5,023 results match your criteria dura spinal

Dura promotes metastatic potential in prostate cancer through the CXCR2 pathway.

J Neurooncol 2021 Apr 9. Epub 2021 Apr 9.

Department of Neurosurgery, University of Michigan, 3552 Taubman Center, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.

Purpose: Spinal metastases are common in cancer. This preferential migration/growth in the spine is not fully understood. Dura has been shown to affect the surrounding microenvironment and promote cancer growth. Read More

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Existence and features of the myodural bridge in Gentoo penguins: A morphological study.

PLoS One 2021 8;16(4):e0244774. Epub 2021 Apr 8.

Department of Anatomy, College of Basic Medicine, Dalian Medical University, Dalian, China.

Recent studies have evidenced that the anatomical structure now known as the myodural bridge (MDB) connects the suboccipital musculature to the cervical spinal dura mater (SDM). In humans, the MDB passes through both the posterior atlanto-occipital and the posterior atlanto-axial interspaces. The existence of the MDB in various mammals, including flying birds (Rock pigeons and Gallus domesticus) has been previously validated. Read More

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Intracerebral haemorrhage following spine surgery: a word of caution on the use of suction drains.

Br J Neurosurg 2021 Apr 6:1-4. Epub 2021 Apr 6.

Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore, Singapore.

Intracranial haemorrhage (ICH) is a rare but devastating complication post spinal surgery. We present three cases of post spine surgery ICH that were associated with high drain outputs postoperatively. The first patient underwent C1-C6 instrumented fusion and C4-C6 decompression. Read More

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Hirayama-like disease in the thoracic spine.

Radiol Case Rep 2021 May 20;16(5):1216-1219. Epub 2021 Mar 20.

Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Road, Suite BG23, Atlanta, GA 30322, USA.

Hirayama disease is a cervical flexion myelopathy that typically causes upper extremity weakness in young male patients. We present two male patients (age 15 and 29) with MRI findings of thoracic ligamentous laxity similar in appearance to Hirayama disease. However, patients presented with atypical symptoms, specifically back pain and paresthesia of the upper and/or lower extremities, likely correlating to the abnormal thoracic spinal levels involved. Read More

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Arachnoid Web Fenestration: Diagnostic and Surgical Nuances.

World Neurosurg 2021 Mar 30. Epub 2021 Mar 30.

Department of Neurologic Surgery, Mayo Clinic, Jacksonville, Florida, USA. Electronic address:

Arachnoid web (AW) is a rare phenomenon that has only been described in small case reports and case series[1], most commonly presenting with upper motor neuron (UMN) signs and subtle radiographic findings, such as the classically described "scalpel sign"[2]. In this report we demonstrate the use of imaging and operative techniques that haven't been previously shown in the literature as a video for AW. These include high-definition MRI sequences for preoperative diagnosis, use of intraoperative ultrasonography for identification of adhesions, and operative technique for AW fenestration. Read More

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Methotrexate-associated lymphoproliferative disorder of the thoracic spine in a patient with rheumatoid arthritis receiving methotrexate: a case report.

Skeletal Radiol 2021 Mar 27. Epub 2021 Mar 27.

Department of Orthopaedic Surgery, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan.

Methotrexate-associated lymphoproliferative disorder is recognized as a lymphoma that occurs following methotrexate administration. The lesion of the spine is extremely rare, and only one case of lesion in the lumbar spine has been reported so far. Here, we present a case of methotrexate-associated lymphoproliferative disorder of the thoracic spine in a 54-year-old woman with rheumatoid arthritis. Read More

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Influence of Cage Design on Radiological and Clinical Outcomes in Dorsal Lumbar Spinal Fusions: A Comparison of Lordotic and Non-Lordotic Cages.

Orthop Surg 2021 Mar 24. Epub 2021 Mar 24.

University Hospital Tübingen, Tübingen, Germany.

Objectives: To evaluate the comparison between lordotic and non-lordotic transforaminal lumbar interbody fusion (TLIF) cages in degenerative lumbar spine surgery and analyze radiological as well as clinical outcome parameters in long-term follow up.

Methods: In a retrospective study design, we compared 37 patients with non-lordotic cage (NL-group) and 40 with a 5° lordotic cage (L-group) implanted mono- or bi-segmental in TLIF-technique from 2013 to 2016 and analyzed radiological parameters of pre- and postoperative (Lumbar lordosis (LL), segmental lordosis (SL), and pelvic tilt (PT), as well as clinical parameters in a follow-up physical examination using the Oswestry disability index (ODI), Roland-Morris Score (RMS), and visual analog scale (VAS).

Results: Surgery was mainly performed in lower lumbar spine with a peak in L4/5 (mono-segmental) and L4 to S1 (bi-segmental), long-term follow-up was on average 4 years postoperative. Read More

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Idiopathic dorsal spinal cord herniation perforating the lamina: a case report and review of the literature.

Acta Neurochir (Wien) 2021 Mar 21. Epub 2021 Mar 21.

Department of Orthopaedic Surgery, School of Medicine, International University of Health and Welfare (IUHW), 852 Hatakeda, Narita City, Chiba, 286-0124, Japan.

Spinal cord herniation (SCH) is a rare condition associated with tethering of the spinal cord at the ventral dural defect. Idiopathic dorsal spinal cord herniation (IDSCH) is an extremely rare clinical entity. Here, we report the first case of IDSCH perforating the lamina in a patient with a history of ossification of the ligamentum flavum and diffuse idiopathic skeletal hyperostosis. Read More

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Intradural extramedullary capillary hemangioma of the cauda equina: case report of a rare spinal tumor.

Spinal Cord Ser Cases 2021 Mar 19;7(1):21. Epub 2021 Mar 19.

Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Introduction: Intradural extramedullary capillary hemangiomas of the cauda equina are exceedingly rare, with only 20 previous cases reported. In the adult population, these tumors are rare and can arise in the central and peripheral nervous systems from the dura or spinal nerve roots. Intradural capillary hemangiomas of the cauda equina can yield symptoms such as lower extremity weakness, pain, and bladder and bowel dysfunction. Read More

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Ultrasonic Osteotome Assisted Full-Endoscopic en Block Resection of Thoracic Ossified Ligamentum Flavum: Technical Note and 2 Years Follow-up.

Pain Physician 2021 Mar;24(2):E239-E248

Department of Orthopedic Surgery, the Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.

Background: Conventional open laminectomy is considered to be the standard procedure for the treatment of thoracic ossified ligamentum flavum, but multi-segment thoracic laminectomy extensively removes the facet joints and ligamentous tissue, destroying the thoracic spine biomechanics and stability, may lead to delayed thoracic spine kyphosis deformities, which in turn can lead to potential neurological deterioration and local intractable pain.

Objective: To introduce the technical notes and clinical outcome of ultrasonic osteotome assisted full-endoscopic en block resection of thoracic ossified ligamentum flavum.

Study Design: A prospective cohort study. Read More

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Intraspinal clear cell meningioma without dural attachment: A case report and literature review.

Medicine (Baltimore) 2021 Mar;100(11):e25167

Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

Rationale: Clear cell meningioma (CCM) is one of the rarest but most aggressive forms of meningioma, with a tendency to occur at a high recurrence rate. Intraspinal CCM, especially the nondura-based type, is even rarer than the intracranial CCM.

Patient Concerns: We report a case of a 45-year-old woman who presented with a 1-month history of episodic pain in the lower back and in both thighs in the front side. Read More

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Far Lateral Approach for Resection of Transverse Ligament Cyst.

J Neurol Surg B Skull Base 2021 Feb 13;82(Suppl 1):S37-S38. Epub 2020 Mar 13.

Department of Neurosurgery, University of Tennessee, Memphis, Tennessee, United States.

 This study was aimed to describe a far lateral approach for microsurgical resection of a transverse ligament cyst, with emphasis on the microsurgical anatomy and technique.  A far lateral craniotomy is performed in the lateral decubitus position. After opening the dura laterally, dural sutures are placed for retraction. Read More

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February 2021

Variations in the cerebrospinal fluid dynamics of the American alligator (Alligator mississippiensis).

Fluids Barriers CNS 2021 Mar 12;18(1):11. Epub 2021 Mar 12.

Family Medicine, Kirksville College of Osteopathic Medicine, A.T. Still University, Kirksville, MO, 63501, USA.

Background: Studies of mammalian CSF dynamics have been focused on three things: paravascular flow, pressure and pulsatility, and "bulk" flow; and three (respective) potential motive forces have been identified: vasomotor, cardiac, and ventilatory. There are unresolved questions in each area, and few links between the different areas. The American alligator (Alligator mississippiensis) has pronounced plasticity in its ventilatory and cardiovascular systems. Read More

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Percutaneous computed tomography-guided radiofrequency ablation of a spinal osteoid osteoma abutting the dura: a case report and review of the literature.

Eur J Orthop Surg Traumatol 2021 Mar 12. Epub 2021 Mar 12.

2nd Department of Radiology, Medical School, University General Hospital "ATTIKON", National and Kapodistrian University of Athens, 1 Rimini str, 12462, Haidari/Athens, Greece.

Purpose: Osteoid osteomas in the spine constitute a challenging group for both surgical and percutaneous approaches. Purpose of the present study is to report a case report of a spinal osteoid osteoma in a challenging spinal location and review literature for safety and efficacy of the technique.

Methods: We report a case of spinal osteoid osteoma extending in the epidural space and abutting the dura in a pediatric patient treated by percutaneous computed tomography-guided radiofrequency ablation. Read More

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Complete Resolution of a Large Hemorrhagic Lumbar Synovial Cyst Following Spinal Fusion Alone.

Asian J Neurosurg 2020 Oct-Dec;15(4):1085-1090. Epub 2020 Dec 21.

Department of Pathology, Prasat Neurological Institute, Bangkok, Thailand.

The authors reported complete regression of a large hemorrhagic lumbar synovial cyst following posterior spinal fusion without direct cystic resection. A 64-year-old woman suffered from sudden onset of the left buttock pain radiating to the left leg after waking up in the morning following the previous history of a minor accident 2 months ago. Magnetic resonance imaging (MRI) of the lumbosacral spine showed a large extradural round mass originating from the left facet joint at the level of L3-L4. Read More

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December 2020

Nerve recognition in percutaneous transforaminal endoscopic discectomy using convolutional neural network.

Med Phys 2021 Mar 8. Epub 2021 Mar 8.

Biomedical Information Engineering Lab, The University of Aizu, Aizu-Wakamatsu City, Fukushima, 965-8580, Japan.

Purpose: Percutaneous transforaminal endoscopic discectomy (PTED) is one of the most common minimally invasive surgery methods used in clinic in recent years. In this study, we developed a computer-aided detection system (CADS) based on convolutional neural network (CNN) to automatically recognize nerve and dura mater images under PTED surgery.

Methods: We collected surgical videos from 65 patients with lumbar disc herniation who underwent PTED; we then converted the videos into images, and randomly divided some images into a training dataset, a validation dataset, test dataset. Read More

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Lumbar Laminoplasty for Resection of Myxopapillary Ependymoma of the Conus Medullaris: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Feb 27. Epub 2021 Feb 27.

Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA.

Myxopapillary ependymomas are slow-growing tumors that are located almost exclusively in the region of the conus medullaris, cauda equina, and filum terminale of the spinal cord. Surgical intervention achieving a gross total resection is the main treatment modality. If, however, a gross total resection cannot be achieved, surgery is augmented with radiation therapy. Read More

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February 2021

Symptomatic Intracranial Hemorrhage after Dural Tear in Spinal Surgery-A Series of 10 Cases and Review of the Literature.

World Neurosurg 2021 Feb 25. Epub 2021 Feb 25.

Department of Spine Surgery, Zentralklinik Bad Berka, Bad Berka, Germany.

Objective: Intracranial hemorrhage (IH) after spinal surgery is a rare but potentially life-threatening complication. Knowledge of predisposing factors and typical clinical signs is essential for early recognition, helping to prevent an unfavorable outcome.

Methods: A retrospective analysis was performed of patients with IH after spinal surgery treated in our institution between 2012 and 2018. Read More

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February 2021

Effectiveness of Repair Techniques for Spinal Dural Tears: A Systematic Review.

World Neurosurg 2021 Feb 25;149:140-147. Epub 2021 Feb 25.

Department of Neurological Surgery, University of California, Irvine, California, USA. Electronic address:

Background: Incidental or intentional durotomy in spine surgery is associated with a risk of cerebrospinal fluid (CSF) leakage and reoperation. Several strategies have been introduced, but the incomplete closure is still relatively frequent and troublesome. In this study, we review current evidence on spinal dural repair strategies and evaluate their efficacy. Read More

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February 2021

Acute Traumatic Spinal Cord Injury in Humans, Dogs, and Other Mammals: The Under-appreciated Role of the Dura.

Front Neurol 2021 3;12:629445. Epub 2021 Feb 3.

Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, United States.

We review human and animal studies to determine whether, after severe spinal cord injury (SCI), the cord swells against the inelastic dura. Evidence from rodent models suggests that the cord swells because of edema and intraparenchymal hemorrhage and because the pia becomes damaged and does not restrict cord expansion. Human cohort studies based on serial MRIs and measurements of elevated intraspinal pressure at the injury site also suggest that the swollen cord is compressed against dura. Read More

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February 2021

Surgical results of the resection of spinal meningioma with the inner layer of dura more than 10 years after surgery.

Sci Rep 2021 Feb 18;11(1):4050. Epub 2021 Feb 18.

Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.

Most spinal meningiomas arise from the thoracic dura in middle-aged and elderly women. Simpson grade 1 resection is recommended to avoid recurrence. For ventral and ventrolateral tumors, reconstruction after total dural resection is difficult, and spinal fluid leakage is likely. Read More

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February 2021

Clinical Outcome and Histological Findings After Induced Leakage of PMMA Loaded With Methotrexate and Cisplatin During Vertebroplasty: Experimental Model in Pigs.

Global Spine J 2021 Feb 19:2192568221994800. Epub 2021 Feb 19.

Department of Orthopedic Surgery, University of Navarra, Pamplona, Spain.

Study Design: Animal experimental model.

Objective: To study the clinical behavior and histological changes in the spinal cord, nerve roots and perivertebral muscles of the spine after induced leakage of polymethylmethacrylate (PMMA) loaded with antiblastic drugs during vertebroplasty in an animal model of pigs.

Methods: We performed vertebroplasty on 25 pigs. Read More

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February 2021

Anatomy of the posterolateral spinal epidural ligaments.

Surg Neurol Int 2021 28;12:33. Epub 2021 Jan 28.

Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, United States.

Background: The epidural ligaments (ELs) (of Hofmann) were described as fibrous bands interconnecting the ventrolateral spinal dura and the posterior longitudinal ligament below L1. They are hardly ever discussed in the literature or considered in hypothesis-driven basic science experiments or spine biomechanical models.

Methods: Intraoperative photographs were obtained to illustrate a group of posterolateral spinal ELs. Read More

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January 2021

Primary spread of caudal blockade in children: the possible limiting role of the lumbar spinal cord enlargement (tumenescence) in combination with the cerebrospinal fluid rebound mechanism.

Paediatr Anaesth 2021 Feb 10. Epub 2021 Feb 10.

Paediatric Anesthesia, Karolinska University Hospital, Stockholm, Sweden.

Background: Despite being the most frequently used pediatric nerve block, certain aspects of the initial intraspinal spread of local anesthetics when performing a caudal block need further elucidation. The fact that injected volumes of 0.7-1. Read More

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February 2021

A Randomized Controlled Trial of Local Delivery of a Rho Inhibitor (VX-210) in Patients with Acute Traumatic Cervical Spinal Cord Injury.

J Neurotrauma 2021 Mar 1. Epub 2021 Mar 1.

BioAxone BioSciences, Inc, Boston, Massachusetts, USA.

Acute traumatic spinal cord injury (SCI) can result in severe, lifelong neurological deficits. After SCI, Rho activation contributes to collapse of axonal growth cones, failure of axonal regeneration, and neuronal loss. This randomized, double-blind, placebo-controlled phase 2b/3 study evaluated the efficacy and safety of Rho inhibitor VX-210 (9 mg) in patients after acute traumatic cervical SCI. Read More

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3D patient-specific spinal cord computational model for SCS management: potential clinical applications.

J Neural Eng 2021 Feb 8. Epub 2021 Feb 8.

Universitat Politècnica de València, Camino de Vera, s/n, Valencia, 46022, SPAIN.

Background And Objective: Although Spinal Cord Stimulation (SCS) is an established therapy for treating neuropathic chronic pain, in tonic stimulation, postural changes, electrode migration or badly-positioned electrodes can produce annoying stimulation (intercostal neuralgia) in about 35% of the patients. SCS models are used to study the effect of electrical stimulation to better manage the stimulation parameters and electrode position. The goal of this work was to develop a realistic 3D patient-specific spinal cord model from a real patient and develop a future clinical application that would help physicians to optimize paresthesia coverage in SCS therapy. Read More

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February 2021

Differential effects of the Piezo1 agonist Yoda1 in the trigeminovascular system: An electrophysiological and intravital microscopy study in rats.

Exp Neurol 2021 May 5;339:113634. Epub 2021 Feb 5.

Valdman Institute of Pharmacology, Pavlov First Saint Petersburg State Medical University, Saint Petersburg 197022, Russia; Laboratory of Cortico-Visceral Physiology, Pavlov Institute of Physiology of the Russian Academy of Sciences, Saint Petersburg 199034, Russia.

Migraine is associated with the activation and sensitisation of the trigeminovascular system and is often accompanied by mechanical hyperalgesia and allodynia. The mechanisms of mechanotransduction during a migraine attack are yet unknown. We have proposed that the ion channel Piezo1 may be involved, since it is expressed in endothelial cells as well as in trigeminal ganglion neurons, and thus, may contribute to the activation of both the vascular and neuronal component of the trigeminovascular system. Read More

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Hypertrophic spinal pachymeningitis caused by ANCA-associated vasculitis revealed by 18F-FDG PET/CT: A case report.

Medicine (Baltimore) 2021 Jan;100(3):e24388

Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital.

Rationale: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) can involve the central nervous system in estimatedly 15% of patients. Hypertrophic pachymeningitis causes inflammatory hypertrophy of the cranial or spinal dura mater and patients present with various neurological deficits. ANCA-associated hypertrophic spinal pachymeningitis has rarely been reported in literature. Read More

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January 2021

Step Back in Order to Go Forward: Willful Enlargement and Sandwich Closure Technique for Spinal Dura Repair after Several Unsuccessful Closure Attempts.

J Neurol Surg A Cent Eur Neurosurg 2021 Feb 4. Epub 2021 Feb 4.

Department of Neurosurgery, Unfallkrankenhaus Berlin, Berlin, Germany.

A CSF leak is a common complication in spine surgery which is usually closed effectivly by suture and/or epidural patches. There is currently no algorithm to treat a recurrent CSF leak that fails to be closed initially. We describe the case of a recurrent cerebrospinal fluid leak that we have successfully treated using an inlay-onlay dural repair technique. Read More

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February 2021