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A new immunochemical strategy for triple-negative breast cancer therapy.

Sci Rep 2021 Jul 21;11(1):14875. Epub 2021 Jul 21.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA.

Triple-negative breast cancer (TNBC) is a highly diverse group of malignant neoplasms which tend to have poor outcomes, and the development of new targets and strategies to treat these cancers is sorely needed. Antibody-drug conjugate (ADC) therapy has been shown to be a promising targeted therapy for treating many cancers, but has only rarely been tried in patients with TNBC. A major reason the efficacy of ADC therapy in the setting of TNBC has not been more fully investigated is the lack of appropriate target molecules. Read More

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Learner Verification: A Methodology to Create Suitable Education Materials.

Health Lit Res Pract 2021 Jan 1;5(1):e49-e59. Epub 2021 Feb 1.

Background: Learner verification and revision (LV&R) is a research methodological approach to inform educational message design with the aim of producing suitable, actionable, and literacy appropriate messages to aid in awareness, adoption of healthy behaviors, and decision-making. It consists of a series of participatory steps that engage users throughout materials development, revision, and refinement. This approach is congruent with Healthy People 2030 communication objectives to improve access to information among diverse, multicultural, multilingual populations, and enhance health care quality toward health equity. Read More

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January 2021

Serous retinal detachment as a presenting sign of acute lymphoblastic leukemia: A case report and literature review.

Am J Ophthalmol Case Rep 2021 Sep 22;23:101142. Epub 2021 Jun 22.

Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Court, Palo Alto, CA, 94303, USA.

Purpose: To describe a unique case of unilateral serous retinal detachment as the presenting sign of B-cell acute lymphoblastic leukemia (ALL).

Observations: A 74 year old woman presented with right eye blurry vision and was found to have an underlying serous retinal detachment, along with cotton wool spots, inner retinal hemorrhages, and retinal pigment epithelial changes throughout her bilateral fundi. Fluorescein angiography demonstrated bilateral vasculitis and ultrasonography revealed asymmetric thickening and enhancement of the affected eyes' choroid. Read More

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September 2021

Index Finger Pollicization Incisions for Congenital Thumb Aplasia: Review and Design of an Educational Anatomical Model for Skin Incisions.

Plast Reconstr Surg 2021 Jun 21. Epub 2021 Jun 21.

From the Plastic Surgery and Burns Unit, Centre FX Michelet, Bordeaux University Hospital; Surgery School, University of Bordeaux; Service de Chirurgie Réparatrice et de la Main, Nice University Hospital; Laboratoire d'Anatomie Humaine, Faculté de Médecine de Nice; Département d'Anatomie, Faculté de médecine, Université de Lorraine; Paediatric Orthopaedic Surgery Department, Lorraine University Hospital Centre, Children's Hospital; and Department of Hand Surgery, Centre Chirurgical Emile Gallé, CHU de Nancy.

Background: Pollicization of the index finger can be considered the gold standard technique for the treatment of congenital thumb aplasia. The aim of this study was to review the described incisions for pollicization and to create an anatomical framework enabling the study and comparison of these incisions.

Methods: A systematic review was performed to collect descriptions of incision sets. Read More

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Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever.

Cell 2021 Jun 1;184(13):3486-3501.e21. Epub 2021 Jun 1.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

Crimean-Congo hemorrhagic fever virus (CCHFV) is a World Health Organization priority pathogen. CCHFV infections cause a highly lethal hemorrhagic fever for which specific treatments and vaccines are urgently needed. Here, we characterize the human immune response to natural CCHFV infection to identify potent neutralizing monoclonal antibodies (nAbs) targeting the viral glycoprotein. Read More

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Expanded natural killer cells augment the antimyeloma effect of daratumumab, bortezomib, and dexamethasone in a mouse model.

Cell Mol Immunol 2021 Jul 12;18(7):1652-1661. Epub 2021 May 12.

Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, Gwangju, Korea.

The use of natural killer (NK) cells is a promising and safe immunotherapeutic approach in the field of cancer immunotherapy. However, combination treatments are required to enhance the effector functions and therapeutic efficacy of NK cells. In this study, we investigated the potential of daratumumab (Dara), bortezomib, and dexamethasone (Dvd) to augment the antitumor effects of NK cells in a multiple myeloma (MM) xenograft mouse model. Read More

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Rapid development of neutralizing and diagnostic SARS-COV-2 mouse monoclonal antibodies.

Sci Rep 2021 05 6;11(1):9682. Epub 2021 May 6.

Immunodiagnostic Development Team/Reagent Diagnostic Services Branch (RDSB)/DSR/NCEZID/CDC, 1600 Clifton Rd NE., Atlanta, GA, 30333, USA.

The need for high-affinity, SARS-CoV-2-specific monoclonal antibodies (mAbs) is critical in the face of the global COVID-19 pandemic, as such reagents can have important diagnostic, research, and therapeutic applications. Of greatest interest is the ~ 300 amino acid receptor binding domain (RBD) within the S1 subunit of the spike protein because of its key interaction with the human angiotensin converting enzyme 2 (hACE2) receptor present on many cell types, especially lung epithelial cells. We report here the development and functional characterization of 29 nM-affinity mouse SARS-CoV-2 mAbs created by an accelerated immunization and hybridoma screening process. Read More

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Thickness, vessel density of retina and choroid on OCTA in young adults (18-24 years old).

Microvasc Res 2021 07 9;136:104169. Epub 2021 Apr 9.

Affiliated Eye Hospital of Shandong, University of Traditional Chinese Medicine, No. 48#, Yingxiongshan Road, Jinan 250002, PR China; Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases in Universities of Shandong, Eye Institute of Shandong University of Traditional Chinese Medicine, No. 48#, Yingxiongshan Road, Jinan 250002, PR China. Electronic address:

Purpose: The purpose of this study was to quantify thickness, vessel density (VD) of retina and choroid in young adults (18-24 years old) using OCTA.

Methods: This observational, cross-sectional study included 154 eyes from 77 young myopic adults. En-face angiogram OCTA was performed on a 3. Read More

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Development of a program to prevent sexual violence among teens in Japan: education using DVD video teaching materials and web-based learning.

Environ Health Prev Med 2021 Mar 26;26(1):41. Epub 2021 Mar 26.

Domestic Violence Countermeasures Prevention Center Kyushu, 2-5-15 Tojin, Saga City, Saga, 840-0813, Japan.

Background: This study aimed to develop an education system using DVD video-based teaching materials or web-based learning to reduce sexual violence among teens in Japan.

Methods: During the first stage, June 2018 to March 2019, an education program using DVD video teaching materials was carried out at three high schools and four universities with research consent from the director of the facility. From 1337 high school students and first- and second-year university students, subjects in their teen years were targeted for analysis. Read More

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Effects of unsupervised behavioral and pelvic floor muscle training programs on nocturia, urinary urgency, and urinary frequency in postmenopausal women: Secondary analysis of a randomized, two-arm, parallel design, superiority trial (TULIP study).

Maturitas 2021 Apr 4;146:42-48. Epub 2021 Feb 4.

Helen W. & Thomas L. Umphlet Distinguished Professor in Aging, University of North Carolina at Chapel Hill, School of Nursing, CB 7460, Chapel Hill, NC 27599-7460, United States. Electronic address:

Objective: To determine and compare the effects of an unsupervised behavioral and pelvic floor muscle training (B-PFMT) program delivered in two formats on nocturia, urinary urgency, and urinary frequency in postmenopausal women.

Study Design: A secondary analysis used data collected from women enrolled in the TULIP study. Women aged 55 years or more with no urinary incontinence were provided the B-PFMT program. Read More

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Daratumumab for the Management of Newly Diagnosed and Relapsed/Refractory Multiple Myeloma: Current and Emerging Treatments.

Front Oncol 2020 17;10:624661. Epub 2021 Feb 17.

Hematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Meldola, Italy.

Immunotherapy is changing the paradigm of multiple myeloma (MM) management and daratumumab is the first-in-class human monoclonal antibody targeting CD38 approved for the treatment of this malignancy. Daratumumab exerts anti-myeloma activity by different mechanisms of action as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement-dependent cytotoxicity (CDC), direct apoptosis, and immunomodulation. After GEN501 and SIRIUS trials showed efficacy of daratumumab monotherapy in heavily pretreated relapsed-refractory multiple myeloma (RRMM), in patients with at least two previous line of therapy, two phase III trials demonstrated superior overall response rate (ORR) and progression free survival (PFS) using triplets daratumumab-bortezomib-dexamethasone (DVd) Vd (CASTOR) or daratumumab-lenalidomide-dexamethasone (DRd) Rd (POLLUX) in relapsed-refractory MM patients; so these combinations have been approved and introduced in clinical practice. Read More

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February 2021

A Novel Anti-HER2 Bispecific Antibody With Potent Tumor Inhibitory Effects and .

Front Immunol 2020 17;11:600883. Epub 2021 Feb 17.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Overexpression of HER2 has been reported in many types of cancer, making it a perfect candidate for targeted immunotherapy. The combination of two FDA approved monoclonal antibodies (mAbs), trastuzumab and pertuzumab, has more robust anti-tumor activity in patients with HER2-overexpressing breast cancer. We recently produced a new humanized anti-HER2 mAb, hersintuzumab, which recognizes a different epitope than trastuzumab and pertuzumab on HER2. Read More

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[The efficacy and safety of daratumumab in relapsed and refractory multiple myeloma].

Zhonghua Xue Ye Xue Za Zhi 2021 Jan;42(1):27-32

Department of Hematology, Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China.

To investigate the efficacy and safety of daratumumab in relapsed and refractory multiple myeloma (RRMM) . The clinical characteristics, adverse reactions, efficacy, and prognosis of 46 patients with RRMM treated with daratumumab in Shanghai Changzheng Hospital from September 2017 to March 2020 were retrospectively analyzed. All patients were treated with daratumumab-based regimen: 8 in the Dd group, 35 in the DRd group, and 3 in the DVd group. Read More

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January 2021

Factors influencing allied health professionals' implementation of upper limb sensory rehabilitation for stroke survivors: a qualitative study to inform knowledge translation.

BMJ Open 2021 02 19;11(2):e042879. Epub 2021 Feb 19.

Department of Neuroscience, Central Clinical School, Monash University, Clayton, Victoria, Australia.

Objectives: Somatosensory loss is common after stroke with one-in-two individuals affected. Although clinical practice guidelines recommend providing somatosensory rehabilitation, this impairment often remains unassessed and untreated. To address the gap between guideline recommendations and clinical practice, this study sought to understand the factors influencing delivery of evidence-based upper limb sensory rehabilitation after stroke. Read More

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February 2021

Real-world effectiveness and safety of daratumumab, bortezomib and dexamethasone in relapsed/refractory multiple myeloma in Slovakia.

Neoplasma 2021 May 11;68(3):626-630. Epub 2021 Feb 11.

Clinic of Hematology and Blood Transfusion, University Hospital, Faculty of Medicine, Medical School Comenius University, Slovak Medical University, Bratislava, Slovakia.

Real-world data on regimens for relapsed/refractory multiple myeloma (RRMM) are limited. Daratumumab in combination with bortezomib and dexamethasone is a promising new treatment. The aim of this analysis was to assess the outcomes of daratumumab-bortezomib-dexamethasone (DVd) combination for the treatment of patients with RRMM in a real-world setting. Read More

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Telerehabilitation for Knee Osteoarthritis in Brazil: A Feasibility Study.

Int J Telerehabil 2020 Dec 8;12(2):137-148. Epub 2020 Dec 8.

La Trobe University - Rural Health School, Rural Department of Allied Health, Bendigo, Victoria, Australia.

Background: The effectiveness of telerehabilitation for a patient with knee osteoarthritis may depend upon the person's adherence to intervention. Thus, the aim of this study was to investigate whether people with knee osteoarthritis would adhere to exercise-therapy facilitated via multiple media in Brazil, a newly industrialized country.

Method: This is a feasibility study, pre-post intervention. Read More

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December 2020

Efficacy of education delivery through multimedia and text messaging on the psychological parameters of patients scheduled for coronary angiography: a single-blind randomized controlled clinical trial.

BMC Cardiovasc Disord 2021 01 4;21(1). Epub 2021 Jan 4.

Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Angiography is a highly effective invasive method for diagnosing coronary artery diseases but can lead to certain psychological problems such as stress, anxiety, and depression. This study aimed to compare the effects of education delivery through multimedia DVD content or text messaging in comparison with conventional printed pamphlets on the psychological parameters of patients scheduled for angiography.

Methods: This study was a randomized controlled clinical trial. Read More

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January 2021

Surgical outcomes and occurrence of associated vertical strabismus during a 10-year follow-up in patients with infantile esotropia.

Indian J Ophthalmol 2021 Jan;69(1):130-134

Nune Eye Hospital, Daegu, South Korea.

Purpose: Authors analyzed long-term surgical outcomes of infantile esotropia and the occurrence of associated strabismus, inferior oblique overaction (IOOA), and dissociated vertical deviation (DVD). Clinical factors related to the occurrence of IOOA and DVD in patients with infantile esotropia were also evaluated.

Methods: Medical records of patients with infantile esotropia, who underwent surgery between 1995 and 2008, were reviewed retrospectively. Read More

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January 2021

Bilateral hypotropic dissociated vertical deviation: a case report.

J Med Case Rep 2020 Dec 10;14(1):241. Epub 2020 Dec 10.

Department of Ophthalmology, Faculty of Medicine, Damascus University, Damascus, Syria.

Background: Hypotropic dissociated vertical deviation (DVD) is a special form of strabismus characterized by a slow drift of the non-fixating eye when the other eye is fixating on a target. In contrast to hypertropic DVD, which is common, hypotropic DVD is exceedingly rare and seldom reported in previous literature. In this case, we report the clinical features of a rare case of a Syrian child with bilateral hypotropic DVD accompanied by manifest latent nystagmus and intermittent exotropia. Read More

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December 2020

Digital Interventions for Autism Spectrum Disorder: A Meta-analysis.

J Autism Dev Disord 2020 Nov 10. Epub 2020 Nov 10.

Department of Child and Adolescent Mental Health Odense, Research Unit (University Function), Mental Health Services in the Region of Southern Denmark, J. B. Winsløws Vej 16, entrance 230, 5000, Odense C, Denmark.

This study aimed to review digital interventions in the treatment of autism spectrum disorder (ASD). A systematic review and meta-analysis was conducted. Nineteen studies were included. Read More

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November 2020

A multicenter review of infusion-related reactions to daratumumab for relapsed multiple myeloma in the real world setting.

J Oncol Pharm Pract 2021 Jun 27;27(4):907-910. Epub 2020 Oct 27.

Section of Hematology/Oncology, Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Background: Daratumumab is used in the treatment of relapsed multiple myeloma. Daratumumab infusion-related reactions can occur with the highest incidence on the first infusion.

Methods: A retrospective review of all daratumumab infusions used as part of the DVd and DRd regimens for relapsed multiple myeloma was undertaken. Read More

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The Tie2 signaling pathway in retinal vascular diseases: a novel therapeutic target in the eye.

Int J Retina Vitreous 2020 13;6:48. Epub 2020 Oct 13.

AsclepiX Therapeutics, Baltimore, MD USA.

Background: Retinal vascular diseases such as neovascular age-related macular degeneration, diabetic retinopathy and/or diabetic macular edema, and retinal vein occlusion with macular edema-share several key pathophysiologic aspects including neovascularization, vascular permeability, and inflammation. The role of vascular endothelial growth factor (VEGF) in these processes, and the therapeutic benefits of VEGF inhibition, have been well characterized. Anti-VEGF therapy is highly effective for many patients but is not uniformly effective in all patients and imposes a significant treatment burden. Read More

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October 2020

Posterior segment inflammatory outcomes assessed using fluorescein angiography in the STOP-UVEITIS study.

Int J Retina Vitreous 2020 6;6:47. Epub 2020 Oct 6.

Spencer Center for Vision Research, Byers Eye Institute, Stanford University, 2370 Watson Court, Suite 200, Palo Alto, CA 94303 USA.

Background: Although fluorescein angiography (FA) is a frequently used imaging modality in patients with non-infectious uveitis (NIU), it has not been reliably used for objective assessment of posterior segment inflammatory outcomes in these patients. In this index study we report the posterior segment inflammatory outcomes of two different doses of intravenous (IV) infusions of tocilizumab (TCZ), an IL-6 inhibitor, in eyes with NIU using a semi-quantitative FA scoring system.

Methods: STOP-Uveitis is a randomized, multi-center clinical trial conducted at 5 clinical centers across the United States. Read More

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October 2020

Effect of rectus sheath block vs. spinal anaesthesia on time-to-readiness for hospital discharge after trans-peritoneal hand-assisted laparoscopic live donor nephrectomy: A randomised trial.

Eur J Anaesthesiol 2021 04;38(4):374-382

From the Department of Anaesthesia, Manchester Royal Infirmary (KB, RW, WM, CJ), Department of Anaesthesia and Intensive Care, Wythenshawe Hospital (MC) and Department of Transplant Surgery, Manchester Royal Infirmary, Manchester University Hospital NHS Foundation Trust, Manchester, UK (TC, DVD).

Background: The role of spinal anaesthesia in patients having a transperitoneal hand-assisted laparoscopic donor nephrectomy in an enhanced recovery setting has never been investigated.

Objective: We explored whether substituting a rectus sheath block (RSB) with spinal anaesthesia, as an adjunct to a general anaesthetic technique, influenced time-to-readiness for discharge in patients undergoing hand-assisted laparoscopic donor nephrectomy.

Design: Prospective randomised open blinded end-point (PROBE) study with two parallel groups. Read More

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The effectiveness of a preoperative multi-component non-pharmacologic preparation on post-tonsillectomy pain: A randomized controlled clinical trial.

Int J Pediatr Otorhinolaryngol 2020 Nov 1;138:110359. Epub 2020 Sep 1.

Otolaryngology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Introduction: Tonsillectomy is a painful operation and some studies have suggested that preoperative non-pharmacologic preparations may decrease postoperative pain. In this randomized clinical trial study, we decided to determine which is more effective in the post-tonsillectomy pain; an informative booklet or a costly, time consuming, sophisticated, and multi-component preparation program.

Materials And Methods: Patients were randomly assigned into two groups. Read More

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November 2020

Comprehensive comparative study of eco-friendly Univariate and multivariate methodological approaches on processing multi-component formulation quality.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Dec 11;243:118816. Epub 2020 Aug 11.

Analytical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th October City, Egypt. Electronic address:

This study presents comprehensive comparative study of different eco-friendly spectrophotometric approaches without any sample treatment on processing quaternary mixture of sulphadimidine sodium (SDS), sulphaquinoxaline sodium (SQS), diaveridine (DVD) and vitamin K (VTK). The different univariate complementary resolutions according to the response used for the assay of the cited drugs after applying the processing steps were implemented using successive ratio subtraction coupled with constant multiplication (SRS-CM), absorbance subtraction (AS) and amplitude modulation (AM). On the other hand, multivariate spectrophotometric models were developed and validated for simultaneous determination of the cited mixture. Read More

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December 2020

Antagonism of proNGF or its receptor p75 reverses remodelling and improves bladder function in a mouse model of diabetic voiding dysfunction.

Diabetologia 2020 09 22;63(9):1932-1946. Epub 2020 Jul 22.

Lady Davis Research Institute, McGill University, 3755 Chemin de la Cote-Ste-Catherine, Montreal, QC, H3T 1E2, Canada.

Aims/hypothesis: Although 80% of diabetic patients will suffer from voiding difficulties and urinary symptoms, defined as diabetic voiding dysfunction (DVD), therapeutic targets and treatment options are limited. We hypothesise that the blockade of the pro-nerve growth factor (NGF)/p75 neurotrophin receptor (p75) axis by an anti-proNGF monoclonal antibody or by a small molecule p75 antagonist (THX-B) can restore bladder remodelling (represented by bladder weight) in an animal model of DVD. Secondary outcomes of the study include improvements in bladder compliance, contractility and morphology, as well as in voiding behaviour, proNGF/NGF balance and TNF-α expression. Read More

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September 2020

Pharmacological agents in development for diabetic macular edema.

Int J Retina Vitreous 2020 8;6:29. Epub 2020 Jul 8.

Byers Eye Institute, Stanford University, Palo Alto, CA 94303 USA.

Background: Diabetic macular edema (DME) is the leading cause of visual loss in patients with diabetic retinopathy. There has been a paradigm shift in the treatment of DME since the advent of anti-vascular endothelial growth factor (anti-VEGF) therapy. The safety and efficacy of anti-VEGF therapy has been well established. Read More

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mHealth education interventions in heart failure.

Cochrane Database Syst Rev 2020 07 2;7:CD011845. Epub 2020 Jul 2.

IMPACCT, Faculty of Health, University of Technology Sydney, Sydney, Australia.

Background: Heart failure (HF) is a chronic disease with significant impact on quality of life and presents many challenges to those diagnosed with the condition, due to a seemingly complex daily regimen of self-care which includes medications, monitoring of weight and symptoms, identification of signs of deterioration and follow-up and interaction with multiple healthcare services. Education is vital for understanding the importance of this regimen, and adhering to it. Traditionally, education has been provided to people with heart failure in a face-to-face manner, either in a community or a hospital setting, using paper-based materials or video/DVD presentations. Read More

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Ready when you are: Answering your questions about psychotherapy.

J Clin Psychol 2020 08 19;76(8):1438-1446. Epub 2020 Jun 19.

Program in Clinical Psychology, Teachers College, Columbia University, New York, New York, USA.

Psychotherapeutic treatment tends to have a high attrition rate ("premature termination") and there have been multiple efforts to help new patients, including those considering treatment, better understand the nature and expectations inherent to this process as a means to improve retention and outcome. These efforts are often grouped under the term "role induction." This script, from a DVD produced in 2010, was written to help prepare new psychotherapy clients for this new role in their lives-specifically, to educate prospective patients about the unique and sometimes surprising features of psychotherapy and to empower them to ask questions of their therapist about the process. Read More

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