL diagnosed in the very early childhood from ALL diagnosed later. The Swedish nation-wide family-cancer data were used until year 2016 to calculate standardized incidence ratios (SIRs) for familial risks in ALL in three diagnostic age-groups: 0-4, 5-34 and 35 + years. Read More

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Zircon record of an Archaean crustal fragment and supercontinent amalgamation in quaternary back-arc volcanic rocks.

Sci Rep 2021 Jun 11;11(1):12367. Epub 2021 Jun 11.

Key Laboratory of Marine Geology and Environment, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China.

Magmatism has profoundly influenced the evolution of the geosphere, hydrosphere, atmosphere, and biosphere in back-arc basins. However, the timing of the magmatism in the Okinawa Trough (OT) is not well constrained by the age spectra of zircons. Here, for the first time, we carry out an integrated study combining in situ analysis of zircon U-Th-Pb and Hf-O isotopes, and trace element compositions of zircons from the volcanic rocks from the southernmost part of the OT. Read More

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Mucosal Invariant T cells are Diminished in Very Early-Onset Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2021 Jun 7. Epub 2021 Jun 7.

Division of Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA 19104 USA Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA 19104 USA.

Objectives: Very early-onset inflammatory bowel disease arises in children less than six years old, a critical time for immunologic development and maturation of the intestinal microbiome. Non-conventional lymphocytes, defined here as mucosal-associated invariant T cells and innate lymphocytes, require microbial products for either development or expansion, aspects that could be altered in very early-onset inflammatory bowel disease. Our objective was to define conventional leukocyte and non-conventional lymphocyte populations in controls and patients using multiparameter flow cytometry to test the hypothesis that their frequencies would be altered in a chronic inflammatory state associated with significant dysbiosis. Read More

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Early Drain Removal is Safe in Patients With Low or Intermediate Risk of Pancreatic Fistula After Pancreaticoduodenectomy: A Multicenter, Randomized Controlled Trial.

Ann Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China Department of General Surgery, Peking University First Hospital, Peking University, Beijing 100034, P.R China Department of General Surgery, Beijing Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R China Department of Hepatobiliary & Pancreatic Surgical Oncology, Chinese People's Liberation Army, General Hospital, Beijing 100853, P.R China Department of Hepato-Biliary-Pancreatic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R China Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R China Department of Visceral, Vascular and Endocrine Surgery, Martin-Luther-University Halle-Wittenberg, 06120, Halle (Saale), Germany.

Objective: This multi-center randomized controlled trial (RCT) was designed to test the hypothesis that early drain removal (EDR) could decrease the incidence of grade 2-4 complications for patients undoing pancreaticoduodenectomy (PD) with low or intermediate risk of postoperative fistula (POPF).

Background: The safety and effects of EDR on postoperative complications after PD are still controversial.

Methods: A multi-center RCT at six tertiary referral hospitals was carried out (NCT03055676). Read More

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Association between sleep quality and type 2 diabetes at 20-year follow-up in the Southall and Brent REvisited (SABRE) cohort: a triethnic analysis.

J Epidemiol Community Health 2021 Jun 11. Epub 2021 Jun 11.

MRC Unit for Lifelong Health and Ageing, Department of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, UK.

Background: The risk of developing type 2 diabetes associated with poor sleep quality is comparable to other lifestyle factors (eg, overweight, physical inactivity). In the UK, these risk factors could not explain the two to three-fold excess risks in South-Asian and African-Caribbean men compared with Europeans. This study investigates (1) the association between mid-life sleep quality and later-life type 2 diabetes risk and (2) the potential modifying effect of ethnicity. Read More

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Novel selection paradigms for endovascular stroke treatment in the extended time window.

J Neurol Neurosurg Psychiatry 2021 Jun 11. Epub 2021 Jun 11.

Neurology, Emory University, Atlanta, Georgia, USA

Background And Purpose: The optimal selection methodology for stroke thrombectomy beyond 6 hours remains to be established.

Methods: Review of a prospectively collected database of thrombectomy patients with anterior circulation strokes, adequate CT perfusion (CTP) maps, National Institute of Health Stroke Scale (NIHSS)≥10 and presenting beyond 6 hours from January 2014 to October 2018. Patients were categorised according to five selection paradigms: DAWN clinical-core mismatch (DAWN-CCM): between age-adjusted NIHSS and CTP core, DEFUSE 3 perfusion imaging mismatch (DEFUSE-3-PIM): between CTP-derived perfusion defect (Tmax >6 s lesion) and ischaemic core volumes and three non-contrast CT Alberta Stroke Program Early CT Score (ASPECTS)-based criteria: age-adjusted clinical-ASPECTS mismatch (aCAM): between age-adjusted NIHSS and ASPECTS, eloquence-adjusted clinical ASPECTS mismatch (eCAM): ASPECTS 6-10 and non-involvement of the right M6 and left M4 areas and standard clinical ASPECTS mismatch (sCAM): ASPECTS 6-10. Read More

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National Early Warning Score for predicting intensive care unit admission among elderly patients with influenza infections in the emergency department: an effective disposition tool during the influenza season.

BMJ Open 2021 Jun 11;11(6):e044496. Epub 2021 Jun 11.

Department of Emergency Medicine, Cathay General Hospital, Taipei, Taiwan

Objective: During the influenza epidemic season, the fragile elderlies are not only susceptible to influenza infections, but are also more likely to develop severe symptoms and syndromes. Such circumstances may pose a significant burden to the medical resources especially in the emergency department (ED). Disposition of the elderly patients with influenza infections to either the ward or intensive care unit (ICU) accurately is therefore a crucial issue. Read More

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Hysteroscopy-assisted laparoscopic salpingectomy for interstitial pregnancy without cornual resection.

Fertil Steril 2021 Jun 8. Epub 2021 Jun 8.

Reproductive Biology Associates, Atlanta, Georgia.

Objective: To illustrate a novel surgical management technique for interstitial ectopic pregnancies (IP).

Design: Video description of the case, demonstration of the surgical technique, reevaluation at the 6-week postoperative follow-up, and review of the advantages of this surgical technique for IP.

Setting: Tertiary referral center. Read More

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The methamphetamine epidemic among persons who inject heroin in Hai Phong, Vietnam.

J Subst Abuse Treat 2021 Jul 4;126:108320. Epub 2021 Feb 4.

Pathogenesis and Control of Chronic Infections, Inserm, Etablissement Français du Sang, University of Montpellier, Montpellier, France.

Aims: To describe the current methamphetamine (MA) use epidemic among persons who inject heroin (PWID) in Hai Phong, Vietnam, and consider possibilities for mitigating adverse effects of methamphetamine use.

Methods: This study conducted surveys of PWID in 2016, 2017, and 2018 (N = 1383, 1451, and 1445, respectively). Trained interviewers administered structured interviews covering drug use histories, current drug use, and related risk behaviors. Read More

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Relationships between motor scores and cognitive functioning in FMR1 female premutation X carriers indicate early involvement of cerebello-cerebral pathways.

Cerebellum Ataxias 2021 Jun 11;8(1):15. Epub 2021 Jun 11.

School of Psychology and Public Health, La Trobe University, Melbourne, Bundoora, Victoria, Australia.

Background: Smaller expansions of CGG trinucleotide repeats in the FMR1 X-linked gene termed 'premutation' lead to a neurodegenerative disorder: Fragile X Associated Tremor/Ataxia Syndrome (FXTAS) in nearly half of aged carrier males, and 8-16% females. Core features include intention tremor, ataxia, and cognitive decline, and white matter lesions especially in cerebellar and periventricular locations. A 'toxic' role of elevated and expanded FMR1 mRNA has been linked to the pathogenesis of this disorder. Read More

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Gastrostomy for infants with severe epidermolysis bullosa simplex in neonatal intensive care.

Orphanet J Rare Dis 2021 Jun 11;16(1):271. Epub 2021 Jun 11.

Department of Dermatology, CRMRPM-Sud, Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, 06200, Nice, France.

Introduction: Severe epidermolysis bullosa simplex (EBS sev) is a rare genodermatosis characterized by congenital generalized blistering and mucosal involvement. Increased needs and decreased intake quickly lead to nutritional imbalance. Enteral nutrition support is proposed, but classical nasogastric tubes are not well tolerated in these patients and gastrostomy is preferred. Read More

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Logistic regression analysis on risk factors of augmented vertebra recompression after percutaneous vertebral augmentation.

J Orthop Surg Res 2021 Jun 11;16(1):374. Epub 2021 Jun 11.

Department of Spinal Surgery, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005, Zhejiang, People's Republic of China.

Objective: To explore the high-risk factors of augmented vertebra recompression after percutaneous vertebral augmentation (PVA) in the treatment of osteoporotic vertebral compression fracture (OVCF) and analyze the correlation between these factors and augmented vertebra recompression after PVA.

Methods: A retrospective analysis was conducted on 353 patients who received PVA for a single-segment osteoporotic vertebral compression fracture from January 2017 to December 2018 in our department according to the inclusion criteria. All cases meeting the inclusion and exclusion criteria were divided into two groups: 82 patients in the recompression group and 175 patients in the non-compression group. Read More

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