85,467 results match your criteria dynamic studies

Screening and identification of microRNAs from plasma-derived extracellular vesicles (EVs) of Dazu black goat (Capra hircus) in early pregnant stages.

Gene 2021 May 9:145706. Epub 2021 May 9.

College of Animal Science and Technology, Southwest University, Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, Chongqing 400715, P. R. China. Electronic address:

Previous studies have shown that extracellular vesicles (EVs) containing proteins, lipids, nucleic acids and other biological components exist in all kinds of body fluids. EVs, as an intercellular communication carrier, regulate the functions of its target cells by transporting biomacromolecules between cells. In this study, a total of six female Dazu black goats were divided into NP group (NP, non-pregnant group) and P30 (P30, 30-day pregnant group). Read More

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Extracellular Matrix Alignment Directs Provisional Matrix Assembly and Three Dimensional Fibrous Tissue Closure.

Tissue Eng Part A 2021 May 12. Epub 2021 May 12.

Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA.

Gap closure is a dynamic process in wound healing, in which a wound contracts and a provisional matrix is laid down, to restore structural integrity to injured tissues. The efficiency of wound closure has been found to depend on the shape of a wound, and this shape dependence has been echoed in various studies. While wound shape itself appears to contribute to this effect, it remains unclear whether the alignment of the surrounding extracellular matrix (ECM) may also contribute. Read More

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Active Flow Control and Dynamic Analysis in Droplet Microfluidics.

Annu Rev Anal Chem (Palo Alto Calif) 2021 May 12. Epub 2021 May 12.

Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849, USA; email:

Droplet-based microfluidics has emerged as an important subfield within the microfluidic and general analytical communities. Indeed, several unique applications such as digital assay readout and single-cell sequencing now have commercial systems based on droplet microfluidics. Yet there remains room for this research area to grow. Read More

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Implicit learning of non-verbal regularities by deaf children with cochlear implants: An investigation with a dynamic temporal prediction task.

PLoS One 2021 12;16(5):e0251050. Epub 2021 May 12.

Department of Developmental Psychology and Socialisation, University of Padua, Padova, Italy.

Some deaf children continue to show difficulties in spoken language learning after cochlear implantation. Part of this variability has been attributed to poor implicit learning skills. However, the involvement of other processes (e. Read More

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Application Value of Lipoprotein-Associated Phospholipase A2 Expression Level in Evaluating the Risk of Major Bleeding in Gestational Diabetes.

Clin Lab 2021 May;67(5)

Background: Studies have shown that obesity and lipid metabolism disorders can lead to increased Lp-PLA2 ac-tivity in the body. However, few studies have reported the correlation between Lp-PLA2 and postpartum hemorrhage in pregnant women with GMD.

Methods: Clinical data was collected from 43 pregnant women with gestational diabetes combined with postpartum hemorrhage and 50 pregnant women with postpartum diabetes without postpartum bleeding during the same period. Read More

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Self-promoted solid-state covalent networking of Au(SR) through reversible disulfide bonds. A critical effect of the nanocluster in oxidation processes.

Nanoscale 2021 May 12. Epub 2021 May 12.

Graduate School of Environmental Science, Hokkaido University, North 10 West 5, Sapporo 060-0810, Japan. and Faculty of Environmental Earth Science, Hokkaido University, North 10 West 5, Sapporo 060-0810, Japan.

Covalent crosslinking of ligand-protected gold nanoclusters offers interesting platforms to investigate the properties associated with the synergetic effects of multiple nanoclusters. In this paper, we report the synthesis of covalent networks of [Au25(SR)18]- nanoclusters using reversible disulfide linkages, which was facilitated by the unique capabilities of the nanocluster to mediate oxidation processes. The conventional Au25 synthesis using 1,6-hexanedithiol afforded a soluble oligodisulfide-appended [Au25(SR)18]- monomer possessing uncoordinated anionic thiolate sites at the terminal ends. Read More

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studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics.

Chem Commun (Camb) 2021 May 12. Epub 2021 May 12.

Department of Chemistry, University of Texas at Austin, 105 E 24th street A5300, Austin, TX 78712-1224, USA.

We report here strategic functionalization of the FDA approved chelator deferasirox (1) in an effort to produce organelle-targeting iron chelators with enhanced activity against A549 lung cancer cells. Derivative 8 was found to have improved antiproliferative activity relative to 1. Fluorescent cell imaging revealed that compound 8 preferentially localises within the lysosome. Read More

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The role of family confidants and caregivers in the care of older cancer patients: Extending the concept of "shared decision-making".

Health Sci Rep 2021 Jun 6;4(2):e281. Epub 2021 May 6.

Institute for Social Medicine and Epidemiology, University of Luebeck Luebeck Germany.

Background And Aims: Family caregivers play an important role in assisting their family members with cancer, but their influence on the treatment decision-making process has not yet been adequately investigated. This exploratory study approached this topic via reconstructive methodology, focusing on assessing patient-caregiver relationships.

Methods: We conducted semi-structured interviews with 37 mostly elderly cancer patients (median age: 74 years) about the context of their diagnosis, treatment decision, and family support. Read More

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Numerical simulation of spatiotemporal red blood cell aggregation under sinusoidal pulsatile flow.

Sci Rep 2021 May 11;11(1):9977. Epub 2021 May 11.

Department of Ocean System Engineering, Jeju National University, Jeju, Korea.

Previous studies on red blood cell (RBC) aggregation have elucidated the inverse relationship between shear rate and RBC aggregation under Poiseuille flow. However, the local parabolic rouleaux pattern in the arterial flow observed in ultrasonic imaging cannot be explained by shear rate alone. A quantitative approach is required to analyze the spatiotemporal variation in arterial pulsatile flow and the resulting RBC aggregation. Read More

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Radiomics-based neural network predicts recurrence patterns in glioblastoma using dynamic susceptibility contrast-enhanced MRI.

Sci Rep 2021 May 11;11(1):9974. Epub 2021 May 11.

Seoul National University College of Medicine, Seoul, Republic of Korea.

Glioblastoma remains the most devastating brain tumor despite optimal treatment, because of the high rate of recurrence. Distant recurrence has distinct genomic alterations compared to local recurrence, which requires different treatment planning both in clinical practice and trials. To date, perfusion-weighted MRI has revealed that perfusional characteristics of tumor are associated with prognosis. Read More

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First comprehensive quantification of annual land use/cover from 1990 to 2020 across mainland Vietnam.

Sci Rep 2021 May 11;11(1):9979. Epub 2021 May 11.

Faculty of Life and Environmental Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8572, Japan.

Extensive studies have highlighted a need for frequently consistent land cover information for interdisciplinary studies. This paper proposes a comprehensive framework for the automatic production of the first Vietnam-wide annual land use/land cover (LULC) data sets (VLUCDs) from 1990 to 2020, using available remotely sensed and inventory data. Classification accuracies ranged from 85. Read More

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Novel study on microbial fuel cells via a comprehensive bibliometric and dynamic approach.

Rev Environ Health 2021 May 11. Epub 2021 May 11.

Department of Environmental Engineering, University of Science and Technology Beijing, Beijing, China.

Microbial fuel cells (MFCs) are eco-friendly and useful bioelectrical devices that harness the natural metabolisms of microbes to produce electrical power directly from organic materials. In this study, a bibliometric analysis is conducted to evaluate MFC research from 2001 to 2018 on the basis of the Science Citation Index Expanded database. Overall, MFC research has experienced a dramatic increase over last 18 years, with an exponential growth in the accumulated number of publications. Read More

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On the estimate of music appraisal from surface EEG: a dynamic-network approach based on cross-sensor PAC measurements.

J Neural Eng 2021 May 11. Epub 2021 May 11.

Informatics, Aristotle University of Thessaloniki Faculty of Sciences, Aristotle University Campus: Biology building, Thessaloniki, 54124, GREECE.

Objective: The aesthetic evaluation of music is strongly dependent on the listener and reflects manifold brain processes that go well beyond the perception of incident sound. Being a high-level cognitive reaction, it is difficult to predict merely from the acoustic features of the audio signal and this poses serious challenges to contemporary music recommendation systems. We attempted to decode music appraisal from brain activity, recorded via wearable EEG, during music listening. Read More

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Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum.

Mol Biochem Parasitol 2021 May 8:111374. Epub 2021 May 8.

Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London, UK. Electronic address:

Recent studies highlight the emerging role of lipids as important messengers in malaria parasite biology. In an attempt to identify interacting proteins and regulators of these dynamic and versatile molecules, we hypothesised the involvement of phospholipid translocases and their substrates in the infection of the host erythrocyte by the malaria parasite Plasmodium spp. Here, using a data base searching approach of the Plasmodium Genomics Resources (www. Read More

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Affinity Series of Genetically Encoded Förster Resonance Energy-Transfer Sensors for Sucrose.

ACS Sens 2021 May 11. Epub 2021 May 11.

Institute for Molecular Physiology, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany.

Genetically encoded fluorescent sugar sensors are valuable tools for the discovery of transporters and for quantitative monitoring of sugar steady-state levels in intact tissues. Genetically encoded Förster resonance energy-transfer sensors for glucose have been designed and optimized extensively, and a full series of affinity mutants is available for in vivo studies. However, to date, only a single improved sucrose sensor FLIPsuc-90μΔ1 with for sucrose of ∼90 μM was available. Read More

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Mushrooms are potential foods against cancer: identified by molecular docking and molecular dynamics simulation.

Nat Prod Res 2021 May 11:1-6. Epub 2021 May 11.

BCDA College of Pharmacy & Technology, Jessore Road South, Hridaypur, Kolkata, West Bengal, India.

Epidermal Growth Factor Receptor (EGFR) is a promising drug target for the discovery of cancer chemotherapeutics. EGFR tyrosine kinase inhibitors become resistant due to mutation after a certain period of clinical application. The objective of the present study is to identify edible mushrooms as EGFR inhibitors. Read More

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Biogenic silver nanoparticles as an antibacterial agent against bacterial leaf blight causing rice phytopathogen Xanthomonas oryzae pv. oryzae.

Bioprocess Biosyst Eng 2021 May 11. Epub 2021 May 11.

Department of Plant Pathology, College of Agriculture, Professor Jayashankar Telangana State Agricultural University (PJTSAU), Rajendranagar, Hyderabad, 500030, India.

Silver nanoparticles (Ag NP) were produced utilizing leaf extract of rice cultivar Taichung native-1. Various factors like leaf extract, silver nitrate concentrations, and duration of autoclaving were standardized during synthesis. Nanoparticles were analyzed with UV-visible absorption spectroscopy (UV-vis), dynamic light scattering, zeta potential, X-ray diffraction and transmission electron microscopy techniques. Read More

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Funm6AViewer: a web server and R package for functional analysis of context-specific m6A RNA methylation.

Bioinformatics 2021 May 11. Epub 2021 May 11.

Department of Biological Sciences.

Motivation: N6-methyladenosine (m6A) is the most abundant mammalian mRNA methylation with versatile functions. To date, although a number of bioinformatics tools have been developed for location discovery of m6A modification, functional understanding is still quite limited. As the focus of RNA epigenetics gradually shifts from site discovery to functional studies, there is an urgent need for user-friendly tools to identify and explore the functional relevance of context-specific m6A methylation to gain insights into the epitranscriptome layer of gene expression regulation. Read More

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Photobiomodulation and Antiviral Photodynamic Therapy in COVID-19 Management.

Adv Exp Med Biol 2021 ;1318:517-547

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa.

Coronavirus disease 2019 (COVID-19) has shocked the world by its spread and contagiousness. There is no approved vaccine and no proven treatment for this infection. Some potential treatments that have already been associated with antiviral and anti-inflammatory effects are under investigation. Read More

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Perspective on computational reaction prediction using machine learning methods in heterogeneous catalysis.

Phys Chem Chem Phys 2021 May 11. Epub 2021 May 11.

Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Centre for Computational Chemistry and Research Institute of Industrial Catalysis, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, P. R. China. and School of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast BT9 5AG, UK.

Heterogeneous catalysis plays a significant role in the modern chemical industry. Towards the rational design of novel catalysts, understanding reactions over surfaces is the most essential aspect. Typical industrial catalytic processes such as syngas conversion and methane utilisation can generate a large reaction network comprising thousands of intermediates and reaction pairs. Read More

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Evaluation of grain boundaries as percolation pathways in quartz-rich continental crust using Atomic Force Microscopy.

Sci Rep 2021 May 10;11(1):9831. Epub 2021 May 10.

Department of Geology and Geophysics, IIT Kharagpur, Kharagpur, West Bengal, 721 302, India.

Hydrous fluids play a vital role in the chemical and rheological evolution of ductile, quartz-bearing continental crust, where fluid percolation pathways are controlled by grain boundary domains. In this study, widths of grain boundary domains in seven quartzite samples metamorphosed under varying crustal conditions were investigated using Atomic Force Microscopy (AFM) which allows comparatively easy, high magnification imaging and precise width measurements. It is observed that dynamic recrystallization at higher metamorphic grades is much more efficient at reducing grain boundary widths than at lower temperature conditions. Read More

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Mathematical model and characteristics analysis of crossed-axis helical gear drive with small angle based on curve contact element.

Sci Prog 2021 Apr-Jun;104(2):368504211016202

The State Key Laboratory of Mechanical Transmission, Chongqing University, Chongqing, China.

To improve load capacity and transmission characteristics of crossed-axis helical gear drive, a generation approach of the gear pair with small-angle based on the curve contact element is proposed. Contact principle based on spatial curve meshing relationships is introduced and geometric models of tooth profiles are developed according to a pair of mated conjugate curves. Furthermore, a mathematical model of crossed-axis helical gear drive with small-angle is established. Read More

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Classification of COVID-19 chest X-Ray and CT images using a type of dynamic CNN modification method.

Comput Biol Med 2021 Apr 29;134:104425. Epub 2021 Apr 29.

Department of Engineering, King's College London, Strand, London, WC2R 2LS, United Kingdom. Electronic address:

Understanding and classifying Chest X-Ray (CXR) and computerised tomography (CT) images are of great significance for COVID-19 diagnosis. The existing research on the classification for COVID-19 cases faces the challenges of data imbalance, insufficient generalisability, the lack of comparative study, etc. To address these problems, this paper proposes a type of modified MobileNet to classify COVID-19 CXR images and a modified ResNet architecture for CT image classification. Read More

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Predictors for inpatient mortality during the first wave of the SARS-CoV-2 pandemic: A retrospective analysis.

PLoS One 2021 10;16(5):e0251262. Epub 2021 May 10.

White Plains Hospital, White Plains, New York, United States of America.

Background: The coronavirus disease 2019 (COVID-19) pandemic overwhelmed healthcare systems, highlighting the need to better understand predictors of mortality and the impact of medical interventions.

Methods: This retrospective cohort study examined data from every patient who tested positive for COVID-19 and was admitted to White Plains Hospital between March 9, 2020, and June 3, 2020. We used binomial logistic regression to analyze data for all patients, and propensity score matching for those treated with hydroxychloroquine and convalescent plasma (CP). Read More

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Pupil size in the evaluation of static and dynamic stimuli in peripheral vision.

PLoS One 2021 10;16(5):e0250027. Epub 2021 May 10.

CRC Prominence in Language, University of Cologne, Cologne, Germany.

It has been evidenced that in attention-window tasks, the participants fixate on the center of a screen while inspecting two stimuli that appear at the same time in parafoveal vision. Such tasks have successfully been used to estimate a person's breadth of attention under various conditions. While behavioral investigations of visual attention have often made use of response accuracy, recent research has shown that the pupil size can also be used to track shifts of attention to the periphery. Read More

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The immune protection induced by a serine protease from the Trichinella spiralis adult against Trichinella spiralis infection in pigs.

PLoS Negl Trop Dis 2021 May 10;15(5):e0009408. Epub 2021 May 10.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.

Trichinellosis is a major foodborne parasitosis caused by Trichinella spiralis. In the present study, a serine protease gene from an adult T. spiralis (Ts-Adsp) cDNA library was cloned, expressed in Escherichia coli and purified by Ni-affinity chromatography. Read More

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Computational investigation of phytochemicals from (Indian ginseng/ashwagandha) as plausible inhibitors of GluN2B-containing NMDA receptors.

J Biomol Struct Dyn 2021 May 10:1-13. Epub 2021 May 10.

Division of Computer Aided Drug Design, Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.

-Methyl-d-aspartate receptor (NMDAR)-mediated excitotoxicity has been implicated in multi-neurodegenerative diseases. Owing to dearth of efficacy and adverse effects of NMDA receptor antagonists, search for herbal remedies acting like salutary agents is a dynamic expanse of investigation to contest neurodegenerative disease. () has been used since antiquity as a nerve tonic and nootropic agents in Ayurveda, an old Indian system of medicine. Read More

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Medicinal plant compounds as promising inhibitors of coronavirus (COVID-19) main protease: an study.

J Biomol Struct Dyn 2021 May 10:1-12. Epub 2021 May 10.

Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

The novel Coronavirus (COVID-19) has spread rapidly across the globe and has involved more than 215 countries and territories. Due to a lack of effective therapy or vaccine, urgent and concerted efforts are needed to identify therapeutic targets and medications. COVID-19 main protease represents a major target for drug treatment to inhibit viral function. Read More

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Identifying and elucidating the roles of Y198N and Y204F mutations in the PAH enzyme through molecular dynamic simulations.

J Biomol Struct Dyn 2021 May 10:1-12. Epub 2021 May 10.

Faculty of Arts and Sciences, Department of Molecular Biology and Genetics, Bogazici University, Istanbul, Turkey.

Phenylketonuria is an autosomal recessive disorder caused by mutations in the phenylalanine hydroxylase gene. In phenylketonuria causes various symptoms including severe mental retardation. PAH gene of a classical Phenylketonuria patient was sequenced, and two novel heterozygous mutations, p. Read More

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A higher flexibility at the SARS-CoV-2 main protease active site compared to SARS-CoV and its potentialities for new inhibitor virtual screening targeting multi-conformers.

J Biomol Struct Dyn 2021 May 10:1-21. Epub 2021 May 10.

Laboratory of Molecular Modeling and Bioinformatics, Department of Exact and Biological Sciences, Universidade Federal de São João Del Rei, Sete Lagoas, Brazil.

The main-protease (M) catalyzes a crucial step for the SARS-CoV-2 life cycle. The recent SARS-CoV-2 presents the main protease (M) with 12 mutations compared to SARS-CoV (M). Recent studies point out that these subtle differences lead to mobility variances at the active site loops with functional implications. Read More

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