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Biomarkers for Impending Risk of Osteoporosis in Premenopausal Women.

J Coll Physicians Surg Pak 2021 Aug;31(8):910-915

Department of Biological & Biomedical Sciences, The Aga Khan University, Karachi, Pakistan.

Objective: To compare 'cytokines' and 'bone turnover markers' in pre- and post-menopausal women and identify their relationship with bone mineral density (BMD) in both groups.  Study Design: A cross-sectional study.

Place And Duration Of Study: Department of Biological & Biomedical Sciences, The Aga Khan University, Karachi, Pakistan, from June 2017 to August 2019. Read More

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Normative Ambulatory Reflux Monitoring Metrics for Laryngopharyngeal Reflux: A Systematic Review of 720 Healthy Individuals.

Otolaryngol Head Neck Surg 2021 Jul 27:1945998211029831. Epub 2021 Jul 27.

Department of Otorhinolaryngology-Head & Neck Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Objectives: To review the normative data for acid, weakly acid, and nonacid proximal esophageal (PRE) and hypopharyngeal reflux (HRE) events in diagnosing laryngopharyngeal reflux (LPR) using ambulatory reflux monitoring.

Data Sources: PubMed, Cochrane Library, and Scopus.

Review Methods: A literature search was conducted about the normative data for PRE and HRE on multichannel intraluminal impedance-pH monitoring (MII-pH), hypopharyngeal-esophageal MII-pH (HEMII-pH), or oropharyngeal pH monitoring using PICOTS (population, intervention, comparison, outcome, timing, and setting) and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statements. Read More

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Childhood Disadvantage, Social and Psychological Stress, and Substance Use Among Homeless Youth: A Life Stress Framework.

Youth Soc 2020 Mar 29;52(2):272-287. Epub 2018 Mar 29.

The University of Texas Rio Grande Valley, Edinburg, USA.

We used a life stress framework to examine linkages between distal or primary stressors (e.g., child abuse) and proximal or secondary stressors (e. Read More

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An Initial Experience of Shoulder Resections and Reconstruction for Bone Tumours from a Cancer Centre in North-East India.

Indian J Surg Oncol 2021 Jun 8;12(2):358-364. Epub 2021 Mar 8.

Department of Surgical Oncology, DR.B. Borooah Cancer Institute, A.K. Azad Road, Gopinath Nagar, Guwahati, Assam India.

Advances in surgery and multidisciplinary approach have made limb salvage surgery feasible in most patients with tumours around the shoulder joint. Although resection and reconstruction options are complex, good outcomes can be achieved when performed at a specialised centre. The data of patients with bone tumours who underwent proximal humeral resection and reconstruction in a single cancer centre were prospectively analysed. Read More

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T-Cell Expression and Release of Kidney Injury Molecule-1 in Response to Glucose Variations Initiates Kidney Injury in Early Diabetes.

Diabetes 2021 Mar 18. Epub 2021 Mar 18.

Mater Young Adult Health Centre, Mater Misericordiae Ltd, South Brisbane, Queensland, Australia.

Half of the mortality in diabetes is seen in individuals <50 years of age and commonly predicted by the early onset of diabetic kidney disease (DKD). In type 1 diabetes, increased urinary albumin-to-creatinine ratio (uACR) during adolescence defines this risk, but the pathological factors responsible remain unknown. We postulated that early in diabetes, glucose variations contribute to kidney injury molecule-1 (KIM-1) release from circulating T cells, elevating uACR and DKD risk. Read More

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Sirt3 promotes the autophagy of HK‑2 human proximal tubular epithelial cells via the inhibition of Notch‑1/Hes‑1 signaling.

Mol Med Rep 2021 Sep 19;24(3). Epub 2021 Jul 19.

Department of Nephrology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China.

Diabetic nephropathy (DN) is a predominant cause of end‑stage renal disease. The impairment of the autophagy of human renal tubular epithelial cells (HK‑2 cells) is involved in the pathogenic mechanisms of DN. Sirtuin (Sirt)3 regulates the scavenging of damaged organelles and maintains energy balance. Read More

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September 2021

A prospective study to compare the operative outcomes of minimally invasive proximal and distal chevron metatarsal osteotomy for moderate-to-severe hallux valgus deformity.

Int Orthop 2021 Jul 17. Epub 2021 Jul 17.

Department of Orthopedic Surgery, Inje University Ilsan Paik Hospital, 170 Juhwa-ro, Ilsanseo-gu, Goyang-si, Gyeonggi-do, South Korea.

Purpose: The effectiveness of minimally invasive surgery (MIS)-distal chevron metatarsal osteotomy (DCMO) for the correction of moderate-to-severe hallux valgus deformity is unclear. This study aimed to compare the radiographic and clinical outcomes of our novel MIS-proximal chevron metatarsal osteotomy (PCMO) with those of MIS-DCMO performed during the same timeframe.

Methods: We prospectively compared the outcomes of patients who underwent MIS-PCMO (n = 20 patients; 22 cases) with those of patients who underwent MIS-DCMO (n = 23 patients; 26 cases) for moderate-to-severe hallux valgus deformity (hallux valgus angle [HVA] ≥ 30° and first-to-second intermetatarsal angle [IMA] ≥ 13°) between June 2017 and January 2019. Read More

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[Incidence of peptic ulcers accompanied by gastrointestinal bleeding after surgery for critical lower limb ischemia].

Khirurgiia (Mosk) 2021 (7):57-64

Volgograd State Medical University, Volgograd, Russia.

Objective: To study the incidence of peptic ulcers accompanied by gastrointestinal bleeding after surgery for critical lower limb ischemia and their relationship with the factors predisposing to mucous membrane damage.

Material And Methods: The study involved 94 patients with critical lower limb ischemia who were eligible for open bypass surgery. All patients underwent preoperative gastro- and duodenoscopy. Read More

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Management and Outcomes of Isolated Distal Deep Vein Thromboses: A Questionable Trend toward Long-Lasting Anticoagulation Treatment. Results from the START-Register.

TH Open 2021 Jul 8;5(3):e239-e250. Epub 2021 Jul 8.

Dipartimento di Emergenza e Accettazione, Centro Trombosi ed Emostasi, Ospedale di Circolo, Università dell'Insubria, Varese, Italy.

 Isolated distal deep vein thromboses (IDDVT) are frequently diagnosed; however, their natural history and real risk of complications are still uncertain. Though treatment is still not well standardized, international guidelines recommend no more than 3 months of anticoagulation therapy. We investigated how Italian clinicians treat IDDVT patients in their real life in our country. Read More

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Do reverse total shoulder replacements have better clinical and functional outcomes than hemiarthroplasty for patients undergoing proximal humeral tumor resection using devitalized autograft composite reconstruction: a case-control study.

J Orthop Surg Res 2021 Jul 14;16(1):453. Epub 2021 Jul 14.

Department of Orthopedic Oncology, Shanghai General Hospital Affiliated with Shanghai Jiaotong University, No. 100 Haining Road, Hongkou District, Shanghai, 200080, China.

Objective: To compare the efficacy and prognosis of reverse total shoulder arthroplasty (rTSA) with shoulder hemiarthroplasty (SHA) using devitalized autograft or allograft composite reconstruction after proximal humeral tumor resection.

Methods: We retrospectively reviewed patients who underwent SHA (32) and rTSA (20) for tumor resections of the proximal humerus from January 2014 to July 2020. The clinical results included duration of the operation, intraoperative blood loss, bone union, visual analog scale (VAS) score, shoulder range of motion (ROM), American Shoulder and Elbow Surgeons (ASES) shoulder score, recurrence, and overall survival. Read More

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Clinical outcomes of osteosynthesis of well-fixed periprosthetic proximal tibial fractures (Felix type 2A) after total knee arthroplasty.

Injury 2021 Jul 1. Epub 2021 Jul 1.

Department of Orthopaedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505,Republic of Korea. Electronic address:

Aims: This study aimed to evaluate the clinical and radiologic outcomes of well-fixed periprosthetic tibial fractures after TKA.

Patients And Methods: The medical records of patients who presented with Felix type 2A periprosthetic tibial fractures after TKA between March 2015 and February 2020 were retrospectively obtained from 5 institutions. Data on injury mechanism, fracture pattern including open fractures and Felix classification, and surgical method were recorded. Read More

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[Laparoscopic substitution of the proximal ureter using buccal mucosa].

Urologiia 2021 Jun(3):13-19

Department of urology of North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia.

Introduction: In patients with long ureteral strictures, bowel substitution of the ureter or kidney autotransplantation can be performed, which are technically demanding. For recurrent uretero-pelvic junction obstruction (UPJO) and proximal ureteral strictures, substitution of the ureter using buccal graft may be an alternative.

Aim: to study the results of laparoscopic ureteral substitution in patients with long proximal ureteral strictures using buccal graft. Read More

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Risk factors for poorly controlled and recurrence-prone ingrown toenails treated with nail braces: A retrospective observational study of 238 cases.

Indian J Dermatol Venereol Leprol 2021 Jul 7:1-5. Epub 2021 Jul 7.

Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Background: Nail braces are reportedly effective for treating both acute inflamed and chronic dystrophic type ingrown toenails.

Aims: In this study, risk factors for poorly controlled and recurrence-prone ingrown toenails treated with nail braces were identified.

Methods: We performed a retrospective study on patients with ingrown toenails between June 1, 2015, and May 31, 2018. Read More

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Late dislodgement of left bundle branch pacing lead and successful extraction.

J Cardiovasc Electrophysiol 2021 Jul 10. Epub 2021 Jul 10.

Geisinger Commonwealth School of Medicine, Geisinger Heart Institute, Wilkes-Barre, Pennsylvania, USA.

A 61-years-old male underwent left bundle branch pacing for nonischemic dilated cardiomyopathy with recurrent heart failure. Left bundle branch pacing (LBBP) resulted in reduction in QRS duration along with improvement in left ventricular ejection fraction (LVEF) to 64% during follow-up. Two years after implantation he had recurrence of symptoms along with decline in LVEF to 51%. Read More

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Contralateral proximal interference.

J Acoust Soc Am 2021 05;149(5):3352

Department of Psychology, Northeastern University, Boston, Massachusetts 02115, USA.

A contralateral "cue" tone presented in continuous broadband noise both lowers the threshold of a signal tone by guiding attention to it and raises its threshold by interference. Here, signal tones were fixed in duration (40 ms, 52 ms with ramps), frequency (1500 Hz), timing, and level, so attention did not need guidance. Interference by contralateral cues was studied in relation to cue-signal proximity, cue-signal temporal overlap, and cue-signal order (cue after: backward interference, BI; or cue first: forward interference, FI). Read More

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Ulnar-Basilic Arteriovenous Fistula for Hemodialysis Access: Utility as the "Second Procedure" after Radio Cephalic Fistula.

Ann Vasc Dis 2021 Jun;14(2):132-138

Department of Anesthesia, Shri Ram Murti Samarak Institute of Medical Sciences, Bareilly (UP), India.

: As per standard guidelines, the recommended order of arteriovenous fistula (AVF) creation for hemodialysis (HD) access is radiocephalic (RC), followed by proximal elbow fistulas and arteriovenous graft. Although ulnar-basilic (UB) fistula has been an alternative to RC-AVF, still this procedure searches clear recommendations. We present here our experience on UB-AVF as the preferred "second procedure" instead of proximal fistula after the RC-AVF. Read More

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Proximal Femoral Lateral Locking Plate versus Short Cephalomedullary Nails for Treating AO/OTA 31 A3 Intertrochanteric Femoral Fractures: a Retrospective Clinical Study.

Acta Chir Orthop Traumatol Cech 2021 ;88(3):196-203

Gaziosmanpaşa Taksim Training and Research Hospital, Department of Orthopaedics and Traumatology, Istanbul, Turkey.

PURPOSE OF THE STUDY In this study we aimed to investigate the clinical and radiographic results of AO/OTA 31 A3 fractures operated on with either a proximal femoral lateral locking plate or short cephalomedullary nails. MATERIAL AND METHODS/RESULTS Medical data of patients treated with either implant were evaluated retrospectively. Patients > 55 years old sustaining an AO 31 A3 type fracture with a minimum follow-up of one year from two institutions were included in the study. Read More

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Staged surgical approach for metastatic GIST, how far should we go? Case report.

Int J Surg Case Rep 2021 Jul 26;84:106044. Epub 2021 May 26.

Hepatobiliary section, General Surgery Department, King Fahad Specialist Hospital-Dammam, Dammam, Saudi Arabia; College of medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. Electronic address:

Introduction: Gastrointestinal stromal tumor (GIST) is an uncommon mesenchymal neoplasm that commonly arises from the stomach and proximal small intestine but can develop in any part of the gastrointestinal tract. The disease can range from primary localized to an advanced metastatic unresectable disease in up to 30% of patients. Usually, metastasis involves the liver, peritoneum, and occasionally the lungs. Read More

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Risk factors and prognosis of humeral head inferior subluxation in proximal humeral fractures after osteosynthesis.

JSES Int 2021 Jul 29;5(4):739-744. Epub 2021 Apr 29.

Department of Orthopaedic Surgery, Saiseikai Utsunomiya Hospital, Utsunomiya-shi, Tochigi, Japan.

Background: Humeral head inferior subluxation often occurs immediately after osteosynthesis for proximal humeral fracture; however, the underlying cause remains largely unknown. In addition, the prognosis of postoperative inferior subluxation has not been fully investigated. This study aimed to clarify the predictive factors that affected the onset of postoperative inferior subluxation using multivariate analysis and examine the postoperative course of inferior subluxation and its influence on postoperative outcomes. Read More

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Unusual Stroke-Like Symptoms in a Patient With Generalized Osteoarthritis.

Cureus 2021 Jun 27;13(6):e15951. Epub 2021 Jun 27.

Rheumatology, Geisinger Medical Center, Danville, USA.

A usual presenting symptom for osteoarthritis (OA) is pain. However, OA of the spine can present as isolated nerve palsy. We present a case of isolated hypoglossal nerve palsy secondary to chronic OA of the cervical spine. Read More

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Comparison of Ultrasonography and X-Rays for the Diagnosis of Synovitis and Bony Erosions in Small Joints of Hands in Early Rheumatoid Arthritis: a Prospective Study.

Maedica (Bucur) 2021 Mar;16(1):22-28

Department of Hospital Administration, PGIMER Chandigarh; PGIMER Satellite Centre, Sangrur, Punjab, India.

Rheumatoid arthritis (RA) is the most common inflammatory joint disease. Many studies have shown that erosions and synovitis can be picked up at an early stage on ultrasonography (US) when X-rays appear normal. Ultrasonography exams in inflammatory arthritis helps in determining objective evidence of inflammatory arthritis- synovitis, erosions, effusions and also help in monitoring therapy in established RA patients. Read More

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Signaling in the crowded cell.

Curr Opin Struct Biol 2021 Jul 1;71:43-50. Epub 2021 Jul 1.

Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Laboratory of Cancer Immunometabolism, National Cancer Institute, Frederick, MD 21702, USA.

High-resolution technologies have clarified some of the principles underlying cellular actions. However, understanding how cells receive, communicate, and respond to signals is still challenging. Questions include how efficient regulation of assemblies, which execute cell actions at the nanoscales, transmits productively at micrometer scales, especially considering the crowded environment, and how the cell organization makes it happen. Read More

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Reaching skills in six-month-old infants at environmental and biological risk.

PLoS One 2021 1;16(7):e0254106. Epub 2021 Jul 1.

Department of Physical Therapy, Federal University of São Carlos, São Carlos, São Paulo, Brazil.

Objectives: To assess kinematic parameters and proximal and distal reaching adjustments of infants at biological or environmental risk and compare with reaching performance of six-month-old full-term infants without known risk factors.

Methods: This blinded cross-sectional study included 62 infants at six months of age divided into three independent groups: Group with no known risk factor (NRF), 28 full-terms with no risk factors; Low SES group (LSES):19 full-terms classified as low socioeconomic status and no biological risk; Very preterm group (VPT), 15 very preterm infants at six months corrected age and no environmental risk. Infants were placed in a reclined baby chair at 45°, and a malleable and unfamiliar object was presented to the infant at 5-second intervals to elicit reaching movements. Read More

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Formation Dominates Resorption With Increasing Mineralized Density and Time Postfracture in Cortical but Not Trabecular Bone: A Longitudinal HRpQCT Imaging Study in the Distal Radius.

JBMR Plus 2021 Jun 8;5(6):e10493. Epub 2021 Apr 8.

Institute for Biomechanics, ETH Zurich Zurich Switzerland.

Clinical evaluation of fracture healing is often limited to an assessment of fracture bridging from radiographic images, without consideration for other aspects of bone quality. However, recent advances in HRpQCT offer methods to accurately monitor microstructural bone remodeling throughout the healing process. In this study, local bone formation and resorption were investigated during the first year post fracture in both the fractured (n = 22) and contralateral (n = 19) radii of 34 conservatively treated patients (24 female, 10 male) who presented with a unilateral radius fracture at the Innsbruck University Hospital, Austria. Read More

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Outcomes of Fixed-Hinged Knee Prosthesis for Distal Femoral Osteosarcoma in Skeletally Immature Patients: First Results.

J Knee Surg 2021 Jun 29. Epub 2021 Jun 29.

Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, P.R. China.

The best surgical choice for distal femur osteosarcoma in skeletally immature patients remains controversial. A fixed hinged knee prosthesis has been designed to preserve the growth plates in the adjacent tibia, expecting tibial growth to be continued. This study aims to report the (1) clinical outcomes after prosthetic replacement, (2) postoperative complications, and (3) length of discrepancy of the operative tibia with the unaffected tibia. Read More

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Scaphoid Nonunion Vascularized Bone Grafting in 2021: Is Avascular Necrosis the Sole Determinant?

J Hand Surg Am 2021 Jun 26. Epub 2021 Jun 26.

The Curtis National Hand Center, Baltimore, MD. Electronic address:

The decision regarding the use of vascularized bone grafting (VBG) or nonvascularized bone grafting for the treatment of scaphoid nonunion (SNU) needs guidelines based on patient- and fracture-specific risk factors. Historically, the presence of avascular necrosis was viewed as the primary indication for VBG; however, avascular necrosis is not the only indicator to determine whether VBG can improve our treatment of difficult SNU cases. The methods of detecting scaphoid avascular necrosis lack consensus and accuracy, limiting their use as decision-making tools. Read More

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Clinical Outcome After Replacement of Distal Femur/Proximal Tibia in a Heterogeneous Patient Cohort: Function Following Tumour, Trauma, and Loosening.

In Vivo 2021 Jul-Aug;35(4):2275-2281

Trauma Department, Klinikum Neustadt am Rübenberge, Neustadt am Rübenberge, Germany.

Background: Distal femur and proximal tibia replacements as limb-salvage procedures with good outcome parameters for patients with tumours have been broadly described. However, the overall midterm outcome in a mixed, heterogeneous patient collective is still unclear.

Patients And Methods: We retrospectively analysed 59 consecutive patients (33 for primary and 26 for revision surgery) between 1998 and 2017. Read More

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[Novel sternoclavicular hook-plate for treatment of proximal clavicle fracture with dislocation of sternoclavicular joint].

Zhongguo Gu Shang 2021 Jun;34(6):563-7

Department of Traumatic Orthopaedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang, China.

Objective: To explore the efficacy of a novel sternoclavicular hook-plate for treatment of proximal clavicle fracture with dislocation of sternoclavicular joint.

Methods: Retrospective analysis of 13 cases of proximal clavicle fracture with dislocation of sternoclavicular joint treated with sternoclavicular hook-plate from June 2011 to January 2019 in our department. There were 9 males and 4 females, aged 26 to 78 years old, with an average age of (54. Read More

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Preoperative femoral vein velocity in maximal flexion is a predictor of deep vein thrombosis in patients undergoing total hip arthroplasty.

Acta Clin Croat 2020 Sep;59(3):416-423

1Department of Vascular Surgery, Sarajevo University Clinical Centre, Sarajevo, Bosnia and Herzegovina; 2Public Health Centre of Sarajevo Canton, Sarajevo, Bosnia and Herzegovina; 3Department of Anesthesiology, Sarajevo University Clinical Centre, Sarajevo, Bosnia and Herzegovina.

The aim of the study was to investigate if preoperative blood flow velocity in femoral vein in different positions of the hip during total hip arthroplasty (THA) is a predictor of postoperative deep vein thrombosis (DVT). In patients undergoing THA, blood flow velocity and diameter of proximal femoral vein on THA side were measured preoperatively in four flexion positions of the hip. After THA, patients were followed up for 42 days for DVT occurrence, and clinical features of patients with and without postoperative DVT were compared. Read More

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September 2020

Cyclic tensile tests of Shetland pony superficial digital flexor tendons (SDFTs) with an optimized cryo-clamp combined with biplanar high-speed fluoroscopy.

BMC Vet Res 2021 Jun 25;17(1):223. Epub 2021 Jun 25.

Institute of Veterinary Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, Leipzig University, An den Tierkliniken 43, 04103, Leipzig, Germany.

Background: Long-term cyclic tensile testing with equine palmar/plantar tendons have not yet been performed due to problems in fixing equine tendons securely and loading them cyclically. It is well established that the biomechanical response of tendons varies during cyclic loading over time. The aim of this study was to develop a clamping device that enables repetitive cyclic tensile testing of equine superficial digital flexor tendon for at least 60 loading cycles and for 5 min. Read More

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