38,079 results match your criteria dynamics clinical

Dynamics of left ventricular myocardial work in patients hospitalized for acute heart failure.

J Card Fail 2021 Jul 28. Epub 2021 Jul 28.

Comprehensive Heart Failure Center, University Hospital and University of Würzburg, Würzburg, Germany; Department of Medicine I, University Hospital Würzburg, Würzburg, Germany. Electronic address:

Aims: . Left ventricular ejection fraction is the most commonly used measure describing pumping efficiency, but it is heavily dependent on loading conditions and therefore not well suited to study pathophysiologic changes. The novel concept of echocardiography-derived myocardial work (MyW) overcomes this disadvantage as it is based on left ventricular (LV) pressure-strain loops. Read More

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Molecular dynamics simulations reveal the disruption mechanism of a 2,4-thiazolidinedione derivative C30 against tau hexapeptide (PHF6) oligomer.

Proteins 2021 Jul 30. Epub 2021 Jul 30.

State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, China.

2,4-thiazolidinedione derivatives have been reported to inhibit the aggregation of tau protein, in which compound 30 (C30) can not only inhibit 80% of PHF6 aggregation, but also inhibit K18 and full-length tau aggregation. However, its inhibitory mechanism is unclear. In this work, to investigate the effect of C30 on tau protein, all-atom molecular dynamics simulation was performed on PHF6 oligomer with and without C30. Read More

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Method for Multiplexed Dynamic Intravital Multiphoton Imaging.

Methods Mol Biol 2021 ;2350:145-156

Biophysical Analytics, Deutsches Rheumaforschungszentrum - a Leibniz Institute, Berlin, Germany.

Intravital two-photon microscopy enables monitoring of cellular dynamics and communication of complex systems, in genuine environment-the living organism. Particularly, its application in understanding the immune system brought unique insights into pathophysiologic processes in vivo. Here we present a method to achieve multiplexed dynamic intravital two-photon imaging by using a synergistic strategy combining a spectrally broad range of fluorophore emissions, a wave-mixing concept for simultaneous excitation of all targeted fluorophores, and an effective unmixing algorithm based on the calculation of spectral similarities with previously acquired fluorophore fingerprints. Read More

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January 2021

Dynamic changes in mitochondrial 3D structure during folliculogenesis and luteal formation in the goat large luteal cell lineage.

Sci Rep 2021 Jul 30;11(1):15564. Epub 2021 Jul 30.

Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan, ROC.

In mammalian ovaries, mitochondria are integral sites of energy production and steroidogenesis. While shifts in cellular activities and steroidogenesis are well characterized during the differentiation of large luteal cells in folliculogenesis and luteal formation, mitochondrial dynamics during this process have not been previously evaluated. In this study, we collected ovaries containing primordial follicles, mature follicles, corpus hemorrhagicum, or corpus luteum from goats at specific times in the estrous cycle. Read More

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Identification of non-classical hCA XII inhibitors using combination of computational approaches for drug design and discovery.

Sci Rep 2021 Jul 30;11(1):15516. Epub 2021 Jul 30.

Pharmaceutical Chemistry Department, College of Pharmacy, Jouf University, Sakaka, 72341, Aljouf, Saudi Arabia.

Human carbonic anhydrase XII (hCA XII) isozyme is of high therapeutic value as a pharmacological target and biomarker for different types of cancer. The hCA XII is one of the crucial effectors that regulates extracellular and intracellular pH and affects cancer cell proliferation, invasion, growth and metastasis. Despite the fact that interaction features of hCAs inhibitors with the catalytic site of the enzyme are well described, lack in the selectivity of the traditional hCA inhibitors based on the sulfonamide group or related motifs is an urgent issue. Read More

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Longitudinal analysis of human pancreatic adenocarcinoma development reveals transient gene expression signatures.

Mol Cancer Res 2021 Jul 30. Epub 2021 Jul 30.

Cell and Developmental Biology, University of Pennsylvania.

Previous transcriptome studies of human pancreatic ductal adenocarcinoma (PDAC) compare non-cancerous pancreatic intraepithelial neoplasias (PanINs) with late-stage PDAC obtained from different patients, thus have limited ability to discern network dynamics that contribute to the disease progression. We demonstrated previously that the 10-22 cell line, an induced pluripotent stem cell (iPS)-like line reprogrammed from late-stage human PDAC cells, recapitulated the progression from PanNs to PDAC upon transplantation into NOD/LtSz-scid/IL2R-gammanull mice. Herein, we investigated the transition from precursor to PDAC using the isogenic model. Read More

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Incorporating emotions into clinical decision-making solutions.

Healthc (Amst) 2021 Jul 27;9(3):100569. Epub 2021 Jul 27.

Decision Science Group, Value & Systems Science Lab, Seattle, WA, USA; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA. Electronic address:

Health and emotions are inexorably connected. Yet there is still little emphasis on emotions in many clinical decision-making tools and interventions. Instead, existing solutions have tended to target cognition - how people comprehend and act on information about health and disease. Read More

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Carpal tunnel syndrome treatment and the subsequent alterations in tendon and connective tissue dynamics.

Clin Biomech (Bristol, Avon) 2021 Jul 24;88:105440. Epub 2021 Jul 24.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, United States. Electronic address:

Background: Carpal tunnel syndrome patients demonstrate diminished motion of the median nerve and fibrotic changes in the subsynovial connective tissue within the carpal tunnel. Currently, there are few prognostic factors to help predict the outcome of commonly performed treatments including surgical carpal tunnel release and corticosteroid injections. This study aimed to non-invasively assess the changes in the dynamic response of the subsynovial tissue relative to tendon motion after the intervention and to correlate this with disease severity. Read More

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Angiography-based estimation of coronary physiology: A frame is worth a thousand words.

Trends Cardiovasc Med 2021 Jul 27. Epub 2021 Jul 27.

First Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration Hospital, Athens, Greece.

Cumulative evidence has shown that coronary revascularization should be guided by functional significance of coronary lesions. Fractional flow reserve (FFR) is the gold standard for assessment of hemodynamic significance of coronary stenosis and FFR-guided percutaneous coronary intervention has improved clinical outcomes in patients with coronary artery disease. However, limitations of FFR such as increased operational time and cost, requirement of pressure wire and adenosine and technical difficulties have led to significant underutilization of the method in clinical practice. Read More

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A study of the effects of age on the dynamics of RSV in animal models.

Virus Res 2021 Jul 27:198524. Epub 2021 Jul 27.

Department of Physics and Astronomy, Texas Christian University, Fort Worth, TX USA. Electronic address:

Respiratory syncytial virus can cause severe illness and even death particularly in infants. The increased severity of disease in young children is thought to be due to a lack of previous exposure to the virus as well as the limited immune response in infants. While studies have examined the clinical differences in disease between infants and adults, there has been limited examination of how the viral dynamics differ as infants develop. Read More

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Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow waves and spindles in healthy young adults.

Sleep 2021 Jul 30. Epub 2021 Jul 30.

School of Physiology, Pharmacology & Neuroscience, University of Bristol, Bristol BS8 1TD, UK.

The rs1344706 polymorphism in ZNF804A is robustly associated with schizophrenia and schizophrenia is, in turn, associated with abnormal non-rapid eye movement (NREM) sleep neurophysiology. To examine whether rs1344706 is associated with intermediate neurophysiological traits in the absence of disease, we assessed the relationship between genotype, sleep neurophysiology, and sleep-dependent memory consolidation in healthy participants. We recruited healthy adult males with no history of psychiatric disorder from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. Read More

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The exploratory value of cross-sectional partial correlation networks: Predicting relationships between change trajectories in borderline personality disorder.

PLoS One 2021 30;16(7):e0254496. Epub 2021 Jul 30.

Department of Clinical Psychology, University of Amsterdam, Amsterdam, The Netherlands.

Objective: Within the network approach to psychopathology, cross-sectional partial correlation networks have frequently been used to estimate relationships between symptoms. The resulting relationships have been used to generate hypotheses about causal links between symptoms. In order to justify such exploratory use of partial correlation networks, one needs to assume that the between-subjects relationships in the network approximate systematic within-subjects relationships, which are in turn the results of some within-subjects causal mechanism. Read More

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Respiratory cryptosporidiosis in Malawian children with diarrheal disease.

PLoS Negl Trop Dis 2021 Jul 30;15(7):e0009643. Epub 2021 Jul 30.

Paediatrics and Child Health Research Group, Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.

Background: Respiratory cryptosporidiosis has been documented in children with diarrhea. We sought to describe the dynamics of respiratory involvement in children hospitalized with gastrointestinal (GI) diarrheal disease.

Methods: We conducted a prospective, observational longitudinal study of Malawian children 2-24 months hospitalized with diarrhea. Read More

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Shotgun metagenomics assessment of the resistome, mobilome, pathogen dynamics and their ecological control modes in full-scale urban wastewater treatment plants.

J Hazard Mater 2021 Jun 11;418:126387. Epub 2021 Jun 11.

Nireas-International Water Research Centre, University of Cyprus, P.O. Box 20537, Nicosia, CY 1678, Cyprus; Department of Civil and Environmental Engineering, University of Cyprus, P.O. Box 20537, Nicosia, CY 1678, Cyprus. Electronic address:

The conventional activated sludge (CAS) process has limited capacity to remove pathogenic microorganisms and antibiotic resistance genes (ARGs), compared to membrane bioreactors (MBRs). However, the full extent of pathogenic microbial fraction, resistome (antibiotic and biocide resistance genes, ARGs and BRGs) and mobilome (mobile genetic elements, MGE) of urban wastewater treatment plant (UWTP) influents and effluents remains unknown. Thus, the fate of putative pathogenic bacteria, ARGs and potential co-occurrence patterns with BRGs, MGEs and bacterial-predatory microorganisms was determined in two full-scale UWTPs, a MBR and a CAS system, using shotgun metagenomics. Read More

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Automatic triangulated mesh generation of pulmonary airways from segmented lung 3DCTs for computational fluid dynamics.

Int J Comput Assist Radiol Surg 2021 Jul 30. Epub 2021 Jul 30.

University of California, Los Angeles, CA, 90095, USA.

Purpose: Computational fluid dynamics (CFD) of lung airflow during normal and pathophysiological breathing provides insight into regional pulmonary ventilation. By integrating CFD methods with 4D lung imaging workflows, regions of normal pulmonary function can be spared during treatment planning. To facilitate the use of CFD simulations in a clinical setup, a robust, automated, and CFD-compliant airway mesh generation technique is necessary. Read More

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Detection of Molecular Residual Disease Using Personalized Circulating Tumor DNA Assay in Patients With Colorectal Cancer Undergoing Resection of Metastases.

JCO Precis Oncol 2021 Jul 21;5. Epub 2021 Jul 21.

Unit of Surgical Pathology, Department of Medicine (DIMED), University of Padua, Padua, Italy.

Purpose: More than 50% of patients with stage IV colorectal cancer (metastatic colorectal cancer [mCRC]) relapse postresection. The efficacy of postoperative systemic treatment is limited in this setting. Thus, these patients would greatly benefit from the use of a reliable prognostic biomarker, such as circulating tumor DNA (ctDNA) to identify minimal or molecular residual disease (MRD). Read More

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The Biology and Pathobiology of Glutamatergic, Cholinergic, and Dopaminergic Signaling in the Aging Brain.

Front Aging Neurosci 2021 13;13:654931. Epub 2021 Jul 13.

Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

The elderly population is growing worldwide, with important health and socioeconomic implications. Clinical and experimental studies on aging have uncovered numerous changes in the brain, such as decreased neurogenesis, increased synaptic defects, greater metabolic stress, and enhanced inflammation. These changes are associated with cognitive decline and neurobehavioral deficits. Read More

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Delayed SARS-CoV-2 Clearance in Patients with Obesity.

Infect Drug Resist 2021 22;14:2823-2827. Epub 2021 Jul 22.

Institute of Hepatology, The Third People's Hospital of Changzhou, Changzhou, People's Republic of China.

Objective: The present study aimed to investigate the correlation between obesity and virus persistence in patients with COVID-19.

Design And Methods: A total of 57 patients with laboratory-confirmed COVID-19 were admitted to two clinical centers, and data were analyzed retrospectively. Among them, 18 patients with body mass index (BMI) ≥ 25 kg/m were diagnosed with obesity, and dynamics of viral replication were compared. Read More

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Osseodensification enables bone healing chambers with improved low-density bone site primary stability: an in vivo study.

Sci Rep 2021 Jul 29;11(1):15436. Epub 2021 Jul 29.

Clinical Research Laboratory, Dentistry School, Universidade Federal Fluminense, Rua Mario Santos Braga, 28/4 Floor, Niterói, RJ, Brazil.

Primary implant stability is a prerequisite for successful implant osseointegration. The osseodensification technique (OD) is a non-subtractive drilling technique that preserves the bone tissue, increases osteotomy wall density, and improves the primary stability. This study aimed to investigate the hypothesis that OD, through a wider osteotomy, produces healing chambers (HCs) at the implant-bone interface without impacting low-density bone primary stability. Read More

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Temporal shifts in antibiotic resistance elements govern phage-pathogen conflicts.

Science 2021 07;373(6554)

Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.

Bacteriophage predation selects for diverse antiphage systems that frequently cluster on mobilizable defense islands in bacterial genomes. However, molecular insight into the reciprocal dynamics of phage-bacterial adaptations in nature is lacking, particularly in clinical contexts where there is need to inform phage therapy efforts and to understand how phages drive pathogen evolution. Using time-shift experiments, we uncovered fluctuations in 's resistance to phages in clinical samples. Read More

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Drug Metab Dispos 2021 Jul 29. Epub 2021 Jul 29.

Groton Laboratories, Pfizer Global Research and Development, United States

Cytochrome P450 3A (CYP3A) is a frequent target for time-dependent inhibition (TDI) that can give rise to drug-drug interactions (DDI). Yet many drugs that exhibit in vitro TDI for CYP3A, do not result in DDI. Twenty-three drugs with published clinical DDI were evaluated for CYP3A TDI in human liver microsomes (HLM) and hepatocytes (HHEP), and these data were utilized in static and dynamic models for projecting DDI caused by inactivation of CYP3A in both liver and intestine. Read More

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Impact of Diabetes on Outcomes After Transcatheter Mitral Valve Repair in Heart Failure: COAPT Trial.

JACC Heart Fail 2021 Aug;9(8):559-567

Clinical Trials Center, Cardiovascular Research Foundation, New York, New York, USA; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

Objectives: This paper sought to determine whether diabetes influences the outcomes of transcatheter mitral valve repair (TMVr) in patients with heart failure (HF) and secondary mitral regurgitation (SMR).

Background: Diabetes is associated with worse outcomes in patients with HF.

Methods: The COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With functional Mitral Regurgitation) trial randomized HF patients with 3+ or 4+ SMR to MitraClip plus guideline-directed medical therapy (GDMT) versus GDMT alone. Read More

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Living with embodied vibrations: Sensory experiences following a traumatic brain injury.

Soc Sci Med 2021 Jul 15;284:114233. Epub 2021 Jul 15.

Department of Health Aging & Society, McMaster University, Canada.

Based on autoethnography, this article adopts a (neuro)phenomenological lens to explore sensory experiences following a traumatic brain injury (TBI). Although focussing particularly on pain, vision, hearing, and somatic experiences connected with sleep, we also touch on how these are interwoven with other symptoms associated with TBIs. We use these experiences to enliven, and thereby enrich, clinical constructions and understandings of 'sensitivity' to light and to noise, as well as 'sleep disturbance'. Read More

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Understanding the DNA double-strand break repair and its therapeutic implications.

DNA Repair (Amst) 2021 Jul 9;106:103177. Epub 2021 Jul 9.

Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India. Electronic address:

Repair of DNA double-strand breaks (DSBs) and its regulation are tightly integrated inside cells. Homologous recombination, nonhomologous end joining and microhomology mediated end joining are three major DSB repair pathways in mammalian cells. Targeting proteins associated with these repair pathways using small molecule inhibitors can prove effective in tumors, especially those with deregulated repair. Read More

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Turbulence intensity as an indicator for ischemic stroke in the carotid web.

World Neurosurg 2021 Jul 26. Epub 2021 Jul 26.

Department of Neurosurgery, College of Medicine, Dankook University, Cheonan, Korea. Electronic address:

Objective: Carotid web (CaW) is reported as one of the causes of cryptogenic strokes. However, its pathophysiology has not been known, which makes clinicians debate CaW treatment. The current study presents the mechanism of ischemic stroke in CaW and finds a potential indicator for ischemic stroke in CaW. Read More

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Computational and experimental characterization of isomers of escin -induced renal cytotoxicity by inhibiting heat shock proteins.

Eur J Pharmacol 2021 Jul 26:174372. Epub 2021 Jul 26.

State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. Electronic address:

Escin is a natural mixture of triterpene saponins, exhibits anti-oedematous properties and promotes venous drainage by oral administration or injection. Upon clinical application of escin, adverse kidney reactions have been reported and the nephrotoxic mechanism responsible for this reaction remains elusive. In the present study, four isomeric escins (β-form: escin Ia and escin Ib; α-form: isoescin Ia and isoescin Ib) were found severely decreasing the cell viability of human kidney (HK-2) cells. Read More

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The Elements of Engagement Framework to Improve Organizational Uptake of Evidence-Based Practice.

J Contin Educ Nurs 2021 Aug 1;52(8):355-358. Epub 2021 Aug 1.

Considerable time, money, and training efforts in organizations have been spent advancing evidence-based practice (EBP). Adding science to clinical decision making is profound, yet organizational strategies to ensure mainstream use of EBP as a return on the training investment is sparse. The Elements of Engagement Framework addresses organizational dynamics: emotion, engagement, energy, expectations, and execution to normalize implementation of EBP within the organizational culture. Read More

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In Silico Mutagenesis-Based Remodelling of SARS-CoV-1 Peptide (ATLQAIAS) to Inhibit SARS-CoV-2: Structural-Dynamics and Free Energy Calculations.

Interdiscip Sci 2021 Jul 29. Epub 2021 Jul 29.

Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.

The prolific spread of COVID-19 caused by a novel coronavirus (SARS-CoV-2) from its epicenter in Wuhan, China, to every nook and cranny of the world after December 2019, jeopardize the prevailing health system in the world and has raised serious concerns about human safety. Multi-directional efforts are made to design small molecule inhibitors, and vaccines and many other therapeutic options are practiced, but their final therapeutic potential is still to be tested. Using the old drug or vaccine or peptides could aid this process to avoid such long experimental procedures. Read More

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Neurofluids-Deep inspiration, cilia and preloading of the astrocytic network.

J Neurosci Res 2021 Jul 29. Epub 2021 Jul 29.

Division of Pediatric Neurosurgery, Department of Neurosurgery, University Medical Center Göttingen, Göttingen, Germany.

With the advent of real-time MRI, the motion and passage of cerebrospinal fluid can be visualized without gating and exclusion of low-frequency waves. This imaging modality gives insights into low-volume, rapidly oscillating cardiac-driven movement as well as sustained, high-volume, slowly oscillating inspiration-driven movement. Inspiration means a spontaneous or artificial increase in the intrathoracic dimensions independent of body position. Read More

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