410 results match your criteria dtt gsh

A Reduction Active Theranostic Nanoparticle for Enhanced Near-Infrared Imaging and Phototherapy by Reducing Glutathione Level in Cancer Cells.

J Nanosci Nanotechnol 2021 12;21(12):5965-5971

Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory for Novel Reactor and Green Chemistry Technology, Hubei Engineering Research Center for Advanced Fine Chemicals , School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, P. R. China.

Facile preparation of a tumoral-stimuli-activated theranostic nanoparticle with simple constituents remains a challenge for tumor theranostic nanosystems. Herein we design a simple reductionresponsive turn-on theranostic nanoparticle for achieving fluorescent imaging and phototherapy combination. The theranostic nanoparticle is prepared by a simple one-step dialysis method of reduction active amphiphilic hyperbranched poly(-amidoamines) and a near-infrared (NIR) dye indocyanine green (ICG). Read More

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December 2021

Non-thermal plasma-induced DMPO-OH yields hydrogen peroxide.

Arch Biochem Biophys 2021 Jul 6;705:108901. Epub 2021 May 6.

Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Showa-Ku, Nagoya, 466-8550, Japan; Center for Low-temperature Plasma Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8603, Japan. Electronic address:

Recent developments in electronics have enabled the medical applications of non-thermal plasma (NTP), which elicits reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as hydroxyl radical (OH), hydrogen peroxide (HO), singlet oxygen (O), superoxide (O), ozone, and nitric oxide at near-physiological temperatures. In preclinical studies or human clinical trials, NTP promotes blood coagulation, eradication of bacterial, viral and biofilm-related infections, wound healing, and cancer cell death. To elucidate the solution-phase biological effects of NTP in the presence of biocompatible reducing agents, we employed electron paramagnetic resonance (EPR) spectroscopy to quantify OH using a spin-trapping probe, 5,5-dimethyl-1-pyrroline-N-oxide (DMPO); O using a fluorescent probe; and O and HO using luminescent probes in the presence of thiols or tempol. Read More

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Sensing stress responses in potato with whole-plant redox imaging.

Plant Physiol 2021 Apr 6. Epub 2021 Apr 6.

The Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, The Hebrew University of Jerusalem, Rehovot 7610000, Israel.

Environmental stresses are among the major factors that limit crop productivity and plant growth. Various nondestructive approaches for monitoring plant stress states have been developed. However, early sensing of the initial biochemical events during stress responses remains a significant challenge. Read More

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[Expression and characterization of recombinant wheat quiescin sulfhydryl oxidase and its effect on bread quality].

Sheng Wu Gong Cheng Xue Bao 2021 Feb;37(2):593-603

Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, Sericultural and Agri-Food Research Institute Guangdong Academy of Agricultural Sciences, Guangzhou 510610, Guangdong, China.

Wheat quiescin sulfhydryl oxidase was expressed in Escherichia coli for developing a new biological flour improver. The synthesized wqsox gene was constructed into the vector pMAL-c5x and expressed in E. coli, then the expression conditions of recombinant protein was optimized. Read More

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February 2021

Reductively modified albumin attenuates DSS-Induced mouse colitis through rebalancing systemic redox state.

Redox Biol 2021 05 5;41:101881. Epub 2021 Feb 5.

Divison of Molecular Signaling, Department of the Advanced Biomedical Research, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan. Electronic address:

Albumin (Alb) is the most abundant plasma protein with multiple biological functions, including antioxidative property through its thiol activity. Given that inflammatory bowel disease is associated with a decreased level of Alb and an increased level of Alb oxidation, we asked whether Alb could have a therapeutic effect on colitis. Here we tested this possibility. Read More

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Remote loading paclitaxel-doxorubicin prodrug into liposomes for cancer combination therapy.

Acta Pharm Sin B 2020 Sep 26;10(9):1730-1740. Epub 2020 Apr 26.

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

The combination of paclitaxel (PTX) and doxorubicin (DOX) has been widely used in the clinic. However, it remains unsatisfied due to the generation of severe toxicity. Previously, we have successfully synthesized a prodrug PTX--DOX (PSD). Read More

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September 2020

Tocopherol Moderately Induces the Expressions of Some Human Sulfotransferases, which are Activated by Oxidative Stress.

Cell Biochem Biophys 2020 Dec 8;78(4):439-446. Epub 2020 Sep 8.

Cell and Molecular Therapeutics Laboratory, Department of Biochemistry and Biotechnology, Oriental Institute of Science and Technology, Midnapore, West Bengal, 721102, India.

Oxidative stress is generated in biological system by several endogenous/exogenous factors like environmental-pollution/toxicity/diseases and by daily-life-stress. We previously showed that oxidative-stress impaired the activities/expressions of phase-II drug-metabolizing enzyme, sulfotransferases (SULTs). The SULT catalyzes sulfation of endogenous/exogenous compounds. Read More

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December 2020

Interactions between gold, thiol and As(iii) for colorimetric sensing.

Analyst 2020 Aug 17;145(15):5166-5173. Epub 2020 Jul 17.

College of Chemistry and Material Science, Shandong Agricultural University, Tai'an, Shandong 271018, P.R. China.

As(iii) or arsenite is extremely toxic, and various colorimetric sensors were reported for its on-site detection. A highly cited example was based on gold nanoparticles (AuNPs) modified with a few thiol-containing compounds including dithiothreitol (DTT), reduced glutathione (GSH), and cysteine (Cys). As(iii) was believed to crosslink these surface ligands to aggregate AuNPs and produce a red-to-blue color change. Read More

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Effect of PM characterization on PM oxidative potential by acellular assays: a review.

Rev Environ Health 2020 Nov 25;35(4):461-470. Epub 2020 Jun 25.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen, China.

The health risks brought by particles cannot be present via a sole parameter. Instead, the particulate matter oxidative potential (PM OP), which expresses combined redox properties of particles, is used as an integrated metric to assess associated hazards and particle-induced health effects. OP definition provides the capacity of PM toward target oxidation. Read More

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November 2020

P38 MAPK and Nrf2 Activation Mediated Naked Gold Nanoparticle Induced Heme Oxygenase-1 Expression in Rat Aortic Vascular Smooth Muscle Cells.

Arch Med Res 2020 07 11;51(5):388-396. Epub 2020 May 11.

School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan. Electronic address:

Background And Aims: Heme oxygenase 1 (HO-1) is mainly regulated by the redox-sensitive transcription factor, namely nuclear factor erythroid 2-related factor 2 (Nrf2). We previously found a physically-made gold nanoparticle (GNP) can affect migration, adhesion, and proliferation of rat aortic vascular smooth muscle cells (VSMCs). This study was sought to investigate whether the GNP can affect HO-1 expression level in VSMCs. Read More

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Butylated Hydroxytoluene (BHT) Inhibits PIN1 Exocytosis From BFA Compartments in Arabidopsis Roots.

Front Plant Sci 2020 8;11:393. Epub 2020 Apr 8.

Institute of Biology II/Botany, Faculty of Biology, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.

The activity of polarly localized PIN-FORMED (PIN) auxin efflux carriers contributes to the formation of auxin gradients which guide plant growth, development, and tropic responses. Both the localization and abundance of PIN proteins in the plasma membrane depend on the regulation of PIN trafficking through endocytosis and exocytosis and are influenced by many external and internal stimuli, such as reactive oxygen species, auxin transport inhibitors, flavonoids and plant hormones. Here, we investigated the regulation of endosomal PIN cycling by using a Brefeldin A (BFA) assay to study the effect of a phenolic antioxidant ionol, butylated hydroxytoluene (BHT), on the endocytosis and exocytosis of PIN1 and PIN2. Read More

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Reduction-Triggered Doxorubicin Delivery by Self-Assembled Nanospheres of Lipoylated Caffeine.

ChemMedChem 2020 05 2;15(9):733-737. Epub 2020 Apr 2.

Department of Chemistry, Malaviya National Institute of Technology, Jawaharlal Nehru Marg, Jaipur, 302017, India.

This study reports a new amphiphilic bioconjugate (CAFF-LA) derived from the lipoylation of a hydroxyethyl derivative of caffeine. In water, CAFF-LA self-assembles into nanospheres with an average size of 155 nm, as evidenced from dynamic light scattering and electron microscopy studies. The nanospheres are stable in serum and could be disintegrated upon exposure to the reducing environment of dithiothreitol (DTT; 10 mM) and glutathione (GSH; 10 mM). Read More

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The protease activity of human ATG4B is regulated by reversible oxidative modification.

Autophagy 2020 10 3;16(10):1838-1850. Epub 2020 Jan 3.

School of Pharmaceutical Sciences, Sun Yat-Sen University, National-Local Joint Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Engineering Laboratory of Druggability and New Drug Evaluation, Provincial Key Laboratory of New Drug Design and Evaluation , Guangzhou, Guangdong, China.

Macroautophagy/autophagy plays a pivotal role in cytoplasmic material recycling and metabolic turnover, in which ATG4B functions as a "scissor" for processing pro-LC3 and lipidated LC3 to drive the autophagy progress. Mounting evidence has demonstrated the tight connection between ROS and autophagy during various pathological situations. Coincidentally, several studies have shown that ATG4B is potentially regulated by redox modification, but the underlying molecular mechanism and its relationship with autophagy is ambiguous. Read More

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October 2020

Stimuli-responsive biohybrid nanogels with self-immolative linkers for protein protection and traceless release.

Colloids Surf B Biointerfaces 2019 Dec 27;184:110526. Epub 2019 Sep 27.

School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, China; Hebei Key laboratory of Functional Polymers, Tianjin 300130, China. Electronic address:

Nanogels have been applied in protein delivery due to the nanoscale sizes and the crosslinked structures. However, the release of protein molecules from the nanogels without damages to the structures and functionalities is quite a challenging research subject. In this research, responsive self-immolative linker dithioethyl carbamate bond is introduced to connect protein and polymer in the nanogel so that traceless release of protein occurs upon addition of glutathione (GSH) or dithiothreitol (DTT). Read More

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December 2019

Fabrication of Polymer Micelles with Zwitterionic Shell and Biodegradable Core for Reductively Responsive Release of Doxorubicin.

Polymers (Basel) 2019 Jun 9;11(6). Epub 2019 Jun 9.

School of Chemical Engineering & Pharmaceutics, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, China.

To achieve a high stability in physiological environment and rapid intracellular drug release, a biodegradable zwitterionic triblock copolymer with a disulfide-linked poly-ε-caprolactone and polycarboxybetaine methacrylate (PCBMA-SS-PCL-SS-PCBMA) was prepared for micellar carrier to delivery doxorubicin (DOX) into tumor cells. PCBMA-SS-PCL-SS-PCBMA was obtained by following steps: i) introducing disulfide bonds through end-group modification of PCL diol with cystamine dihydrochloride; ii) preparing PCL-RAFT macromolecular chain transfer agent by EDC/NHS chemistry; iii) RAFT polymerization of zwitterionic monomer. Self-assembling from PCBMA-SS-PCL-SS-PCBMA, polymeric micelles had many advantages, such as ultra-low protein absorption in serum and obvious reduction-responsiveness in the presence of DTT. Read More

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l-Dehydroascorbic acid recycled by thiols efficiently scavenges non-thermal plasma-induced hydroxyl radicals.

Arch Biochem Biophys 2019 07 31;669:87-95. Epub 2019 May 31.

Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Showa-Ku, Nagoya, 466-8550, Japan. Electronic address:

Recent development in electronics has enabled the use of non-thermal plasma (NTP) to strictly direct oxidative stress in a defined location at near-physiological temperature. In preclinical studies or human clinical trials, NTP promotes blood coagulation, wound healing with disinfection, and selective killing of cancer cells. Although these biological effects of NTP have been widely explored, the stoichiometric quantitation of free radicals in liquid phase has not been performed in the presence of biocompatible reducing agents, which may modify the final biological effects of NTP. Read More

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Redox-sensitive prodrug nanoassemblies based on linoleic acid-modified docetaxel to resist breast cancers.

Acta Pharm Sin B 2019 Mar 31;9(2):421-432. Epub 2018 Aug 31.

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

Prodrug nanoassemblies, which can refrain from large excipients, achieve higher drug loading and control drug release, have been placed as the priority in drug delivery system. Reasoning that glutathione (GSH) and reactive oxygen species (ROS) are highly upgraded in tumor tissues which makes them attractive targets for drug delivery system, we designed and synthetized a novel prodrug which utilized mono thioether bond as a linker to bridge linoleic acid (LA) and docetaxel (DTX). This mono thioether-linked conjugates (DTX-S-LA) could self-assemble into nanoparticles without the aid of much excipients. Read More

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Dual-targeting and microenvironment-responsive micelles as a gene delivery system to improve the sensitivity of glioma to radiotherapy.

Acta Pharm Sin B 2019 Mar 8;9(2):381-396. Epub 2018 Dec 8.

Department of Pharmaceutics, Shanghai General Hospital, Shanghai Jiao Tong University of Medicine, Shanghai 200080, China.

Dbait is a small double-stranded DNA molecule that has been utilized as a radiosensitizer to enhance the sensitivity of glioma to radiotherapy (RT). However, there is no effective drug delivery system to effectively overcome the blood-brain barrier (BBB). The aim of this study was to develop a gene delivery system by using the BBB and glioma dual-targeting and microenvironment-responsive micelles (ch-K(s-s)R8-An) to deliver Dbait into glioma for RT. Read More

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Vph2 is required for protection against a reductive stress in Candida albicans.

Biochem Biophys Res Commun 2019 05 27;512(4):758-762. Epub 2019 Mar 27.

Pediatric Research Institute, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, PR China; Children's Heart Center, Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, PR China. Electronic address:

Vph2 is a putative V-ATPase assembly factor. Our previous study has characterized its roles in localization of V-ATPase subunit, cell wall composition, hyphal development and virulence. In this study, our results further demonstrated that Vph2 was localized around the nucleus and in patches close to the periphery of the cell, indicating that Vph2 was located to the endoplasmic reticulum (ER), which was consistent with that in Saccharomyces cerevisiae. Read More

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2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach.

Photochem Photobiol Sci 2019 Jun;18(6):1398-1407

Otto Diels-Institute of Organic Chemistry, Christian Albrechts University Kiel, Otto-Hahn-Platz 4, 24118 Kiel, Germany.

In photopharmacology, photoswitchable compounds including azobenzene or other diarylazo moieties exhibit bioactivity against a target protein typically in the slender E-configuration, whereas the rather bulky Z-configuration usually is pharmacologically less potent. Herein we report the design, synthesis and photochemical/inhibitory characterization of new photoswitchable kinase inhibitors targeting p38α MAPK and CK1δ. A well characterized inhibitor scaffold was used to attach arylazo- and diazocine moieties. Read More

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Icariin protects vascular endothelial cells from oxidative stress through inhibiting endoplasmic reticulum stress.

J Integr Med 2019 May 31;17(3):205-212. Epub 2019 Jan 31.

Department of Traditional Chinese Medicine, Army Medical Center in Traditional Chinese Medicine, Xijing Hospital, Forth Military Medical University, Xi'an 710032, Shaanxi Province, China. Electronic address:

Objective: To investigate the protective effect and underlying mechanism(s) of icariin (ICA) in preventing hydrogen peroxide (HO)-induced vascular endothelial cell injury via endoplasmic reticulum stress (ERS).

Methods: To study the effects of ICA on HO-induced damage, we used the cell counting kit-8 assay to detect cell viability and the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay to determine cell adhesion and apoptosis, respectively. Spectrophotometry and enzyme-linked immunosorbent assay were used to measure the expression levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Read More

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Lipoic acid-derived cross-linked liposomes for reduction-responsive delivery of anticancer drug.

Int J Pharm 2019 Apr 12;560:246-260. Epub 2019 Feb 12.

School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China. Electronic address:

Liposomes have emerged as a fascinating nanocarriers for the delivery of cancer therapeutics. However, their efficacy for cancer therapy is reduced partially because of the serum-instability and incomplete drug release. In this study, a novel disulfide cross-linked liposomes (CLs) assembled from dimeric lipoic acid-derived glycerophosphorylcholine (di-LA-PC) conjugate was developed. Read More

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Within-City Spatial Variations in Multiple Measures of PM Oxidative Potential in Toronto, Canada.

Environ Sci Technol 2019 03 20;53(5):2799-2810. Epub 2019 Feb 20.

Department of Civil Engineering , University of Toronto , Toronto , Ontario M5S 1A4 , Canada.

Few studies have characterized within-city spatial variations in the oxidative potential of fine particulate air pollution (PM). In this study, we evaluated multiple measures of PM oxidative potential across Toronto, Canada (2016-2017), including glutathione/ascorbate-related oxidative potential (OP and OP) and dithiothreitol depletion (OP). Integrated 2-week samples were collected from 67 sites in summer and 42 sites in winter. Read More

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Fluorescent sensor array for discrimination of biothiols based on poly(thymine/cytosine)-templated copper nanoparticles.

Anal Chim Acta 2019 Mar 12;1051:147-152. Epub 2018 Nov 12.

Department of Chemistry, Capital Normal University, Beijing, 100048, China. Electronic address:

In medicine, the detection and identification of biothiols have received increasing attention due to their crucial roles in life activities. Hence, we present a facile, rapid, and effective method for identification of five kinds of biothiols including glutathione (GSH), l-cysteine (Cys), dithiothreitol (DTT), 2-mercaptoethanol (MCE), and 3-mercaptopropionic acid (MPA). The proposed sensor array is fabricated based on single-stranded poly (thymine/cytosine)-templated fluorescent copper nanoparticles (CuNPs), which are controlled through thymine-Hg-thymine (T-Hg-T) and cytosine-Ag-cytosine (CAgC) coordination. Read More

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Inhibition of Glutathione Synthesis via Decreased Glucose Metabolism in Stored RBCs.

Cell Physiol Biochem 2018 7;51(5):2172-2184. Epub 2018 Dec 7.

Department of Immunology, Binzhou Medical University, Yantai,

Background/aims: Although red blood cells (RBCs) transfusions can be lifesaving, they are not without risk. RBCs storage is associated with the abnormal metabolism of glutathione (GSH), which may increase the risk of the oxidative damage of RBCs after transfusion. The responsible mechanisms remain unknown. Read More

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January 2019

A natural compound derivative P-13 inhibits STAT3 signaling by covalently inhibiting Janus kinase 2.

Invest New Drugs 2019 06 3;37(3):452-460. Epub 2018 Aug 3.

Division of Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, China.

We investigated the function and molecular mechanisms of 2-desoxy-4β-propylcarbamate-pulchellin (P-13), a sesquiterpene lactone derivative of 2-desoxy-4-epi-pulchellin from the traditional Chinese medicinal herb Carpesium abrotanoides L, in regulating STAT3 signaling and cancer cell growth. We found that P-13 inhibited the IL-6-induced, as well as the constitutive, STAT3 activation in a dose and time-dependent manner. In vitro kinase activity analyses demonstrated that P-13 directly inhibited JAK2 kinase activity. Read More

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Evidence that Thiosulfate Inhibits Creatine Kinase Activity in Rat Striatum via Thiol Group Oxidation.

Neurotox Res 2018 Oct 28;34(3):693-705. Epub 2018 Jul 28.

Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, 90035-003, Brazil.

Sulfite oxidase, molybdenum cofactor, and ETHE1 deficiencies are autosomal recessive disorders that affect the metabolism of sulfur-containing amino acids. Patients with these disorders present severe neurological dysfunction and basal ganglia abnormalities, accompanied by high levels of thiosulfate in biological fluids and tissues. Aiming to better elucidate the pathophysiology of basal ganglia damage in these disorders, we evaluated the in vivo effects of thiosulfate administration on bioenergetics, oxidative stress, and neural damage in rat striatum. Read More

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October 2018

Bioresponsive functional nanogels as an emerging platform for cancer therapy.

Expert Opin Drug Deliv 2018 07 16;15(7):703-716. Epub 2018 Jul 16.

b Biomedical Polymers Laboratory, Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationCollege of Chemistry, Chemical Engineering and Materials Science , Soochow University , Suzhou , P. R. China.

Introduction: Bioresponsive nanogels with a crosslinked three-dimensional structure and an aqueous environment that undergo physical or chemical changes including swelling and dissociation in response to biological signals such as mild acidity, hyperthermia, enzymes, reducing agents, reactive oxygen species (ROS), and adenosine-5'-triphosphate (ATP) present in tumor microenvironments or inside cancer cells have emerged as an appealing platform for targeted drug delivery and cancer therapy.

Areas Covered: This review highlights recent designs and development of bioresponsive nanogels for facile loading and triggered release of chemotherapeutics and biotherapeutics. The in vitro and in vivo antitumor performances of drug-loaded nanogels are discussed. Read More

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Lycii fructus extract ameliorates hydrogen peroxide-induced cytotoxicity through indirect antioxidant action.

Biosci Biotechnol Biochem 2018 Oct 18;82(10):1812-1820. Epub 2018 Jun 18.

a Graduate School of Environmental and Life Science , Okayama University , Okayama , Japan.

Lycii Fructus is the dried ripe fruits of Lycium chinense and L. barbarum, which has long been used as a traditional food material in East Asia. The purpose of this study was to investigate the role of the indirect antioxidative action in the Lycii fructus extract (LFE)-induced cytoprotective effect in vitro. Read More

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October 2018

Chemical Design of Both a Glutathione-Sensitive Dimeric Drug Guest and a Glucose-Derived Nanocarrier Host to Achieve Enhanced Osteosarcoma Lung Metastatic Anticancer Selectivity.

J Am Chem Soc 2018 01 19;140(4):1438-1446. Epub 2018 Jan 19.

Departments of Chemistry, Chemical Engineering, and Materials Science & Engineering, Texas A&M University , College Station, Texas 77842, United States.

Although nanomedicines have been pursued for nearly 20 years, fundamental chemical strategies that seek to optimize both the drug and drug carrier together in a concerted effort remain uncommon yet may be powerful. In this work, two block polymers and one dimeric prodrug molecule were designed to be coassembled into degradable, functional nanocarriers, where the chemistry of each component was defined to accomplish important tasks. The result is a poly(ethylene glycol) (PEG)-protected redox-responsive dimeric paclitaxel (diPTX)-loaded cationic poly(d-glucose carbonate) micelle ([email protected]). Read More

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January 2018