1,801 results match your criteria durations oral

Early combined rehabilitation intervention to improve the short-term prognosis of premature infants.

BMC Pediatr 2021 Jun 9;21(1):269. Epub 2021 Jun 9.

Department of Neonatology, Sichuan Provincial Maternity and Child Health Care Hospital, No. 290 West Second Street, Shayan Road, Chengdu, 610031, Sichuan, China.

Background: To explore the clinical effect of early combined rehabilitation intervention on premature infants in the neonatal intensive care unit (NICU).

Methods: Premature infants with gestational ages less than 32 weeks or birth weights less than 1500 g were included in the present study.The participants were divided into the intervention group and control group. Read More

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Pain management at iliac donor sites after grafting of alveolar clefts.

Int J Oral Maxillofac Surg 2021 Jun 2. Epub 2021 Jun 2.

Cleft & Craniofacial Team, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Belgium.

The aim of this study was to answer the question: which analgesic protocol is most efficient and most effective in overcoming pain and promoting functional recovery after iliac bone grafting in cleft alveolus patients? A systematic review of the literature was performed. The population consisted of cleft lip and alveolus patients with or without cleft palate undergoing iliac crest bone grafting; the outcomes analysed were represented by the duration of hospital stay, subjective pain rating, and degree of impaired mobility. A total of 15 articles were selected for review. Read More

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Positive Human Contact and Housing Systems Impact the Responses of Piglets to Various Stressors.

Animals (Basel) 2021 May 30;11(6). Epub 2021 May 30.

The Animal Welfare Science Centre, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.

This experiment studied the effects of lactation housing systems and human interaction on piglets' responses to routine stressors. Forty litters of piglets were reared in either a standard farrowing crate (FC) or a loose farrowing and lactation pen (LP; PigSAFE pen) and received either routine contact with humans (C) or regular opportunities for positive human contact (+HC; 3 min of patting, stroking and scratching 5 times/week). Behavioural and physiological responses to routine husbandry procedures, weaning, novelty and humans were studied in addition to effects on piglet growth, injuries and survival. Read More

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L. Leaf: A Systematic Scoping Review on Biological Safety and Herb-Drug Interactions.

Evid Based Complement Alternat Med 2021 7;2021:5511221. Epub 2021 May 7.

Herbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam 40170, Shah Alam, Malaysia.

Introduction: The L. leaf is gaining interest as a potential therapeutic agent for alleviating dengue- and non-dengue-associated thrombocytopaenia. In that regard, safety considerations are as important as efficacy potential. Read More

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Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet.

Mol Pharm 2021 Jun 5;18(6):2254-2262. Epub 2021 May 5.

Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark.

Poor aqueous drug solubility represents a major challenge in oral drug delivery. A novel approach to overcome this challenge is drug amorphization inside a tablet, that is, on-demand drug amorphization. The amorphous form is a thermodynamically instable, disordered solid-state with increased dissolution rate and solubility compared to its crystalline counterpart. Read More

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'Novel' Ear Injuries in Novel Corona Virus Era.

J Maxillofac Oral Surg 2021 Apr 28:1-3. Epub 2021 Apr 28.

Department of ENT and General Surgery, Gattani Hospital, Jodhpur, 342027 Rajasthan India.

The COVID-19 pandemic springs new challenges to medical personnel, scientists and policy makers every single day. Mask use is the singular policy that stood the test of time in containing the transmission of the disease. However, novel and unthought of side effects of continuous usage of masks for long durations are being reported. Read More

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Intraoral versus extraoral photobiomodulation therapy in the prevention of oral mucositis in HSCT patients: a randomized, single-blind, controlled clinical trial.

Support Care Cancer 2021 Apr 27. Epub 2021 Apr 27.

Stomatology Department, A.C. Camargo Cancer Center, Sao Paulo, Brazil.

To compare the efficacy of intraoral and extraoral photobiomodulation (PBM) protocols for the prevention of oral mucositis (OM) in hematopoietic stem cell transplantation (HSCT) patients. A total of 60 patients was randomized into intraoral PBM (IOPBM) and extraoral PBM (EOPBM) groups. Both PBM protocols were well tolerated and no side effects were observed. Read More

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Dydrogesterone versus medroxyprogesterone acetate co-treatment ovarian stimulation for IVF: a matched cohort study of 236 freeze-all-IVF cycles.

J Obstet Gynaecol 2021 Apr 23:1-8. Epub 2021 Apr 23.

Antalya IVF, Antalya, Turkey.

This matched cohort study was retrospectively performed, with cycles extracted from freeze-all-IVF treatments performed between March and November 2019, to compare the efficacy of flexible-start dydrogesterone (DYG) co-treatment ovarian stimulations (OS) with flexible-start medroxyprogesterone acetate (MPA) co-treatment OS. DYG cycles were matched 1:1 with MPA cycles using female age and antral follicle count, resulting in 236 matched cycles. OS durations and total FSH doses were similar in DYG and MPA OS cycles. Read More

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Oral Antiplatelet Therapy After Acute Coronary Syndrome: A Review.

JAMA 2021 Apr;325(15):1545-1555

Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas.

Importance: Acute coronary syndrome (ACS) is a major cause of morbidity and mortality in the United States with an annual incidence of approximately 1 million. Dual antiplatelet therapy (DAPT), consisting of aspirin and a P2Y12 inhibitor (clopidogrel, ticagrelor, or prasugrel) reduces cardiovascular event rates after ACS.

Observations: In 2016, the updated guidelines from the American College of Cardiology/American Heart Association (ACC/AHA) recommended aspirin plus a P2Y12 inhibitor for at least 12 months for patients with ACS. Read More

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Duration of Antiplatelet Therapy Following Transcatheter Aortic Valve Replacement: Systematic Review and Network Meta-Analysis.

J Am Heart Assoc 2021 May 17;10(9):e019490. Epub 2021 Apr 17.

Division of Cardiovascular Medicine New York University School of Medicine New York NY.

Background Although current guidelines recommend dual antiplatelet therapy (DAPT) for 3 to 6 months following transcatheter aortic valve replacement (TAVR), there are no studies directly comparing outcomes of different durations of DAPT following TAVR. Methods and Results PubMed, EMBASE, and Cochrane Database were searched through November 2020 to identify clinical studies that investigated single antiplatelet therapy versus DAPT use following TAVR. Studies using oral anticoagulants and antiplatelet therapy concomitantly were excluded. Read More

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The effect of sevoflurane anesthesia for dental procedure on neurocognition in children: a prospective, equivalence, controlled trial.

BMC Pediatr 2021 04 16;21(1):177. Epub 2021 Apr 16.

Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing, China.

Background: Dental procedures under general anesthesia (DGA) was found to improve the oral health-related quality of children's life. However, some parents and pediatricians expressed concern about the neurotoxicity of general anesthesia. The purpose of this trial was to whether DGA in children has an adverse effect on neurocognition. Read More

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The surgical management of the cavity and bone defects in enchondroma cases: A prospective randomized trial.

Surg Oncol 2021 Apr 5;37:101565. Epub 2021 Apr 5.

Science Research Department, Alexander Muss High School in Israel (AMHSI) Affiliated with Alexander Muss Institute for Israel Education (AMIIE), Hod HaSharon, Israel. Electronic address:

Background: We compared the curettage/bone grafting and the curettage/bone graft substitutes surgical techniques in their relation to functional outcomes, oncologic outcome (recurrence, malignant transformation), the rate of postsurgical complications, durations of surgery and of postsurgical immobilization for hand-localized cases of solitary and multiple enchondromas.

Methods: The current prospective randomized trial analyzed 200 adult patients (2012-2017) with enchondroma who underwent surgical intervention. The cases were randomly divided into Group 1 (n = 100; F 56, M 44) for surgeries with curettage and autogenous bone grafting, and Group 2 (n = 100; F 55, M 45) for surgeries with curettage and bone graft substitutes. Read More

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Citicoline Modulates Glaucomatous Neurodegeneration Through Intraocular Pressure-Independent Control.

Neurotherapeutics 2021 Apr 13. Epub 2021 Apr 13.

UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.

Glaucoma is a neurodegenerative disease that causes progressive, irreversible vision loss. Currently, intraocular pressure (IOP) is the only modifiable risk factor for glaucoma. However, glaucomatous degeneration may continue despite adequate IOP control. Read More

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Factors influencing an eruption of teeth associated with a dentigerous cyst: a systematic review and meta-analysis.

BMC Oral Health 2021 04 7;21(1):180. Epub 2021 Apr 7.

Department of Dentofacial Orthopedics and Orthodontics, Wroclaw Medical University, Krakowska 26, 50-425, Wrocław, Poland.

Background: A dentigerous cyst (DC) is a pathology embracing the crown of an unerupted tooth at risk of malignant transformation. The causal tooth is usually removed together with the cyst. However, if there are orthodontic contraindications for extraction, two questions arise. Read More

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Screening Methods for Diagnosing Cystic Fibrosis-Related Diabetes: A Network Meta-Analysis of Diagnostic Accuracy Studies.

Biomolecules 2021 Mar 31;11(4). Epub 2021 Mar 31.

Institute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.

Background: Cystic fibrosis-related diabetes (CFRD) has become more common due to higher life expectancy with cystic fibrosis. Early recognition and prompt treatment of CFRD leads to improved outcomes.

Methods: We performed a network meta-analysis (NMA) in order to identify the most valuable diagnostic metrics for diagnosing CFRD out of available screening tools (index test), using the oral glucose tolerance test as a reference standard. Read More

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Reappraisal of the Prognostic Factors of Outcome and Recovery Time in Patients with Idiopathic Bell's Palsy: A Retrospective Single-Center Analysis.

J Pers Med 2021 Mar 2;11(3). Epub 2021 Mar 2.

Department of Neurology, Chang Gung Memorial Hospital, Taipei 105, Taiwan.

Study Objectives: This retrospective study investigated prognostic factors and recovery time in patients with Bell's palsy after different doses and durations of oral glucocorticoid treatments.

Subjects And Methods: A total of 396 patients initially diagnosed with Bell's palsy that had visited the Department of Neurology of Chang Gung Memorial Hospital, Taoyuan, a tertiary referral medical center in Taiwan, between January 2014 and December 2018 were included. Medical records, facial electroneurography (fENoG), and blink reflex (BR) tests were reviewed and analyzed. Read More

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Characteristics of Non-Ablative Resurfacing of Soft Tissues by Repetitive Er:YAG Laser Pulse Irradiation.

Lasers Surg Med 2021 Apr 1. Epub 2021 Apr 1.

Faculty of Mechanical Engineering, University of Ljubljana, Askerceva 6 SI-1000, Ljubljana, Slovenia.

Background And Objectives: Recently, several minimally invasive gynecological, ENT and esthetic procedures have been introduced that are based on delivering "smooth" sequences of Er:YAG laser pulses to cutaneous or mucosal tissue at moderate cumulative fluences that are not only below the ablation threshold but typically also do not require local anesthesia.  To explain the observed clinical results using "smooth-resurfacing," it has been suggested that in addition to the direct heat injury to deeper-lying connective tissues, there is an additional mechanism based on indirect triggering of tissue regeneration through short-exposure, intense heat shocking of epithelia. The goal of this study is to improve understanding of the complex dynamics of the exposure of tissues to a series of short Er:YAG laser pulses, during which the thermal exposure times transition from extremely short to long durations. Read More

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Comparison of linezolid step-down therapy to standard parenteral therapy in methicillin-resistant Staphylococcus aureus bloodstream infections.

Int J Antimicrob Agents 2021 May 27;57(5):106329. Epub 2021 Mar 27.

Department of Pharmacy, University of Tennessee Medical Center, Knoxville, TN 37920, USA; Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Knoxville, TN 37920, USA. Electronic address:

Data supporting oral step-down therapy in methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI) are sparse; linezolid offers potential in this setting. This study aimed to determine the effectiveness and safety of oral step-down linezolid compared with standard parenteral therapy (SPT) in MRSA-BSI. This was a retrospective cohort performed in adults receiving step-down/outpatient linezolid or SPT (vancomycin, daptomycin) for MRSA-BSI from 2011-2019. Read More

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Phase III, Randomized, Placebo-Controlled Trial of CC-486 (Oral Azacitidine) in Patients With Lower-Risk Myelodysplastic Syndromes.

J Clin Oncol 2021 May 25;39(13):1426-1436. Epub 2021 Mar 25.

Marienhospital Düsseldorf, Düsseldorf, Germany.

Purpose: Treatment options are limited for patients with lower-risk myelodysplastic syndromes (LR-MDS). This phase III, placebo-controlled trial evaluated CC-486 (oral azacitidine), a hypomethylating agent, in patients with International Prognostic Scoring System LR-MDS and RBC transfusion-dependent anemia and thrombocytopenia.

Methods: Patients were randomly assigned 1:1 to CC-486 300-mg or placebo for 21 days/28-day cycle. Read More

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TiO Nanonetwork on Rough Ti Enhanced Osteogenesis In Vitro and In Vivo.

W E Yang H H Huang

J Dent Res 2021 Mar 20:220345211001017. Epub 2021 Mar 20.

Department of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan.

The objective in this study was to enhance osteogenic responses (in vitro and in vivo) to roughened titanium (Ti) dental implants through the formation of superhydrophilic TiO nanonetwork surface structure. Sandblasting and acid etching (SLA) was used to roughen the Ti surface. An electrochemical anodization process was then used to form a superhydrophilic TiO nanonetwork on the SLA Ti surfaces. Read More

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Intravenous cannula used for continuous intraoral mandibular nerve block in trigeminal neuralgia.

BMJ Case Rep 2021 Mar 18;14(3). Epub 2021 Mar 18.

Department of Oral and Maxillofacial Surgery, Western Sussex Hospital Foundation Trust, St Richards Hospital and Worthing Hospital, Chichester and Worthing, UK

Trigeminal neuralgia is a chronic pain condition affecting one or more distributions of the trigeminal nerve. Patients with this condition experience short, sharp, shooting pain attacks, which can progress to longer, more frequent durations. The pain is often difficult to control. Read More

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Safety, pharmacokinetics, and pharmacodynamics of the oral TLR8 agonist selgantolimod in chronic hepatitis B.

Hepatology 2021 Mar 11. Epub 2021 Mar 11.

Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background & Aims: In patients with chronic hepatitis B (CHB) infection, activation of toll-like receptor 8 (TLR8) may induce antiviral immunity and drive functional cure. Selgantolimod, a novel TLR8 agonist, was evaluated in CHB patients who were virally suppressed on oral antiviral treatment (OAV) or viremic not on OAV.

Approach & Results: In this Phase 1b study, patients were randomized 4:1 to receive either selgantolimod or placebo once-weekly. Read More

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Unanticipated Consequences of Switching to Sugammadex: Anesthesia Provider Survey on the Hormone Contraceptive Drug Interaction.

Anesth Analg 2021 Mar 8. Epub 2021 Mar 8.

From the Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: Sugammadex binds progesterone with high affinity and may interfere with hormonal contraceptive effectiveness. The clinical, economical, and ethical implications of unintended pregnancy should prompt anesthesiologists to actively consider and manage this pharmacologic interaction. We surveyed anesthesiology providers at our institution about knowledge of this potential adverse drug interaction, how they manage it clinically, and the extent to which they involve patients in shared decision-making regarding choice of neuromuscular blocker antagonist. Read More

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Risk of Non-infectious Uveitis with Metformin Therapy in a Large Healthcare Claims Database.

Ocul Immunol Inflamm 2021 Mar 8:1-7. Epub 2021 Mar 8.

Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Purpose: To determine if metformin is associated with noninfectious uveitis (NIU).

Methods: Patients in an insurance claims database who initiated metformin (n = 359,139) or other oral anti-diabetic medications (n = 162,847) were followed for NIU development. Both cohort and case-control analyses were performed to assess differing exposure lengths using Cox and conditional logistic regression, respectively. Read More

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Rural-urban differences in antibiotic prescribing for uncomplicated urinary tract infection.

Infect Control Hosp Epidemiol 2021 Feb 24:1-8. Epub 2021 Feb 24.

Division of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri.

Objective: To examine rural-urban differences in temporal trends and risk of inappropriate antibiotic use by agent and duration among women with uncomplicated urinary tract infection (UTI).

Design: Observational cohort study.

Methods: Using the IBM MarketScan Commercial Database (2010-2015), we identified US commercially insured women aged 18-44 years coded for uncomplicated UTI and prescribed an oral antibiotic agent. Read More

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February 2021

Darunavir/Cobicistat Is Associated with Negative Outcomes in HIV-Negative Patients with Severe COVID-19 Pneumonia.

AIDS Res Hum Retroviruses 2021 04;37(4):283-291

Department of Surgical, Medical, Dental, and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.

The aim of this study was to evaluate both positive outcomes, including reduction of respiratory support aid and duration of hospital stay, and negative ones, including mortality and a composite of invasive mechanical ventilation or death, in patients with coronavirus disease 2019 (COVID-19) pneumonia treated with or without oral darunavir/cobicistat (DRV/c, 800/150 mg/day) used in different treatment durations. The secondary objective was to evaluate the percentage of patients treated with DRV/c who were exposed to potentially severe drug-drug interactions (DDIs) and died during hospitalization. This observational retrospective study was conducted in consecutive patients with COVID-19 pneumonia admitted to a tertiary care hospital in Modena, Italy. Read More

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Voriconazole Versus Amphotericin B as Induction Therapy for Talaromycosis in HIV/AIDS Patients: A Retrospective Study.

Mycopathologia 2021 May 22;186(2):269-276. Epub 2021 Feb 22.

Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.

Disseminated talaromycosis caused by Talaromyces marneffei is a life-threatening opportunistic infection. Although amphotericin B deoxycholate (dAmB) remains the first-line induction treatment, voriconazole can also be used. However, no clinical trials have compared dAmB and voriconazole in the administration of talaromycosis. Read More

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Onset, duration and unresolved symptoms, including smell and taste changes, in mild COVID-19 infection: a cohort study in Israeli patients.

Clin Microbiol Infect 2021 Feb 16. Epub 2021 Feb 16.

Institute of Biochemistry, Food and Nutrition, Hebrew University, Rehovot, Israel. Electronic address:

Objectives: To characterize longitudinal symptoms of mild coronavirus disease 2019 (COVID-19) patients for a period of 6 months, to potentially aid in disease management.

Methods: Phone interviews were conducted with 103 patients with mild COVID-19 in Israel over a 6-month period (April 2020 to October 2020). Patients were recruited via social media and word to mouth and were interviewed up to 4 times, depending on reports of their unresolved symptoms. Read More

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February 2021

Duration of effect of Biotène spray in patients with symptomatic dry mouth: A pilot study.

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Apr 16;131(4):415-421. Epub 2021 Jan 16.

Professor, Faculty, and Study PI, Department of General Dentistry, Eastman Institute for Oral Health, Rochester, NY, USA.

Objectives: The objective of this study was to assess the duration of effect of a single dose of Biotène Moisturizing Spray on xerostomia compared to water spray.

Study Design: This double-blind randomized controlled crossover trial compared the duration of effect of 2 agents on relieving xerostomia in adult patients recruited through convenience sampling. Following a xerostomia questionnaire, qualifying patients with an unstimulated whole saliva flow rate of ≤0. Read More

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Risk Factors and Patient Profile of Infective Endocarditis due to

Am J Med Case Rep 2021 13;9(2):103-115. Epub 2020 Dec 13.

Division of Cardiovascular Disease and Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA.

Background: The diagnosis of infective endocarditis is difficult, especially when it involves atypical organisms. Therefore, our study identified risk factors of infective endocarditis caused by rare pathogen, .

Methods: A systematic review was conducted to investigate characteristics of endocarditis patients infected with using the search term "" and "endocarditis. Read More

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December 2020