1,641 results match your criteria dvd dvd

A new immunochemical strategy for triple-negative breast cancer therapy.

Sci Rep 2021 Jul 21;11(1):14875. Epub 2021 Jul 21.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA.

Triple-negative breast cancer (TNBC) is a highly diverse group of malignant neoplasms which tend to have poor outcomes, and the development of new targets and strategies to treat these cancers is sorely needed. Antibody-drug conjugate (ADC) therapy has been shown to be a promising targeted therapy for treating many cancers, but has only rarely been tried in patients with TNBC. A major reason the efficacy of ADC therapy in the setting of TNBC has not been more fully investigated is the lack of appropriate target molecules. Read More

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Congenital ocular counter-roll: a review of cases treated exclusively by ophthalmologists.

Int J Ophthalmol 2021 18;14(7):1073-1080. Epub 2021 Jul 18.

The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China.

Aim: To review the demographics, clinical manifestations, and surgical experiences of patients with congenital ocular counter-roll, whose treatments were performed exclusively by ophthalmologists.

Methods: A retrospective review was conducted consisting of patients who received strabismus surgery between 2017 to 2019. Patients with obvious ocular counter-roll were included. Read More

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The Associations Between Media Use, Midpoint of Sleep, and Sleep Quality in German Preschoolers: A Mediation Analysis Based on the Ulm SPATZ Health Study.

Nat Sci Sleep 2021 5;13:1025-1035. Epub 2021 Jul 5.

Pediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, Leipzig, Germany.

Introduction: The relation of electronic media use with sleep quality among preschoolers is a matter of ongoing debate. Longitudinal data are scarce and do not account for sleeping schedules.

Methods: We used the German Children's Sleep Habits Questionnaire to measure parent-reported child's sleep quality; its score is computed by the sum of 34 items defined by a 1-3 level Likert scale (score ranging 34-102), with higher values representing lower sleep quality. Read More

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Learner Verification: A Methodology to Create Suitable Education Materials.

Health Lit Res Pract 2021 Jan 1;5(1):e49-e59. Epub 2021 Feb 1.

Background: Learner verification and revision (LV&R) is a research methodological approach to inform educational message design with the aim of producing suitable, actionable, and literacy appropriate messages to aid in awareness, adoption of healthy behaviors, and decision-making. It consists of a series of participatory steps that engage users throughout materials development, revision, and refinement. This approach is congruent with Healthy People 2030 communication objectives to improve access to information among diverse, multicultural, multilingual populations, and enhance health care quality toward health equity. Read More

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January 2021

Serous retinal detachment as a presenting sign of acute lymphoblastic leukemia: A case report and literature review.

Am J Ophthalmol Case Rep 2021 Sep 22;23:101142. Epub 2021 Jun 22.

Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Court, Palo Alto, CA, 94303, USA.

Purpose: To describe a unique case of unilateral serous retinal detachment as the presenting sign of B-cell acute lymphoblastic leukemia (ALL).

Observations: A 74 year old woman presented with right eye blurry vision and was found to have an underlying serous retinal detachment, along with cotton wool spots, inner retinal hemorrhages, and retinal pigment epithelial changes throughout her bilateral fundi. Fluorescein angiography demonstrated bilateral vasculitis and ultrasonography revealed asymmetric thickening and enhancement of the affected eyes' choroid. Read More

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September 2021

Associations between daily screen time and sleep in a racially and socioeconomically diverse sample of US infants: a prospective cohort study.

BMJ Open 2021 06 24;11(6):e044525. Epub 2021 Jun 24.

Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Objective: To determine the associations between screen media use and sleep throughout infancy (3-12 months).

Design: Prospective Nurture birth cohort.

Setting: North Carolina, USA, 2013-2015. Read More

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Index Finger Pollicization Incisions for Congenital Thumb Aplasia: Review and Design of an Educational Anatomical Model for Skin Incisions.

Plast Reconstr Surg 2021 Jun 21. Epub 2021 Jun 21.

From the Plastic Surgery and Burns Unit, Centre FX Michelet, Bordeaux University Hospital; Surgery School, University of Bordeaux; Service de Chirurgie Réparatrice et de la Main, Nice University Hospital; Laboratoire d'Anatomie Humaine, Faculté de Médecine de Nice; Département d'Anatomie, Faculté de médecine, Université de Lorraine; Paediatric Orthopaedic Surgery Department, Lorraine University Hospital Centre, Children's Hospital; and Department of Hand Surgery, Centre Chirurgical Emile Gallé, CHU de Nancy.

Background: Pollicization of the index finger can be considered the gold standard technique for the treatment of congenital thumb aplasia. The aim of this study was to review the described incisions for pollicization and to create an anatomical framework enabling the study and comparison of these incisions.

Methods: A systematic review was performed to collect descriptions of incision sets. Read More

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Implementation of iPads to Increase Compliance With Delivery of New Parent Education in the Mother-Baby Unit: Retrospective Study.

JMIR Pediatr Parent 2021 Jun 15;4(2):e18830. Epub 2021 Jun 15.

University of South Carolina School of Medicine Greenville, Greenville, SC, United States.

Background: Abusive head trauma (AHT) is a serious health problem affecting more than 3000 infants annually in the United States. The American Academy of Pediatrics and the Centers for Disease Control and Prevention (CDC) recommend that health care providers counsel new parents about the dangers of AHT. Previous studies demonstrate that parental education is effective at reducing AHT events. Read More

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Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever.

Cell 2021 Jun 1;184(13):3486-3501.e21. Epub 2021 Jun 1.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

Crimean-Congo hemorrhagic fever virus (CCHFV) is a World Health Organization priority pathogen. CCHFV infections cause a highly lethal hemorrhagic fever for which specific treatments and vaccines are urgently needed. Here, we characterize the human immune response to natural CCHFV infection to identify potent neutralizing monoclonal antibodies (nAbs) targeting the viral glycoprotein. Read More

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Is Potimirim potimirim (Crustacea, Decapoda, Atyidae) a protandric hermaphrodite species? Behavioral and morphological aspects of the reproductive system.

Arthropod Struct Dev 2021 Jul 25;63:101060. Epub 2021 May 25.

Group of Studies on Crustacean Biology, Ecology and Culture (NEBECC), University of the State of São Paulo (UNESP), Institute of Biosciences, Campus of Botucatu, Zoology Sector, 18618-970, Botucatu, State of São Paulo, Brazil.

We evaluated the mating behavior of Potimirim potimirim in the laboratory based on the assumption that this caridean might be hermaphroditic. We also performed histology and scanning electron microscopy analyses of the reproductive system of females, males, and differentiated individuals. The mating experiments produced three behavioral stages, namely, interaction, lateral positioning, and copulation (which did not necessarily occur in this sequence). Read More

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Expanded natural killer cells augment the antimyeloma effect of daratumumab, bortezomib, and dexamethasone in a mouse model.

Cell Mol Immunol 2021 Jul 12;18(7):1652-1661. Epub 2021 May 12.

Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, Gwangju, Korea.

The use of natural killer (NK) cells is a promising and safe immunotherapeutic approach in the field of cancer immunotherapy. However, combination treatments are required to enhance the effector functions and therapeutic efficacy of NK cells. In this study, we investigated the potential of daratumumab (Dara), bortezomib, and dexamethasone (Dvd) to augment the antitumor effects of NK cells in a multiple myeloma (MM) xenograft mouse model. Read More

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Rapid development of neutralizing and diagnostic SARS-COV-2 mouse monoclonal antibodies.

Sci Rep 2021 05 6;11(1):9682. Epub 2021 May 6.

Immunodiagnostic Development Team/Reagent Diagnostic Services Branch (RDSB)/DSR/NCEZID/CDC, 1600 Clifton Rd NE., Atlanta, GA, 30333, USA.

The need for high-affinity, SARS-CoV-2-specific monoclonal antibodies (mAbs) is critical in the face of the global COVID-19 pandemic, as such reagents can have important diagnostic, research, and therapeutic applications. Of greatest interest is the ~ 300 amino acid receptor binding domain (RBD) within the S1 subunit of the spike protein because of its key interaction with the human angiotensin converting enzyme 2 (hACE2) receptor present on many cell types, especially lung epithelial cells. We report here the development and functional characterization of 29 nM-affinity mouse SARS-CoV-2 mAbs created by an accelerated immunization and hybridoma screening process. Read More

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[From learning reflective awareness to using screens].

Soins Pediatr Pueric 2021 Mar-Apr;42(319):42-46. Epub 2021 Jan 26.

Institut de formation des infirmiers puériculteurs Houphouët-Boigny, 416 chemin de la Madrague-Ville, 13015 Marseille, France.

The emergence of new technologies in our rapidly changing society has significantly changed the way people live. Children of all ages are surrounded daily by a multitude of screens, such as television, computers, video games, smartphones and digital tablets. In the face of this influx, the aim is to bring children to adopt a reflective consciousness, teaching them to question and relate to reality what they see when they watch a DVD or a programme broadcast on television. Read More

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Effects of upper limb exercise programs on the arteriovenous fistula in patients on hemodialysis: A systematic review and meta-analysis.

J Vasc Access 2021 Apr 27:11297298211001166. Epub 2021 Apr 27.

Programa de Pós Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Background: The arteriovenous fistula (AVF) is a commonly used vascular access for chronic kidney disease (CKD) patients; exercise interventions may boost its maturation and help in its maintenance. A systematic review and meta-analysis of clinical trials on the effects of upper limb exercise programs on the AVF was conducted.

Methods: The primary outcomes were draining vein diameter (DVD) and draining vein blood flow rate (DVBFR), and secondary outcomes were handgrip strength (HGS) and brachial artery flow rate (BAFR). Read More

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Urban mining of obsolete computers by manual dismantling and waste printed circuit boards by chemical leaching and toxicity assessment of its waste residues.

Environ Pollut 2021 Aug 30;283:117033. Epub 2021 Mar 30.

Department of Chemical and Environmental Engineering, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga-43500 Semenyih, Selangor Darul Ehsan, Malaysia.

Waste residues and acidic effluents (post-processing of E-waste) released into the local surroundings cause perilous environmental threats and potential risks to human health. Only limited research and information are available toward the sustainable management of waste residues generated post resource recovery of E-waste components. In the present study, the manual processing of obsolete computer (keyboard, monitor, CPU, and mouse) and chemical leaching of waste printed circuit boards (WPCBs) (motherboard, hard drive, DVD drive, and power supply) were performed for urban mining. Read More

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Home-based Pilates for symptoms of anxiety, depression and fatigue among persons with multiple sclerosis: An 8-week randomized controlled trial.

Mult Scler 2021 Apr 19:13524585211009216. Epub 2021 Apr 19.

Physical Activity for Health Research Cluster, Health Research Institute, University of Limerick, Limerick, Ireland/Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland.

Background: Symptoms of anxiety, depression and fatigue are common comorbidities among persons with multiple sclerosis (PwMS). A previous pilot study supported Pilates as a feasible exercise modality that may improve these outcomes among PwMS.

Objective: To quantify the effects of 8 weeks of home-based Pilates on symptoms of anxiety, depression and fatigue among PwMS. Read More

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Relationship Between High Glycated Hemoglobin and Severity of Coronary Artery Disease in Type II Diabetic Patients Hospitalized With Acute Coronary Syndrome.

Cureus 2021 Mar 6;13(3):e13734. Epub 2021 Mar 6.

Cardiology, Lady Reading Hospital, Peshawar, PAK.

Introduction Diabetes mellitus (DM) is a chronic metabolic disease. It is the principal cause behind the high morbidity and mortality attributed to cardiovascular disease. This article's objective was to determine a connection between high glycated haemoglobin levels (HbA1c) and coronary artery disease (CAD). Read More

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Thickness, vessel density of retina and choroid on OCTA in young adults (18-24 years old).

Microvasc Res 2021 Jul 9;136:104169. Epub 2021 Apr 9.

Affiliated Eye Hospital of Shandong, University of Traditional Chinese Medicine, No. 48#, Yingxiongshan Road, Jinan 250002, PR China; Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases in Universities of Shandong, Eye Institute of Shandong University of Traditional Chinese Medicine, No. 48#, Yingxiongshan Road, Jinan 250002, PR China. Electronic address:

Purpose: The purpose of this study was to quantify thickness, vessel density (VD) of retina and choroid in young adults (18-24 years old) using OCTA.

Methods: This observational, cross-sectional study included 154 eyes from 77 young myopic adults. En-face angiogram OCTA was performed on a 3. Read More

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Does the extent of collaterals influence the severity of the myocardial injury as assessed by elevation in biomarkers?

J Cardiovasc Thorac Res 2021 28;13(1):49-53. Epub 2021 Jan 28.

Department of Cardiology, U.N.Mehta Institute of Cardiology and Research Centre (UNMICRC), Civil Hospital Campus, Asarwa, Ahmedabad-380016, Gujarat, India.

Quantitative analysis of cardiac biomarkers, troponin I and CPK-MB, estimates the extent of myocardial injury while extent of benefit from coronary collateral circulation (CCC) to protect myocardium during acute myocardial infarction (AMI) needs validation. We analysed if the extent of collaterals had impact on baseline biomarkers at the time of coronary angiogram. We analysed 3616 consecutive patients who presented with AMI and underwent invasive coronary angiography (CAG) with intent to revascularisation with biomarkers assessment at the time of CAG. Read More

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January 2021

A rapid sap-direct reverse transcription-polymerase chain reaction method for detection of dendrobium viroid in Dendrobium plants.

Lett Appl Microbiol 2021 Jul 19;73(1):26-30. Epub 2021 May 19.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.

Dendrobium viroid (DVd) was first reported in China in 2020, and it is the only viroid known to infect Orchidaceae family plants. In this study, we developed a simple reverse transcription-polymerase chain reaction (RT-PCR) method for the rapid detection of DVd in Dendrobium plants. When extracting the sap template from the leaves, they are first clamped between two layers of plastic film, and the sap is pressed out and collected with a pipette. Read More

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Expression pattern of mitogen-activated protein kinase kinase 4 and regulation to antibacterial factor ABF-1/2 in response to bacterial challenge from Artemia parthenogenetica.

Fish Shellfish Immunol 2021 Aug 27;115:35-42. Epub 2021 Mar 27.

The International Centre for Precision Environmental Health and Governance, College of Life Sciences, Hebei University, 071002, Baoding, PR China. Electronic address:

Mitogen-activated protein kinase 4, MKK4, is a key upstream kinase in the JNK/p38 MAPK pathway that has been reported to participate in multiple immune responses. In this study, the gene that encodes ApMKK4 was isolated and identified from Artemia parthenogenetica. It was found to contain a 1134 bp open reading frame encoding 378 amino acids. Read More

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Development of a program to prevent sexual violence among teens in Japan: education using DVD video teaching materials and web-based learning.

Environ Health Prev Med 2021 Mar 26;26(1):41. Epub 2021 Mar 26.

Domestic Violence Countermeasures Prevention Center Kyushu, 2-5-15 Tojin, Saga City, Saga, 840-0813, Japan.

Background: This study aimed to develop an education system using DVD video-based teaching materials or web-based learning to reduce sexual violence among teens in Japan.

Methods: During the first stage, June 2018 to March 2019, an education program using DVD video teaching materials was carried out at three high schools and four universities with research consent from the director of the facility. From 1337 high school students and first- and second-year university students, subjects in their teen years were targeted for analysis. Read More

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Association of mentally-passive and mentally-active sedentary behaviors with device-measured bouts and breaks of sedentary time in adolescents.

Health Promot Perspect 2021 7;11(1):109-114. Epub 2021 Feb 7.

Physical Activity and Health Laboratory, Department of Physical Education, Universidade Estadual de Londrina, Londrina, Brazil.

Our aim was to analyze the association of self-reported mentally-passive and mentally-active sedentary behaviors with different patterns (bouts and breaks) of device-measured sedentary time in adolescents. This was a cross-sectional study conducted among 375 adolescents (177 boys) aged 1015 years. Total time, bouts and breaks of sedentary time were measured through accelerometers. Read More

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February 2021

Effects of unsupervised behavioral and pelvic floor muscle training programs on nocturia, urinary urgency, and urinary frequency in postmenopausal women: Secondary analysis of a randomized, two-arm, parallel design, superiority trial (TULIP study).

Maturitas 2021 Apr 4;146:42-48. Epub 2021 Feb 4.

Helen W. & Thomas L. Umphlet Distinguished Professor in Aging, University of North Carolina at Chapel Hill, School of Nursing, CB 7460, Chapel Hill, NC 27599-7460, United States. Electronic address:

Objective: To determine and compare the effects of an unsupervised behavioral and pelvic floor muscle training (B-PFMT) program delivered in two formats on nocturia, urinary urgency, and urinary frequency in postmenopausal women.

Study Design: A secondary analysis used data collected from women enrolled in the TULIP study. Women aged 55 years or more with no urinary incontinence were provided the B-PFMT program. Read More

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Retinal Microcirculation Alterations in Microalbuminuric Diabetic Patients With and Without Retinopathy.

Semin Ophthalmol 2021 Mar 10:1-7. Epub 2021 Mar 10.

Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.

: To investigate the effect of microalbuminuria (MA) on superficial vessel density (SVD), deep vessel density (DVD), and choriocapillaris vessel density (CVD) in type-2 diabetic patients.: Twenty patients without diabetic retinopathy (DR) and MA (group 1), 20 patients without DR but with MA (group 2) and 30 patients with mild DR and MA (group 3) were enrolled in this prospective and cross-sectional study. SVD, DVD, and CVD of all patients were screened with optical coherence tomography angiography (OCTA). Read More

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Daratumumab for the Management of Newly Diagnosed and Relapsed/Refractory Multiple Myeloma: Current and Emerging Treatments.

Front Oncol 2020 17;10:624661. Epub 2021 Feb 17.

Hematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Meldola, Italy.

Immunotherapy is changing the paradigm of multiple myeloma (MM) management and daratumumab is the first-in-class human monoclonal antibody targeting CD38 approved for the treatment of this malignancy. Daratumumab exerts anti-myeloma activity by different mechanisms of action as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement-dependent cytotoxicity (CDC), direct apoptosis, and immunomodulation. After GEN501 and SIRIUS trials showed efficacy of daratumumab monotherapy in heavily pretreated relapsed-refractory multiple myeloma (RRMM), in patients with at least two previous line of therapy, two phase III trials demonstrated superior overall response rate (ORR) and progression free survival (PFS) using triplets daratumumab-bortezomib-dexamethasone (DVd) Vd (CASTOR) or daratumumab-lenalidomide-dexamethasone (DRd) Rd (POLLUX) in relapsed-refractory MM patients; so these combinations have been approved and introduced in clinical practice. Read More

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February 2021

A Novel Anti-HER2 Bispecific Antibody With Potent Tumor Inhibitory Effects and .

Front Immunol 2020 17;11:600883. Epub 2021 Feb 17.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Overexpression of HER2 has been reported in many types of cancer, making it a perfect candidate for targeted immunotherapy. The combination of two FDA approved monoclonal antibodies (mAbs), trastuzumab and pertuzumab, has more robust anti-tumor activity in patients with HER2-overexpressing breast cancer. We recently produced a new humanized anti-HER2 mAb, hersintuzumab, which recognizes a different epitope than trastuzumab and pertuzumab on HER2. Read More

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[The efficacy and safety of daratumumab in relapsed and refractory multiple myeloma].

Zhonghua Xue Ye Xue Za Zhi 2021 Jan;42(1):27-32

Department of Hematology, Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China.

To investigate the efficacy and safety of daratumumab in relapsed and refractory multiple myeloma (RRMM) . The clinical characteristics, adverse reactions, efficacy, and prognosis of 46 patients with RRMM treated with daratumumab in Shanghai Changzheng Hospital from September 2017 to March 2020 were retrospectively analyzed. All patients were treated with daratumumab-based regimen: 8 in the Dd group, 35 in the DRd group, and 3 in the DVd group. Read More

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January 2021

Colorful Efficient Moiré-Perovskite Solar Cells.

Adv Mater 2021 Apr 6;33(15):e2008091. Epub 2021 Mar 6.

Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

Light harvesting is crucial for thin-film solar cells. To substantially reduce optical loss in perovskite solar cells (PSCs), hierarchical light-trapping nano-architectures enable absorption enhancement to exceed the conventional upper limit and have great potential for achieving state-of-the art optoelectronic performances. However, it remains a great challenge to design and fabricate a superior hierarchical light-trapping nano-architecture, which exhibits extraordinary light-harvesting ability and simultaneously avoids deteriorating the electrical performance of PSCs. Read More

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Changes in the cortisol and oxytocin levels of first-time pregnant women during interaction with an infant: a randomized controlled trial.

BMC Pregnancy Childbirth 2021 Feb 24;21(1):162. Epub 2021 Feb 24.

Graduate School of Nursing Science, St. Luke's International University, 10-1 Akashi-cho, Chuo-ku, Tokyo, 104-0044, Japan.

Background: During pregnancy, physiological, psychological, and social changes affect pregnant women's childcare anxiety and childrearing behavior. However, there are scarce reports on hormonal evaluation related to such anxiety and behavior. Herein, we evaluated changes in salivary cortisol (primary outcome) and oxytocin (secondary outcome) levels of first-time pregnant women when interacting with an infant and discussed the relation of these changes to the women's stress level. Read More

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February 2021