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The effect of gap duration on the perception of fluent versus disfluent speech.

J Fluency Disord 2022 Jan 7;71:105896. Epub 2022 Jan 7.

Department of Communicative Sciences and Disorders, New York University, 665 Broadway, 9th Floor, New York, NY, 10012, United States.

Purpose: Gap duration contributes to the perception of utterances as fluent or disfluent, but few studies have systematically investigated the impact of gap duration on fluency judgments. The purposes of this study were to determine how gaps impact disfluency perception, and how listener background and experience impact these judgments.

Methods: Sixty participants (20 adults who stutter [AWS], 20 speech-language pathologists [SLPs], and 20 naïve listeners) listened to four tokens of the utterance, "Buy Bobby a puppy," produced at typical speech rates. Read More

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January 2022

Polymerase Spiral Reaction (PSR) as a novel rapid colorimetric isothermal point of care assay for detection of Trypanosoma evansi genomic DNA.

Vet Parasitol 2021 Dec 28;302:109644. Epub 2021 Dec 28.

Parasitology Lab, ICAR-National Research Centre on Equines, Hisar, Haryana, 125001, India. Electronic address:

Polymerase spiral reaction (PSR) opens new avenues for specific diagnosis of pathogens known for cryptic infection at field level and its application is still unexplored in the field of parasitology. The present study aimed to explore and optimize colorimetric based PSR technique for the detection of Trypanosoma evansi in the blood of the host by targeting the 196bp Invariable Surface Glycoprotein (ISG) gene of Trypanosoma evansi. The specificity of the test was determined against Theileria equi, Theileria annulata, Babesia caballi, Burkholderia mallei and Equine herpes virus. Read More

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December 2021

Associations of variability in body weight and glucose levels with the risk of hip fracture in people with diabetes.

Metabolism 2022 Jan 12:155135. Epub 2022 Jan 12.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea; Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea. Electronic address:

Background: Diabetes is associated with a high risk of fragility fracture. However, there are controversies regarding the effect of fluctuations in metabolic parameters on the risk of fracture. We aimed to investigate the associations of body weight or glucose variability or their combination with the risk of hip fracture in people with diabetes. Read More

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January 2022

Dipeptidyl-peptidase IV inhibitor (DPP4i) confers increased odds of bullous pemphigoid even years after drug initiation.

Arch Dermatol Res 2022 Jan 15. Epub 2022 Jan 15.

Clalit Health Services, Tel-Aviv, Israel.

The timing pattern in which dipeptidyl-peptidase IV inhibitors (DPP4i) confer the risk of bullous pemphigoid (BP) is unknown. To investigate the odds of BP following exposure to DPP4i and to perform a duration-response analysis evaluating the risk of BP in relation to the duration of exposure to the culprit drug. A population-based nested case-control study was performed comparing diabetic patients with BP (n = 1458) with age-, sex- and ethnicity-matched diabetic control subjects (n = 6051) with respect to the prevalence of exposure to DPP4i. Read More

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January 2022

Baseline fat fraction is a strong predictor of disease progression in Becker muscular dystrophy.

NMR Biomed 2022 Jan 14:e4691. Epub 2022 Jan 14.

C.J. Gorter Center for High Field MRI, Dept. of Radiology, Leiden University Medical Center (LUMC), Leiden, Netherlands.

In Becker muscular dystrophy (BMD), muscle weakness progresses relatively slowly, with a highly variable rate between patients. This complicates clinical trials, as clinically relevant changes are difficult to capture within the typical duration of a trial. Therefore, predictors for disease progression are needed. Read More

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January 2022

Metacontrast masking reduces the estimated duration of visible persistence.

Atten Percept Psychophys 2022 Jan 14. Epub 2022 Jan 14.

Department of Psychology, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.

A brief visual display can give rise to a sensation that outlasts the duration of the physical stimulus. The duration of this visible persistence has been estimated with paradigms that require the temporal integration of two brief sequential displays (frames) separated by a blank temporal gap. Temporal integration is said to occur when the visible persistence generated by the first frame is sufficiently long to bridge the inter-frame temporal gap. Read More

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January 2022

Development of Duration-Based Non-Mutagenic Thresholds of Toxicological Concern (TTC) Relevant to Parenteral Extractables and Leachables (E&Ls).

PDA J Pharm Sci Technol 2022 Jan 14. Epub 2022 Jan 14.

Faegre Drinker Biddle & Reath LLP.

The threshold of toxicological concern (TTC), i.e., the dose of a compound lacking sufficient experimental toxicity data that is unlikely to result in an adverse health effect in humans, is important for evaluating extractables and leachables (E&Ls) as it guides analytical testing and minimizes the use of animal studies. Read More

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January 2022

Efficacy and Safety of Intravenous Iron Therapy for Treating Anaemia in Critically ill Adults: A Rapid Systematic Review With Meta-Analysis.

Transfus Med Rev 2021 Dec 24. Epub 2021 Dec 24.

Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Our objective was to systematically evaluate the efficacy and safety of intravenous (IV) iron therapy for treating anaemia in critically ill adults (>16 years) admitted to intensive care or high dependency units. We excluded quasi-RCTs and other not truly randomised trials. We searched 7 electronic databases (including CENTRAL, MEDLINE, and Embase) using a pre-defined search strategy from inception to June 14, 2021. Read More

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December 2021

The influence of primary care quality on nursing home admissions in a multimorbid population with and without dementia in Germany: a retrospective cohort study using health insurance claims data.

BMC Geriatr 2022 Jan 14;22(1):52. Epub 2022 Jan 14.

Faculty 11: Human and Health Sciences, Institute for Public Health and Nursing Research, University of Bremen, Grazer Str. 4, 28359, Bremen, Germany.

Background: Multimorbidity poses a challenge for high quality primary care provision for nursing care-dependent people with (PWD) and without (PWOD) dementia. Evidence on the association of primary care quality of multimorbid PWD and PWOD with the event of a nursing home admission (NHA) is missing. This study aimed to investigate the contribution of individual quality of primary care for chronic diseases in multimorbid care-dependent PWD and PWOD on the duration of ongoing residence at home before the occurrence of NHA. Read More

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January 2022

Hippocampal injury in patients with status epilepticus: Quantitative analysis of hippocampal volume and structural co-variance network.

Seizure 2022 Jan 7;95:84-89. Epub 2022 Jan 7.

Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea. Electronic address:

Objective: This study aimed to evaluate the differences in hippocampal structural volumes and intra-hippocampal networks between patients with status epilepticus (SE) and healthy controls.

Methods: We enrolled 45 patients with SE and 35 age- and sex-matched healthy controls. We excluded patients with active structural lesions, which could be a direct cause of SE, but included patients with co-existing lesions. Read More

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January 2022

Modified internal limiting membrane flap technique for large chronic macular hole: Two case reports.

Medicine (Baltimore) 2022 Jan;101(1):e28412

Department of Fundus Disease, The Affiliated Eye Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Rationale: Internal limiting membrane (ILM) peeling and gas tamponade are the standardized treatments for macular holes (MHs). However, the close rate is low, and postoperative vision is unsatisfactory in large, chronic MHs. Currently, various modifications of the ILM flap techniques are being gradually applied for large MHs in the hope of obtaining better postoperative effects. Read More

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January 2022

Factors Associated With Normal Physiologic Birth for Women Who Labor In Water: A Secondary Analysis of A Prospective Observational Study.

J Midwifery Womens Health 2022 Jan 14. Epub 2022 Jan 14.

Faculty of Health Sciences, Hull University, Hull, United Kingdom.

Introduction: Research to understand factors associated with normal physiologic birth (unassisted vaginal birth, spontaneous labor onset without epidural analgesia, spinal, or general anesthetic, without episiotomy) is required. Laboring and/or giving birth in water has been shown to be associated with a high proportion of physiologic birth but with little understanding of factors that may influence this outcome. This study explored factors associated with normal physiologic birth for women who labored in water. Read More

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January 2022

Early Detection of Prolonged Decreases in Maximal Voluntary Contraction Force after Eccentric Exercise of the Knee Extensors.

Med Sci Sports Exerc 2022 Feb;54(2):267-279

Centre for Exercise and Sports Science Research, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, AUSTRALIA.

Purpose: We examined whether the magnitude of muscle damage indicated by changes in maximal voluntary isometric contraction (MVIC) strength 1 to 3 d after unaccustomed eccentric exercise (ECC) was correlated with changes in central and peripheral neuromuscular parameters immediately post-ECC.

Methods: Twenty participants (19-36 yr) performed six sets of eight eccentric contractions of the knee extensors. Rate of force development (RFD) during knee extensor MVIC, twitch force, rate of force development (RFDRT) and rate of relaxation (RRRT) of the resting twitch, maximal M-wave (MMAX), voluntary activation, silent period duration, motor-evoked potentials (MEP) and short-interval intracortical inhibition were assessed before, immediately after, and 1 to 3 d post-ECC. Read More

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February 2022

Proteomic Investigation in Plasma from Women with Fibromyalgia in Response to a 15-wk Resistance Exercise Intervention.

Med Sci Sports Exerc 2022 Feb;54(2):232-246

Pain and Rehabilitation Centre, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SWEDEN.

Purpose: Fibromyalgia (FM) is a complex pain condition, and exercise is considered the first option of treatment. Few studies have examined the effect of exercise on molecular mechanisms in FM. The aim of this study was to analyze the plasma proteome in women with FM and healthy controls (CON) before and after 15 wk of resistance exercise. Read More

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February 2022

Angiotensin II Infusion in COVID-19: An International, Multicenter, Registry-based Study.

J Med Virol 2022 Jan 14. Epub 2022 Jan 14.

Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.

In order to expand our understanding of the role of angiotensin II (ANGII) in COVID-19, we conducted an international, multicenter registry study to assess the use of ANGII in patients with COVID-19 compared to patients not receiving ANGII. Critically ill adult patients who were diagnosed with COVID-19 and received ANGII were matched with COVID-19 patients not receiving ANGII according to age, respiratory support, history of hypertension, use of angiotensin converting enzyme inhibitors and/or angiotensin II receptor blocker, and date of admission. All outcomes were exploratory in nature and included improvement in oxygenation, duration of organ support and mortality. Read More

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January 2022

Clustering of Physical Activity, Sleep, Diet, and Screen-Based Device Use Associated with Self-Rated Health in Adolescents.

Int J Behav Med 2022 Jan 14. Epub 2022 Jan 14.

School of Sports, Research Centre in Physical Activity and Health, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.

Background: Little is known about how the interplay among health-related behaviors impacts self-rated health (SRH). We examined the clustering of physical activity (PA), sleep, diet, and specific screen-based device use, and the associations between the emergent clusters and SRH among Brazilian adolescents.

Method: The data used in this cross-sectional study were from the baseline of the Movimente Program. Read More

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January 2022

Reconstruction of paralyzed arm function in patients with hemiplegia through contralateral seventh cervical nerve cross transfer: a multicenter study and real-world practice guidance.

EClinicalMedicine 2022 Jan 4;43:101258. Epub 2022 Jan 4.

The National Clinical Research Center for Aging and Medicine, Center for the Reconstruction of Limb Function, Hand Surgery department, Rehabilitation department, Huashan Hospital, Fudan University, Shanghai, China.

Background: A previous randomized controlled trial showed contralateral seventh cervical nerve (CC7) cross transfer to be safe and effective in restoring the arm function of spastic arm paralysis patients in a specified population. Guidance on indications, safety and expected long-term improvements of the surgery are needed for clinical practice.

Methods: This is a retrospective, multicenter, propensity score-matched cohort study. Read More

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January 2022

Tailoring mechanical properties and degradation rate of maxillofacial implant based on sago starch/polylactid acid blend.

Heliyon 2022 Jan 13;8(1):e08600. Epub 2021 Dec 13.

Research Center on Biomedical Engineering, Universitas Indonesia, Indonesia.

A polymeric bone implants have a distinctive advantage compared to metal implants due to their degradability in the local bone host. The usage of degradable implant prevents the need for an implant removal surgery especially if they fixated in challenging position such as maxillofacial area. Additionally, this fixation system has been widely applied in fixing maxillofacial fracture in child patients. Read More

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January 2022

Sequential Intravenous-Oral Therapy for Pediatric Intracranial Infections.

Open Forum Infect Dis 2022 Jan 6;9(1):ofab628. Epub 2022 Jan 6.

Section of Infectious Diseases, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.

Background: group is a common cause of pediatric intracranial infections but treatment recommendations, including use of oral therapy, are poorly defined.

Methods: We performed a retrospective review from 2004 to 2019 of all patients with group pyogenic intracranial infections at Children's Hospital Colorado, highlighting patients transitioned to oral therapy. The primary endpoint was worsening infection necessitating intravenous antibiotics or a source control procedure after transition to oral therapy. Read More

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January 2022

Machine Learning Techniques for Human Age and Gender Identification Based on Teeth X-Ray Images.

J Healthc Eng 2022 4;2022:8302674. Epub 2022 Jan 4.

Department of Electrical Engineering, Tamale Technical University, Tamale, Ghana.

The use of digital medical images is increasing with advanced computational power that has immensely contributed to developing more sophisticated machine learning techniques. Determination of age and gender of individuals was manually performed by forensic experts by their professional skills, which may take a few days to generate results. A fully automated system was developed that identifies the gender of humans and age based on digital images of teeth. Read More

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January 2022

Long-Term Mortality and Morbidity Related to Congestive Heart Failure with Reduced Ejection Fraction (CHFrEF) in Palestinian Patients Maintained on Submaximal Sacubitril/Valsartan Doses: A Pilot Study.

J Renin Angiotensin Aldosterone Syst 2021 28;2021:1829873. Epub 2021 Dec 28.

Al-Quds University, Faculty of Medicine, Jerusalem, State of Palestine.

Background: The efficacy of sacubitril/valsartan, a newly introduced combination drug for heart failure with reduced ejection fraction (HFrEF), was demonstrated in the PARADIGM-HF trial conducted in Western countries. However, these findings need to be verified in the Middle Eastern context, where patients may exhibit a different response due to different environmental and racial factors.

Objectives: The goal of this study was to evaluate the efficacy of submaximal sacubitril/valsartan doses in terms of improving the disease symptoms, as measured by the New York Heart Association (NYHA) classification and left ventricular ejection fraction (LVEF) percentage, as well as establish long-term morbidity and mortality associated with HFrEF among Palestinian patients administered target doses of an angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARBs). Read More

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December 2021

The Effect of Inner Engineering Online (IEO) Program on Reducing Stress for Information Technology Professionals: A Randomized Control Study.

Evid Based Complement Alternat Med 2022 4;2022:9001828. Epub 2022 Jan 4.

Sadhguru Center for a Conscious Planet, Department of Anesthesia, Critical Care & Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

In recent years, mindfulness-based interventions (MBIs) are rapidly growing in the workplace. Several meta-analyses conclude that overall MBIs have a moderate effect of alleviating deficit-based experiences, such as burnout and stress, but a small to no effect of promoting asset-based experiences, such as positive affect and well-being. While workplace MBIs vary greatly in their content, format, and duration, the dominant format is still face to face in a group setting, which limits scalability. Read More

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January 2022

Hemoglobin A1c Threshold for Reduction in Bone Turnover in Men With Type 2 Diabetes Mellitus.

Front Endocrinol (Lausanne) 2021 28;12:788107. Epub 2021 Dec 28.

Division of Endocrinology Diabetes and Metabolism, Baylor College of Medicine, Houston, TX, United States.

Background: Emerging data suggest that type 2 diabetes mellitus (T2D) is associated with an increased risk for fractures despite relatively normal or increased bone mineral density (BMD). Although the mechanism for bone fragility in T2D patients is multifactorial, whether glycemic control is important in generating this impairment in bone metabolism remains unclear. The purpose of our study is to identify a hemoglobin A1c (A1c) threshold level by which reduction in bone turnover begins in men with T2D. Read More

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December 2021

Factors influencing recovery of SARS-CoV-2 RNA in raw sewage and wastewater sludge using polyethylene glycol-based concentration method.

J Biomol Tech 2021 Sep;32(3):172-179

Department of Civil and Environmental Engineering, University of Vermont, Burlington, Vermont, USA.

Wastewater surveillance for monitoring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important epidemiologic tool for the assessment of population-wide coronavirus disease 2019 (COVID-19). This tool can be successfully implemented only if SARS-CoV-2 RNA in wastewater can be accurately recovered and quantified. The lack of standardized procedure for wastewater virus analysis has resulted in varying SARS-CoV-2 concentrations for the same sample. Read More

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September 2021

Central Venous-to-Arterial CO2 Difference-Assisted Goal-Directed Hemodynamic Management During Major Surgery-A Randomized Controlled Trial.

Anesth Analg 2022 Jan 13. Epub 2022 Jan 13.

From the Department of Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Bhubaneswar, India.

Background: Different goals have guided goal-directed therapy (GDT). Protocols aiming for central venous-to-arterial carbon dioxide gap (DCO2) <6 mm Hg have improved organ function in septic shock. Evidence for use of DCO2 in the perioperative period is scarce. Read More

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January 2022

Antenatal fetal surveillance of women with severe obesity.

J Matern Fetal Neonatal Med 2022 Jan 13:1-6. Epub 2022 Jan 13.

UConn Center on Aging, UConn Health, Farmington, CT, USA.

Objective: To estimate the impact of body mass index (BMI) categories on duration of the nonstress test (NST), and the need for additional tests of fetal wellbeing or interventions.

Methods: We conducted a retrospective cohort study of women with singleton pregnancies who had an NST for the indications of severe obesity (BMI ≥40 kg/m), diabetes (pre-gestational or gestational), hypertensive disorders (chronic, gestational, and preeclampsia), and others between 1 January 2015 until 31 December 2016. NST durations (<30 and ≥30 min) were compared between groups first based on BMI (kg/m) categories (<30, 30-39, 40-49, and ≥50) and then based on BMI and comorbidities: (1) severe obesity alone, (2) severe obesity and comorbidities, and (3) comorbidities alone. Read More

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January 2022

Low-intensity ultrasound promotes uterine involution after cesarean section: the first multicenter, randomized, controlled clinical trial.

Int J Hyperthermia 2022 ;39(1):181-189

State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering; Chongqing Key Laboratory of Biomedical Engineering; Chongqing Medical University, Chongqing, China.

Objective: To evaluate the clinical efficacy and safety of low-intensity ultrasound (LIUS) in promoting uterine involution and relieving postpartum pain.

Methods: The randomized controlled clinical trial in this study was conducted at five centers in three regions across China from June 2014 to December 2014. A total of 498 subjects were randomly divided into two groups. Read More

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January 2022

The Safety and Efficacy of Induced Hypertension and Hypervolemia in Preventing Neurological Complications After Combined Direct and Indirect Bypass in Hemorrhagic Onset Moyamoya Disease.

World Neurosurg 2022 Jan 10. Epub 2022 Jan 10.

Department of Neurosurgery and Stanford Stroke Center, Stanford University School of Medicine and Stanford Health Center, Stanford CA. Electronic address:

Background: Perioperative management of blood pressure in patients undergoing surgical revascularization for moyamoya disease (MMD) remains a controversial topic. We evaluated the safety and efficacy of induced hypertension and hypervolemia (IHH) in preventing neurological complications during the perioperative period after direct surgical revascularization in a large hemorrhagic onset moyamoya disease (HOMMD) cohort.

Methods: We retrospectively reviewed a prospectively managed departmental database of all HOMMD patients treated between 1987 and 2019. Read More

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January 2022

Trans-omics analyses revealed key epigenetic genes associated with overall survival in secondary progressive multiple sclerosis.

J Neuroimmunol 2022 Jan 7;364:577809. Epub 2022 Jan 7.

Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: Secondary progressive multiple sclerosis (SPMS) is the second most common presentation of multiple sclerosis (MS) and is characterized by a gradually deteriorating disease with or without relapses. Approximately 80% of patients with relapsing-remitting MS (RRMS) develop SPMS within 20 years. Epidemiological investigations have revealed an average 7-year life expectancy decrease (more severe in progressive subtypes) in patients with MS. Read More

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January 2022

Dabrafenib plus trametinib in patients with BRAF V600E-mutant anaplastic thyroid cancer: updated analysis from the phase II ROAR basket study.

Ann Oncol 2022 Jan 10. Epub 2022 Jan 10.

Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:

Background: Combined therapy with dabrafenib plus trametinib was approved in several countries for treatment of BRAF V600E-mutant anaplastic thyroid cancer (ATC) based on an earlier interim analysis of 23 response-evaluable patients in the ATC cohort of the phase II Rare Oncology Agnostic Research (ROAR) basket study. We report an updated analysis describing the efficacy and safety of dabrafenib plus trametinib in the full ROAR ATC cohort of 36 patients with approximately 4 years of additional study follow-up.

Patients And Methods: ROAR is an open-label, nonrandomized, phase II basket study evaluating dabrafenib plus trametinib in BRAF V600E-mutant rare cancers. Read More

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January 2022