6,166 results match your criteria e‑cadherin expression

PLAN-M; Mycobacteriophage Endolysins Fused to Biodegradable Nanobeads Mitigate Mycobacterial Growth in Liquid and on Surfaces.

Front Microbiol 2021 26;12:562748. Epub 2021 Apr 26.

Massey Phage Whānau, School of Natural and Computational Sciences, Massey University, Auckland, New Zealand.

The Mycobacteria are a genus of Actinobacteria that include human pathogens such as (TB). Active TB disease can spread by airborne transmission to healthcare workers and to their community. The HHMI SEA-PHAGES program has contributed to discovering bacteriophages that are able to infect MC 155, a close relative of . Read More

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The detrimental invasiveness of glioma cells controlled by gadolinium chelate-coated gold nanoparticles.

Nanoscale 2021 May 12. Epub 2021 May 12.

Université de Lorraine, CNRS, CRAN, F-54000 Nancy, France.

Glioblastoma are characterized by an invasive phenotype, which is thought to be responsible for recurrences and the short overall survival of patients. In the last decade, the promising potential of ultrasmall gadolinium chelate-coated gold nanoparticles (namely Au@DTDTPA(Gd)) was evidenced for image-guided radiotherapy in brain tumors. Considering the threat posed by invasiveness properties of glioma cells, we were interested in further investigating the biological effects of Au@DTDTPA(Gd) by examining their impact on GBM cell migration and invasion. Read More

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Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation.

Proc Natl Acad Sci U S A 2021 May;118(20)

Mucosal Inflammation Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045;

Metabolic changes associated with tissue inflammation result in significant extracellular acidosis (EA). Within mucosal tissues, intestinal epithelial cells (IEC) have evolved adaptive strategies to cope with EA through the up-regulation of SLC26A3 to promote pH homeostasis. We hypothesized that EA significantly alters IEC gene expression as an adaptive mechanism to counteract inflammation. Read More

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Trastuzumab deruxtecan (DS-8201) in patients with HER2-expressing metastatic colorectal cancer (DESTINY-CRC01): a multicentre, open-label, phase 2 trial.

Lancet Oncol 2021 May 4. Epub 2021 May 4.

National Cancer Center Hospital East, Kashiwa, Japan. Electronic address:

Background: HER2 amplification has been identified in 2-3% of patients with colorectal cancer, although there are currently no approved HER2-targeted therapies for colorectal cancer. We aimed to study the antitumour activity and safety of trastuzumab deruxtecan (an antibody-drug conjugate of humanised anti-HER2 antibody with topoisomerase I inhibitor payloads) in patients with HER2-expressing metastatic colorectal cancer.

Methods: DESTINY-CRC01 is an open-label, phase 2 study that recruited patients from 25 clinics and hospitals in Italy, Japan, Spain, the UK, and the USA. Read More

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Arousing Effects of Electroacupuncture on the "Shuigou Point" in Rats with Disorder of Consciousness after Traumatic Brain Injury.

Evid Based Complement Alternat Med 2021 19;2021:6611461. Epub 2021 Apr 19.

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

Orexin is an important neuropeptide that stimulates cortical activation and arousal and is involved in the regulation of wakefulness and arousal. Our previous meta-analysis showed that acupuncture fared well in the treatment of TBI-induced DOC in which "shuigou (DU 26)" was the most important and frequent point targeted. In the present study, we investigated whether electroacupuncture (EA) promotes TBI-induced unconsciousness wakefulness via orexin pathway. Read More

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Ellagic acid induces beige remodeling of white adipose tissue by controlling mitochondrial dynamics and SIRT3.

FASEB J 2021 Jun;35(6):e21548

Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea.

To determine whether ellagic acid (EA) induces the "beige remodeling" of white adipose tissue (WAT), we treated cold-exposed mice and mouse stromal vascular fraction (SVF) cells with EA, a phytochemical abundant in fruits and vegetables, in particular berries. We then investigated the mechanism of EA in beige remodeling with a particular focus on DRP1-mediated mitochondrial fission and SIRT3. EA induced the trans-differentiation of white adipocytes to beige adipocytes by promoting the expression of UCP1 and other brown and beige adipocytes/fat factors (PRDM16, UCP1, PGC1α, CD137, and TBX1) and mitochondrial dynamics-related factors (SIRT3, NRF1, CPT1β, DRP1, and FIS1) in 3T3-L1/SVF cells, and these were confirmed in the inguinal WAT of a cold-exposed mouse model. Read More

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Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis.

Mol Med Rep 2021 Jul 6;24(1). Epub 2021 May 6.

Department of Clinical Medicine, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China.

The acupuncture penetrating line of Baihui (GV20) to Qubin (GB7) spans the parietal, frontal and temporal lobes. The present study aimed to elucidate the mechanism by which electroacupuncture (EA) at GV20‑GB7 regulates mitophagy in intracerebral hemorrhage (ICH) and whether it serves a neuroprotective role. A whole blood‑induced ICH model was used. Read More

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Cadmium induces plasminogen activator inhibitor-1 via Smad2/3 signaling pathway in human endothelial EA.hy926 cells.

J Toxicol Sci 2021 ;46(5):249-253

Faculty of Pharmaceutical Sciences, Toho University.

Modulation of the blood coagulation fibrinolytic system is an essential function of vascular endothelial cells. Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) are major fibrinolytic regulatory proteins synthesized by vascular endothelial cells; fibrinolytic activity is dependent on the balance between these proteins. Previously, we have reported that cadmium, an initiator of ischemic heart disease, induces PAI-1 expression and suppresses fibrinolytic activity in cultured human vascular endothelial cells. Read More

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January 2021

Integrated microRNA and mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Ebstein's Anomaly.

Cells 2021 Apr 30;10(5). Epub 2021 Apr 30.

Department of Pediatric Cardiology, Saarland University Medical Center, 66421 Homburg/Saar, Germany.

Little is known about abundance level changes of circulating microRNAs (miRNAs) and messenger RNAs (mRNA) in patients with Ebstein's anomaly (EA). Here, we performed an integrated analysis to identify the differentially abundant miRNAs and mRNA targets and to identify the potential therapeutic targets that might be involved in the mechanisms underlying EA. A large panel of human miRNA and mRNA microarrays were conducted to determine the genome-wide expression profiles in the blood of 16 EA patients and 16 age and gender-matched healthy control volunteers (HVs). Read More

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Electroacupuncture Improves Pregnancy Outcomes in Rats with Thin Endometrium by Promoting the Expression of Pinopode-Related Molecules.

Biomed Res Int 2021 15;2021:6658321. Epub 2021 Apr 15.

Acupuncture and Tuina College, Nanjing University of Traditional Chinese Medicine, Nanjing 210023, China.

A thin endometrium affects the success of assisted reproduction due to low endometrial receptivity. Acupuncture improves endometrial receptivity and promotes the formation of pinopodes, the ultrastructure marker implantation window. However, the specific underlying mechanisms remain unclear. Read More

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Targeting the Urotensin II/UT G Protein-Coupled Receptor to Counteract Angiogenesis and Mesenchymal Hypoxia/Necrosis in Glioblastoma.

Front Cell Dev Biol 2021 14;9:652544. Epub 2021 Apr 14.

UNIROUEN, INSERM U1239, DC2N, Institute for Research and Innovation in Biomedicine (IRIB), Normandie Rouen Université, Rouen, France.

Glioblastomas (GBMs) are the most common primary brain tumors characterized by strong invasiveness and angiogenesis. GBM cells and microenvironment secrete angiogenic factors and also express chemoattractant G protein-coupled receptors (GPCRs) to their advantage. We investigated the role of the vasoactive peptide urotensin II (UII) and its receptor UT on GBM angiogenesis and tested potential ligand/therapeutic options based on this system. Read More

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[TGF-β1/ERK/CTGF pathway involved in effect of acupuncture on exercise-induced skeletal muscle fibrosis].

Zhen Ci Yan Jiu 2021 Apr;46(4):306-11

School of Sports Human Science, Beijing Sport University, Beijing 100084, China.

Objective: To observe the changes of the skeletal muscle fibrosis and changes of transforming growth factor-β1(TGF-β1)/ extracellular signal-regulated kinase (ERK) / connective tissue growth factor (CTGF)pathway in rats after long-term eccentric exercise and acupuncture intervention, so as to explore the mechanism of acupuncture in regulating exercise-induced skeletal muscle fibrosis.

Methods: A total of 30 male SD rats were randomly divided into normal control, exercise and acupuncture group, with 10 rats in each group. The rat model of skeletal muscle fibrosis was established by eccentric exercise for 3 weeks. Read More

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[Cathepsin-B involved in effect of electroacupuncture by inhibiting the activation of NLRP3 inflammasome in rats with acute gouty arthritis].

Zhen Ci Yan Jiu 2021 Apr;46(4):295-300

College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016,China.

Objective: To observe the effect of electroacupuncture (EA) on Cathepsin-B in the synovium of the knee joint of acute gouty arthritis(AGA) rats, so as to explore the mechanism of EA in the treatment of AGA.

Methods: A total of 60 male Wistar rats were randomly divided into normal control,model, medication and EA groups, with 15 rats in each group. Rat model of AGA was established by injection of 0. Read More

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[Involvement of Pirt /TRPV1 signaling in acupuncture-induced reduction of visceral hypersensitivity in diarrhea-predominant irritable bowel syndrome rats].

Zhen Ci Yan Jiu 2021 Apr;46(4):278-83

School of Acupuncture-moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

Objective: To observe the effect of electroacupuncture (EA) on the expression of Pirt (a regulator of TRPV1) in the dorsal root ganglia (DRG) and transient receptor potential vanilloid 1 (TRPV1, a molecular sensor of noxious heat and capsaicin) in the colonic mucosa in rats suffering from diarrhea-predominant irritable bowel syndrome (IBS-D), so as to explore its mechanisms underlying alleviation of visceral hypersensitivity of IBS-D.

Methods: Forty SD rats (half male and half female) were randomly assigned to control, model, EA, and medication groups by lottery, with 10 rats in each group. The IBS-D model was established by chronic unpredictable mild stress (CUMS) and gavage of senna soaking fluid. Read More

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[Intervention mechanism of moxa-cone moxibustion at Shu- and Mu-acupoints on the expression of RORγt/Foxp3 in asthma mice: an analysis based on PI3K signaling pathway].

Zhen Ci Yan Jiu 2021 Apr;46(4):272-7

College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China.

Objective: To explore the effect of moxa-cone moxibustion at "Feishu" (BL13) and "Zhongfu" (LU1) on the contents of related inflammatory factors in serum and bronchoalveolar lavage fluid (BALF), and the expression of phosphatidy-linositol-3-kinase (PI3K), retinoic acid related orphan receptor γt (RORγt) and fork/wing helix transcription factor 3 (Foxp3) in lung tissue in asthma mice.

Methods: Sixty male Balb/c mice were divided into normal, model, LY294002 (an inhibitor of PI3K, LY), electroacupuncture (EA) and moxa-cone moxibustion (moxibustion) groups (=12 in each group). The asthma model was established by intraperitoneal injection of ovalbumin sensitization. Read More

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[Effect of electroacupuncture on the expression of autophagy related protein in lung tissue of rats with chronic obstructive pulmonary disease].

Zhen Ci Yan Jiu 2021 Apr;46(4):266-71

Department of Physiology, College of Integrated Traditional Chinese and Western Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei 230038, China; Institute of Acupuncture and Meridian, College of Acupuncture-moxibustion and Massage, Ministry of Education, Anhui University of Chinese Medicine, Hefei 230038, China.

Objective: To observe the effect of electroacupuncture (EA) at "Zusanli" (ST36) and "Feishu" (BL13) on the expression of autophagy related proteins in the lung tissue of rats with chronic obstructive pulmonary disease (COPD), so as to explore the mechanism of EA underlying improvement of COPD.

Methods: Thirty male SD rats were randomly divided into normal, model and EA groups (=10 in each group). The COPD model was established by intratracheal infusion of Lipopolysaccharide (LPS, 1 mg/kg) and exposure in cigarette smoke. Read More

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[Influence of electroacupuncture on locomotor function and expression of spinal HMGB1 and TLR4 in mice with spinal cord injury].

Zhen Ci Yan Jiu 2021 Apr;46(4):259-65

College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.

Objective: To observe the effect of electroacupuncture(EA)on locomotor activity and the expression of high-mobility group box-1(HMGB1) and Toll-like receptor 4(TLR4) in mice with spinal cord injury(SCI), so as to explore its mechanisms underlying improvement of SCI at the acute stage.

Methods: Forty-eight female C57BL/6 mice were equally randomized into 3 groups: sham operation, model and EA. The SCI model was established by clamping the spinal cord with a serrefine after laminectomy at the 1st lumbar vertebra(L1). Read More

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Ellagic Acid Resensitizes Gemcitabine-Resistant Bladder Cancer Cells by Inhibiting Epithelial-Mesenchymal Transition and Gemcitabine Transporters.

Cancers (Basel) 2021 Apr 22;13(9). Epub 2021 Apr 22.

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan.

Gemcitabine (GCB) resistance is a major issue in bladder cancer chemoresistance, but its underlying mechanism has not been determined. Epithelial-mesenchymal transition (EMT) has been shown to be comprehensively involved in GCB resistance in several other cancer types, but the direct connection between EMT and GCB remains unclear. This study was designed to elucidate the mechanism of EMT-related GCB resistance in bladder cancer and identify a potential phytochemical to modulate drug sensitivity. Read More

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Metabolic, Organoleptic and Transcriptomic Impact of Genes Involved in the Biosynthesis of Linear and Substituted Esters.

Int J Mol Sci 2021 Apr 14;22(8). Epub 2021 Apr 14.

University Bordeaux, ISVV, Unité de Recherche Œnologie EA 4577, USC 1366 INRA, Bordeaux INP, F-33140 Villenave d'Ornon, France.

Esters constitute a broad family of volatile compounds impacting the organoleptic properties of many beverages, including wine and beer. They can be classified according to their chemical structure. Higher alcohol acetates differ from fatty acid ethyl esters, whereas a third group, substituted ethyl esters, contributes to the fruitiness of red wines. Read More

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Exploring the Diversity of Fungal DyPs in Mangrove Soils to Produce and Characterize Novel Biocatalysts.

J Fungi (Basel) 2021 Apr 21;7(5). Epub 2021 Apr 21.

INRAE, UMR1163, Biodiversité et Biotechnologie Fongiques, Aix-Marseille Université, 13288 Marseille, France.

The functional diversity of the New Caledonian mangrove sediments was examined, observing the distribution of fungal dye-decolorizing peroxidases (DyPs), together with the complete biochemical characterization of the main DyP. Using a functional metabarcoding approach, the diversity of expressed genes encoding fungal DyPs was investigated in surface and deeper sediments, collected beneath either or trees, during either the wet or the dry seasons. The highest DyP diversity was observed in surface sediments beneath the area during the wet season, and one particular operational functional unit (OFU1) was detected as the most abundant DyP isoform. Read More

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Carrot Supplementation Improves Blood Pressure and Reduces Aortic Root Lesions in an Atherosclerosis-Prone Genetic Mouse Model.

Nutrients 2021 Apr 2;13(4). Epub 2021 Apr 2.

UMR 1280 Physiopathologie des Adaptations Nutritionnelles (PhAN), INRAE, Université de Nantes, 44 093 Nantes, France.

Epidemiological studies have shown that carrot consumption may be associated with a lower risk of developing several metabolic dysfunctions. Our group previously determined that the Bolero (Bo) carrot variety exhibited vascular and hepatic tropism using cellular models of cardiometabolic diseases. The present study evaluated the potential metabolic and cardiovascular protective effect of Bo, grown under two conditions (standard and biotic stress conditions (BoBS)), in apolipoprotein E-knockout (ApoE) mice fed with high fat diet (HFD). Read More

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Nitric oxide donor sodium nitroprusside-induced transcriptional changes and hypocrellin biosynthesis of Shiraia sp. S9.

Microb Cell Fact 2021 Apr 28;20(1):92. Epub 2021 Apr 28.

College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.

Background: Nitric oxide (NO) is a ubiquitous signaling mediator in various physiological processes. However, there are less reports concerning the effects of NO on fungal secondary metabolites. Hypocrellins are effective anticancer photodynamic therapy (PDT) agents from fungal perylenequinone pigments of Shiraia. Read More

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Emergence of immunosuppressive LOX-1+ PMN-MDSC in septic shock and severe COVID-19 patients with acute respiratory distress syndrome.

J Leukoc Biol 2021 Apr 28. Epub 2021 Apr 28.

Hospices Civils de Lyon, Edouard Herriot Hospital, Immunology Laboratory, Lyon, France.

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells with immunosuppressive properties. In cancer patients, the expression of lectin-type oxidized LDL receptor 1 (LOX-1) on granulocytic MDSC identifies a subset of MDSC that retains the most potent immunosuppressive properties. The main objective of the present work was to explore the presence of LOX-1+ MDSC in bacterial and viral sepsis. Read More

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Ellagic Acid Prevents Ca Dysregulation and Improves Functional Abnormalities of Ventricular Myocytes via Attenuation of Oxidative Stress in Pathological Cardiac Hypertrophy.

Cardiovasc Toxicol 2021 Apr 28. Epub 2021 Apr 28.

Department of Biophysics, Akdeniz University Faculty of Medicine, Antalya, Turkey.

The aim of this study was to investigate whether ellagic acid (EA) treatment can prevent changes in contractile function and Ca regulation of cardiomyocytes in pathologic cardiac hypertrophy. Groups were assigned as Con group; an ISO group in which the rats received isoproterenol alone (5 mg/kg/day); and an ISO + EA group in which the rats received isoproterenol and EA (20 mg/kg/day) for 4 weeks. Subsequently, fractional shortening, intracellular Ca signals, and L-type Ca currents of isolated ventricular myocytes were recorded. Read More

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Genome-wide association study of neck circumference identifies sex-specific loci independent of generalized adiposity.

Int J Obes (Lond) 2021 Apr 27. Epub 2021 Apr 27.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Background/objectives: Neck circumference, an index of upper airway fat, has been suggested to be an important measure of body-fat distribution with unique associations with health outcomes such as obstructive sleep apnea and metabolic disease. This study aims to study the genetic bases of neck circumference.

Methods: We conducted a multi-ethnic genome-wide association study of neck circumference, adjusted and unadjusted for BMI, in up to 15,090 European Ancestry (EA) and African American (AA) individuals. Read More

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Ethanol extract of reduces atherosclerosis risk by enhancing antioxidant capacity and reducing adhesion molecule levels.

Pharm Biol 2021 Dec;59(1):504-512

Department of Food and Nutrition, Providence University, Taichung, Taiwan.

Context: (Roxb. and Willd.) DC (Asteraceae) leaf is a common vegetable. Read More

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December 2021

Ellagic acid protects against diabetic cardiomyopathy in rats by stimulating cardiac silent information regulator 1 signaling.

J Physiol Pharmacol 2020 Dec 22;71(6). Epub 2021 Apr 22.

Department of Food Science and Nutrition, College of Food and Agricultural Science, King Saud University, Riyadh, Saudi Arabia.

This study investigated the protective effect of ellagic acid (EA) against diabetic cardiomyopathy (DC) in streptozotocin (STZ)-treated rats and examined if the mechanism of protection involves modulating silent information regulator 1 (SIRT1). Adult male rats were divided into 5 groups (n = 12/each) as control, control + EA, diabetes mellitus (DM), STZ + EA, and STZ + EA + EX-527 (a SIRT1 inhibitor). With a hypoglycemic and insulin-releasing effect, EA preserved cardiomyocyte structure and suppressed the increase in heart weights and collagen deposition in the left ventricle (LV) of DM rats. Read More

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December 2020

Ameliorative role of ellagic acid against acute liver steatosis in adult zebrafish experimental model.

Comp Biochem Physiol C Toxicol Pharmacol 2021 Apr 24;247:109061. Epub 2021 Apr 24.

Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur Campus, Chennai 603 203, Tamil Nadu, India. Electronic address:

Non-alcoholic fatty liver disease (NAFLD), also known as hepatic steatosis, is highly prevalent in developed countries despite advancements in clinical modalities. Therefore, there is a need for identifying the bioactive molecular entity (BME) that can therapeutically intervene with liver steatosis progression. In this study, we investigated the efficacy of one such BME - ellagic acid (EA) to ascertain its molecular therapeutic potential against iodoacetamide (IAA) mediated liver steatosis in an adult zebrafish model. Read More

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Electroacupuncture Alleviates Inflammation of Dry Eye Diseases by Regulating the 7nAChR/NF-B Signaling Pathway.

Oxid Med Cell Longev 2021 9;2021:6673610. Epub 2021 Apr 9.

Ophthalmology Department of Traditional Chinese Medicine, The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing City, Jiangsu Province 210023, China.

Purpose: We tried to investigate whether electroacupuncture (EA) can reduce inflammation of dry eye disease (DED) by regulating 7nAChR and inhibiting the NF-B signaling pathway.

Methods: Healthy New Zealand white rabbits were treated with scopolamine hydrobromide (Scop) for 21 consecutive days to establish the DED animal model. After 21 days, EA, fluorometholone (Flu), and 7nAChR antagonist (-BGT) treatments were performed, and the Scop injection was continued until day 35. Read More

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Gene Expression Differences Between Young Adults Based on Trauma History and Post-traumatic Stress Disorder.

Front Psychiatry 2021 8;12:581093. Epub 2021 Apr 8.

Virginia Institute for Psychiatry and Behavioral Genetics, Virginia Commonwealth University (VCU), Richmond, VA, United States.

The purpose of this study was to identify gene expression differences associated with post-traumatic stress disorder (PTSD) and trauma exposure (TE) in a three-group study design comprised of those with and without trauma exposure and PTSD. We conducted gene expression and gene network analyses in a sample ( = 45) composed of female subjects of European Ancestry (EA) with PTSD, TE without PTSD, and controls. We identified 283 genes differentially expressed between PTSD-TE groups. Read More

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