29,243 results match your criteria dysfunction childhood

A prospective survey study of lower urinary tract dysfunction in childhood cancer survivors after vincristine and/or doxorubicin chemotherapy.

Pediatr Blood Cancer 2021 Jul 10:e29226. Epub 2021 Jul 10.

Department of Pediatric Urology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.

Background: Two chemotherapeutic agents used widely in pediatric oncology are vincristine (VCR) and doxorubicin (DOX), which may cause neuropathy and myopathy, respectively. The study hypothesis is that neurotoxic effects of VCR and/or myotoxic effects of DOX affect bladder physiology and manifest clinically as lower urinary tract dysfunction (LUTD).

Procedure: Based on a priori power analysis, 161 children divided evenly by gender were recruited. Read More

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Adolescent and young adult childhood cancer survivors' preferences for screening and education of sexual function.

Pediatr Blood Cancer 2021 Jul 10:e29229. Epub 2021 Jul 10.

Adult & Child Consortium for Health Outcomes Research & Delivery Science (ACCORDS), University of Colorado School of Medicine, Aurora, Colorado, USA.

Background: Sexual dysfunction (SD) is a common yet underrecognized concern among childhood cancer survivors (CCS). CCS who are now adolescent and young adult (AYA-CCS) identify SD as an unmet need. This study sought to explore AYA-CCS preferences on how, when, where, and by whom SD-focused communication should occur. Read More

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Prevalence, comorbidity, and predictors of obsessive-compulsive disorder in Iranian children and adolescents.

J Psychiatr Res 2021 Jun 23;141:192-198. Epub 2021 Jun 23.

Department of Occupational Medicine, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:

Background And Objectives: Obsessive-compulsive disorder (OCD) is a disease that causes personal distress or social dysfunction, especially in childhood. The present study aimed to provide the prevalence, comorbidity, and predictors of OCD among children and adolescents.

Methods: This was a cross-sectional national project conducted on 29,858 children and adolescents using the multi-stage cluster random sampling in Iran. Read More

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Friedreich Ataxia: Multidisciplinary Clinical Care.

J Multidiscip Healthc 2021 28;14:1645-1658. Epub 2021 Jun 28.

Division of Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia and the Perelman School of Medicine, Philadelphia, PA, 19104, USA.

Friedreich ataxia (FRDA) is a multisystem disorder affecting 1 in 50,000-100,000 person in the United States. Traditionally viewed as a neurodegenerative disease, FRDA patients also develop cardiomyopathy, scoliosis, diabetes and other manifestation. Although it usually presents in childhood, it continues throughout life, thus requiring expertise from both pediatric and adult subspecialist in order to provide optimal management. Read More

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Hypothalamus volume and DNA methylation of stress axis genes in major depressive disorder: A CAN-BIND study report.

Psychoneuroendocrinology 2021 Jun 29;132:105348. Epub 2021 Jun 29.

Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Mood Disorders Program and Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada. Electronic address:

Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is considered one of the mechanisms underlying the development of major depressive disorder (MDD), but the exact nature of this dysfunction is unknown. We investigated the relationship between hypothalamus volume (HV) and blood-derived DNA methylation in MDD. We obtained brain MRI, clinical and molecular data from 181 unmedicated MDD and 90 healthy control (HC) participants. Read More

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Attachment anxiety as mediator of the relationship between childhood trauma and personality dysfunction in borderline personality disorder.

Clin Psychol Psychother 2021 Jul 6. Epub 2021 Jul 6.

Department of Neurosciences, University of the Basque Country UPV/EHU, Leioa, Spain.

Insecure attachment has been described as mediating the relationship between childhood trauma and dysfunctional personality traits in different mental disorders. Despite the role insecure attachment and childhood trauma have independently demonstrated to play as determinants of borderline personality disorder, less is known about the mediating mechanisms explaining these associations. For the first time, we assessed adult attachment, childhood trauma and dimensional personality pathology in a sample of outpatients with borderline personality disorder and tested whether the association between childhood trauma and personality dysfunction was at least partially attributable to insecure attachment. Read More

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Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936.

Transl Psychiatry 2021 07 6;11(1):376. Epub 2021 Jul 6.

Lothian Birth Cohorts, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.

Slowed processing speed is considered a hallmark feature of cognitive decline in cerebral small vessel disease (SVD); however, it is unclear whether SVD's association with slowed processing might be due to its association with overall declining general cognitive ability. We quantified the total MRI-visible SVD burden of 540 members of the Lothian Birth Cohort 1936 (age: 72.6 ± 0. Read More

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The Challenges of Children with Bipolar Disorder.

Medicina (Kaunas) 2021 Jun 11;57(6). Epub 2021 Jun 11.

Psychiatrie Schwäbisch Hall, Campus ZfPG, 74523 Schwäbisch Hall, Germany.

Childhood onset bipolar disorder (CO-BD) presents a panoply of difficulties associated with early recognition and treatment. CO-BD is associated with a variety of precursors and comorbidities that have been inadequately studied, so treatment remains obscure. The earlier the onset, the longer is the delay to first treatment, and both early onset and treatment delay are associated with more depressive episodes and a poor prognosis in adulthood. Read More

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Infancy and Childhood Obesity Grade Predicts Weight Loss in Adulthood: The ONTIME Study.

Nutrients 2021 Jun 22;13(7). Epub 2021 Jun 22.

Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain.

We examined the relationships between intergenerational obesity, weight and size at birth, and obesity from infancy to adolescence with weight loss in response to a dietary intervention. We studied 4264 participants (3369 women; mean age 41.5 ± 12. Read More

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Can Adverse Childhood Experiences Heighten Risk for Problematic Internet and Smartphone Use? Findings from a College Sample.

Int J Environ Res Public Health 2021 06 2;18(11). Epub 2021 Jun 2.

Department of Health Sciences, College of Health and Human Development, California State University, Northridge, Los Angeles, CA 91330, USA.

Background: College students are among the heaviest users of smartphones and the Internet, and there is growing concern regarding problematic Internet (PIU) and smartphone use (PSU). A subset of adverse childhood experiences, household dysfunction [(HHD) e.g. Read More

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Atrial and Ventricular Structural and Functional Alterations in Obese Children.

Medicina (Kaunas) 2021 Jun 2;57(6). Epub 2021 Jun 2.

Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LT 44307 Kaunas, Lithuania.

: Childhood obesity has reached epidemic levels in the world. Obesity in children is defined as a body mass index (BMI) equal to or above the 95th percentile for age and sex. The aim of this study was to determine early changes in cardiac structure and function in obese children by comparing them with their nonobese peers, using echocardiography methods. Read More

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Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity.

Children (Basel) 2021 Jun 27;8(7). Epub 2021 Jun 27.

Pediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milano, Italy.

In the last few decades, obesity has increased dramatically in pediatric patients. Obesity is a chronic disease correlated with systemic inflammation, characterized by the presence of CD4 and CD8 T cell infiltration and modified immune response, which contributes to the development of obesity related diseases and metabolic disorders, including impaired glucose metabolism. In particular, Treg and Th17 cells are dynamically balanced under healthy conditions, but imbalance occurs in inflammatory and pathological states, such as obesity. Read More

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Can the Cumulative Adverse Childhood Experiences (ACE) Score Actually Identify the Victims of Intrafamilial Childhood Maltreatment? Findings from a Study in the Child Welfare System.

Int J Environ Res Public Health 2021 06 27;18(13). Epub 2021 Jun 27.

Department of Behavioural Sciences, University of Debrecen Faculty of Medicine, 4032 Debrecen, Hungary.

Studies show that a significant proportion of children in the Child Welfare System (CWS) have suffered adverse childhood experiences (ACEs), which have led to well documented serious consequences. This study assessed and compared the ACE status of adolescents aged 12 to 17 placed in a family style group care (FGC) setting ( = 240) to the ACE status of adolescents living with their biological parents ( = 516). The ACE Score Calculator was employed. Read More

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A Mathematical Description of the Bone Marrow Dynamics during CAR T-Cell Therapy in B-Cell Childhood Acute Lymphoblastic Leukemia.

Int J Mol Sci 2021 Jun 14;22(12). Epub 2021 Jun 14.

Department of Mathematics, Universidad de Cádiz, Puerto Real, 11510 Cádiz, Spain.

Chimeric Antigen Receptor (CAR) T-cell therapy has demonstrated high rates of response in recurrent B-cell Acute Lymphoblastic Leukemia in children and young adults. Despite this success, a fraction of patients' experience relapse after treatment. Relapse is often preceded by recovery of healthy B cells, which suggests loss or dysfunction of CAR T-cells in bone marrow. Read More

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Cortical Electrical Stimulation Ameliorates Traumatic Brain Injury-Induced Sensorimotor and Cognitive Deficits in Rats.

Front Neural Circuits 2021 14;15:693073. Epub 2021 Jun 14.

School of Physical Therapy and Graduate Institute of Rehabilitation Science, Chang Gung University, Taoyuan, Taiwan.

: Individuals with different severities of traumatic brain injury (TBI) often suffer long-lasting motor, sensory, neurological, or cognitive disturbances. To date, no neuromodulation-based therapies have been used to manage the functional deficits associated with TBI. Cortical electrical stimulation (CES) has been increasingly developed for modulating brain plasticity and is considered to have therapeutic potential in TBI. Read More

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Methodological Aspects of Diet Quality Indicators in Childhood: A Mapping Review.

Adv Nutr 2021 Jun 30. Epub 2021 Jun 30.

Iberoamerican Nutrition Foundation (FINUT), Granada, Spain.

Diet quality indicators (DQIns) are tools that aim to assess an individual's overall diet quality. Previous reviews focused mainly on health-related outcomes but did not provide detailed information about components, assessment variables, or important methodological issues for the development and application of DQIns in the pediatric age. The current mapping review aims to provide comprehensive guidance regarding DQIns developed through a priori methodology in children aged ≤14 y that have been applied worldwide. Read More

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Patterns of adverse childhood experiences and depressive symptoms: self-esteem as a mediating mechanism.

Soc Psychiatry Psychiatr Epidemiol 2021 Jun 30. Epub 2021 Jun 30.

Department of Social Welfare, Sunchon National University, 255 Jungang-ro, Suncheon, Jeonnam, South Korea, 57922.

Purpose: There is a growing interest in the co-occurring natures of adverse childhood experiences (ACEs) and unmeasured types of adversity. The current body of knowledge may also lack plausible mechanisms linking ACEs to mental health in young adulthood. This study aims to identify early adversity patterns using expanded ACEs items and investigate the pathway of ACEs and self-esteem to depressive symptoms in young adulthood. Read More

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Bee honey and exercise for improving physical performance, reducing fatigue, and promoting an active lifestyle during COVID-19.

Sports Med Health Sci 2021 Jun 25. Epub 2021 Jun 25.

Department of Animal and Poultry Production, Faculty of Agriculture, Damanhour University, Damanhour, Egypt.

Active lifestyle has enormous health benefits. However, physical activity has globally decreased since the beginning of the current coronavirus disease 2019 (COVID-19) outbreak because of social distancing measures. Older adults and people with age-related diseases (e. Read More

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Influences on catch-up growth using relative versus absolute metrics: evidence from the MAL-ED cohort study.

BMC Public Health 2021 06 29;21(1):1246. Epub 2021 Jun 29.

The Johns Hopkins University, 615 North Wolfe Street, Room W2041, Baltimore, MD, 21205, USA.

Background: Poor growth in early childhood has been considered irreversible after 2-3 years of age and has been associated with morbidity and mortality over the short-term and with poor economic and cognitive outcomes over the long-term. The MAL-ED cohort study was performed in eight low-income settings with the goal of evaluating relationships between the child's environment and experience (dietary, illness, and pathogen exposure, among others) and their growth and development. The goal of this analysis is to determine whether there are differences in the factors associated with growth from 24 to 60 months using two different metrics. Read More

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Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder.

Autism Res 2021 Jun 29. Epub 2021 Jun 29.

Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.

Compared to typically developing (TD) children, people with autism spectrum disorder (ASD) have an increased risk of adverse childhood experiences (ACEs). Exposure to ACEs is associated with adult ASD psychological comorbidities, such as posttraumatic stress disorder (PTSD). Occurrence of intrusive event reexperiencing, characteristic of PTSD, often causes social dysfunction in adults with ASD, but its pathological basis is unclear. Read More

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A Novel Variation in the Mitochondrial Complex I Assembly Factor NDUFAF5 Causes Isolated Bilateral Striatal Necrosis in Childhood.

Front Neurol 2021 10;12:675616. Epub 2021 Jun 10.

Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Bilateral striatal necrosis (BSN) is characterized by symmetrical degeneration, predominantly of the caudate and putamen nucleus, in the basal ganglia. It is associated with numerous acquired and hereditary neuro-developmental and motor dysfunction-related pathological conditions. BSN results in high morbidity and mortality among infants and children, and its diagnosis is clinically challenging due to several overlapping disease phenotypes. Read More

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Monocyte mitochondrial dysfunction, inflammaging, and inflammatory pyroptosis in major depression.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Jun 23;111:110391. Epub 2021 Jun 23.

Department of Immunology, Erasmus Medical Center, Rotterdam 3015 GD, Netherlands.

Background: The macrophage theory of depression states that macrophages play an important role in Major Depressive Disorder (MDD).

Methods: MDD patients (N = 140) and healthy controls (N = 120) participated in a cross-sectional study investigating the expression of apoptosis/growth and lipid/cholesterol pathway genes (BAX, BCL10, EGR1, EGR2, HB-EGF, NR1H3, ABCA1, ABCG1, MVK, CD163, HMOX1) in monocytes (macrophage/microglia precursors). Gene expressions were correlated to a set of previously determined and reported inflammation-regulating genes and analyzed with respect to various clinical parameters. Read More

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Endothelial impairment evaluation by peripheral arterial tonometry in pediatric endocrinopathies: A narrative review.

World J Diabetes 2021 Jun;12(6):810-826

Pediatric Clinic and Endocrinology, IRCCS Istituto Giannina Gaslini, Genoa16147, Italy.

Endothelial dysfunction (ED) is characterized by an imbalance between vasodilator and vasoconstriction agents. Several pathological conditions clinically diagnosed in childhood and adolescence are characterized by ED and increased risk for early development of microangiopathic and macroangiopathic impairment, in particular type 1 diabetes mellitus (T1DM), T2DM, obesity, metabolic syndromeand pituitary dysfunction associated to various endocrinopathies. More recently insulin resistance following chemotherapy or radiotherapy for tumors, bone marrow transplantation for hematological malignancies (, cancer survivors), or immunosuppressive treatment for solid organ transplantation has been observed. Read More

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A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency.

SLAS Discov 2021 Jun 24:24725552211018198. Epub 2021 Jun 24.

Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Triose phosphate isomerase deficiency (TPI Df) is an untreatable, childhood-onset glycolytic enzymopathy. Patients typically present with frequent infections, anemia, and muscle weakness that quickly progresses with severe neuromusclar dysfunction requiring aided mobility and often respiratory support. Life expectancy after diagnosis is typically ~5 years. Read More

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Epidemiology of Allergy: Natural Course and Risk Factors of Allergic Diseases.

Handb Exp Pharmacol 2021 Jun 25. Epub 2021 Jun 25.

Helmholtz Zentrum München - German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany.

The prevalences of allergic diseases, asthma, atopic dermatitis, allergic rhinitis and lately food allergy have been increasing over the last decades. It has been suggested that the prevalence of allergic diseases has reached a plateau in high income countries, while it is still on the rise in low and middle income countries. Generally, allergic diseases more often set on in childhood than in adulthood and affected children contribute more to the rise in allergic disease prevalence than affected adults. Read More

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Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen.

Mucosal Immunol 2021 Jun 22. Epub 2021 Jun 22.

Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.

Despite the impact of childhood diarrhea on morbidity and mortality, our understanding of its sequelae has been significantly hampered by the lack of studies that examine samples across the entire intestinal tract. Infant rhesus macaques are naturally susceptible to human enteric pathogens and recapitulate the hallmarks of diarrheal disease such as intestinal inflammation and growth faltering. Here, we examined intestinal biopsies, lamina propria leukocytes, luminal contents, and fecal samples from healthy infants and those experiencing growth faltering with distant acute or chronic active diarrhea. Read More

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The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents.

Sci Rep 2021 Jun 22;11(1):13022. Epub 2021 Jun 22.

Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.

Childhood obesity continues to escalate worldwide and may affect left ventricular (LV) geometry and function. The aim of this study was to investigate the impact of obesity on prevalence of left ventricular hypertrophy (LVH) and diastolic dysfunction in children. In this analysis of prospectively collected cross-sectional data of children between 5 and 16 years of age from randomly selected schools in Peru, parameters of LV geometry and function were compared according to presence or absence of obesity (body mass index z-score > 2). Read More

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Childhood snoring has long-term adverse effects on cardiovascular health.

Respirology 2021 Aug 21;26(8):725-726. Epub 2021 Jun 21.

Department of Paediatrics, Monash University, Melbourne, Victoria, Australia.

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Multichamber Dysfunction in Children and Adolescents With Severe Obesity: A Cardiac Magnetic Resonance Imaging Myocardial Strain Study.

J Magn Reson Imaging 2021 Jun 21. Epub 2021 Jun 21.

Laboratoire d'Imagerie Biomédicale, Sorbonne Université, INSERM, CNRS, Paris, France.

Background: In severe obesity, left ventricular (LV) and right ventricular (RV) remodeling and contractile dysfunction have been documented, but less is known regarding left atrial (LA) dysfunction and its association with LV/RV remodeling, especially in children.

Purpose: To assess the effects of severe childhood obesity on cardiac function by using multichamber strain analysis with MRI.

Study Type: Prospective. Read More

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