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Associations of Chinese Herbal Medicine Usage with Risk of Dementia in Patients with Parkinson's Disease: A Population-Based, Nested Case-Control Study.

J Altern Complement Med 2021 May 12. Epub 2021 May 12.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Patients who have Parkinson's disease (PD) comorbid with dementia is common. With the prolonged life expectancy, dementia is gradually becoming prevalent and affects most patients' life qualities. However, the efficacy of current treatments in dementia of PD is limited. Read More

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The duration of antibiotic treatment is associated with carriage of toxigenic and non-toxigenic strains of Clostridioides difficile in dogs.

PLoS One 2021 12;16(5):e0245949. Epub 2021 May 12.

Veterinary Pathology, Public Health and Disease Investigation, School of Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.

Clostridioides difficile is a leading cause of human antibiotic-associated diarrhoeal disease globally. Zoonotic reservoirs of infection are increasingly suspected to play a role in the emergence of this disease in the community and dogs are considered as one potential source. Here we use a canine case-control study at a referral veterinary hospital in Scotland to assess: i) the risk factors associated with carriage of C. Read More

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The impact of mass drug administration expansion to low onchocerciasis prevalence settings in case of connected villages.

PLoS Negl Trop Dis 2021 May 12;15(5):e0009011. Epub 2021 May 12.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: The existence of locations with low but stable onchocerciasis prevalence is not well understood. An often suggested yet poorly investigated explanation is that the infection spills over from neighbouring locations with higher infection densities.

Methodology: We adapted the stochastic individual based model ONCHOSIM to enable the simulation of multiple villages, with separate blackfly (intermediate host) and human populations, which are connected through the regular movement of the villagers and/or the flies. Read More

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Gastric Mucosal Immune Profiling and Dysregulation in Idiopathic Gastroparesis.

Clin Transl Gastroenterol 2021 May 12;12(5):e00349. Epub 2021 May 12.

Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Stanford, USA.

Introduction: It is unclear how immune perturbations may influence the pathogenesis of idiopathic gastroparesis, a prevalent functional disorder of the stomach which lacks animal models. Several studies have noted altered immune characteristics in the deep gastric muscle layer associated with gastroparesis, but data are lacking for the mucosal layer, which is endoscopically accessible. We hypothesized that immune dysregulation is present in the gastroduodenal mucosa in idiopathic gastroparesis and that specific immune profiles are associated with gastroparesis clinical parameters. Read More

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Evaluating the Effect of Stimulus Duration on Vibrotactile Cue Localizability with a Tactile Sleeve.

IEEE Trans Haptics 2021 May 12;PP. Epub 2021 May 12.

Vibrotactile arrays are appealing as wearable haptic devices, since designers can vary parameters including cue location and duration to create distinct haptic icons to represent a wide range of information. Vibrotactile sleeves have typically used cues that vary in duration from 100 to 400 ms, but it is not well understood how cue duration might affect localizability of stimuli. Using an experimental protocol typically employed to understand how our visual system can localize stimuli, we examined localization of tactile cues for tactors spaced at fixed locations along the forearm while we varied cue duration between 100 and 400 ms. Read More

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Diagnostic features of the presumed focal viral retinitis: A case series.

Anu Manandhar

Nepal J Ophthalmol 2020 Jul;12(24):339-346

Tilganga Institute of Ophthalmology, Gaushala, Kathmandu, Nepal.

Introduction: Other than well-known herpetic retinopathies like acute retinal necrosis, progressive outer retinal necrosis and cytomegalovirus retinitis, there are few reports on atypical forms of viral retinitis caused by herpes virus from around the world.

Cases: Presenting symptom was sudden onset of diminution of vision in all 6 cases. Mean duration of symptoms at presentation was 7. Read More

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Frequency, signs and symptoms, and criteria adopted for long COVID: a systematic review.

Int J Clin Pract 2021 May 11:e14357. Epub 2021 May 11.

Researcher at Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.

Aims: to identify, systematically evaluate and summarise the best available evidence on the frequency of long COVID (post-acute COVID-19 syndrome), its clinical manifestations and the criteria used for diagnosis.

Methods: Systematic review conducted with a comprehensive search including formal databases, COVID-19 or SARS-CoV-2 data sources, grey literature, and manual search. We considered for inclusion clinical trials, observational longitudinal comparative and non-comparative studies, cross-sectional, before-and-after and case series. Read More

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An evaluation of the correlation between the severity and frequency of migraine and the Buss-Perry Aggression Scale.

Acta Neurol Belg 2021 May 11. Epub 2021 May 11.

Department of Neurology, University of Health Sciences, Prof.Dr.Cemil Taşçıoğlu City Hospital, Istanbul, Turkey.

It is important to identify concomitant psychological factors such as depression and aggression in patients with migraine. In this study, our objective was to demonstrate the difference of aggression scores in patients with migraine compared with normal scores, and whether the severity of the disease and the frequency of pain had an impact. Ninety-nine patients with migraine and 67 healthy controls who presented to the Okmeydanı Training and Research Hospital were included in the study. Read More

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Improving the gnomonic approach with the R-package to estimate natural mortality throughout different life stages.

PeerJ 2021 19;9:e11229. Epub 2021 Apr 19.

Instituto Politécnico Nacional, Centro Interdisciplinario de Ciencias Marinas, La Paz, Baja California Sur, México.

Natural mortality () is defined as the rate of loss that occurs in a fish stock due to natural (non-fishing) causes and can be influenced by density-dependent or density-independent factors. Different methods have been used to estimate , one of these is the gnomonic approach. This method estimates rates by dividing the life cycle of a species into subunits of time that increase as a constant proportion of the time elapsed from birth up to the initiation of each subdivision. Read More

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Protracted Hiccups Induced by Aripiprazole and Regressed after Administration of Gabapentin.

Case Rep Psychiatry 2021 22;2021:5567152. Epub 2021 Apr 22.

Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 57, 56100 Pisa, Italy.

Hiccups are sudden, repeated, and involuntary contractions of the diaphragm muscle (myoclonic contraction). It involves a reflex arc that, once activated, causes a strong contraction of the diaphragm immediately followed by the closure of the glottis translating into the classic "hic" sound. Hiccups can be short, persistent, and intractable depending on the duration. Read More

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Millard-Gubler Syndrome Associated with Cerebellar Ataxia in a Patient with Isolated Paramedian Pontine Infarction - A Rarely Observed Combination with a Benign Prognosis: A Case Report.

Case Rep Neurol 2021 Jan-Apr;13(1):239-245. Epub 2021 Apr 13.

Department of Neurology, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.

Isolated pontine infarction accounts for 7% of all ischemic strokes. Millard-Gubler syndrome is a clinical syndrome which occurs following lesions involving the ventral portion of the caudal pons, resulting in classic clinical features such as ipsilateral abducens and facial nerve palsy and contralateral hemiparesis. We report the case of a 55-year-old male patient having presented to the Yehuleshet Specialty Clinic 6 years back with sudden-onset dysarthria and appendicular ataxia of 10 days duration. Read More

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Diabetic Cystopathy Occurs Independently from Other Atherosclerotic Risks.

Case Rep Neurol 2021 Jan-Apr;13(1):200-204. Epub 2021 Mar 19.

Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan.

It has not yet been clarified whether atherosclerotic risks other than diabetes are related to bladder small fiber neuropathy (cystopathy) in type 2 diabetes. The aim of this study was to answer this question by urodynamics. This was a retrospective study. Read More

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Combination of Crizotinib and Osimertinib in T790M+ EGFR-Mutant Non-Small Cell Lung Cancer with Emerging MET Amplification Post-Osimertinib Progression in a 10-Year Survivor: A Case Report.

Case Rep Oncol 2021 Jan-Apr;14(1):477-482. Epub 2021 Mar 18.

Department of Thoracic Oncology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany.

Tyrosine kinase inhibitors (TKIs) represent the standard treatment for patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. The duration of the response is, however, limited in time owing to the development of resistance mechanisms to both first- and second-generation agents such as oncogene amplification. This report describes the successful results obtained with the combination of the third-generation TKI osimertinib with the multitargeted TKI and MET inhibitor crizotinib in a patient with EGFR-mutant NSCLC with emerging MET amplification with a tolerable toxicity profile. Read More

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Sociodemographic and clinical characteristics of the first cohort of COVID-19 recoveries at two national treatment centres in Accra, Ghana.

Ghana Med J 2020 Dec;54(4 Suppl):16-22

Department of Medicine and Therapeutics, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra.

Introduction: COVID-19 is a new disease, knowledge on the mode of transmission and clinical features are still evolving, new tests are being developed with inherent challenges regarding interpretation of tests results. There is generally, a gap in knowledge on the virus globally as the pandemic evolves and in Ghana, there is dearth of information and documentation on the clinical characteristics of the virus. With these in mind, we set out to profile the initial cohort of COVID-19 patients who recovered in Ghana. Read More

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December 2020

D-Cystine di(m)ethyl ester reverses the deleterious effects of morphine on ventilation and arterial blood gas chemistry while promoting antinociception.

Sci Rep 2021 May 11;11(1):10038. Epub 2021 May 11.

Department of Pharmacology, Case Western Reserve University, Cleveland, OH, 44106, USA.

We have identified thiolesters that reverse the negative effects of opioids on breathing without compromising antinociception. Here we report the effects of D-cystine diethyl ester (D-cystine diEE) or D-cystine dimethyl ester (D-cystine diME) on morphine-induced changes in ventilation, arterial-blood gas chemistry, A-a gradient (index of gas-exchange in the lungs) and antinociception in freely moving rats. Injection of morphine (10 mg/kg, IV) elicited negative effects on breathing (e. Read More

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Tunnelling times, Larmor clock, and the elephant in the room.

Sci Rep 2021 May 11;11(1):10040. Epub 2021 May 11.

Basque Center for Applied Mathematics (BCAM), Alameda de Mazarredo 14, 48009, Bilbao, Bizkaia, Spain.

A controversy surrounding the "tunnelling time problem" stems from the seeming inability of quantum mechanics to provide, in the usual way, a definition of the duration a particle is supposed to spend in a given region of space. For this reason, the problem is often approached from an "operational" angle. Typically, one tries to mimic, in a quantum case, an experiment which yields the desired result for a classical particle. Read More

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Perioperative adherence to continuous positive airway pressure and its effect on postoperative nocturnal hypoxemia in obstructive sleep apnea patients: a prospective cohort study.

BMC Anesthesiol 2021 May 11;21(1):142. Epub 2021 May 11.

Department of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, MCL 2-405, 399 Bathurst St., Toronto, ON, M5T2S8, Canada.

Background: Although continuous positive airway pressure (CPAP) is the first line treatment for obstructive sleep apnea (OSA) patients, the perioperative adherence rate is unclear. The objective of this study was to determine the perioperative adherence rate of patients with OSA with a CPAP prescription and the effect of adherence on nocturnal oxygen saturation.

Methods: This prospective cohort study included adult surgical patients with a diagnosis of OSA with CPAP prescription undergoing elective non-cardiac surgery. Read More

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Risk Factors and Clinical Characteristics of Metabolic Bone Disease of Prematurity.

Am J Perinatol 2021 May 11. Epub 2021 May 11.

Department of Pediatric Endocrinology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.

Objective:  The study aimed to analyze the risk factors and clinical features of metabolic bone disease of prematurity (MBDP) in premature infants compared with infants of similar gestational age and birthweight without MBDP.

Study Design:  This retrospective case-control study was performed by comparing 81 cases of MBDP with 63 controls to identify potential risk factors. Premature infants with a gestational age ≤33 weeks and birthweight <1,500 g were included. Read More

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A descriptive analysis of the impact of public health and social measures on COVID-19: How the U.S. compares to other countries.

JMIR Public Health Surveill 2021 Apr 21. Epub 2021 Apr 21.

Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, US.

Background: The United States of America (US) has the highest global number of COVID-19 cases and deaths, which may be due in part to delays and inconsistencies in implementing public health and social measures (PHSMs).

Objective: In this descriptive analysis, we analyzed the epidemiological evidence for PHSM impact on COVID-19 transmission in the US compared to that in ten other countries of varying income levels, population sizes, and geographies.

Methods: We compared PHSM implementation timing and stringency against COVID-19 daily case counts in the US to that in Canada, China, Ethiopia, Japan, Kazakhstan, New Zealand, Singapore, South Korea, Vietnam, and Zimbabwe from January 1 to November 25, 2020. Read More

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The impacts of background error covariance on particulate matter assimilation and forecast: An ideal case study with a modal aerosol model over China.

Sci Total Environ 2021 Apr 29;786:147417. Epub 2021 Apr 29.

Guangdong-Hong Kong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality, Guangzhou 510632, China; Institute for Environmental and Climate Research, Jinan University, Guangzhou 510632, China. Electronic address:

Accurate estimation of background error covariance (BEC) is the key to successful data assimilation (DA). In aerosol three-dimensional variational (3DVAR) DA, the National Meteorological Center (NMC) method is typically applied to estimate BEC, which uses the difference between forecasts of dissimilar lengths valid at the common time. The difference will be considerably small when the underestimation of the aerosol is caused by the lack of emissions or the missing of chemical progress, which makes the aerosol concentration field too difficult to constrain. Read More

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[Care of rheumatology patients during the lockdown in early 2020 : Telemedicine, delegation, patient satisfaction and vaccination behavior].

Z Rheumatol 2021 May 11. Epub 2021 May 11.

Klinik für Rheumatologie und Immunologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Background: Telemedicine was implemented in outpatient care during the lockdown between March and May 2020. The aim of the study was to assess patients from a private practice and the university outpatient department with respect to patient satisfaction with telemedicine, COVID-19 worries and vaccination behavior and to compare the teleconsultation by a medical assistant for rheumatology (RFA) and a physician.

Methods: Patients with rheumatoid arthritis, psoriatric arthropathy or spondylarthritis without treatment modifications since the previous presentation were offered a telemedical replacement appointment within the framework of this study in the case of appointment cancellation by the treating center. Read More

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Evaluation of systemic estrogen for preventing urinary tract infections in postmenopausal women.

Menopause 2021 May 10. Epub 2021 May 10.

Medical School, University of Washington School of Medicine, Seattle, WA Department of Global Health, University of Washington School of Medicine, Seattle, WA Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA Department of Obstetrics and Gynecology, University of Texas Southwestern, Dallas, TX.

Importance: Current guidelines for postmenopausal recurrent urinary tract infection (rUTI) prevention recommend the use of vaginal topical estrogen products but not systemic estrogens. Studies show that vaginal estrogen decreases the risk of rUTI, but evidence against use of systemic estrogen is less convincing.

Objective: We performed a comprehensive literature review to evaluate the effect of systemic estrogen on UTI occurrence among postmenopausal women. Read More

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Assessing the Effect of Global Travel and Contact Restrictions on Mitigating the COVID-19 Pandemic.

Engineering (Beijing) 2021 May 6. Epub 2021 May 6.

WorldPop, School of Geography and Environmental Science, University of Southampton, Southampton, SO17 1BJ, UK.

Travel restrictions and physical distancing have been implemented across the world to mitigate the coronavirus disease 2019 (COVID-19) pandemic, but studies are needed to understand their effectiveness across regions and time. Based on the population mobility metrics derived from mobile phone geolocation data across 135 countries or territories during the first wave of the pandemic in 2020, we built a metapopulation epidemiological model to measure the effect of travel and contact restrictions on containing COVID-19 outbreaks across regions. We found that if these interventions had not been deployed, the cumulative number of cases could have shown a 97-fold (interquartile range 79-116) increase, as of May 31, 2020. Read More

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Cost and social distancing dynamics in a mathematical model of COVID-19 with application to Ontario, Canada.

R Soc Open Sci 2021 Feb 24;8(2):201770. Epub 2021 Feb 24.

Department of Mathematics and Statistics, York University, Toronto, Canada.

A mathematical model of COVID-19 is presented where the decision to increase or decrease social distancing is modelled dynamically as a function of the measured active and total cases as well as the perceived cost of isolating. Along with the cost of isolation, we define an overburden healthcare cost and a total cost. We explore these costs by adjusting parameters that could change with policy decisions. Read More

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February 2021

Quantification of training load distribution in mixed martial arts athletes: A lack of periodisation and load management.

PLoS One 2021 10;16(5):e0251266. Epub 2021 May 10.

Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.

The aim of this study was to quantify typical training load and periodisation practices of MMA athletes. MMA competitors (n = 14; age = 22.4 ± 4. Read More

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Efficacy and safety of direct oral anticoagulants for treatment of left ventricular thrombus; a systematic review.

Acta Cardiol 2021 May 10:1-5. Epub 2021 May 10.

Department of Internal Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Michigan State University, Kalamazoo, MI, USA.

Introduction: Left ventricular thrombus (LVT) is a well-recognised complication of ischaemic and non-ischaemic heart disease. The incidence of this complication has drastically reduced due to reperfusion therapies. Current guidelines recommend using warfarin for at least three months. Read More

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The rationale for selenium supplementation in patients with autoimmune thyroiditis, according to the current state of knowledge.

Endokrynol Pol 2021 ;72(2):153-162

Department of Endocrinology, Metabolism, and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

Selenium (Se) supplements are commonly prescribed to autoimmune thyroiditis (AIT) patients by European endocrinologists, despite the lack of official guidelines. The majority of Europe is depleted of natural Se sources, and the daily population intake does not comply with recommended values. Optimal individual plasma Se concentration is reached when the selenoproteins (selenoprotein P, glutathione peroxidase) are fully saturated. Read More

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January 2021


V Kayamba P Kelly

Health Press 2019 Feb;3(2):14-19

Tropical Gastroenterology & Nutrition group, Department of Internal Medicine, PO Box 50398, Nationalist Road, Lusaka, Zambia.

There is evidence that 15 % of gastric cancer patients in Zambia survive more than one-year after diagnosis. The major contributing factor to these poor outcomes is late case detection. We set out to investigate the time course of gastric cancer diagnosis in Zambia. Read More

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February 2019

Correlation between Occupational Stress and Coronary Heart Disease in Northwestern China: A Case Study of Xinjiang.

Biomed Res Int 2021 20;2021:8127873. Epub 2021 Apr 20.

Cardiovascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 Xinjiang, China.

Objective: To study the correlation between occupational stress and coronary heart disease in western China.

Method: A case-control design was used. From June 2016 to May 2017, 310 patients with coronary heart disease (CHD) confirmed by coronary angiography (CAG) at the Heart Center of the First Affiliated Hospital of Xinjiang Medical University were recruited by cluster sampling, along with 536 healthy controls. Read More

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Misdiagnosed dystrophic epidermolysis bullosa pruriginosa: A case report.

World J Clin Cases 2021 May;9(13):3090-3094

Department of Dermatology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100000, China.

Background: Dystrophic epidermolysis bullosa pruriginosa (DEB-Pr) is a rare subtype of DEB, characterized by recurrent pruritus of the extremities, pruritus papules, nodules, and mossy-like plaques. To date, fewer than 100 cases have been reported. We report a misdiagnosed 30-year-old man with sporadic late-onset DEB-Pr who responded well to tacrolimus treatment, thereby serving as a guide to correct diagnosis and treatment. Read More

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