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[Heidelberg Milestones Communication (HeiMeKOM) - Experiences, Best Practice Examples and Recommendations from the Final Symposium on January 30 and 31 in 2020].

Gesundheitswesen 2021 Apr 16. Epub 2021 Apr 16.

Abteilung Internistische Onkologie, Thoraxklinik am Universitätsklinikum Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), Mitglied des Deutschen Zentrums für Lungenforschung (DZL), Heidelberg, Deutschland.

The National Cancer Plan emphasises the importance of medical communication and calls for its integration into medical education and training. In this context, the Milestone Communication Approach meets the communicative challenges in dealing with lung cancer patients. Interprofessional tandems, consisting of doctors and nurses, conduct structured conversations at defined moments with patients and their relatives. Read More

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Review of Approaches to Developing Intersegmental Plane during Segmentectomy.

Thorac Cardiovasc Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

In recent years, with the popularity of computed tomography (CT) scanning, early lung cancer has been found in a large number of patients, and segmentectomy has been widely used in clinical practice. The development of intersegmental plane is the most critical step in segmentectomy. At present, there are many methods to identify the intersegmental plane. Read More

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Priority issues and key findings from evaluation of disposal records for a legacy radioactive waste site.

J Radiol Prot 2021 Apr 16. Epub 2021 Apr 16.

Australian Nuclear Science and Technology Organisation, Kirrawee, AUSTRALIA.

This paper reports on a detailed investigation into the disposal procedures and records from the operational period (1960-1968) of the Little Forest Legacy Site (LFLS) in eastern Australia. The aims of the paper are firstly, to highlight the priority issues which are relevant to the radiological assessment of the LFLS, and secondly, to present key lessons that may help to guide future investigations of the records at similar sites. Particular effort was put into assessing the various types of relevant documents and the relationships between them. Read More

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Flow-diverter stents in the early management of acutely ruptured brain aneurysms: effective rebleeding protection with low thromboembolic complications.

J Neurosurg 2021 Apr 16:1-8. Epub 2021 Apr 16.

4Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; and.

Objective: Flow-diverter stents (FDSs) are not generally used for the management of acutely ruptured aneurysms with associated subarachnoid hemorrhage (SAH). Herein, the authors present their experience with FDSs in this scenario, focusing on the antiplatelet regimen, perioperative management, and outcome.

Methods: The authors retrospectively reviewed their institutional database for the treatment and outcomes of all patients with acutely ruptured aneurysms and associated SAH from July 2010 to September 2018 who had received an FDS implant as stand-alone treatment within 4 days after diagnosis. Read More

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Human challenge study with a Shigella bioconjugate vaccine: Analyses of clinical efficacy and correlate of protection.

EBioMedicine 2021 Apr 13;66:103310. Epub 2021 Apr 13.

LimmaTech Biologics AG, Schlieren, Switzerland.

Background: Shigellosis is a major cause of moderate to severe diarrhoea and dysentery in children under 5 years of age in low and middle-income countries. The Flexyn2a vaccine conjugates the O-polysaccharide of Shigella flexneri 2a to Pseudomonas aeruginosa exotoxin A. We describe a Phase 2b proof-of-concept challenge study that evaluated safety, immunogenicity, and efficacy of the Flexyn2a vaccine to protect against shigellosis. Read More

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A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: Results from the CONKO-005 trial.

EBioMedicine 2021 Apr 13;66:103327. Epub 2021 Apr 13.

Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, Berlin 13353, Germany; German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

Background: high recurrence rates of up to 75% within 2 years in pancreatic ductal adenocarcinoma (PDAC) patients resected for cure indicate a high medical need for clinical prediction tools and patient specific treatment approaches. Addition of the EGFR inhibitor erlotinib to adjuvant chemotherapy failed to improve outcome but its efficacy in some patients warrants predictors of responsiveness.

Patients And Methods: we analysed tumour samples from 293 R0-resected patients from the randomized, multicentre phase III CONKO-005 trial (gemcitabine ± erlotinib) with targeted sequencing, copy number, and RNA expression analyses. Read More

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Benthic macroinvertebrate community response to environmental changes over seven decades in an urbanized estuary in the northeastern United States.

Mar Environ Res 2021 Apr 6;169:105323. Epub 2021 Apr 6.

US Environmental Protection Agency, Office of Research and Development, Center for Environmental Measurement and Modeling, Atlantic Coastal Environmental Science Division, Narragansett, RI, USA.

Narragansett Bay is representative of New England, USA urbanized estuaries, with colonization in the early 17th century, and development into industrial and transportation centers in the late 18th and early 20th century. Increasing nationwide population and lack of infrastructure maintenance led to environmental degradation, and then eventual improvement after implementation of contaminant control and sewage treatment starting in the 1970s. Benthic macroinvertebrate community structure was expected to respond to these environmental changes. Read More

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MiR-25 and KLF4 relationship has early prognostic significance in the development of cervical cancer.

Pathol Res Pract 2021 Apr 9;222:153435. Epub 2021 Apr 9.

Ankara University, Biotechnology Institute, Ankara, Turkey. Electronic address:

Cervical squamous cell carcinoma (SCC) is one of the common cancer types among women. MicroRNAs (miRNAs) are small non-coding RNAs that play an important role in the formation and development of many cancer types by regulating expression of their targets. While many studies have investigated the relationship between miRNAs and cervical cancer, no robust miRNA biomarkers have been defined yet for diagnosis of cervical lesions. Read More

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5-aminolevulinic acid combined with sodium ferrous citrate ameliorated lupus nephritis in a mouse chronic graft-versus-host disease model.

Int Immunopharmacol 2021 Apr 13;96:107626. Epub 2021 Apr 13.

Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address:

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the abnormal activation of immune cells and hypersecretion of autoantibodies and causes irreversible chronic damage, such as lupus nephritis. Chronic graft-versus-host-disease (cGvHD) in mice induced by the injection of parental mouse lymphocytes into F1 hybrids leads to a disease similar to SLE. 5-aminolevulinic acid (5-ALA) is a key progenitor of heme, and its combination with sodium ferrous citrate (SFC) can up-regulate the heme oxygenase (HO-1) expression, resulting in an anti-inflammatory effect. Read More

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Quantitative determination of creatinine from serum of prostate cancer patients by N-doped porous carbon antimony (Sb/NPC) nanoparticles.

Bioelectrochemistry 2021 Apr 5;140:107815. Epub 2021 Apr 5.

Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. Electronic address:

Creatinine is an indicator of hindrance in urination and renal insufficiency. Creatinine levels are the marker of the late stages of prostate cancer. Early and sensitive detection of creatinine can reduce deaths associated with prostate cancer. Read More

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Patient Characteristics and Outcomes Associated with Decline in Stroke Volumes During the Early COVID-19 Pandemic.

J Stroke Cerebrovasc Dis 2020 Dec 26;30(6):105569. Epub 2020 Dec 26.

Department of Neurointerventional Surgery, Ascension Columbia St. Mary's Hospital, Milwaukee, WI. Electronic address:

Background And Purpose: Delayed evaluation of stroke may contribute to COVID-19 pandemic-related morbidity and mortality. This study evaluated patient characteristics, process measures and outcomes associated with the decline in stroke presentation during the early pandemic.

Methods: Volumes of stroke presentations, intravenous thrombolytic administrations, and mechanical thrombectomies from 52 hospitals from January 1-June 30, 2020 were analyzed with piecewise linear regression and linear spline models. Read More

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December 2020

Clinical features and outcomes of neonatal dengue at the Children's Hospital 1, Ho Chi Minh, Vietnam.

J Clin Virol 2021 Feb 9;138:104758. Epub 2021 Feb 9.

School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan; Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam. Electronic address:

Objectives Neonatal dengue has been reported in the literature with contradictory findings of clinical characteristics and diagnosis; thereby, misdiagnosis of neonatal dengue has been frequently reported. We aim to delve into the epidemiology, clinical features, and outcomes of neonatal dengue, thus avoid misdiagnosis and obtain early intervention. Study design A retrospective study was conducted at Children's Hospital 1, Ho Chi Minh, Vietnam with laboratory-confirmed dengue in neonates by positive viral antigen nonstructural protein one rapid test (NS1) and positive IgM antibody for dengue by MAC-ELISA. Read More

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February 2021

Decoding molecular markers and transcriptional circuitry of naive and primed states of human pluripotency.

Stem Cell Res 2021 Apr 8;53:102334. Epub 2021 Apr 8.

Centre of Bioinformatics, Institute of Interdisciplinary Studies, University of Allahabad, Prayagraj 211002, India. Electronic address:

Pluripotent stem cells (PSCs) have been observed to occur in two distinct states - naive and primed. Both naive and primed state PSCs can give rise to tissues of all the three germ layers in vitro but differ in their potential to generate germline chimera in vivo. Understanding the molecular mechanisms that govern these two states of pluripotency in human can open a plethora of opportunities for studying early embryonic development and in biomedical applications. Read More

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Number line development of Chilean children from preschool to the end of kindergarten.

J Exp Child Psychol 2021 Apr 13;208:105144. Epub 2021 Apr 13.

Department of Psychology, Carleton University, Ottawa, Ontario K1S 5B6, Canada; Department of Cognitive Science, Carleton University, Ottawa, Ontario K1S 5B6, Canada.

Children's performance on number line tasks reflects their developing number system knowledge. Before 5 years of age, most children perform poorly on even the simplest number lines (i.e. Read More

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Associations among response inhibition, motivational beliefs, and task persistence in early elementary school.

J Exp Child Psychol 2021 Apr 13;208:105141. Epub 2021 Apr 13.

School of Education & Information Studies, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Task persistence is an important learning-related behavior associated with academic success. Although persistence has been related to motivational beliefs and cognitive skills, these constructs are typically studied independently, limiting our understanding of relations among them. The current investigation was designed to understand how these concepts are related in early elementary school, a developmental period characterized by high motivational beliefs, growth in cognitive control, and the transition to school. Read More

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Five-month-old infants attribute inferences based on general knowledge to agents.

J Exp Child Psychol 2021 Apr 13;208:105126. Epub 2021 Apr 13.

Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA. Electronic address:

To make sense of others' actions, we generally consider what information is available to them. This information may come from different sources, including perception and inference. Like adults, young infants track what information agents can obtain through perception: If an agent directly observes an event, for example, young infants expect the agent to have information about it. Read More

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D-dimer driven deep vein thrombosis prophylaxis strategy for hospitalized patients with COVID-19.

Thromb Res 2021 Apr 9;201:151-153. Epub 2021 Apr 9.

Section of Cardiovascular Medicine, Yale New Haven Health Bridgeport Hospital, United States of America.

COVID-19 induces a hypercoagulable state with early case reports of death from undetected venous thromboembolism. Various protocols and consensus statements have been proposed to address the optimal prophylaxis strategy for hospitalized patients. We offer our single institution experience with a d-dimer driven prophylaxis model with no deep vein thrombosis identified on discharge lower extremity ultrasounds. Read More

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Modeling patient-related workload in the emergency department using electronic health record data.

Int J Med Inform 2021 Apr 9;150:104451. Epub 2021 Apr 9.

University at Buffalo, United States.

Introduction: Understanding and managing clinician workload is important for clinician (nurses, physicians and advanced practice providers) occupational health as well as patient safety. Efforts have been made to develop strategies for managing clinician workload by improving patient assignment. The goal of the current study is to use electronic health record (EHR) data to predict the amount of work that individual patients contribute to clinician workload (patient-related workload). Read More

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Fatty acid modulation and desaturase gene expression are differentially triggered in grapevine incompatible interaction with biotrophs and necrotrophs.

Plant Physiol Biochem 2021 Apr 6;163:230-238. Epub 2021 Apr 6.

BioISI - Biosystems & Integrative Sciences Institute, Faculdade de Ciências da Universidade de Lisboa, Lisboa, Portugal. Electronic address:

Grapevine (Vitis vinifera L.) is prone to fungal and oomycete diseases. Downy and powdery mildews and grey mold, are caused by Plasmopara viticola, Erisiphe necator and Botrytis cinerea, respectively. Read More

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Involvement of salicylic acid in the response to potassium deficiency revealed by metabolomics.

Plant Physiol Biochem 2021 Apr 6;163:201-204. Epub 2021 Apr 6.

Research School of Biology, ANU College of Science, Australian National University, 2601, Canberra, ACT, Australia; Institut de Recherche en Horticulture et Semences, Université d'Angers, INRAe, 42 rue Georges Morel, 49070, Beaucouzé, France. Electronic address:

Potassium (K) deficiency has consequences not only on cellular ion balance and transmembrane potential but also on metabolism. In fact, several enzymes are K-dependent including enzymes in catabolism, causing an alteration in glycolysis and respiration. In addition, K deficiency is associated with the induction of specific pathways and accumulation of metabolic biomarkers, such as putrescine. Read More

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High-mobility group box 2 protein is essential for the early phase of adipogenesis.

Biochem Biophys Res Commun 2021 Apr 13;557:97-103. Epub 2021 Apr 13.

Department of Endocrinology and Diabetes Mellitus, School of Medicine, Fukuoka University, Fukuoka, Japan; Seiwakai Muta Hospital, Fukuoka, Japan.

Understanding of the mechanism of adipogenesis is essential for the control of obesity, which predisposes toward numerous health problems. High-mobility group box protein 2 (HMGB2) is a non-histone chromosomal protein that facilitates DNA replication, transcription, recombination, and repair. Here, we studied the role of HMGB2 in adipogenic differentiation. Read More

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SPOP suppresses testicular germ cell tumors progression through ubiquitination and degradation of DPPA2.

Biochem Biophys Res Commun 2021 Apr 13;557:55-61. Epub 2021 Apr 13.

The Affiliated Hospital of Medical School, Ningbo University, Ningbo, 315020, China; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China. Electronic address:

Dysregulation of the ubiquitin-proteasome pathway is strongly associated with cancer initiation and progression. Speckle-type POZ(pox virus and zinc finger protein) protein(SPOP) is an adapter protein of CUL3-based E3 ubiquitin ligase complexes. Gene expression profiling from the Cancer Genome Atlas (TCGA) suggests that SPOP is downregulated in testicular germ cell tumors (TGCTs), but the specific contribution of this protein remains to be explored. Read More

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Loss of androgen receptor promotes HCC invasion and metastasis via activating circ-LNPEP/miR-532-3p/RAB9A signal under hypoxia.

Biochem Biophys Res Commun 2021 Apr 13;557:26-32. Epub 2021 Apr 13.

Department of General Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China; International Joint Research Center of Minimally Invasive Endoscopic Technology Equipment and Standards, China. Electronic address:

Development of novel targeted therapies remains the priority in hepatocellular carcinoma (HCC) treatments. Early reports have demonstrated that androgen receptor (AR) plays a suppressive role in HCC progression. However, the underlying mechanisms by which AR attenuates HCC development are still elusive, especially under hypoxic conditions. Read More

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The attentional template in high and low similarity search: Optimal tuning or tuning to relations?

Cognition 2021 Apr 13;212:104732. Epub 2021 Apr 13.

School of Psychology, The University of Queensland, Brisbane, Australia.

The attentional template is often described as the mental representation that drives attentional selection and guidance, for instance, in visual search. Recent research suggests that this template is not a veridical representation of the sought-for target, but instead an altered representation that allows more efficient search. The current paper contrasts two such theories. Read More

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Capitalist theory and socialist practice: The organization of Chinese mathematics in the early 1950s.

Authors:
John Hanzhang Ye

Endeavour 2021 Apr 13;45(1-2):100767. Epub 2021 Apr 13.

Program in History of Science and Technology, University of Minnesota, Minneapolis, Minnesota 55455, United States. Electronic address:

This article explores how the Chinese state organized scientific research in the 1950s, through a case study of mathematics. By examining the organizing process of the Chinese Mathematical Society and the establishment of the Institute of Mathematics of the Chinese Academy of Sciences, the article explains how a number of state agents were selected to lead national level research institutes as a means for guiding scientists in serving the needs of the state. In addition, under state corporatism, all scientists were attached to discipline-specific academic societies, forming a large hierarchy consisting of societies at different levels. Read More

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A predictive framework based on brain volume trajectories enabling early detection of Alzheimer's disease.

Comput Med Imaging Graph 2021 Apr 2;90:101910. Epub 2021 Apr 2.

Data used in the preparation of this article was obtained from the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) funded by the Commonwealth Scientific and Industrial Research Organisation (CSIRO) which was made available at the ADNI database. The AIBL researchers contributed data but did not participate in analysis or writing of this report. AIBL researchers are listed at www.aibl.csiro.au.

We present a framework for constructing predictive models of cognitive decline from longitudinal MRI examinations, based on mixed effects models and machine learning. We apply the framework to detect conversion from cognitively normal (CN) to mild cognitive impairment (MCI) and from MCI to Alzheimer's disease (AD), using a large collection of subjects sourced from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Aging (AIBL). We extract subcortical segmentation and cortical parcellation from corresponding T1-weighted images using FreeSurfer v. Read More

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Speech pathology telepractice intervention during the COVID-19 pandemic for Spanish-speaking children with cleft palate: A systematic review.

Int J Pediatr Otorhinolaryngol 2021 Apr 2;144:110700. Epub 2021 Apr 2.

Speech Therapy Unit, Alfredo Gantz Mann Foundation, Santiago, Chile.

Background: Due to the lockdown and quarantines caused by the COVID-19 pandemic, the need to study and use telepractice for providing speech pathology interventions for children with cleft palate has arisen.

Objective: To carry out a systematic review of the use of telepractice during the COVID-19 pandemic for providing speech pathology interventions for Spanish-speaking children with cleft palate.

Methods: In July and August 2020, the authors searched the electronic databases Medline, LILACS, SciELO, and the Cochrane Library using the following keywords in English (MeSH): Cleft palate combined with Early intervention, Speech therapy, Rehabilitation of speech and language disorders, Speech production measurement, Speech articulation tests and Telemedicine. Read More

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Unconventional endocytic mechanisms.

Curr Opin Cell Biol 2021 Apr 13;71:120-129. Epub 2021 Apr 13.

Institute of Structural and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK; Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London, WC1E 7HX, UK. Electronic address:

Endocytosis mediates the uptake of extracellular proteins, micronutrients and transmembrane cell surface proteins. Importantly, many viruses, toxins and bacteria hijack endocytosis to infect cells. The canonical pathway is clathrin-mediated endocytosis (CME) and is active in all eukaryotic cells to support critical house-keeping functions. Read More

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Long-term epilepsy control, motor function, cognition, sleep and quality of life in children with West syndrome.

Epilepsy Res 2021 Apr 2;173:106629. Epub 2021 Apr 2.

Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India. Electronic address:

Purpose: To assess epilepsy, motor function, cognitive, sleep, and quality of life outcomes and their predictors in a follow-up cohort with West syndrome (WS) at ≥5 years of age.

Methods: Cross-sectional evaluation in a follow-up cohort of WS (aged 5-14 years), between July 2018 and December 2019, was performed at a tertiary-care referral center in Northern India. 164 children were assessed in-person for epilepsy severity, functional status (gross motor and hand function), social quotient, behavioral comorbidities, sleep problems, and quality of life (QoL) using Early Childhood Epilepsy Severity Scale, Gross Motor Function Classification System, Manual Ability Classification System, Vineland Social Maturity Scale, Diagnostic and Statistical Manual of Mental disorders-5 criteria, Children's Sleep Habits Questionnaire, and PedsQL-Epilepsy module respectively. Read More

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Short and long term effects of Nabiximols on balance and walking assessed by 3D-gait analysis in people with Multiple Sclerosis and spasticity.

Mult Scler Relat Disord 2021 Jan 30;51:102805. Epub 2021 Jan 30.

University of Campania "Luigi Vanvitelli", Department of Advanced Medical and Surgical Sciences, 2nd Division of Neurology, Naples, Italy.

Background: Spasticity in people with Multiple Sclerosis (pwMS) is one of the most disabling symptoms on walking ability and balance. Among the systemic antispastic drugs, Nabiximols showed a good tolerability, safety profile and relevant efficacy. A few studies assessed long-term effects of this drug through clinical scales and instrumental tools, but no study investigated short-term effects. Read More

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January 2021