25,045 results match your criteria e-cadherin expression

Inhibition of FSTL3 abates the proliferation and metastasis of renal cell carcinoma via the GSK-3╬▓/╬▓-catenin signaling pathway.

Aging (Albany NY) 2021 Sep 23;13(undefined). Epub 2021 Sep 23.

Department of Urology, Zaozhuang Municipal Hospital, Zaozhuang 277100, Shandong, China.

Renal cell carcinoma (RCC) is a lethal malignancy of the genitourinary system. Follistatin-like 3 (FSTL3), which mediates cell differentiation and growth, acts as a biomarker of tumors and participates in cancer development and progression. Presently, the FSTL3's functions in RCC were investigated. Read More

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September 2021

Upregulated bone morphogenetic protein 5 enhances proliferation and epithelial-mesenchymal transition process in benign prostatic hyperplasia via BMP/Smad signaling pathway.

Prostate 2021 Sep 23. Epub 2021 Sep 23.

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: Benign prostatic hyperplasia (BPH) is one of the most common illnesses in aging men. Recent studies found that bone morphogenetic protein 5 (BMP5) is upregulated in BPH tissues, however, the role of BMP5 in the development of BPH has not been examined. The current study aims to elucidate the potential roles of BMP5 and related signaling pathways in BPH. Read More

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September 2021

Overexpression of Circular RNA circ_0013587 Reverses Erlotinib Resistance in Pancreatic Cancer Cells Through Regulating the miR-1227/E-Cadherin Pathway.

Front Oncol 2021 6;11:754146. Epub 2021 Sep 6.

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Erlotinib, a small-molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, demonstrated therapeutic efficacy against pancreatic cancer. However, acquired resistance to erlotinib in pancreatic cancer is widely observed, and the exact mechanisms have not been fully explored until now. We examined the role of circular RNA circ_0013587 in the acquired resistance to erlotinib in pancreatic cancer cells and explored the underlying mechanisms. Read More

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September 2021

Transgelin Inhibits the Malignant Progression of Esophageal Squamous Cell Carcinomas by Regulating Epithelial-Mesenchymal Transition.

Front Oncol 2021 26;11:709486. Epub 2021 Aug 26.

Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin Institute of Digestive Disease, Tianjin, China.

Objective: This article investigates the role of Transgelin (TAGLN) in the epithelial-mesenchymal transition (EMT) of esophageal squamous cell carcinomas (ESCC) and its possible mechanism of inhibiting the invasion of these cancers.

Methods: Tissue specimens and clinical information of patients with ESCC were collected to analyze the relationship between Transgelin expression level and prognosis of patients with ESCC. Transgelin siRNA was used to knock down Transgelin expression. Read More

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MiR-9-3p regulates the biological functions and drug resistance of gemcitabine-treated breast cancer cells and affects tumor growth through targeting MTDH.

Cell Death Dis 2021 Sep 22;12(10):861. Epub 2021 Sep 22.

Department of Surgery, Women's Hospital School of Medicine Zhejiang University, Hangzhou, Zhejiang, China.

This study explored the role of MTDH in regulating the sensitivity of breast cancer cell lines to gemcitabine (Gem) and the potential miRNAs targeting MTDH. The expression of MTDH in cancer tissues and cells was detected by immunohistochemical staining or qRT-PCR. The target genes for MTDH were predicted by bioinformatics and further confirmed by dual-luciferase reporter assay and qRT-PCR. Read More

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September 2021

AKR1B10 inhibits the proliferation and migration of gastric cancer via regulating epithelial-mesenchymal transition.

Aging (Albany NY) 2021 Sep 22;13(undefined). Epub 2021 Sep 22.

Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China.

Gastric cancer (GC) is a common malignancy around the world with a poor prognosis. Aldo-keto reductase family 1 member B10 (AKR1B10) is indispensable to cancer development and progression, which has served as a diagnostic biomarker for tumors. In our study, we demonstrated that the expression of AKR1B10 in GC tissues was significantly lower compared with normal gastric tissues. Read More

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September 2021

Type 2 diabetes mellitus promotes the proliferation, metastasis and suppresses the apoptosis in oral squamous cell carcinoma.

J Oral Pathol Med 2021 Sep 22. Epub 2021 Sep 22.

Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya hospital of Central South University, Changsha, Hunan, 410008, China.

Background: Our previous study revealed that patients with oral squamous cell carcinoma and concomitant type 2 diabetes mellitus presented a lower 5-year survival rate. Hyperglycemia has been increasingly recognized as a risk factor for more advanced disease and poorer prognosis in patients with oral squamous cell carcinoma. However, its role remains unclear. Read More

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September 2021

Multiplexed DNA-Directed Patterning of Antibodies for Applications in Cell Subpopulation Analysis.

ACS Appl Mater Interfaces 2021 Sep 21. Epub 2021 Sep 21.

California Institute of Quantitative Biosciences, University of California, Berkeley, 174 Stanley Hall, Berkeley, California 94720, United States.

Antibodies provide the functional biospecificity that has enabled the development of sensors, diagnostic tools, and assays in both laboratory and clinical settings. However, as multimarker screening becomes increasingly necessary due to the heterogeneity and complexity of human pathology, new methods must be developed that are capable of coordinating the precise assembly of multiple, distinct antibodies. To address this technological challenge, we engineered a bottom-up, high-throughput method in which DNA patterns, comprising unique 20-base pair oligonucleotides, are patterned onto a substrate using photolithography. Read More

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September 2021

Endoglin promotes cell migration and invasion in endometriosis by regulating EMT.

Ginekol Pol 2021 Sep 20. Epub 2021 Sep 20.

People's Hospital of AnJi, Dipu Town, Anji County, Huzhou, China.

Objectives: This study aims to investigate the expression and role of Endoglin (ENG) in endometriosis (EM).

Material And Methods: In this study, quantitative real-time polymerase chain reaction, western blot and immunohistochemistry were used to examine the expression of ENG in tissues. Cellular experiments were performed to evaluate the effect of ENG on cellular biological function. Read More

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September 2021

Long non-coding RNA MALAT1 regulates cell proliferation, invasion and apoptosis by modulating the Wnt signaling pathway in squamous cell carcinoma.

Am J Transl Res 2021 15;13(8):9233-9240. Epub 2021 Aug 15.

Department of Dermatology, Shanghai Baoshan Hospital of Integerated Traditional Chinese and Western Medicine Shanghai 201999, China.

Objective: To explore the mechanisms by which long non-coding RNA, (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) regulates cell proliferation, invasion and apoptosis through signaling axes in cutaneous squamous cell carcinoma (CSCC) cells.

Methods: A total of 60 CSCC samples and 15 normal skin tissue samples were collected. qRT-PCR was used to determine MALAT1 expression. Read More

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The regulatory relationship and function of LncRNA FAM225A-miR-206-ADAM12 in gastric cancer.

Am J Transl Res 2021 15;13(8):8632-8652. Epub 2021 Aug 15.

Cancer Center, Taikang Xianlin Drum Tower Hospital, Nanjing University School of Medicine Nanjing, Jiangsu, China.

Objective: To investigate the role and functions of FAM225A in gastric cancer.

Methods: The expressions of FAM225A, miR-206, ADAM12 and epithelial-mesenchymal transition (EMT)-related genes were detected by quantitative real-time PCR and Western blot. Functional experiments including cell counting kit-8, colony formation, wound-healing, and Transwell assays were conducted to analyze the biological characteristics of gastric cancer cells in different groups. Read More

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Dihydromyricetin Inhibits Tumor Growth and Epithelial-Mesenchymal Transition through regulating miR-455-3p in Cholangiocarcinoma.

J Cancer 2021 22;12(20):6058-6070. Epub 2021 Aug 22.

Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China, 410011.

Cholangiocarcinoma (CCA) leads to poor prognosis due to high aggressiveness and common chemoresistance. Dihydromyricetin (DMY), the main bioactive compound isolated from Ampelopsis grossedentata, exhibits broad anti-tumor effects. This study aimed to investigate the inhibitory effect of DMY on CCA tumor growth and epithelial-mesenchymal transition (EMT) and its underlying mechanism in CCA. Read More

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Bevacizumab and anexelekto inhibitor, TP-0903 inhibits TGF-╬▓1-induced epithelial-mesenchymal transition of colon cancer cells.

Anticancer Drugs 2021 Sep 17. Epub 2021 Sep 17.

Gachon Medical Research Institute, Gil Medical Center, Gachon University Department of Surgery and Peritoneal Surface Malignancy Clinic, Gil Medical Center, Colloege of Medicine, Gachon University, Incheon, Korea.

The incidence of colorectal cancer (CRC) is reported to be increasing nowadays, with a large proportion of newly diagnosed CRC patients being affected by metastasis. Epithelial-mesenchymal transition (EMT) is an important event in the development of metastasis of CRC. In this study, we investigated whether the anticancer drug bevacizumab and anexelekto inhibitor, TP-0903, regulate EMT of colon cancer cells induced by transforming growth factor-beta 1 (TGF-╬▓1). Read More

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September 2021

Role of SIX1, EYA2, and E-cadherin in ovarian carcinoma. Evidence on epithelial-mesenchymal transition from an immunohistochemical study.

Ann Diagn Pathol 2021 Sep 8;55:151815. Epub 2021 Sep 8.

Department of Pathology, Faculty of Medicine, Menoufia University, Egypt.

This study aims to investigate the expression of SIX1, EYA2, and E-cadherin in ovarian cancer (OC). It was conducted on 97 cases of surface epithelial tumors (SEOTs). Immunohistochemistry (IHC) staining for the three markers was applied to archival paraffin-embedded sections. Read More

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September 2021

MUC5AC serves as the nexus for ╬▓-catenin/c-Myc interplay to promote glutamine dependency during pancreatic cancer chemoresistance.

Gastroenterology 2021 Sep 14. Epub 2021 Sep 14.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center; Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.. Electronic address:

Background And Aims: A major clinical challenge for pancreatic cancer (PC) patients is metabolic adaptation. Neoplastic cells harboring molecular perturbations suffice for their increased anabolic demand and nucleotide biosynthesis to acquire chemoresistance. The mucin 5AC expressed de novo in malignant pancreas promotes cancer cell stemness and is significantly associated with poor patient survival. Read More

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September 2021

Altered expression of junctional proteins as a potential biomarker in oral precancerous and cancerous patients.

Tissue Barriers 2021 Sep 17. Epub 2021 Sep 17.

Department of E.N.T., Silchar Medical College and Hospital, Silchar, Ghungoor, Assam, India.

Due to a lower survival rate in patients with advanced clinical stages of oral cancer, discovering a biomarker that could diagnose and predict disease progression is vital. Cell-cell junctional proteins play a crucial role in the maintenance of tissue architecture but are often deregulated in different cancer. The present study investigates the expression of cell-cell junctional proteins : e-cadherin (E-cad) and zonula occludens-1 (ZO-1) in oral precancerous (OED) and cancerous (OSCC) patients to monitor if they can serve as practicable molecular markers. Read More

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September 2021

[Multi-target kinase inhibitor dasatinib inhibits cell proliferation, dissociation and migration via up-regulating E-cadherin expression in SK-Hep-1 human hepatocellular cancer cells].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Sep;37(9):801-807

Department of Biochemistry and Molecular Biology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, China. *Corresponding authors, E-mail:

Objective To investigate the effects of dasatinib (a multi-target kinase inhibitor) on the proliferation, adhesion and migration ability of SK-Hep-1 human hepatocellular cancer cells and the underlying mechanism. Methods SK-Hep-1, Bel-7402, SNU-423, SNU-387 and Huh-7 hepatocellular cancer cells were treated with dasatinib. Then MTT assay was used to detect the effect of dasatinib on the survival and proliferation of cancer cells, and the sensitive cells were obtained. Read More

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September 2021

TPM3 mediates epithelial-mesenchymal transition in esophageal cancer via MMP2/MMP9.

Ann Transl Med 2021 Aug;9(16):1338

Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.

Background: Esophageal cancer (EC) is a malignant tumor with high mortality. Correlations have been found between the expression level of tropomyosin 3 (TPM3) and the depth of tumor invasion, lymph node metastasis, and the 5-year survival rate. However, the specific mechanisms underlying EC remain unclear. Read More

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Triptolide reverses epithelial-mesenchymal transition in glioma cells via inducing autophagy.

Ann Transl Med 2021 Aug;9(16):1304

Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.

Background: To observe the effects of triptolide (TP) on the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of glioma cells, and to explore the possible mechanisms of phenotypic changes in EMT.

Methods: The U87 and U251 glioma cell lines were treated TP. The Cell Counting Kit-8 (CCK-8) method was used to detect the half-maximal inhibitory concentration (IC) of TP in these two cell lines and the inhibition of cell proliferation at the IC concentration. Read More

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Downregulation of LINC00115 inhibits the proliferation and invasion of lung cancer cells and .

Ann Transl Med 2021 Aug;9(15):1256

Department of Medical Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Background: Lung cancer is a common malignant tumor in clinical practice. Its morbidity and mortality rank first among malignant tumors. However, the pathogenesis of lung cancer has not been fully clarified. Read More

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High BTBD7 expression positive is correlated with SLUG-predicted poor prognosis in hormone receptor-negative breast cancer.

Ann Transl Med 2021 Aug;9(15):1252

Department of Rheumatology, The First Affiliated Hospital, Shantou University Medical College, Shantou, China.

Background: Hormone receptor-negative breast cancer (HRNBC), which includes triple-negative breast cancer (TNBC) and human epidermal growth factor receptor 2 (HER-2) overexpressing breast cancer, is prone to metastasis and has a poor prognosis. BTB/POZ domain-containing protein 7 (Btbd7) is thought to regulate SLUG and the epithelial-mesenchymal transition (EMT) process. However, the role of Btbd7 in HRNBC is unclear. Read More

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MD2 blockage prevents the migration and invasion of hepatocellular carcinoma cells via inhibition of the EGFR signaling pathway.

J Gastrointest Oncol 2021 Aug;12(4):1873-1883

Department of Pharmacy, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.

Background: The toll-like receptor (TLR) is an emerging signaling pathway in tumor invasion and metastasis. The activation of TLRs requires specific accessory proteins, such as the small secreted glycoprotein myeloid differentiation protein 2 (MD2), which contributes to ligand responsiveness. However, the role of MD2 in tumorigenesis and metastasis has rarely been reported. Read More

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XPA serves as an autophagy and apoptosis inducer by suppressing hepatocellular carcinoma in a PI3K/Akt/mTOR dependent manner.

J Gastrointest Oncol 2021 Aug;12(4):1797-1810

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: To explore the potential biological function of XPA (Xeroderma pigmentosum group A) in hepatic neoplasms and the underlying molecular mechanisms.

Methods: Liver cells were used as experimental models to establish HCC (hepatocellular carcinoma) in vitro. Protein extractions were subjected to Western blotting to detect the proteins expression. Read More

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Slug and CD133 expression are associated with peritoneal carcinomatosis and survival in gastric cancer.

J Gastrointest Oncol 2021 Aug;12(4):1326-1337

Division of Medical Oncology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Background: Slug is an activating transcription factor involved in epithelial-mesenchymal transition, and CD133 is a cancer stem cell marker found in various cancers, including gastric cancer (GC). We investigated the relationship between Slug and CD133 and the occurrence of peritoneal carcinomatosis and survival in patients with GC.

Methods: This retrospective study included 196 patients with stage 2 or 3 GC who underwent curative surgery with D2 lymph node dissection and adjuvant chemotherapy between 2001 and 2009. Read More

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lncRNA FEZF1-AS1 regulates biological behaviors of cervical cancer by targeting miRNA-1254.

Food Sci Nutr 2021 Sep 14;9(9):4722-4737. Epub 2021 Jul 14.

Department of gynaecology and obstetrics Chongqing General Hospital University of Chinese Academy of Sciences Chongqing China.

Aim: The purpose of this research was to evaluate lncRNA FEZF1-AS1 in cervical cancer development and clinical significance.

Materials And Methods: Collecting cervical cancer tissues, measuring FEZF1-AS1 expression, and analysis correlation between FEZF1-AS1 and prognosis. In cell vitro study, using MTT assay to measure cell proliferation, evaluating cell apoptosis by flow cytometry, measuring cell invasion and migration by Transwell and wound healing assay; lncRNA FEZF1-AS1 and miR-1254 gene expressions were evaluated by RT-qPCR assay; relative protein (Smurf1, E-cadherin, Vimentin, N-cadherin, AKT, p-AKT, c-Myc, and ZEB1) expressions were measured by Western blot assay. Read More

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September 2021

Low Abundance Supports Early Pregnancy Development - An Study.

Front Immunol 2021 31;12:698045. Epub 2021 Aug 31.

Department of Obstetrics and Gynecology, University of Greifswald, Greifswald, Germany.

Pregnancy success depends greatly on a balanced immune homeostasis. The detection of bacterial components in the upper reproductive tract in non-pregnant and pregnant women raised questions on its possible beneficial role in reproductive health. The local conditions that allow the presence of bacteria to harmonize with the establishment of pregnancy are still unknown. Read More

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TGF-╬▓-MTA1-SMAD7-SMAD3-SOX4-EZH2 Signaling Axis Promotes Viability, Migration, Invasion and EMT of Hepatocellular Carcinoma Cells.

Cancer Manag Res 2021 10;13:7087-7099. Epub 2021 Sep 10.

Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan City, Hubei Province, People's Republic of China.

Introduction: Enhancer of zeste homolog 2 (EZH2) is implicated in hepatocellular carcinoma (HCC), but whether transforming growth factor-╬▓ (TGF-╬▓)-metastasis associated 1 (MTA1)-SMAD7-SMAD3-SRY-Box Transcription Factor 4 (SOX4)-EZH2 signaling axis, in which EZH2 participates, is also involved in HCC remained unknown.

Methods: Data on EZH2 expression in liver hepatocellular carcinoma (LIHC) and its relation with prognosis of HCC patients were predicted and analyzed using online databases. Following transfection with or without TGF-╬▓1, HCC cell viability, migration and invasion were determined with MTT, Scratch and Transwell assays. Read More

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September 2021

Protective effects of sunscreen (50+) and octatrienoic acid 0.1% in actinic keratosis and UV damages.

J Investig Med 2021 Sep 16. Epub 2021 Sep 16.

Human Microbiome Advanced Project, Milan, Italy.

Actinic keratosis is a form of dysplastic epidermal lesion resulting from chronic and excessive UV exposure with a certain risk of becoming cancerous. Current guidelines advocated the use of sunscreens to prevent photodamage. An efficient photoprotection must involve both primary protective factors such as UV filters and secondary factors (eg, antioxidants) able to disrupt the photochemical and genetic cascade triggered by UVs. Read More

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September 2021

MicroRNA-214 promotes alveolarization in neonatal rat models of bronchopulmonary dysplasia via the PlGF-dependent STAT3 pathway.

Mol Med 2021 09 16;27(1):109. Epub 2021 Sep 16.

Department of Neonatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, No. 261, Huansha Road, Hangzhou, 310000, Zhejiang Province, People's Republic of China.

Background: Recently, the role of several microRNAs (miRNAs or miRs) in pulmonary diseases has been described. The molecular mechanisms by which miR-214 is possibly implicated in bronchopulmonary dysplasia (BPD) have not yet been addressed. Hence, this study aimed to investigate a putative role of miR-214 in alveolarization among preterm neonates with BPD. Read More

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September 2021