41,160 results match your criteria dysfunction seizure


Activated Charcoal and Bicarbonate for Aspirin Toxicity: a Retrospective Series.

J Med Toxicol 2021 Nov 29. Epub 2021 Nov 29.

Clinical Toxicology Research Group, University of Newcastle, Newcastle, NSW, Australia.

Introduction: Aspirin overdose causes acid-base disturbances and organ dysfunction. Management is guided by research reported over 50 years ago when chronic aspirin toxicity was common and accounted for significant morbidity. We investigate our experience of aspirin overdose and the effectiveness of charcoal and bicarbonate administration over 20 years. Read More

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November 2021

Different circuitry dysfunction in drug-naive patients with juvenile myoclonic epilepsy and juvenile absence epilepsy.

Epilepsy Behav 2021 Nov 24;125:108443. Epub 2021 Nov 24.

Neurophysiology Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Rationale: Juvenile myoclonic epilepsy (JME) and juvenile absence epilepsy (JAE) are generalized epileptic syndromes presenting in the same age range. To explore whether uneven network dysfunctions may underlie the two different phenotypes, we examined drug-naive patients with JME and JAE at the time of their earliest presentation.

Methods: Patients were recruited based on typical JME (n = 23) or JAE (n = 18) presentation and compared with 16 age-matched healthy subjects (HS). Read More

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November 2021

Gray Matter Changes in Juvenile Myoclonic Epilepsy. A Voxel-Wise Meta-Analysis.

Medicina (Kaunas) 2021 Oct 20;57(11). Epub 2021 Oct 20.

Third Department of Neurology, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.

. Juvenile myoclonic epilepsy (JME) is an idiopathic generalized epileptic syndrome, with a genetic basis clinically identified by myoclonic jerks of the upper limbs upon awaking, generalized tonic-clonic seizures and less frequent absences. Although the brain magnetic resonance imaging (MRI) is by definition normal, computer-based Voxel-Based morphometry studies have shown a number of volumetric changes in patients with juvenile myoclonic epilepsy. Read More

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October 2021

Heart Rate Variability in Insulo-Opercular Epilepsy.

Brain Sci 2021 Nov 13;11(11). Epub 2021 Nov 13.

CHUM Research Center, University of Montreal, Montreal, QC H2X 0A9, Canada.

Background: We aimed to evaluate heart rate variability (HRV) changes in insulo-opercular epilepsy (IOE) and after insulo-opercular surgery.

Methods: We analyzed 5-min resting HRV of IOE patients before and after surgery. Patients' SUDEP-7 risk inventory scores were also calculated. Read More

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November 2021

Recent Developments in Diagnosis of Epilepsy: Scope of MicroRNA and Technological Advancements.

Biology (Basel) 2021 Oct 25;10(11). Epub 2021 Oct 25.

Department of Pharmacology, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India.

Epilepsy is one of the most common neurological disorders, characterized by recurrent seizures, resulting from abnormally synchronized episodic neuronal discharges. Around 70 million people worldwide are suffering from epilepsy. The available antiepileptic medications are capable of controlling seizures in around 60-70% of patients, while the rest remain refractory. Read More

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October 2021

Astrocyte Reactivity in a Mouse Model of SCN8A Epileptic Encephalopathy.

Epilepsia Open 2021 Nov 26. Epub 2021 Nov 26.

Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA, USA.

Objective: SCN8A epileptic encephalopathy is caused predominantly by de novo gain-of-function mutations in the voltage-gated-sodium channel Na 1.6. The disorder is characterized by early onset of seizures and developmental delay. Read More

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November 2021

Seizure detection from multi-channel EEG using entropy-based dynamic graph embedding.

Authors:
Gen Li Jason J Jung

Artif Intell Med 2021 Dec 3;122:102201. Epub 2021 Nov 3.

Department of Computer Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea. Electronic address:

An epileptic seizure is a chronic disease with sudden abnormal discharge of brain neurons, which leads to transient brain dysfunction. To detect epileptic seizures, we propose a novel idea based on a dynamic graph embedding model. The dynamic graph is built by identifying the correlation among the multi-channel EEG signals. Read More

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December 2021

Growth and Overall Health of Patients with Citrate Transporter Disorder.

Metabolites 2021 Oct 29;11(11). Epub 2021 Oct 29.

Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA 94070, USA.

We were interested in elucidating the non-neurologic health of patients with autosomal recessive Citrate Transporter (NaCT) Disorder. Multiple variants have been reported that cause a loss of transporter activity, resulting in significant neurologic impairment, including seizures, as well as motor and cognitive dysfunction. Additionally, most patients lack tooth enamel (amelogenesis imperfecta). Read More

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October 2021

Maternal COVID-19 Infection and Possible Associated Adverse Neurological Fetal Outcomes, Two Case Reports.

Am J Perinatol 2021 Nov 23. Epub 2021 Nov 23.

Creighton University School of Medicine Phoenix Regional Campus, Phoenix, United States.

Introduction: The long-term effects of prenatal COVID-19 infection on the fetal brain are mostly unknown at this time however, there is increasing evidence being published.

Case Report: Two cases of severe ventriculomegaly, neurological dysfunction, and seizures were found in neonates with prenatal exposure to COVID-19 infection during the first and third trimesters of pregnancy.

Conclusion: Inflammation during the prenatal and neonatal period may be associated with neurological disorders or injury. Read More

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November 2021

Focal status epilepticus may trigger relapse of primary angiitis of the CNS.

Epileptic Disord 2021 Nov 19. Epub 2021 Nov 19.

Saint-Luc University Hospital, Department of Neurology, Brussels, Belgium, Saint-Luc University Hospital, Centre for Refractory Epilepsy, Brussels, Belgium.

The role of neuroinflammation in epileptogenesis is extensively investigated, but short-term effects of seizures on established CNS pathologies are less studied and less predictable. We describe the case of a woman with previous recurrent episodes of focal cerebral haemorrhage of unknown cause who developed a pseudo-tumoural oedema triggered by provoked focal status epilepticus. A brain biopsy revealed that the underlying condition was primary angiitis of the CNS. Read More

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November 2021

The clinical features, treatment and outcomes of 33 children from Northwestern China with Anti-N-methyl-D-aspartate receptor encephalitis.

Neurol Res 2021 Nov 21:1-10. Epub 2021 Nov 21.

Department of Pediatric Neurology, Xi'an Children' Hospital, China.

Objectives: We analyzed the clinical features and outcomes of children with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis in Northwestern China.

Methods: We retrospectively recruited 33 pediatric patients with anti-NMDAR encephalitis in Northwestern China from December 2013 to April 2020. The demographics, clinical features, treatments, and outcomes were reviewed. Read More

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November 2021

Pediatric cervical kyphosis in the MRI era (1984-2008) with long-term follow up: literature review.

Childs Nerv Syst 2021 Nov 22. Epub 2021 Nov 22.

Department of Neurosurgery, Rush University Medical Center, Chicago, IL, USA.

Objective: Cervical kyphosis is rare in the pediatric population. It may be syndromic or acquired secondary to laminectomy, neoplasia, or trauma. Regardless, this should be avoided to prevent progressive spinal deformity and neurological deficit. Read More

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November 2021

Leigh syndrome in an infant: autopsy and histopathology findings.

Autops Case Rep 2021 12;11:e2021334. Epub 2021 Nov 12.

Postgraduate Institute of Medical Education and Research, Department of Pediatrics, Chandigarh, India.

Leigh syndrome is an inherited neurodegenerative disorder of infancy that typically manifests between 3 and 12 months of age. The common neurological manifestations are developmental delay or regression, progressive cognitive decline, dystonia, ataxia, brainstem dysfunction, epileptic seizures, and respiratory dysfunction. Although the disorder is clinically and genetically heterogeneous, the histopathological and radiological features characteristically show focal and bilaterally symmetrical, necrotic lesions in the basal ganglia and brainstem. Read More

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November 2021

Network dysfunction in pre and postsurgical epilepsy: connectomics as a tool and not a destination.

Curr Opin Neurol 2021 Nov 18. Epub 2021 Nov 18.

Departments of Biomedical Engineering at Vanderbilt University Vanderbilt University Institute of Imaging Science at Vanderbilt University Medical Center Vanderbilt University Institute for Surgery and Engineering Electrical and Computer Engineering at Vanderbilt University Departments of Neurological Surgery Neurology Radiology and Radiological Sciences at Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Purpose Of Review: Patients with focal drug-resistant epilepsy (DRE) sometimes continue to have seizures after surgery. Recently, there is increasing interest in using advanced network analyses (connectomics) to better understand this problem. Connectomics has changed the way researchers and clinicians view DRE, but it must be applied carefully in a hypothesis-driven manner to avoid spurious results. Read More

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November 2021

Long-term medical and social outcomes of patients with Lennox-Gastaut syndrome.

Epilepsy Res 2021 Nov 13;178:106813. Epub 2021 Nov 13.

Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Objective: The aim of the current study was to investigate the long-term outcome in a large cohort of patients with Lennox-Gastaut syndrome (LGS).

Methods: This was a longitudinal study (a retrospective database review with a telephone follow-up interview). All patients 18 years of age and older, with a diagnosis of LGS were studied at the outpatient epilepsy clinic at Shiraz University of Medical Sciences, Shiraz, Iran, from 2008 until 2020. Read More

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November 2021

Deleterious neurological impact of diagnostic delay in immune-mediated thrombotic thrombocytopenic purpura.

PLoS One 2021 19;16(11):e0260196. Epub 2021 Nov 19.

Internal Medicine Department, Nantes University Hospital, Nantes, France.

Background: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare life-threatening thrombotic microangiopathy requiring urgent therapeutic plasma exchange (TPE). However, the exact impact of a slight delay in TPE initiation on the subsequent patients' outcome is still controversial.

Aim: We aimed to study the frequency, short-term neurological consequences, and determinants of diagnostic delay in iTTP. Read More

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November 2021

Cardioprotective effects of Amiodarone in a rat model of epilepsy-induced cardiac dysfunction.

Clin Exp Pharmacol Physiol 2021 Nov 19. Epub 2021 Nov 19.

Department of Medical Pharmacology, Faculty of Medicine, Cairo University, Egypt.

Cardiac dysfunction is one of the leading causes of death in epilepsy. The antiarrhythmic drug amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury during status epilepticus, as it can cause prolongation of the QT interval. Read More

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November 2021

Clinical Features, Immunotherapy, and Outcomes of Anti-Leucine-Rich Glioma-Inactivated-1 Encephalitis.

J Neuropsychiatry Clin Neurosci 2021 Nov 19:appineuropsych20120303. Epub 2021 Nov 19.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing.

Objective: The investigators aimed to explore the clinical characteristics, immunotherapy, and outcomes of patients with antileucine-rich glioma-inactivated-1 (anti-LGI1) encephalitis.

Methods: Data on participants' clinical characteristics, laboratory findings, radiological and electroencephalogram (EEG) features, treatment, and outcomes from January 2012 to December 2016 were collected. Statistical analysis was conducted to assess the factors associated with patient functional outcome. Read More

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November 2021

[NEUROLOGICAL COMPLICATIONS OF COVID-19: REVIEW OF LITERATURE AND OWN EXPERIENCE].

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2021 Aug;29(Special Issue):1304-1310

Center of diagnostics and treatment for epilepsy «PlanetaMed», 117105, Moscow, Russia.

According to the literature, the main neurological complications of COVID-19 are hyposmia, hypogeia, headache, dizziness, myalgia, and severe neurological syndromes like encephalopathy, stroke, and coma. The mechanisms of neurological complications of the acute period are direct viral damage, hypoxic damage, and immune damage due to the activation of inflammation, including autoantibodies. After the end of the acute phase of the disease, neurological complications in the form of asthenic syndrome, vascular syndrome, exacerbation of chronic diseases (deterioration of cognitive and communication functions in patients with autism, schizophrenia, exacerbation of autoimmune neurological diseases, aggravation of the condition of patients with tics, increased frequency of epileptic seizures in adults and children, resumption of epileptic seizures in patients who were previously in stable remission, the debut of epileptic seizures). Read More

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Region-Specific KCC2 Rescue by rhIGF-1 and Oxytocin in a Mouse Model of Rett Syndrome.

Cereb Cortex 2021 Nov 16. Epub 2021 Nov 16.

Neuroscience Theme, Biosciences Institute, Newcastle University, United Kingdom.

Rett syndrome (RTT) is characterized by dysfunction in neuronal excitation/inhibition (E/I) balance, potentially impacting seizure susceptibility via deficits in K+/Cl- cotransporter 2 (KCC2) function. Mice lacking the Methyl-CpG binding protein 2 (MeCP2) recapitulate many symptoms of RTT, and recombinant human insulin-like growth factor-1 (rhIGF-1) restores KCC2 expression and E/I balance in MeCP2 KO mice. However, clinical trial outcomes of rhIGF-1 in RTT have been variable, and increasing its therapeutic efficacy is highly desirable. Read More

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November 2021

Fabry Disease: A Atypical Presentation.

Cureus 2021 Oct 12;13(10):e18708. Epub 2021 Oct 12.

Internal Medicine, Hospital do Espirito Santo de Évora, Évora, PRT.

Fabry Disease (FD) is a rare X-linked recessive disease caused by mutations in the GLA gene that lead to a decrease or lack of activity of the enzyme alpha galactosyl A. This lysosomal storage disorder results in progressive damage and dysfunction of several organs and, depending on the type of mutation and gender of the patient, and it may have different manifestations. As FD is a multisystem disease with a progressive character and varying severity, the diagnosis can be challenging, especially when it comes to non-classical forms. Read More

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October 2021

Hippocampal injury and learning deficits following non-convulsive status epilepticus in periadolescent rats.

Epilepsy Behav 2021 Nov 14;125:108415. Epub 2021 Nov 14.

Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Division of Child Neurology, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

The effects of non-convulsive status epilepticus (NCSE) on the developing brain remain largely elusive. Here we investigated potential hippocampal injury and learning deficits following one or two episodes of NCSE in periadolescent rats. Non-convulsive status epilepticus was induced with subconvulsive doses of intrahippocampal kainic acid (KA) under continuous EEG monitoring in postnatal day 43 (P43) rats. Read More

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November 2021

Interictal autonomic changes in persons with epilepsy (PWE) on carbamazepine (CBZ) versus other anti-seizure drug monotherapy: A cross-sectional study.

Epilepsy Behav 2021 Nov 14;125:108396. Epub 2021 Nov 14.

Department of Biostatistics, Jawarharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Objective: Epilepsy is one of the most prevalent neurological conditions and carbamazepine is a commonly used anti-seizure drug (ASD), especially in developing nations. There are reports of carbamazepine causing atrioventricular conduction defects and autonomic dysfunctions and its implication in Sudden Unexpected Death in Epilepsy (SUDEP) is controversial. We planned this study to assess the effect of carbamazepine (CBZ) on autonomic function compared to other ASDs in persons with epilepsy. Read More

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November 2021

Reversible Cerebral Vasoconstriction Syndrome in a Background of Eclampsia Responding to Milrinone Infusion.

Am J Case Rep 2021 Nov 16;22:e934528. Epub 2021 Nov 16.

Department of Neurology, King Fahd University Hospital, Imam Abdulrahman Bin Faisal University, Al Khobar, Saudi Arabia.

BACKGROUND Reversible cerebral vasoconstriction syndrome (RCVS) is a rare neurological disorder with a complex physiopathology that is not fully understood. Suggested underlying mechanisms include failure of autoregulation, endothelial dysfunction, and oxidative stress. It is characterized by reversible multifocal constriction of the cerebral arteries, and can be triggered by many conditions, including, vasoactive medications (eg, triptans), cerebrovascular events, primary headache disorders, and metabolic causes (eg, hypercalcemia). Read More

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November 2021

NADPH Oxidase: a Possible Therapeutic Target for Cognitive Impairment in Experimental Cerebral Malaria.

Mol Neurobiol 2021 Nov 16. Epub 2021 Nov 16.

F-23/71, Neuroscience Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, 500 046, India.

Long-term cognitive impairment associated with seizure-induced hippocampal damage is the key feature of cerebral malaria (CM) pathogenesis. One-fourth of child survivors of CM suffer from long-lasting neurological deficits and behavioral anomalies. However, mechanisms on hippocampal dysfunction are unclear. Read More

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November 2021

Cerebral and systemic hemodynamic effect of recurring seizures.

Sci Rep 2021 Nov 15;11(1):22209. Epub 2021 Nov 15.

Department of Neurology, Erasme Hospital, Free University of Brussels, Brussels, Belgium.

The increase in neuronal activity induced by a single seizure is supported by a rise in the cerebral blood flow and tissue oxygenation, a mechanism called neurovascular coupling (NVC). Whether cerebral and systemic hemodynamics are able to match neuronal activity during recurring seizures is unclear, as data from rodent models are at odds with human studies. In order to clarify this issue, we used an invasive brain and systemic monitoring to study the effects of chemically induced non-convulsive seizures in sheep. Read More

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November 2021

A Case Study on Differential Diagnosis of Episodic Left Arm Numbness.

Authors:
Adam Shugan

Neurodiagn J 2021 Nov 15:1-7. Epub 2021 Nov 15.

Department of Neurology, Malcom Randall VA Medical Center, Gainesville, Florida.

According to the World Health Organization, cardiovascular disease is the number one cause of death globally. Cardiac-related maladies are a common occurrence in emergency rooms across the United States. The most common symptoms of a myocardial infarction include pain or discomfort in the arms, left shoulder or elbows. Read More

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November 2021

Characteristics of olfactory dysfunction in patients with temporal lobe epilepsy.

Epilepsy Behav 2021 Nov 11;125:108402. Epub 2021 Nov 11.

International University of Health and Welfare Graduate School of Medicine, Tokyo, Japan; International University of Health and Welfare School of Medicine, Department of Neurology, Narita, Japan; International University of Health and Welfare School of Medical Sciences at Okawa, Department of Laboratory Medicine, Okawa, Japan.

Objective: To determine the characteristics of olfactory dysfunction in patients with temporal lobe epilepsy (TLE).

Methods: Odor identification was assessed using the odor stick identification test for Japanese (OSIT-J, full score 12 points) in 65 patients with TLE and in 74 controls.

Results: The mean OSIT-J score was significantly lower in patients with TLE (mean ± SD = 8. Read More

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November 2021

Carbonic Anhydrase Inhibitors and Epilepsy: State of the Art and Future Perspectives.

Molecules 2021 Oct 22;26(21). Epub 2021 Oct 22.

Department of Earth Sciences, University of Pisa, via Santa Maria 53, 56126 Pisa, Italy.

Carbonic anhydrases (CAs) are a group of ubiquitously expressed metalloenzymes that catalyze the reversible hydration/dehydration of CO/HCO. Thus, they are involved in those physiological and pathological processes in which cellular pH buffering plays a relevant role. The inhibition of CAs has pharmacologic applications for several diseases. Read More

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October 2021

Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome.

Mol Neurobiol 2021 Nov 11. Epub 2021 Nov 11.

Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.

Dravet syndrome (DS) is a form of severe childhood-onset refractory epilepsy typically caused by a heterozygous loss-of-function mutation. DS patient-derived induced pluripotent stem cells (iPSCs) are appropriate human cells for exploring disease mechanisms and testing new therapeutic strategies in vitro. Repeated spontaneous seizures can cause neuroinflammatory reactions and oxidative stress, resulting in neuronal toxicity, neuronal dysfunction, blood-brain barrier disruption, and hippocampal inflammation. Read More

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November 2021