991 results match your criteria duodenal atresia

Duodenal and Pyloric Web in Children: Clinical Presentation and Management.

J Indian Assoc Pediatr Surg 2022 Mar-Apr;27(2):125-130. Epub 2022 Mar 1.

Department of Pediatric Surgery, PGIMER, Chandigarh, India.

Background: Duodenal and pyloric web (DW/PW) can present at any age, symptoms depend upon the location of the web along with the presence and size of the opening in the web. The surgical management is not straightforward always. Here, in this study, we aim to assess clinical characteristics, management, and outcome of children with DW/PW. Read More

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Postoperative feeding in neonatal duodenal obstruction.

BMC Pediatr 2022 08 3;22(1):467. Epub 2022 Aug 3.

Division Of Pediatric Surgery, Department Of Surgery, Faculty Of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Findings from manometry studies and contrast imaging reveal functioning gastric physiology in newborns with duodenal atresia and stenosis. Stomach reservoir function should therefore be valuable in aiding the postoperative phase of gastric feeding. The aim of this study was therefore to compare the feasibility of initiating oral or large volume(s) gavage feeds vs small volume bolus feeds following operation for congenital duodenal anomalies. Read More

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How should we treat representative neonatal surgical diseases with congenital heart disease?

Pediatr Surg Int 2022 Sep 15;38(9):1235-1240. Epub 2022 Jul 15.

Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890 -8520, Japan.

Purpose: Representative neonatal surgical diseases are often complicated by congenital heart disease (CHD). We reviewed our decade of experience from the perspective of the prognosis and report on the management of infants with CHD.

Methods: Cases with and without CHD between 2011 and 2020 were retrospectively compared. Read More

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September 2022

Incidence of late severe intestinal complications after bowel atresia/stenosis.

Pediatr Int 2022 Jan;64(1):e15208

Department of Radiology, Saitama Children's Medical Center, Saitama, Japan.

Background: To determine the incidence and risk factors for late severe intestinal complications after surgical repair for intra-abdominal congenital intestinal atresia/stenosis.

Methods: We included 51 patients who underwent surgical repair for congenital intestinal atresia/stenosis. Late severe intestinal complications included adhesive ileus, incisional hernia, or volvulus. Read More

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January 2022

Mitchell-Riley Syndrome: Improving Clinical Outcomes and Searching for Functional Impact of RFX-6 Mutations.

Front Endocrinol (Lausanne) 2022 22;13:802351. Epub 2022 Jun 22.

Department of Endocrinology, Metabolism and Diabetes, Inserm U1016, Cochin Institute, Paris, France.

Aims/hypothesis: Caused by biallelic mutations of the gene encoding the transcription factor , the rare Mitchell-Riley syndrome (MRS) comprises neonatal diabetes, pancreatic hypoplasia, gallbladder agenesis or hypoplasia, duodenal atresia, and severe chronic diarrhea. So far, sixteen cases have been reported, all with a poor prognosis. This study discusses the multidisciplinary intensive clinical management of 4 new cases of MRS that survived over the first 2 years of life. Read More

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Chromosomal Abnormalities and Pregnancy Outcomes for Fetuses With Gastrointestinal Tract Obstructions.

Front Pediatr 2022 6;10:918130. Epub 2022 Jun 6.

Department of Medical Genetic Diagnosis and Therapy Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.

Fetal gastrointestinal tract obstruction (GITO) is the most frequently encountered gastrointestinal defect in the prenatal period. This study aimed to investigate the genetic disorders and pregnancy outcomes of fetal GITO. We reviewed data from 70 pregnancies that were referred for invasive prenatal testing because of fetal GITO. Read More

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Prenatal diagnosis of Williams-Beuren syndrome by ultrasound and chromosomal microarray analysis.

Mol Cytogenet 2022 Jun 28;15(1):27. Epub 2022 Jun 28.

Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Background: There are a few literature reports of prenatal ultrasound manifestations of Williams-Beuren syndrome. We aimed to explore the prenatal diagnosis of Williams-Beuren syndrome by ultrasound and chromosomal microarray analysis and describe the prenatal ultrasound performance of this syndrome.

Methods: In this retrospective study, we reported eight cases of Williams-Beuren syndrome diagnosed at our prenatal diagnostic center from 2016 to 2021. Read More

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Use of trans-biliary rendezvous technique for stenting of an impassable duodenal stricture.

Diagn Interv Radiol 2022 May;28(3):257-259

Department of Radiology, Healthcare Imaging Services, Warnambool, Victoria, Australia.

Stenting of the gastric outlet is an accepted method for palliation of symptoms secondary to inoperable malignancy and is successful in most cases. Failure of stenting is most commonly due to inability to cross the stricture. We describe a rendezvous technique of duodenal stenting via transhepatic biliary access when conventional endoscopic or fluoroscopic methods fail. Read More

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Clinical Profile, Outcomes and Predictors of Mortality in Neonates Operated for Gastrointestinal Anomalies in a Tertiary Neonatal Care Unit- An Observational Study.

J Indian Assoc Pediatr Surg 2022 May-Jun;27(3):287-292. Epub 2022 May 12.

Department of Neonatology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Background: Gastrointestinal (GI) malformations have varied short-term and long-term outcomes reported across various neonatal units in India.

Methods: This descriptive study was done to study the clinical profile, outcomes and predictors of mortality in neonates operated for congenital GI malformations in a tertiary neonatal care unit in South India between years 2011 and 2020. Details were collected by retrospective review of the case sheets. Read More

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The Effect of Kangaroo Mother Care After Duodenal Obstruction in Neonates.

Front Surg 2022 17;9:813052. Epub 2022 May 17.

Department of Neonatology, Kunming Children's Hospital, Kunming, China.

Objective: The present study aimed to explore the effectiveness of clinical application of kangaroo mother care (KMC) in neonates after surgery for duodenal obstruction in achieving total enteral nutrition (TEN) and shortening the length of hospital stay.

Methods: A prospective study of 60 cases of surgery for duodenal obstruction in pediatric patients in the neonatal intensive care unit of Kunming Children's Hospital between January 2018 and December 2019 was conducted. The study subjects included 15 cases with intestinal malrotation, 18 cases with circular pancreas, 10 cases with a duodenal septum, and 17 cases with duodenal atresia or duodenal stenosis. Read More

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Outcomes of patients with malignant duodenal obstruction after receiving self-expandable metallic stents: A single center experience.

PLoS One 2022 25;17(5):e0268920. Epub 2022 May 25.

Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Objectives: Self-expandable metallic stent (SEMS) placement is a safe and effective palliative treatment for malignant gastric outlet obstruction; however, the clinical outcomes of gastric and duodenal stenoses may differ. This study aimed to investigate the clinical efficacy of SEMS placement and the predictors of clinical outcomes, specifically in malignant duodenal obstruction (MDO).

Methods: Between September 2009 and March 2021, 79 patients with MDO who received SEMS placement in our hospital were retrospectively enrolled. Read More

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Social media communities for patients and families affected by congenital pediatric surgical conditions.

Pediatr Surg Int 2022 Jul 19;38(7):1047-1055. Epub 2022 May 19.

International Center for Colorectal and Urogenital Care, Division of Pediatric Surgery, Anschutz Medical Campus, Children's Hospital Colorado, 13213 E 16th Ave, Box 323, Aurora, CO, 80045, USA.

Background: Social media has become a means to allow individuals affected by rare diseases to connect with others. This study aimed to characterize the use of three popular social media platforms by individuals affected by common pediatric surgery index conditions.

Methods: A systematic search of Instagram, Facebook, and Twitter was performed using standardized terms for the following pediatric surgical conditions: anorectal malformation, biliary atresia, bronchopulmonary sequestration, congenital diaphragmatic hernia (CDH), congenital pulmonary airway malformation, duodenal atresia, esophageal atresia/tracheoesophageal fistula (EA/TEF), gastroschisis, Hirschsprung disease (HD), and omphalocele. Read More

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Treatment of esophageal atresia with duodenal atresia in a very low birthweight infant.

Pediatr Int 2022 01;64(1):e15179

Department of Neonatology, Yamanashi Prefectural Central Hospital, Kofu, Japan.

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January 2022

Intestinal Atresias.

Pediatr Rev 2022 May;43(5):266-274

Division of Pediatric Surgery, Cohen Children's Medical Center, Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY.

Intestinal atresia is a form of congenital bowel obstruction that requires operative repair in the early neonatal period. Duodenal atresia and jejunoileal (JI) atresia are appropriately seen as distinct entities. Both can be suspected with fetal imaging, which can assist with prenatal counseling of families. Read More

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Biallelic variants in CENPF causing a phenotype distinct from Strømme syndrome.

Am J Med Genet C Semin Med Genet 2022 03 30;190(1):102-108. Epub 2022 Apr 30.

Department of Translational Medicine, Section of Pediatrics, Federico II University, Naples, Italy.

Biallelic loss-of-function (LoF) variants in CENPF gene are responsible for Strømme syndrome, a condition presenting with intestinal atresia, anterior ocular chamber anomalies, and microcephaly. Through an international collaboration, four individuals (three males and one female) carrying CENPF biallelic variants, including two missense variants in homozygous state and four LoF variants, were identified by exome sequencing. All individuals had variable degree of developmental delay/intellectual disability and microcephaly (ranging from -2. Read More

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Laparoscopic Versus Open Surgical Repair of Duodenal Atresia: An NSQIP-Pediatric Analysis.

J Surg Res 2022 Apr 26. Epub 2022 Apr 26.

Division of General Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Johns Hopkins Children's Center, Baltimore, Maryland. Electronic address:

Introduction: Laparoscopic repair of duodenal atresia in neonates has gained popularity among some pediatric surgeons. Single-center studies suggest comparable short-term outcomes to open surgery. The purpose of this study was to utilize a large, multi-institutional pediatric dataset to examine 30-day post-operative outcomes by operative approach for newborns who underwent duodenal atresia repairs. Read More

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Biliary atresia associated with small intestinal atresia: An association with high morbidity and mortality.

Asian J Surg 2022 Apr 24. Epub 2022 Apr 24.

The Department of Pediatric Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

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Genotype-phenotype and outcome associations in patients with Fanconi anemia: The National Cancer Institute cohort.

Haematologica 2022 Apr 14. Epub 2022 Apr 14.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Fanconi anemia (FA) is caused by pathogenic variants in the FA/BRCA DNA repair pathway genes, and is characterized by congenital abnormalities, bone marrow failure (BMF) and increased cancer risk. We conducted a genotype-phenotype and outcomes study of 203 patients with FA in our cohort. We compared across the genes, FA/BRCA DNA repair pathways (upstream, ID complex and downstream), and type of pathogenic variants (hypomorphic or null). Read More

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VACTERL syndrome with late presentation of annular pancreas with duodenal web: Case report.

Radiol Case Rep 2022 Jun 5;17(6):1853-1857. Epub 2022 Apr 5.

Department of Radiology, Brooke Army Medical Center, Fort Sam Houston, San Antonio, TX, 78234, USA.

VACTERL Syndrome affects multiple body systems and can include various anomalies of the Vertebral column, Anus and/or rectum, heart (Cardiac), Tracheo-Esophagus, kidneys (Renal), and Limbs. Patients with VACTERL syndrome are at increased risk of having a congenital duodenal obstruction that may be extrinsic in the form of an annular pancreas or intrinsic in the form of duodenal atresia, stenosis or web. Simultaneous presentation of both the annular pancreas and duodenal web is a rare clinical entity and typically presents in neonates. Read More

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Factors Associated With Adverse Outcomes Following Duodenal Atresia Surgery in Neonates: A Retrospective Study.

Cureus 2022 Feb 17;14(2):e22349. Epub 2022 Feb 17.

Department of Pediatric Surgery, National Center for Child Health and Development, Tokyo, JPN.

Objectives There is limited evidence on the infants' postoperative complications who have undergone surgical repair of duodenal atresia and stenosis. This study aimed to identify the factors associated with poor surgical outcomes after the initial repair. Methods We retrospectively reviewed the data of 82 patients who underwent surgery for duodenal atresia and stenosis between January 1994 and December 2013 at our institution. Read More

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February 2022

Influenza vaccination during pregnancy and risk of selected major structural noncardiac birth defects, National Birth Defects Prevention Study 2006-2011.

Pharmacoepidemiol Drug Saf 2022 Aug 22;31(8):851-862. Epub 2022 Apr 22.

Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa, USA.

Purpose: To assess associations between influenza vaccination during etiologically-relevant windows and selected major structural non-cardiac birth defects.

Study Design: We analyzed data from the National Birth Defects Prevention Study, a multisite, population-based case-control study, for 8233 case children diagnosed with a birth defect and 4937 control children without a birth defect with delivery dates during 2006-2011. For all analyses except for neural tube defects (NTDs), we classified mothers who reported influenza vaccination 1 month before through the third pregnancy month as exposed; the exposure window for NTDs was 1 month before through the first pregnancy month. Read More

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Demographics and histopathological characteristics of enucleated microphthalmic globes.

Sci Rep 2022 03 28;12(1):5283. Epub 2022 Mar 28.

Pathology and Laboratory Medicine Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Microphthalmia is a rare ocular anomaly with a poorly understood etiology that is most likely related to heritable and/or environmental factors. Many papers have been published pertaining to the clinical manifestations and management of this condition; however, few reports have reported detailed histopathological findings, which are the focus of this study, in addition to highlighting the basic demographics in these cases. This was a retrospective, observational study of all consecutive enucleated microphthalmic globes (with or without cysts) at 2 tertiary eye hospitals in Riyadh, Saudi Arabia. Read More

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First multivisceral transplantation in Mitchell-Riley/Martinez-Frias syndrome.

Pediatr Transplant 2022 08 20;26(5):e14270. Epub 2022 Mar 20.

Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain.

Background: MRS/MFS is a rare multisystem disorder with a poor prognosis. The high mortality rate of this syndrome is related to the severity of the associated gastrointestinal, pancreatic, and hepatobiliary conditions, as most of them are not amenable to conventional medical and surgical treatments.

Methods: We report the case of a Romani girl with all the key clinical features of MRS/MFS, and a review of cases reported in the literature. Read More

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Use of trans-anastomotic tubes in congenital duodenal obstruction.

J Pediatr Surg 2022 Feb 6. Epub 2022 Feb 6.

Department of Paediatric Surgery and Urology, Southampton Children's Hospital, Tremona Rd, Southampton SO16 6YD, UK; Paediatric Surgery Department, Faculty of Medicine, Aim Shams University, Abassia, Cairo, Egypt. Electronic address:

Aim: Despite data to suggest benefit of trans- anastomotic tube (TAT) feeding in infants following repair of congenital duodenal obstruction (CDO), TAT usage is limited. We aimed to report a large series of infants with CDO treated with or without TAT in order to improve the evidence underlying this simple intervention.

Method: Single centre retrospective review of all infants CDO over a 20-year period (January 1999 - November 2020, inclusive). Read More

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February 2022

Congenital duodenal obstruction - Advances in diagnosis, surgical management, and associated controversies.

Semin Pediatr Surg 2022 Feb 18;31(1):151140. Epub 2022 Feb 18.

Division of Pediatric Surgery, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205. Electronic address:

Congenital duodenal obstruction (CDO) occurs due to intrinsic and extrinsic mechanisms but is most often caused by intrinsic duodenal atresia and stenosis. This review will summarize the history, epidemiology, and etiologies associated with the most common causes of CDO. The clinical presentation, complex diagnostic considerations, and current surgical repair options for duodenal atresia and stenosis will also be discussed. Read More

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February 2022

Incidence of and risk factors for perioperative blood transfusion in infants undergoing index pediatric surgery procedures.

J Pediatr Surg 2022 Jun 12;57(6):1067-1071. Epub 2022 Feb 12.

Division of Pediatric Surgery, Children's Hospital Colorado, Aurora, CO, United States; Department of Surgery, University of Colorado School of Medicine, Aurora, CO, United States.

Background: There is a paucity of data on the frequency of transfusion during pediatric surgery index cases and guidelines for pretransfusion testing, defined as type and screen and crossmatch testing, prior to operation are not standardized. This study aimed to determine the incidence of perioperative blood transfusions during index neonatal operations and identify risk factors associated with perioperative blood transfusion to determine which patients benefit from pretransfusion testing.

Methods: A retrospective review of infants who underwent index neonatal cases between 2013 and 2019 was performed. Read More

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Delayed Presentation of Duodenal Atresia in a Male With Trisomy 21.

Cureus 2022 Jan 28;14(1):e21700. Epub 2022 Jan 28.

Pediatric Surgery, University of Central Florida College of Medicine, Orlando, USA.

The duodenum is the secondmost common site of congenital intestinal obstruction. There are three types of congenital duodenal atresia according to the severity of obstruction. Duodenal atresia is thought to develop due to the failure of recanalization of the gut lumen during embryonic development. Read More

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January 2022

Joubert Syndrome Presenting With Oculomotor Apraxia and Motor Developmental Delay: A Case Report From a Neuro-Ophthalmology Clinic in Saudi Arabia.

Cureus 2022 Jan 26;14(1):e21638. Epub 2022 Jan 26.

Neuro-ophthalmology, Jeddah Eye Hospital, Jeddah, SAU.

Joubert syndrome is an autosomal recessive genetic disorder that was first described in 1969. It can present with neonatal respiratory distress, ocular motility abnormalities, developmental delays, and other congenital cerebellar malformations. It is also connected to autism, hydrocephalus, and duodenal atresia. Read More

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January 2022

Dual duodenojejunostomies in the repair of megaduodenum, duodenal stenosis and prior missed diagnosis of annular pancreas.

BMJ Case Rep 2022 Feb 28;15(2). Epub 2022 Feb 28.

University of Central Florida College of Medicine, Orlando, Florida, USA.

Duodenal stenosis and atresia are some of the most common forms of congenital bowel obstruction. The gold standard approach to treatment is duodenoduodenostomy, while rare, gastrojejunostomy and duodenojejunostomies may still be used. We report a case of a 7-year-old male presenting with annular pancreas with duodenal stenosis that was diagnosed at birth as primary duodenal atresia and repaired by gastrojejunostomy with a Braun enteroenterostomy. Read More

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February 2022

Prenatal Detection of Congenital Duodenal Obstruction-Impact on Postnatal Care.

Children (Basel) 2022 Jan 26;9(2). Epub 2022 Jan 26.

Department of Pediatric Surgery, Helios-Klinikum, 13125 Berlin, Germany.

Background: Duodenal obstruction is a rare cause of congenital bowel obstruction. Prenatal ultrasound could be suggestive of duodenal atresia if polyhydramnios and the double bubble sign are visible. Prenatal diagnosis should prompt respective prenatal care, including surgery. Read More

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January 2022