262 results match your criteria duration akinesia


Midbrain atrophy related to parkinsonism in a non-coding repeat expansion disorder: five cases of spinocerebellar ataxia type 31 with nigrostriatal dopaminergic dysfunction.

Cerebellum Ataxias 2021 Mar 30;8(1):11. Epub 2021 Mar 30.

Department of Neurology, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu, Tokyo, 183-0042, Japan.

Background: Spinocerebellar ataxia type 31 (SCA31) is caused by non-coding pentanucleotide repeat expansions in the BEAN1 gene. Clinically, SCA31 is characterized by late adult-onset, pure cerebellar ataxia. To explore the association between parkinsonism and SCA31, five patients with SCA31 with concomitant nigrostriatal dopaminergic dysfunction (NSDD) development, including three cases of L-DOPA responsive parkinsonism, were analyzed. Read More

View Article and Full-Text PDF

Deciphering the saccade velocity profile of progressive supranuclear palsy: A sign of latent cerebellar/brainstem dysfunction?

Clin Neurophysiol 2021 Feb 3. Epub 2021 Feb 3.

Department of Human Neurophysiology, School of Medicine, Fukushima Medical University, Fukushima, Japan.

Objective: To study whether the velocity profile of horizontal saccades could be used as an indicator of brainstem and cerebellar output dysfunction, depending on progressive supranuclear palsy (PSP) subtype.

Methods: We compared the velocity profiles in 32 PSP patients of various subtypes with 38 age-matched normal subjects, including Richardson syndrome (RS), PSP-parkinsonism (PSPp), and pure akinesia (PAGF), and cerebellar subtypes of PSP (PSPc).

Results: PSP patients showed reduced peak velocity along with increased duration, especially in the deceleration phase. Read More

View Article and Full-Text PDF
February 2021

Effects of Levodopa on quality of sleep and nocturnal movements in Parkinson's Disease.

J Neurol 2021 Feb 5. Epub 2021 Feb 5.

Department of Neurology, Christian-Albrecht-University Kiel, Arnold-Heller-Straße 3, Kiel, Germany.

Background: Sleep disturbances are common in Parkinson's Disease (PD), with nocturnal akinesia being one of the most burdensome. Levodopa is frequently used in clinical routine to improve nocturnal akinesia, although evidence is not well proven.

Methods: We assessed associations of Levodopa intake with quality of sleep and perception of nocturnal akinesia in three PD cohorts, using the Parkinson's Disease Sleep Scale (PDSS-2) in two cohorts and a question on nocturnal immobility in one cohort. Read More

View Article and Full-Text PDF
February 2021

Postoperative supplementary motor area syndrome: clinical evolution and prognosis in nine patients after left hemispheric tumor resection.

Hippokratia 2020 Jan-Mar;24(1):38-42

Department of Neurology, Ibn Sina Hospital, Safat, Kuwait.

Background: The postoperative supplementary motor area (SMA) syndrome may complicate unilateral surgery involving the SMA cortex and manifests as contralateral or global akinesia, mutism, or speech deficit, with complete or major recovery in weeks to months.

Case Series: We observed retrospectively nine patients (median age 47 years, range 27-60, five female) who underwent surgery for left premotor area tumors (six intra-axial and three extra-axial). Volumetric microsurgical resection was performed with neuro-navigational assistance (Vector Vision-BrainLab™ or SonoWand Invite™). Read More

View Article and Full-Text PDF
December 2020

Lacrimal dilator-facilitated incisionless vs. standard sub-Tenon's block: a randomized, prospective and non-inferiority comparative study.

Eye (Lond) 2020 Oct 1. Epub 2020 Oct 1.

Department of Anaesthesia, Khoo Teck Puat Hospital, Yishun Central 90, Singapore, Singapore.

Background/objectives: Standard sub-Tenon's block (STB) involves incision (dissection) of conjunctiva and Tenon's capsule with the help of blunt scissors and forceps, insertion of a blunt sub-Tenon's cannula under the Tenon's capsule and injection of local anaesthetic agent. STB is frequently associated with minor complications such as chemosis and postoperative subconjunctival haemorrhage but rare sight and life-threatening complications. To reduce these minor complications, several variations of incisionless STB have been described however, there are no comparative data. Read More

View Article and Full-Text PDF
October 2020

Trimetazidine-Induced Parkinsonism: A Systematic Review.

Front Neurol 2020 25;11:44. Epub 2020 Feb 25.

Section of Neurology, Department of Internal Medicine, Cardinal Santos Medical Center, San Juan, Philippines.

Trimetazidine (TMZ) is a medication given to patients with stable coronary artery disease. While it is reportedly well-tolerated, there are increasing numbers of reports of adverse events such as parkinsonism. The purpose of this study was to systematically review the currently available literature on TMZ-induced parkinsonism. Read More

View Article and Full-Text PDF
February 2020

Antipsychotic Treatment Effectiveness in First Episode of Psychosis: PAFIP 3-Year Follow-Up Randomized Clinical Trials Comparing Haloperidol, Olanzapine, Risperidone, Aripiprazole, Quetiapine, and Ziprasidone.

Int J Neuropsychopharmacol 2020 04;23(4):217-229

CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain.

Background: Different effectiveness profiles among antipsychotics may be a key point to optimize treatment in patients suffering a first episode of psychosis to impact on long-term outcome. The aim of this study is to compare the clinical effectiveness of olanzapine, risperidone, haloperidol, aripiprazole, ziprasidone, and quetiapine in the treatment of first episode of psychosis at 3-year follow-up.

Method: From February 2001 to January 2011, 2 phases of a prospective, randomized, open-label study were undertaken. Read More

View Article and Full-Text PDF

Gait bradykinesia: difficulty in switching posture/gait measured by the anatomical y-axis vector of the sole in Parkinson's disease.

Exp Brain Res 2020 Jan 10;238(1):139-151. Epub 2019 Dec 10.

Clinical Brain Research Laboratory, Department of Neurology, Toyokura Memorial Hall, Sapporo Yamanoue Hospital, Yamanote 6-9-1-1, Nishi-ku, Sapporo, Hokkaido, 063-0006, Japan.

This study in Parkinson's disease examined how spatiotemporal parameters in gait bradykinesia link to difficulty in terminating posture and initiating gait locomotion. 41 idiopathic Parkinson's disease patients and 15 age-matched healthy subjects participated in this study. After the patients fixated on a visual-fixation-target, gait was triggered by visual or vocal cue-stimulus. Read More

View Article and Full-Text PDF
January 2020

Efficacy and Safety of a Novel Blunt Cannula Trans-Sub-Tenon's Retrobulbar Block for Vitreoretinal Surgery.

Middle East Afr J Ophthalmol 2019 Jul-Sep;26(3):163-167. Epub 2019 Sep 30.

Cardiff Eye Unit, University Hospital of Wales, Cardiff, Wales.

Purpose: To evaluate a novel trans-sub-Tenon's retrobulbar block (TSTRB) compared to sub-Tenon's block (STB) and peribulbar block (PBB) anesthesia for vitreoretinal surgery.

Methods: This study was a prospective evaluation of cases undergoing TSTRB, STB, or PBB. The Kallio scale and Brahma scales were used to score hemorrhage and extraocular motility, respectively. Read More

View Article and Full-Text PDF
January 2020

Quantitative associations between objective sleep measures and early-morning mobility in Parkinson's disease: cross-sectional analysis of the PHASE study.

Sleep 2020 01;43(1)

Department of Epidemiology, Nara Medical University School of Medicine, Japan.

Study Objectives: Previous studies have suggested associations between sleep measures and early-morning akinesia; however, objective evidence is limited. The purpose of this study was to evaluate the associations between objective sleep measures and morning mobility among patients with Parkinson's disease (PD).

Methods: In this cross-sectional study, we measured objective sleep parameters and morning mobility in 157 patients with PD (mean age, 71. Read More

View Article and Full-Text PDF
January 2020

Are PSP patients included in clinical trials representative of the general PSP population?

Parkinsonism Relat Disord 2019 09 10;66:202-206. Epub 2019 Jul 10.

Sorbonne Université, Assistance Publique Hôpitaux de Paris, Institut du Cerveau et de la Moelle épinière, ICM, Inserm U 1127, CNRS UMR 7225, Department of Neurology, Hôpital Pitié-Salpêtrière, F-75013, Paris, France. Electronic address:

Background: Progressive supranuclear palsy (PSP) is a rare parkinsonian syndrome with a wide spectrum of clinical presentations. Recently, the MDS published revised diagnosis criteria to provide early and reliable diagnosis of PSP and its variants. Two large randomized clinical trials were initiated in 2017, but the question remains regarding the extrapolation of their results to the general PSP population. Read More

View Article and Full-Text PDF
September 2019

Clinical features of freezing of gait in Parkinson's disease patients.

Brain Behav 2019 04 9;9(4):e01244. Epub 2019 Mar 9.

National Hospital Organization Matsue Medical Center, Matue, Japan.

Objective: To clarify the clinical features of freezing of gait (FOG) in Parkinson's disease (PD) patients by classification into two groups: Clinically observed FOG (CFOG) and self-reported FOG (SFOG).

Methods: Two hundred twenty-nine PD patients were medically examined in an examination room as well as subjected to a New Freezing of Gait Questionnaire (NFOG-Q) and analysis of nonmotor symptoms including sleep, cognition, depression, and fatigue.

Results: The prevalence of CFOG was 17. Read More

View Article and Full-Text PDF

Regional Anesthesia for Pediatric Ophthalmic Surgery: A Review of the Literature.

Anesth Analg 2020 05;130(5):1351-1363

Department of Anesthesiology, Perioperative Medicine and Pain Management, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami Health System, Miami, Florida.

Ophthalmic pediatric regional anesthesia has been widely described, but infrequently used. This review summarizes the available evidence supporting the use of conduction anesthesia in pediatric ophthalmic surgery. Key anatomic differences in axial length, intraocular pressure, and available orbital space between young children and adults impact conduct of ophthalmic regional anesthesia. Read More

View Article and Full-Text PDF

Efficacy of midazolam addition to local anesthetic in peribulbar block : Randomized controlled trial.

Authors:
M Ibrahim E Gomaa

Anaesthesist 2019 03 9;68(3):143-151. Epub 2019 Jan 9.

Department of Anesthesiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background: Peribulbar block is considered a safe option for patients undergoing cataract surgery. The limited duration of regional eye blocks was shown to be the main problem. The objective of this study was to evaluate the effects of adjuvant midazolam (in two concentrations) to lidocaine in the peribulbar block. Read More

View Article and Full-Text PDF

Modulation of specific components of sleep disturbances by simultaneous subthalamic and nigral stimulation in Parkinson's disease.

Parkinsonism Relat Disord 2019 05 28;62:141-147. Epub 2018 Dec 28.

Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. Electronic address:

Objective: To compare the effect of simultaneous deep brain stimulation of the subthalamic nucleus and substantia nigra pars reticulata (STN+SNr-DBS) to conventional subthalamic stimulation (STN-DBS) on sleep quality in Parkinson's disease (PD) patients.

Methods: The study was a single-center, randomized, double-blind, cross-over clinical trial to compare the effect of STN-DBS vs. combined STN+SNr-DBS on subjective measures of sleep quality. Read More

View Article and Full-Text PDF

[Questionnaire survey of Scans Without Evidence of Dopaminergic Deficit (SWEDD) in Japan].

Rinsho Shinkeigaku 2018 Sep 31;58(9):549-555. Epub 2018 Aug 31.

Department of Neurology, National Center Hospital, Parkinson's Disease & Movement Disorders Center, National Center of Neurology and Psychiatry, Japan.

We conducted a questionnaire survey to collect epidemiological information on patients with Scans Without Evidence of Dopaminergic Deficit (SWEDD). We sent questionnaires to 4,970 neurology specialists in Japan in July 2015 and received responses from 933 of them. The total number of patients reported to have Parkinson's disease was 39,532, which included 237 cases of SWEDD in patients (111 males, 125 females, and 1 case without a gender description). Read More

View Article and Full-Text PDF
September 2018

Dexamethasone Compared to Dexmedetomidine as an Adjuvant to Local Anesthetic Mixture in Peribulbar Block for Vitreoretinal Surgery. A Prospective Randomized Study.

Anesth Essays Res 2018 Apr-Jun;12(2):359-365

Lecturer of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Tanta University, Tanta, Egypt.

Background: Dexamethasone or dexmedetomidine may improve the quality of peribulbar block.

Aim: The aim of this study is to compare the effects of adding either dexamethasone or dexmedetomidine to peribulbar block on the efficacy, intraocular pressure (IOP), time to first analgesic request, total analgesic requirement, and side effects in patients undergoing vitreoretinal surgery.

Design: This was a clinical prospective randomized study. Read More

View Article and Full-Text PDF

Levodopa Reduces the Phase lag Index of Parkinson's Disease Patients: A Magnetoencephalographic Study.

Clin EEG Neurosci 2019 Mar 18;50(2):134-140. Epub 2018 Jun 18.

Department of Functional Neurosurgery, Ruijin Hospital, Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, China.

. As a method of measuring the phase difference between 2 signals, the phase lag index (PLI) of the alpha and beta bands in patients with Parkinson's disease (PD) was investigated by using magnetoencephalography (MEG). . Read More

View Article and Full-Text PDF

Analysis of nocturnal hypokinesia and sleep quality in Parkinson's disease.

J Clin Neurosci 2018 Aug 13;54:96-101. Epub 2018 Jun 13.

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Institute of Neuroscience, Soochow University, Suzhou 215123, China. Electronic address:

Nocturnal hypokinesia/akinesia and sleep disorder are believed to be common in Parkinson's disease (PD), but are often underestimated. To date, only a few studies have focused on nocturnal symptoms related to motor function and sleep quality in PD patients, and the assessments were based mainly on the subjective descriptions of the patients. In this study, we assessed the relationships between motor symptoms and sleep quality in 29 PD patients (17 PD patients reporting impaired bed mobility (IBM) and 12 patients without IBM). Read More

View Article and Full-Text PDF

Onset and Remission of Psychosis in Parkinson's Disease: Pharmacologic and Motoric Markers.

Mov Disord Clin Pract 2018 Jan-Feb;5(1):31-38. Epub 2017 Sep 15.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States.

Background: Psychosis is among the most disabling complications of Parkinson's disease (PD). The chronicity of PD psychosis remains understudied and the relative importance of dopaminergic therapy versus the disease process itself in engendering psychosis remains unclear.

Objectives: To examine pharmacologic and motoric correlates of PD psychosis onset and remission in a longitudinally monitored PD cohort. Read More

View Article and Full-Text PDF
September 2017

Brain Atrophy and Reorganization of Structural Network in Parkinson's Disease With Hemiparkinsonism.

Front Hum Neurosci 2018 27;12:117. Epub 2018 Mar 27.

Department of Radiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Hemiparkinsonism duration in patients with Parkinson's disease (PD) is a key time window to study early pathology of PD. We aimed to comprehensively explore the alterations of deformation and structural network in PD patients with hemiparkinsonism, which could potentially disclose the early biomarker for PD. Thirty-one PD patients with hemiparkinsonism and 37 age- and gender- matched normal controls were included in the present study. Read More

View Article and Full-Text PDF

An 8-Week Low-Intensity Progressive Cycling Training Improves Motor Functions in Patients with Early-Stage Parkinson's Disease.

J Clin Neurol 2018 Apr;14(2):225-233

School of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan City, Taiwan.

Background And Purpose: The effects of high-intensity cycling as an adjuvant therapy for early-stage Parkinson's disease (PD) were highlighted recently. However, patients experience difficulties in maintaining these cycling training programs. The present study investigated the efficacy of cycling at a mild-to-moderate intensity in early-stage PD. Read More

View Article and Full-Text PDF

Antidepressant-like effect of active fraction of Polyrhachisvicina Roger in a rat depression model.

J Tradit Chin Med 2018 Feb;38(1):12-21

College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.

Objective: To investigate the antidepressant-like effect of active fraction of Polyrhachis vicina Roger (AFPR) in a rat depression model, and to elucidate the underlying mechanism.

Methods: AFPR was extracted with ethanol followed by petroleum ether. Its antidepressant-like effect was investigated in mice by tail suspension test (TST), forced swimming test (FST) and open field test (OPT). Read More

View Article and Full-Text PDF
February 2018

Optimal Dose of Dexmedetomidine Retrobulbar Anesthesia during Phacoemulsification Cataract Surgery.

Anesth Essays Res 2017 Oct-Dec;11(4):1046-1050

Department of Ophthalmology, Menoufia University, Menoufia, Egypt.

Background: The cataract surgery anesthesia should be to make the procedure as safe and as satisfactory as possible for all concerned. The recent progress in anesthesia and surgery now allow cataract extraction to be done with minimal physiological changes to the patient. We aimed in the study to compare between two different doses of dexmedetomidine combined with lidocaine and bupivacaine during retrobulbar anesthesia for cataract extraction by phacoemulsification. Read More

View Article and Full-Text PDF
December 2017

Anti-Parkinsonian and anti-dyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists.

Br J Pharmacol 2018 03 31;175(5):782-796. Epub 2018 Jan 31.

Department of Medical Sciences, Section of Pharmacology, University of Ferrara, Ferrara, Italy.

Background And Purpose: We previously showed that nociceptin/orphanin FQ opioid peptide (NOP) receptor agonists attenuate the expression of levodopa-induced dyskinesia in animal models of Parkinson's disease. We now investigate the efficacy of two novel, potent and chemically distinct NOP receptor agonists, AT-390 and AT-403, to improve Parkinsonian disabilities and attenuate dyskinesia development and expression.

Experimental Approach: Binding affinity and functional efficacy of AT-390 and AT-403 at the opioid receptors were determined in radioligand displacement assays and in GTPγS binding assays respectively, conducted in CHO cells. Read More

View Article and Full-Text PDF

Targeted kinase inhibition relieves slowness and tremor in a model of LRRK2 Parkinson's disease.

NPJ Parkinsons Dis 2017 4;3:34. Epub 2017 Dec 4.

Department of Biology, University of York, York, YO1 5DD UK.

In a number of models of genetic Parkinson's disease (PD) flies climb more slowly than wild-type controls. However, this assay does not distinguish effects of PD-related genes on gravity sensation, "arousal", central pattern generation of leg movements, or muscle. To address this problem, we have developed an assay for the fly proboscis extension response (PER). Read More

View Article and Full-Text PDF
December 2017

D-512, a novel dopamine D receptor agonist, demonstrates greater anti-Parkinsonian efficacy than ropinirole in Parkinsonian rats.

Br J Pharmacol 2017 Sep 11;174(18):3058-3071. Epub 2017 Aug 11.

Behavioral Neuroscience Program, Department of Psychology, Binghamton University - State University of New York, Binghamton, NY, USA.

Background And Purpose: Symptoms of Parkinson's disease are commonly managed using selective dopamine D receptor agonists, including ropinirole. While D agonists are useful in early-stage Parkinson's disease, they tend to lose efficacy in later disease stages and do not appear to modify disease progression. We have recently developed a novel 'multifunctional' compound, D-512: a high-affinity D receptor agonist with antioxidant and other neuroprotective properties that may limit Parkinson's disease progression. Read More

View Article and Full-Text PDF
September 2017

Baseline motor findings and Parkinson disease prognostic subtypes.

Neurology 2017 Jul 7;89(2):138-143. Epub 2017 Jun 7.

From the Division of Neurology (A.H.R., A.R.), Saskatoon Health Region/University of Saskatchewan, Rosthern; and Movement Disorders Program (M.L.R.) and College of Medicine (L.W.F.), University of Saskatchewan, Saskatoon, Canada.

Objective: To identify the significance of baseline motor features to the lifelong prognostic motor subtypes in a Parkinson disease (PD) cohort.

Methods: In a previous study of 166 PD cases, we observed different prognosis in tremor-dominant, akinetic-rigid, and mixed subtypes. This study includes the same cases, but we excluded 10 cases with symptoms of ≥15 years duration at baseline. Read More

View Article and Full-Text PDF

Effect of Addition of Fentanyl and Clonidine to Local Anesthetic Solution in Peribulbar Block.

J Pharmacol Pharmacother 2017 Jan-Mar;8(1):3-7

Department of Anesthesiology, P. D. U. Medical College, Rajkot, Gujarat, India.

Objective: To compare the effect of addition of fentanyl and clonidine as adjuvants to bupivacaine and lignocaine in peribulbar block.

Methods: The study was conducted on 105 adult patients of either sex, of ASA grade I and II undergoing ophthalmic surgeries. Patients were randomly divided into 3 groups of 35 each. Read More

View Article and Full-Text PDF