622,309 results match your criteria duration


A qualitative trajectory analysis of patients' experiences tapering opioids for chronic pain.

Pain 2021 May 10. Epub 2021 May 10.

Pain Management Research Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia. School of Medicine and Public Health, University of Newcastle, NSW, Australia.

Abstract: Tapering opioids for chronic pain can be challenging for both patients and prescribers, both of whom may be unsure of what to expect in terms of pain, distress, activity interference, and withdrawal symptoms over the first few weeks and months of the taper. In order to better prepare clinicians to provide patient-centred tapering support, the current research used prospective longitudinal qualitative methods to capture individual-level variation in patients' experience over the first few months of a voluntary physician-guided taper. The research aimed to identify patterns in individuals' experience of tapering, and explore whether patient characteristics, readiness to taper, opioid-tapering self-efficacy, or psychosocial context were related to tapering trajectory. Read More

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Circadian typology and implications for adolescent sleep health. Results from a large, cross-sectional, school-based study.

Sleep Med 2021 Apr 22;83:63-70. Epub 2021 Apr 22.

Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Norway; Centre for Sleep Medicine, Haukeland University Hospital, Norway; Department of Global Public Health and Primary Care, University of Bergen, Norway.

Study Objectives: To investigate circadian typology in a large, representative sample of Norwegian adolescents, and its implications for sleep health.

Methods: The sample included 3920 1 year high school students aged 16-17 years. Respondents completed a web-based survey, including the short version of the Horne-Ostberg Morningness-Eveningness Questionnaire (rMEQ), the Munich Chronotype Questionnaire (MCTQ) and items on sleep-related behaviors (eg electronic media usage in bed, consumption of caffeinated beverages), sleep beliefs and daytime sleepiness. Read More

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The association of sleep duration and feeling rested with health in U.S. Hispanic women.

Sleep Med 2021 Apr 9;83:54-62. Epub 2021 Apr 9.

University of South Carolina, Columbia, SC, United States.

This study aims to understand the health correlates of sleep deficiencies in non-elderly U.S. Hispanic women. Read More

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Shared genetic architecture underlying sleep and weight in children.

Sleep Med 2021 Apr 26;83:40-44. Epub 2021 Apr 26.

Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.

Meta-analyses suggest shorter sleep as a risk factor for obesity in children. The prevailing hypothesis is that shorter sleep causes obesity by impacting homeostatic processes. Sleep duration and adiposity are both heritable, and the association may reflect shared genetic aetiology. Read More

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COVID-19 and sleep patterns in adolescents and young adults.

Sleep Med 2021 Apr 15;83:26-33. Epub 2021 Apr 15.

Département de Psychoéducation et de Psychologie, Université du Québec en Outaouais, Gatineau, J8X 3X7, Canada. Electronic address:

Objective: In March 2020, the world experienced a global pandemic, which involved the shutdown of schools or a transposition to remote teaching in most countries. The objective of the present study was to investigate the impact of the COVID-19 pandemic related lockdown on sleep patterns and sleep quality in adolescents and young adults.

Methods: An online survey was conducted in June 2020 with adolescents and young adults (n = 498) aged 12-25 years. Read More

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Association between household solid fuel use for cooking and sleep disturbance in rural China: findings from the China Kadoorie Biobank data.

Sleep Med 2021 Apr 28;83:13-20. Epub 2021 Apr 28.

The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

Background: Solid fuel use for cooking is a main source of household air pollution, particularly in rural China. Evidence on the association between household air pollution and sleep quality remains limited. This study aimed to examine the association between household solid fuels used for cooking and sleep disturbance. Read More

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Impact of prone position in non-intubated spontaneously breathing patients admitted to the ICU for severe acute respiratory failure due to COVID-19.

J Crit Care 2021 May 1;64:199-204. Epub 2021 May 1.

Service de Médecine intensive et réanimation, Hôpital Ambroise Paré, Assistance Publique Hôpitaux de Paris, France; INSERM UMR 1018, Clinical Epidemiology Team, CESP, Université de Paris Saclay, Villejuif, France. Electronic address:

Purpose: Studies performed in spontaneously breathing patients with mild to moderate respiratory failure suggested that prone position (PP) in COVID-19 could be beneficial.

Materials And Methods: Consecutive critically ill patients with COVID-19 were enrolled in four ICUs. PP sessions lasted at least 3 h each and were performed twice daily. Read More

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Disseminated peritoneal leiomyomatosis and malignant transformation: A case series in a single referral center.

Eur J Obstet Gynecol Reprod Biol 2021 May 5;262:21-27. Epub 2021 May 5.

Division of Gynecologic Oncology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: The aim of this study was to describe one of the largest series of disseminated peritoneal leiomyomatosis (DPL) and its malignant counterpart, evaluating possible risk factors for both the benign and malignant condition, and highlighting any differences between them in terms of surgical and clinical management.

Study Design: Clinical, surgical and histopathological characteristics of patients diagnosed with DPL (group 1) and malignant-DPL (group 2), between July 2010 and July 2020, were retrospectively retrieved.

Results: A total of 14 benign and 5 malignant cases were selected. Read More

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The localization of the photosensitizer determines the dynamics of the secondary production of hydrogen peroxide in cell cytoplasm and mitochondria.

J Photochem Photobiol B 2021 May 6;219:112208. Epub 2021 May 6.

Lobachevsky State University of Nizhny Novgorod, 23 Gagarin ave., Nizhny Novgorod 603950, Russia. Electronic address:

Photodynamic therapy (PDT) is based on the production of the cytotoxic reactive oxygen species (ROS) by light irradiation of a photosensitizer dye in the presence of molecular oxygen. Along with photochemical ROS production, it becomes evident that PDT induces massive secondary production of ROS which is registered long after the irradiation is completed. We created cell lines of human epidermoid carcinoma with the cytoplasmic and mitochondrial localization of protein sensor HyPer sensitive to hydrogen peroxide to compare its concentration in two cellular compartments. Read More

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Quantification of the impact of traffic incidents on speed reduction: A causal inference based approach.

Accid Anal Prev 2021 May 11;157:106163. Epub 2021 May 11.

School of Traffic and Transportation, Beijing Jiaotong University, Beijing, 100044, China.

This paper designs a systemic framework to quantify speed reduction induced by traffic incidents using a causal inference framework. The results can provide a reference to traffic managers for evaluating incident severities, thus take proper control measures after the incident in order not to underestimate or overestimate the negative impact. A two-phase scheme is proposed, including impacted region determination and speed reduction quantification. Read More

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Single-well injection-withdrawal tests as a contaminant transport characterisation tool for landfilled waste.

Waste Manag 2021 May 11;128:142-153. Epub 2021 May 11.

Faculty of Engineering and Physical Sciences, University of Southampton, Southampton SO17 1BJ, UK.

A new single well injection withdrawal (SWIW) test was trialled at four landfills using the tracers lithium and deuterium, and by injecting clean water and measuring electrical conductivity. The aim of the research was to develop a practical test for measuring lateral contaminant transport to aid in the design of landfill flushing. Borehole dilution tests using dyes were undertaken prior to each SWIW test to determine background flow velocities. Read More

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Process-based LCA of ultrafiltration for drinking water production.

Water Res 2021 Apr 16;199:117156. Epub 2021 Apr 16.

TBI, Université de Toulouse, CNRS, INRAE, INSA, Toulouse, France. Electronic address:

Researchers and industrials need decision-making tools to make informed decisions on environmental mitigation strategies and proceed with the overall ecodesign of processes. In this study, a tool that couples membrane filtration process modelling and life cycle analysis has been developed, for which material and energy flows are calculated for variable operating conditions and are the basis for environmental impact assessment. The resulting generic model has been applied to dead-end ultrafiltration of ground and surface waters for drinking water production with cellulose triacetate hollow fibers. Read More

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Treatment planning factors associated with long-term outcomes of Gamma Knife surgery in patients with trigeminal neuralgia.

World Neurosurg 2021 May 11. Epub 2021 May 11.

Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea; GammaKnife Radiosurgery Center, Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: Gamma Knife surgery (GKS) is an established treatment option for trigeminal neuralgia (TN). However, the long-term efficacy of GKS for patients with TN has not been well-studied. The aim of the study is to evaluate the sequential course of pain control after GKS and analyze the factors associated with the long-term analgesic effect, focusing on radiation dosimetry and neurovascular conflict (NVC) factors. Read More

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Comparison of percutaneous endoscopic lumbar discectomy and open lumbar discectomy in the treatment of adolescent lumbar disc herniation: A retrospective analysis.

World Neurosurg 2021 May 11. Epub 2021 May 11.

Department of Orthopedics, Peking University Third Hospital, Beijing, China. Electronic address:

Objective: To compare and analyze the efficacy and safety of percutaneous endoscopic lumbar discectomy (PELD) and open lumbar discectomy (OLD) for adolescent lumbar disc herniation (ALDH).

Methods: The clinical data of 257 patients with single-segment ALDH who underwent surgical treatment at our hospital from January 2015 to December 2019 were retrospectively collected. According to different surgical methods, these patients were divided into PELD group and OLD group. Read More

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Pediatric Vulvar Lichen Sclerosus: A Survey of Disease Course.

J Pediatr Adolesc Gynecol 2021 May 11. Epub 2021 May 11.

Department of Dermatology, University of North Carolina at Chapel Hill. Electronic address:

Study Objective: To assess long-term outcomes of Lichen Sclerosus (LS) in the female pediatric population, specifically in relation to patient age, treatment type and duration, and remission.

Design: Retrospective chart review was conducted to identify female pediatric patients (0-18 years of age) who were diagnosed with LS between 1/1/2015 and 1/1/2020 at the University of North Carolina Dermatology and/or OB/GYN Departments. Patients were contacted via telephone for follow-up interviews consisting of a series of questions regarding patient age, symptom onset, time of diagnosis, treatment, and current symptoms. Read More

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P-wave signal averaged ECG: reference values, clinical correlates, and heritability in the Framingham Heart Study.

Heart Rhythm 2021 May 11. Epub 2021 May 11.

National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, Framingham, MA, USA; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Background: P-wave signal-averaged electrocardiography (P-SAECG) quantifies atrial electrical activity. P-SAECG measures and their clinical correlates and heritability have had limited characterization in community-based cohorts.

Objectives: To 1) Establish reference values; 2) Identify clinical risk factors associated with P-SAECG; and 3) Estimate genetic heritability for P-SAECG traits. Read More

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Effect of synbiotic supplementation on migraine characteristics and inflammatory biomarkers in women with migraine: results of a randomised controlled trial.

Pharmacol Res 2021 May 11:105668. Epub 2021 May 11.

Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences. Electronic address:

Literature suggests a relationship between gut microbiome and migraine headache pathogenesis. However, the effect of manipulating gut microbiome on migraine remains unclear. This study aimed to investigate the effect of synbiotics on migraine characteristics and inflammatory markers in women with migraine. Read More

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COVID-19 after lung resection in Northern Italy.

Semin Thorac Cardiovasc Surg 2021 May 11. Epub 2021 May 11.

Thoracic Surgery, Memorial Sloan Kettering, Cornell University, New York, USA.

We reviewed surgical cases from 4 Thoracic Surgery departments in the Lombardia region of Italy, the area mostly affected by Coronavirus pandemic in Europe, with the aim to describe the impact of COVID-19 on the treatment of thoracic surgical patients. Clinical, radiological and laboratory data from patients who underwent lung resection from December 2019 to March 2020 were retrospectively collected until June 2020. Univariable Cox regression models were estimated to evaluate potential prognostic factors for developing COVID-19 and to investigate postoperative mortality among patients who developed symptomatic COVID-19 infection. Read More

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Hydrophilic nanofibers as a supersaturating delivery system for carvedilol.

Int J Pharm 2021 May 11:120700. Epub 2021 May 11.

University of Ljubljana, Faculty of Pharmacy, 1000 Ljubljana, Aškerčeva 7, Slovenia. Electronic address:

Polymer nanofibers represent a promising delivery system for poorly water-soluble drugs; however, their supersaturating potential has not been explored yet. Here, carvedilol-loaded nanofibers based on poly(ethyleneoxide) and on amphiphilic block copolymer poloxamer 407 were produced by electrospinning. These nanofibers provided high carvedilol loading and improved dissolution of carvedilol. Read More

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Human serum albumin as multifunctional nanocarrier for cancer therapy.

J Pharm Sci 2021 May 11. Epub 2021 May 11.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi - 110062, India. Electronic address:

Human serum albumin or simply called albumin is a flexible protein employed as a carrier in the fabrication of albumin-based nanocarriers (ANCs) for the administration of cancer therapeutics. Albumin can contribute enhanced tumour specificity, reduced drug induced cytotoxicity and retain concentration of the therapeutically active agent such as drug, peptide, protein, and gene for a prolonged time duration. Nevertheless, apart from cancer management, ANCs are also employed in the diagnosis, imaging, and multimodal cancer therapy. Read More

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Meningiomas in patients with long-term exposition to progestins: Characteristics and outcome.

Neurochirurgie 2021 May 11. Epub 2021 May 11.

Aix Marseille Univ, APHM, INSERM, MMG, Department of Neursurgery, CHU Timone, Marseille, France.

Objective: The aim of this study was to describe progestin-associated meningiomas' characteristics, outcome and management.

Material And Methods: We included 53 patients operated on and/or followed in the department for meningioma with progestin intake longer than one year and with recent drug discontinuation.

Results: Cyproterone acetate (CPA), nomegestrol acetate (NomA), and chlormadinone acetate (ChlA) were involved in most cases. Read More

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Pembrolizumab plus cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma: an open-label, multi-arm, non-randomised, multicentre, phase 2 trial.

Lancet Oncol 2021 May 11. Epub 2021 May 11.

Moores Comprehensive Cancer Center, University of California, San Diego, La Jolla, CA, USA.

Background: Pembrolizumab (PD-1 inhibitor) and cetuximab (EGFR inhibitor) are active as single agents and in combination with cytotoxic chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). Given each drug's single agent activity and unique mechanism of action, we aimed to evaluate the anti-tumour activity of PD-1 blockade with EGFR inhibition in recurrent or metastatic HNSCC.

Methods: This study is an open-label, non-randomised, multi-arm, phase 2 trial done at four academic centres in the USA. Read More

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Phylogeny and mechanisms of shared hierarchical patterns in birdsong.

Curr Biol 2021 May 11. Epub 2021 May 11.

Department of Biology, McGill University, Montreal, QC H3A 1B1, Canada; Centre for Research on Brain, Language, and Music, McGill University, Montreal, QC H3G 2A8, Canada. Electronic address:

Organizational patterns can be shared across biological systems, and revealing the factors shaping common patterns can provide insight into fundamental biological mechanisms. The behavioral pattern that elements with more constituents tend to consist of shorter constituents (Menzerath's law [ML]) was described first in speech and language (e.g. Read More

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Social cognition and executive functioning in multiple sclerosis: A cluster-analytic approach.

J Neuropsychol 2021 May 14. Epub 2021 May 14.

Psychopathology and Neuropsychology Lab, University of Paris 8, Saint-Denis, France.

Multiple sclerosis (MS) is associated with deficits in social cognition, the process underlying social interaction and cognitive function. However, the relationships between executive impairment and social cognition remain unclear in MS. Previous studies exclusively focused on group comparisons between healthy controls and patients with MS, treating the latter as a homogeneous population. Read More

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Effects of Physical Therapist Intervention on the Pulmonary Function in Children With Cerebral Palsy: A Systematic Review and Meta-Analysis.

Phys Ther 2021 May 13. Epub 2021 May 13.

The Jerzy Kukuczka Academy of Physical Education in Katowice, Poland, Institute of Physiotherapy and Health Sciences, Musculoskeletal Elastography and Ultrasonography.

Objective: The purpose of this study was to evaluate the effects of physical therapy on pulmonary function and respiratory muscle strength in children with cerebral palsy (CP).

Methods: A search of 10 databases was conducted for this systematic review. Initially, there were no language, study design, or time frame restrictions. Read More

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Targeted antiviral treatment using non-ionizing radiation therapy for SARS-CoV-2 and viral pandemics preparedness: Technique, methods and practical notes for clinical application.

PLoS One 2021 14;16(5):e0251780. Epub 2021 May 14.

Department of Physics, Faculty of Natural Sciences, Ariel University, Ariel, Israel.

Objective: Pandemic outbreaks necessitate effective responses to rapidly mitigate and control the spread of disease and eliminate the causative organism(s). While conventional chemical and biological solutions to these challenges are characteristically slow to develop and reach public availability; recent advances in device components operating at Super High Frequency (SHF) bands (3-30 GHz) of the electromagnetic spectrum enable novel approaches to such problems.

Methods: Based on experimentally documented evidence, a clinically relevant in situ radiation procedure to reduce viral loads in patients is devised and presented. Read More

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EEG microstate features for schizophrenia classification.

PLoS One 2021 14;16(5):e0251842. Epub 2021 May 14.

Department of Biomedical Science and Engineering (BMSE), Institute Integrated Technology (IIT), Gwangju Institute of Science and Technology (GIST), Cheomdan-gwagiro, Gwangju, South Korea.

Electroencephalography (EEG) microstate analysis is a method wherein spontaneous EEG activity is segmented at sub-second levels to analyze quasi-stable states. In particular, four archetype microstates and their features are known to reflect changes in brain state in neuropsychiatric diseases. However, previous studies have only reported differences in each microstate feature and have not determined whether microstate features are suitable for schizophrenia classification. Read More

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Incidence and predictors of mortality within the first year of antiretroviral therapy initiation at Debre-Markos Referral Hospital, Northwest Ethiopia: A retrospective follow up study.

PLoS One 2021 14;16(5):e0251648. Epub 2021 May 14.

Department of Anesthesiology, College of Medicine and Health Science, Debre-Tabor University, Debre-Tabor, Ethiopia.

Background: Acquired Immunodeficiency Syndrome (AIDS) is one of the most fatal infectious diseases in the world, especially in Sub-Saharan Africa, including Ethiopia. Even though Antiretroviral therapy (ART) significantly decreases mortality overall, death rates are still highest especially in the first year of ART initiation.

Objective: To assess the incidence and predictors of mortality within the first year of ART initiation among adults on ART at Debre-Markos Referral Hospital, Northwest Ethiopia. Read More

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Acute otitis externa: Consensus definition, diagnostic criteria and core outcome set development.

PLoS One 2021 14;16(5):e0251395. Epub 2021 May 14.

Salford Royal Hospital, Salford, United Kingdom.

Objective: Evidence for the management of acute otitis externa (AOE) is limited, with unclear diagnostic criteria and variably reported outcome measures that may not reflect key stakeholder priorities. We aimed to develop 1) a definition, 2) diagnostic criteria and 3) a core outcome set (COS) for AOE.

Study Design: COS development according to Core Outcome Measures in Effectiveness Trials (COMET) methodology and parallel consensus selection of diagnostic criteria/definition. Read More

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A systematic scoping review of the methodological approaches and effects of pesticide exposure on solitary bees.

PLoS One 2021 14;16(5):e0251197. Epub 2021 May 14.

ORISE Researcher, Oak Ridge Associated Universities, Research Triangle Park, Oak Ridge, North Carolina, United States of America.

Background: Pollination services provided by solitary bees, the largest group of bees worldwide, are critical to the vitality of ecosystems and agricultural systems alike. Disconcertingly, bee populations are in decline, and while no single causative factor has been identified, pesticides are believed to play a role in downward population trends. The effects of pesticides on solitary bee species have not been previously systematically cataloged and reviewed. Read More

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