2,340 results match your criteria duration 184

Laparoscopic cholecystectomy after endoscopic trans-papillary gallbladder stenting for acute cholecystitis: a pilot study of surgical feasibility.

BMC Surg 2021 Apr 7;21(1):184. Epub 2021 Apr 7.

Department of Hepatobiliary-Pancreatic Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: Percutaneous transhepatic gallbladder drainage (PTGBD) is indicated for patients with acute cholecystitis (AC) who are not indicated for urgent surgery, but external tubes reduce quality of life (QOL) while waiting for elective surgery. The objective of the present study was to investigate the feasibility of laparoscopic cholecystectomy after endoscopic trans-papillary gallbladder stenting (ETGBS) comparing with after PTGBD.

Methods: Intraoperative and postoperative outcomes of patients with ETGBS and PTGBD were retrospectively compared. Read More

View Article and Full-Text PDF

Peri-operative blood management of Jehovah's Witnesses undergoing cytoreductive surgery for advanced ovarian cancer.

Blood Transfus 2021 Feb 25. Epub 2021 Feb 25.

Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy.

Background: The aim of this study was to evaluate the efficacy and feasibility of a peri-operative bloodless medicine and surgery (BMS) protocol in reducing severe post-operative anaemia (haemoglobin [Hb] <7 g/dL) in Jehovah's Witnesses undergoing cytoreductive surgery for advanced epithelial ovarian cancer.

Materials And Methods: This was a single-institution retrospective study enrolling Jehovah's Witnesses who underwent elective bloodless surgery for advanced epithelial ovarian cancer between October 2017 and April 2020. All patients followed a standardised bloodless medicine and surgery protocol based on ferric carboxymaltose and erythropoietin if indicated. Read More

View Article and Full-Text PDF
February 2021

Prognostic Factors for Radiographic Progression in Patients with Seronegative Rheumatoid Arthritis.

J Pers Med 2021 Mar 5;11(3). Epub 2021 Mar 5.

Division of Rheumatology, Department of Medicine, Jeju National University School of Medicine, Jeju 63241, Korea.

(1) Background: It has long been suggested that seronegative rheumatoid arthritis (RA) represents a clinical entity quite distinct from that of seropositive. However, analytical studies of seronegative RA dedicated to clinical outcomes regarding radiographic progression and related risk factors are scarce. The aim of this study is to evaluate radiographic outcome and prognostic factors for radiographic progression in patients with seronegative rheumatoid arthritis. Read More

View Article and Full-Text PDF

Treatment Protocol for COVID-19 Based on T2R Phenotype.

Viruses 2021 03 18;13(3). Epub 2021 Mar 18.

Rhinology and Skull Base Research Group, Baton Rouge General Medical Center, 8585 Picardy Ave., Suite 210, Baton Rouge, LA 70809, USA.

COVID-19 has become a global pandemic of the highest priority. Multiple treatment protocols have been proposed worldwide with no definitive answer for acure. A prior retrospective study showed association between bitter taste receptor 38 (T2R38) phenotypes and the severity of COVID-19. Read More

View Article and Full-Text PDF

Continuous versus routine EEG in critically ill adults: reimbursement analysis of a randomised trial.

Swiss Med Wkly 2021 Mar 16;151:w20477. Epub 2021 Mar 16.

Department of Neurology, Lausanne University Hospital and University of Lausanne, Switzerland.

Background: Continuous EEG (cEEG) is increasingly used in critically ill patients, but it is more resource-intensive than routine EEG (rEEG). In the US, cEEG generates increased hospitalisation charges. This study analysed hospital-related reimbursement for participants in a Swiss multicentre randomised controlled trial that assessed the relationship of cEEG versus repeated rEEG with outcome. Read More

View Article and Full-Text PDF

Survival analysis and treatment strategies for limb liposarcoma patients with metastasis at presentation.

Medicine (Baltimore) 2021 Apr;100(13):e25296

Department of Orthopedics, Ningbo No. 6 Hospital, Ningbo.

Abstract: Limited data exist on patients with limb liposarcoma (LLS) with metastasis at presentation Moreover, the potential prognostic factors of this patient population are poorly documented because of its rarity. Therefore, we conducted this study to evaluate the clinicopathologic characteristics and prognostic factors for patients with metastatic LLS.All patients with LLS with metastasis at presentation from 1975 to 2016 were identified by using the Surveillance, Epidemiology, and End Results (SEER) database. Read More

View Article and Full-Text PDF

A Therapeutic Education Program with a Diabetes Specialist Nurse for Type 2 Diabetes Patients Using Insulin in a Primary Care Setting. A Diabetes Education Program with a Diabetes Specialist Nurse in a Primary Care Setting.

Endocrinol Diabetes Nutr 2021 Mar 23. Epub 2021 Mar 23.

Unidad de Diabetes, Endocrinología y Nutrición, Hospital Clínic i Universitari, Barcelona, España; IDIBAPS, Institut d'investigacions Biomèdiques August Pi i Sunyer, Barcelona, España; CIBERDEM. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades metabólicas, Barcelona, España.

Introduction: Therapeutic education is an essential part in the management of type 2 diabetes mellitus (T2D). Implementing a therapeutic education program with the participation of a diabetes specialist nurse (DSN) addressed to patients with T2D using more than 2insulin injections and sub-optimal metabolic control in primary care (PC) could improve health care and clinical outcomes. Our purpose was to evaluate the clinical, educational and patient satisfaction outcomes of this program. Read More

View Article and Full-Text PDF

Combined Effect of Smoking and Obesity on Coronary Heart Disease Mortality in Male Veterans: A 30-year Cohort Study.

Biomed Environ Sci 2021 Mar;34(3):184-191

Department of Epidemiology and Statistics, The Graduate School of the Chinese PLA General Hospital, Beijing 100853, China.

Objective: Evidence is lacking regarding the combined effects of smoking and obesity on mortality from coronary heart disease in male veterans. This study aimed to explore the combined effect of smoking and obesity on coronary heart disease mortality in male veterans in China.

Methods: A cohort of 1,268 male veterans from 22 veteran centers in Xi'an (Shaanxi Province, China) were followed up once every 2 years from February 1, 1987 to October 30, 2016. Read More

View Article and Full-Text PDF

Planning acetabular fracture reduction using a patient-specific biomechanical model: a prospective and comparative clinical study.

Int J Comput Assist Radiol Surg 2021 Mar 24. Epub 2021 Mar 24.

TIMC-IMAG Lab, Univ. Grenoble Alpes, CNRS UMR 5525, La Tronche, France.

Purpose: A simple, patient-specific biomechanical model (PSBM) is proposed in which the main surgical tools and actions can be simulated, which enables clinicians to evaluate different strategies for an optimal surgical planning. A prospective and comparative clinical study was performed to assess early clinical and radiological results.

Methods: From January 2019 to July 2019, a PSBM was created for every operated acetabular fracture (simulation group). Read More

View Article and Full-Text PDF

FDA Approval Summary: Fam-trastuzumab deruxtecan-nxki for the treatment of unresectable or metastatic HER2-positive breast cancer.

Clin Cancer Res 2021 Mar 22. Epub 2021 Mar 22.

Office of Hematology and Oncology, United States Food and Drug Administration.

On December 20, 2019, the FDA granted accelerated approval to fam-trastuzumab deruxtecan-nxki (DS-8201a, T-DXd, tradename ENHERTU) for the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received two or more prior anti-HER2-based regimens in the metastatic setting. Approval was based on data from study DS8201-A-U201 (DESTINY-Breast01) with supportive safety data from study DS8201-A-J101. The primary efficacy endpoint in DESTINY-Breast01 was overall response rate (ORR) based on confirmed responses by blinded independent central review (ICR) using RECIST v1. Read More

View Article and Full-Text PDF

Prospective Study of White Matter Health for an Altitude Chamber Research Program.

Aerosp Med Hum Perform 2021 Apr;92(4):215-222

Hypobaric decompression has been associated with brain white matter injury. Relevant exposure limits are unknown, raising ethical concerns over safety of volunteers for altitude chamber research. To inform this, a prospective study of white matter status using brain Magnetic Resonance Imaging (MRI) was conducted before and after a 9-mo program of hypobaric research. Read More

View Article and Full-Text PDF

Prevalence of spp. in translocated wild reptiles and effect of duration of quarantine on their body condition.

M Baling C Mitchell

N Z Vet J 2021 May 19;69(3):174-179. Epub 2021 Mar 19.

Friends of Matakohe/Limestone Island Society, Whangarei, New Zealand.

Aims: To assess the prevalence of carriage of spp. in wild reptiles translocated from multiple locations to a single island, and determine changes in their body condition (BC) during quarantine.

Methods: Between 2007 and 2009, six endemic reptile species (, , , , , and ) were caught from several locations in the northern North Island of New Zealand. Read More

View Article and Full-Text PDF

Safety and side effects of transperineal prostate biopsy without antibiotic prophylaxis.

Urol Oncol 2021 Mar 15. Epub 2021 Mar 15.

Department of Urology, Faculty of Medicine, University of Freiburg - Medical Centre, Freiburg, Germany.

Study Aims: To investigate safety and side effects of transperineal prostate biopsy without antibiotic prophylaxis. Secondary aim was to identify whether the number of cores influenced the occurrence of complications.

Patients And Methods: A cohort of 184 patients undergoing perineal prostate biopsy without antibiotic prophylaxis from 2015 to 2017 was analyzed retrospectively. Read More

View Article and Full-Text PDF

Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia.

ERJ Open Res 2021 Jan 8;7(1). Epub 2021 Mar 8.

Servei de Pneumologia i Al·lèrgia Respiratòria, Institut Clínic del Tórax, Hospital Clínic de Barcelona, CIBERES, Barcelona, Spain.

Background: The relationship between early oseltamivir treatment (within 48 h of symptom onset) and mortality in patients admitted to intensive care units (ICUs) with severe influenza is disputed. This study aimed to investigate the association between early oseltamivir treatment and ICU mortality in critically ill patients with influenza pneumonia.

Methods: This was an observational study of patients with influenza pneumonia admitted to 184 ICUs in Spain during 2009-2018. Read More

View Article and Full-Text PDF
January 2021

Clinical and Laboratory Profile of Hospitalized Symptomatic COVID-19 Patients: Case Series Study From the First COVID-19 Center in the UAE.

Front Cell Infect Microbiol 2021 26;11:632965. Epub 2021 Feb 26.

Department of Medicine, Oman Medical Specialty Board, The Royal Hospital, Muscat, Oman.

Introduction: COVID-19 is raising with a second wave threatening many countries. Therefore, it is important to understand COVID-19 characteristics across different countries.

Methods: This is a cross-sectional descriptive study of 525 hospitalized symptomatic COVID-19 patients, from the central federal hospital in Dubai-UAE during period of March to August 2020. Read More

View Article and Full-Text PDF

Clinical application of a digital thoracic drainage system for objectifying and quantifying air leak versus the traditional vacuum system: a retrospective observational study.

J Thorac Dis 2021 Feb;13(2):1020-1035

Department of Thoracic and Cardiovascular Surgery, School of Medicine, Konkuk University, Konkuk University Chungju Hospital, Chungju-si, Chungbuk, Republic of Korea.

Background: Digital thoracic drainage systems have recently been introduced and widely used in clinical practices in developed countries. These systems can monitor intrathoracic pressure changes and air leaks in real time, and also allow for objective and quantitative analyses, which aid in managing patients with a prolonged persistent air leak into the pleural space. We investigated the feasibility and effectiveness of such a new device versus the traditional vacuum system for treating patients with pneumothorax. Read More

View Article and Full-Text PDF
February 2021

A Randomized Controlled Trial Comparing Alloderm-RTU with DermACELL in Immediate Subpectoral Implant-Based Breast Reconstruction.

Curr Oncol 2020 Dec 25;28(1):184-195. Epub 2020 Dec 25.

Ottawa Hospital Research Institute and University of Ottawa, Ottawa, ON K1H 8L6, Canada.

Background: The effectiveness of different acellular dermal matrices (ADM) used for implant-based reconstruction immediately following mastectomy is an important clinical question. A prospective randomized clinical trial was performed to evaluate the superiority of DermACELL over Alloderm-RTU in reducing drain duration.

Methods: Patients undergoing mastectomy with subpectoral immediate and permanent implant-based breast reconstruction were randomized to Alloderm-RTU or DermACELL. Read More

View Article and Full-Text PDF
December 2020

Motor Imagery Deficits in High-Functioning Older Adults and its Impact on Fear of Falling and Falls.

J Gerontol A Biol Sci Med Sci 2021 Mar 8. Epub 2021 Mar 8.

Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, Japan.

Background: Older adults at risk of falling or who have fear of falling (FoF) present a discrepancy between "imagined" and "performed" actions. Using the gait-related motor imagery (MI) paradigm, we investigated whether prediction accuracy in motor execution is associated with the onset of FoF and with prospective falls among older adults with FoF.

Methods: A cohort of 184 community-dwelling older adults was tested for imaginary and executed Timed Up and Go (TUG) tests at a fast pace at baseline. Read More

View Article and Full-Text PDF

Effect of triple antimicrobial therapy on electrocardiography parameters in patients with mild-to-moderate coronavirus disease 2019.

Anatol J Cardiol 2021 03;25(3):184-190

Department of Cardiology, Faculty of Medicine, Gazi University; Ankara-Turkey.

Objective: The effects of treatment of coronavirus disease 2019 (COVID-19) with a triple combination composed of hydroxychloroquine, an an-tiviral, and an antibiotic on electrocardiography (ECG) parameters in patients with mild-to-moderate symptoms are not wholly understood. We aimed to explore the changes in ECG parameters after treatment with triple combination therapy in patients with mild-to-moderate symptomatic COVID-19.

Methods: This retrospective, single-center case series analyzed 91 patients with mild-to-moderate symptomatic COVID-19 at Ankara Gazi Mus-tafa Kemal State Hospital of Ankara City, Turkey, from April 1, 2020, to April 30, 2020. Read More

View Article and Full-Text PDF

Evaluating the effect of ursodeoxycholic acid on total bilirubin of neonates with glucose-6-phosphate dehydrogenase deficiency complicated by indirect hyperbilirubinaemia.

J Paediatr Child Health 2021 Mar 8. Epub 2021 Mar 8.

Department of Family medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Aim: This study aimed to investigate the effect of adding ursodeoxycholic acid (UDCA) to phototherapy in neonates with glucose-6-phosphate dehydrogenase (G6PD) deficiency and hyperbilirubinaemia. G6PD deficiency is a common cause of severe hyperbilirubinaemia in neonates.

Methods: This study was a triple blind, clinical trial study of 40 neonates with G6PD deficiency and hyperbilirubinaemia who admitted for phototherapy in hospitals affiliated to the University of Medical Sciences. Read More

View Article and Full-Text PDF

Multicenter evaluation of four immunoassays for the performance of early diagnosis of COVID-19 and assessment of antibody responses of patients with pneumonia in Taiwan.

J Microbiol Immunol Infect 2021 Feb 23. Epub 2021 Feb 23.

Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Background/purpose: Our study goals were to evaluate the diagnostic performance of four anti-SARS-CoV-2 antibodies tests and the differences in dynamic immune responses between COVID-19 patients with and without pneumonia.

Methods: We collected 184 serum samples from 70 consecutively qRT-PCR-confirmed COVID-19 patients at four participating hospitals from 23 January 2020 to 30 September 2020. COVID-19 pneumonia was defined as the presence of new pulmonary infiltration. Read More

View Article and Full-Text PDF
February 2021

Self-reported suboptimal sleep and receipt of sleep assessment and treatment among persons with and without a mental health condition in Australia: a cross sectional study.

BMC Public Health 2021 Mar 6;21(1):463. Epub 2021 Mar 6.

University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia.

Background: Poor sleep and poor mental health go hand in hand and, together, can have an adverse impact on physical health. Given the already disproportionate physical health inequities experienced by people with a mental health condition worldwide, the need to consider and optimise sleep has been highlighted as a means of improving both physical and mental health status. Sleep recommendations recently developed by the United States' National Sleep Foundation incorporate a range of sleep parameters and enable the identification of 'suboptimal' sleep. Read More

View Article and Full-Text PDF

Seizure Clusters, Seizure Severity Markers, and SUDEP Risk.

Front Neurol 2021 12;12:643916. Epub 2021 Feb 12.

National Institute of Neurological Disorders and Stroke Center for Sudden Unexpected Death in Epilepsy Research (CSR), McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.

Seizure clusters may be related to Sudden Unexpected Death in Epilepsy (SUDEP). Two or more generalized convulsive seizures (GCS) were captured during video electroencephalography in 7/11 (64%) patients with monitored SUDEP in the MORTEMUS study. It follows that seizure clusters may be associated with epilepsy severity and possibly with SUDEP risk. Read More

View Article and Full-Text PDF
February 2021

Analysis of clinical and methodological characteristics of early COVID-19 treatment clinical trials: so much work, so many lost opportunities.

BMC Med Res Methodol 2021 02 26;21(1):42. Epub 2021 Feb 26.

Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Avenida Prof. Egas Moniz, 1649-028, Lisbon, Portugal.

Background: The COVID-19 pandemic continues to rage on, and clinical research has been promoted worldwide. We aimed to assess the clinical and methodological characteristics of treatment clinical trials that have been set forth as an early response to the COVID-19 pandemic.

Methods: First, we reviewed all registered clinical trials on COVID-19. Read More

View Article and Full-Text PDF
February 2021

Effects of transport and altitude on hormones and oxidative stress parameters in sheep.

PLoS One 2021 26;16(2):e0244911. Epub 2021 Feb 26.

Department of Medical Biochemistry, Faculty of Medicine, Ordu University, Altınordu, Ordu, Turkey.

In study, it was aimed to determine the stress effects that can be caused by transporting and altitude in sheep. Karayaka sheeps were used in the study. Karayaka sheeps are a valuable breed of meat quality and fleece, which is raised in the Black Sea region. Read More

View Article and Full-Text PDF
February 2021

Possible protective role of metformin therapy on colonic polyps in acromegaly: an exploratory cross-sectional study.

Eur J Endocrinol 2021 Mar;184(3):423-429

Endocrinology Unit, IRCCS AOU San Martino, Genoa, Italy.

Context: Colonic polyps occur in 30-40% of acromegalic patients, increasing the risk of colon carcinoma. Although debated, there is emerging evidence that metformin may play a protective role in diabetic and non-diabetic patients with colonic polyps and its use in chemoprevention is currently explored.

Objective: Evaluate the prevalence of colonic polyps in acromegalic patients treated or not with metformin and explore its possible protective role. Read More

View Article and Full-Text PDF

High-intensity interval training in breast cancer survivors: a systematic review.

BMC Cancer 2021 Feb 22;21(1):184. Epub 2021 Feb 22.

Division of Health Care Research, Center for Public Health Sciences, National Cancer Center Japan, Tokyo, Japan.

Background: To review the settings and outcomes of high-intensity interval training (HIIT) interventions for breast cancer survivors, and to explore the feasibility of prescribing exercise for breast cancer survivors.

Methods: A systematic search of electronic databases was conducted for studies published up to May 31, 2020. Eligibility criteria included randomized controlled trials of HIIT intervention in breast cancer survivors. Read More

View Article and Full-Text PDF
February 2021

Genomic Insights Into Clinical Shiga Toxin-Producing Strains: A 15-Year Period Survey in Jönköping, Sweden.

Front Microbiol 2021 5;12:627861. Epub 2021 Feb 5.

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden.

Shiga toxin-producing (STEC) are important foodborne pathogens that can cause human infections ranging from asymptomatic carriage to bloody diarrhea (BD) and fatal hemolytic uremic syndrome (HUS). However, the molecular mechanism of STEC pathogenesis is not entirely known. Here, we demonstrated a large scale of molecular epidemiology and in-depth genomic study of clinical STEC isolates utilizing clinical and epidemiological data collected in Region Jönköping County, Sweden, over a 15-year period. Read More

View Article and Full-Text PDF
February 2021

Visual outcomes following cataract surgery in age-related macular degeneration patients.

Can J Ophthalmol 2021 Feb 17. Epub 2021 Feb 17.

Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:

Objective: To evaluate visual acuity (VA) outcomes, prognostic factors, and changes in disease severity in patients with age-related macular degeneration (AMD) undergoing cataract surgery.

Design: Retrospective cohort study PARTICIPANTS: Patients with AMD or healthy control patients who underwent cataract surgery between 2012 and 2017.

Methods: Eyes were categorized into 3 AMD groups-intermediate AMD (iAMD), fovea-involving geographic atrophy (GA), neovascular AMD (nAMD)-and 3 preoperative VA-matched control groups (iAMDc), fovea-involving geographic atrophy control (GAc), neovaascular AMD control (nAMDc). Read More

View Article and Full-Text PDF
February 2021

Risk of bone fractures after the diagnosis of adrenal adenomas: a population-based cohort study.

Eur J Endocrinol 2021 Apr;184(4):597-606

Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.

Objective: Several small studies reported increased prevalence and incidence of asymptomatic vertebral fractures in patients with non-functioning adrenal adenomas and adenomas with mild autonomous cortisol secretion. However, the risk of symptomatic fractures at vertebrae, and at other sites remains unknown. Our objective was to determine the prevalence and incidence of symptomatic site-specific fractures in patients with adrenal adenomas. Read More

View Article and Full-Text PDF