1,137 results match your criteria dss determined


Selenium-Enriched Ameliorates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice by Regulating Inflammatory Cytokines and Intestinal Microbiota.

Front Med (Lausanne) 2021 31;8:716816. Epub 2021 Aug 31.

Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, China.

To evaluate the effect of Selenium-enriched (Se-enriched ) on dextran sulfate sodium (DSS)-induced colitis in mice. Mice were randomly divided into four groups: a control group, a control + Se-enriched group, a chronic colitis group, and a chronic colitis + Se-enriched group ( = 10 each group). The mice were sacrificed on the 26th day. Read More

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Protective mechanisms of Agrimonia pilosa Ledeb in dextran sodium sulfate-induced colitis as determined by a network pharmacology approach.

Acta Biochim Biophys Sin (Shanghai) 2021 Sep 15. Epub 2021 Sep 15.

Department of Gastroenterology, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Previous studies reported that Agrimonia pilosa (AP) Ledeb possessed diverse biological activities, including anti-inflammatory, antioxidant, and anti-tumor activities. However, the effect of AP on ulcerative colitis (UC) remains unclear. In this study, we investigated the therapeutic effect and mechanisms of AP on dextran sodium sulfate (DSS)-induced colitis. Read More

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September 2021

Resveratrol Alleviates Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Mice by Mediating PI3K/Akt/VEGFA Pathway.

Front Pharmacol 2021 23;12:693982. Epub 2021 Aug 23.

Department of Pharmacy, The First People's Hospital of Yongkang Affiliated to Hangzhou Medical College, Jinhua, China.

Ulcerative colitis (UC) is a chronic inflammatory disease that affects the colon, and its incidence is on the rise worldwide. Resveratrol (RSV), a polyphenolic compound, was recently indicated to exert anti-inflammatory effects on UC. Consequently, the current study was conducted to investigate the mechanism of RSV on alleviating UC in mice by mediating intestinal microflora homeostasis. Read More

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Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease.

Gut Microbes 2021 Jan-Dec;13(1):1968257

Center for IBD Research, Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Host-microbial cross-talk plays a crucial role in maintenance of gut homeostasis. However, how microbiota-derived metabolites, e.g. Read More

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September 2021

Functional Heterogeneity of Reelin in the Oral Squamous Cell Carcinoma Microenvironment.

Front Oncol 2021 17;11:692390. Epub 2021 Aug 17.

Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.

Background: Reelin, an extracellular glycoprotein, is expressed on neuronal cells and participates in neuronal migration during brain development. Recently, Reelin also has a vital role in carcinogenesis. However, its role in oral squamous cell carcinoma (OSCC) remains to be explored. Read More

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[Mechanism of Sanhuang Decoction in alleviating dextran sulfate sodium induced ulcerative colitis in mice with Candida albicans colonization:based on high-throughput transcriptome sequencing].

Zhongguo Zhong Yao Za Zhi 2021 Aug;46(15):3915-3925

College of Integrated Chinese and Western Medicine/College of Life Science,Anhui University of Chinese Medicine Hefei 230012,China Institute of Integrated Chinese and Western Medicine,Anhui Academy of Chinese Medicine Hefei 230012,China Key Laboratory of Xin'An Medicine,Ministry of Education,Anhui Academy of Chinese Medicine Hefei 230012,China.

This study explored the mechanism of Sanhuang Decoction(SHD) in treating dextran sulfate sodium(DSS)-induced ulcerative colitis(UC) in mice with Candida albicans(Ca) colonization via high-throughput transcriptome sequencing. Specifically, the animal model was established by oral administration of 3.0% DSS for 7 days followed by intragastrical administration of Ca suspension at 1. Read More

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[Effect of Nrf2/HO-1 signaling pathway in intestinal protection by Sishen Pills against ulcerative colitis in mice].

Zhongguo Zhong Yao Za Zhi 2021 Aug;46(16):4187-4192

Henan Academy of Chinese Medicine Zhengzhou 450004, China.

The present study aimed to explore the effect of nuclear factor erythroid 2 related factor 2(Nrf2)/heme oxygenase-1(HO-1) signaling pathway in intestinal protection by Sishen Pills against ulcerative colitis(UC). After the UC model was induced by 3% dextran sodium sulfate(DSS), experimental animals were randomly divided into control group, model group, salazosulfapyridine(SASP) group, and low-and high-dose Sishen Pills groups. Drug intervention(ig) was performed for seven consecutive days during modeling. Read More

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Butyrate functions in concert with myeloid-derived suppressor cells recruited by CCR9 to alleviate DSS-induced murine colitis.

Int Immunopharmacol 2021 Oct 10;99:108034. Epub 2021 Aug 10.

Department of Clinical Laboratory, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213000, China. Electronic address:

Ulcerative colitis (UC) is a precancerous disease caused mainly by a combination of genetic susceptibility, environmental factors and microbiota dysbiosis. As a kind of short-chain fatty acid (SCFA), butyrate has been shown to be closely related to the progression of colitis. However, the exact regulatory mechanism of butyrate in colitis needs to be further elucidated. Read More

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October 2021

Protective Effect of the Flower Extract on DSS-Induced Ulcerative Colitis in Mice.

Evid Based Complement Alternat Med 2021 9;2021:7422792. Epub 2021 Aug 9.

Department of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China.

Background: The flower of (AM) has been widely used in the treatment of chronic inflammatory diseases, including ulcerative colitis. This paper aimed to confirm the therapeutic effect of AM on ulcerative colitis (UC) and explore its mechanism.

Methods: Mouse models were induced by 2. Read More

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Body composition is associated with operative and oncologic outcomes in the management of retroperitoneal and trunk soft tissue sarcoma.

Am J Surg 2021 Aug 8. Epub 2021 Aug 8.

Department of Surgery, Trinity College Dublin, and Tallaght University Hospital, Dublin, 24, Ireland.

Background: Sarcopenia, myosteatosis and obesity in cancer may confer negative clinical outcomes, but their prevalence and impact among patients with retroperitoneal and trunk soft tissue sarcoma have not been systematically studied. The aim of this study was to determine body composition among patients with retroperitoneal and trunk sarcoma, and assess impact on operative and oncologic outcomes.

Methods: Consecutive patients undergoing treatment with curative intent from 2009 to 2019 were studied. Read More

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Pharmacologic Activation of Hepatic Farnesoid X Receptor Prevents Parenteral Nutrition Associated Cholestasis in Mice.

Hepatology 2021 Aug 13. Epub 2021 Aug 13.

Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Pediatric Liver Center, Digestive Health Institute, Children's Hospital Colorado, Aurora, 80045.

Background And Aims: Parenteral nutrition (PN) associated cholestasis (PNAC) complicates the care of patients with intestinal failure. In PNAC, phytosterol containing PN synergizes with intestinal injury and IL-1β derived from activated hepatic macrophages to suppress hepatocyte FXR signaling and promote PNAC. We hypothesized that pharmacological activation of FXR would prevent PNAC in a mouse model. Read More

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Anti-inflammatory and -apoptotic effects of a long-term herbal extract treatment on DSS-induced colitis in mice fed with high AGEs-fat diet.

Nutr Metab (Lond) 2021 Aug 11;18(1):77. Epub 2021 Aug 11.

Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Hezar Jerib Ave., Azadi Sq., 81746-73441, Isfahan, Iran.

Background: Obesity is associated with many comorbidities including inflammatory bowel disease (IBD). We investigated prophylactic effects of an herbal extract (HE) on the DSS-induced colitis mice challenged with high AGEs-fat diet 60% (HFD).

Methods: Six-week-old C57BL/6 male mice were fed with either HFD (8 groups, 6 mice in each group), or normal diet (ND) (8 groups, 6 mice in each group). Read More

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Kaempferol Alleviates Murine Experimental Colitis by Restoring Gut Microbiota and Inhibiting the LPS-TLR4-NF-κB Axis.

Front Immunol 2021 22;12:679897. Epub 2021 Jul 22.

Clinical Laboratory, Inner Mongolia People's Hospital, Hohhot, China.

Intestinal microbiota dysbiosis is an established characteristic of ulcerative colitis (UC). Regulating the gut microbiota is an attractive alternative UC treatment strategy, considering the potential adverse effects of synthetic drugs used to treat UC. Kaempferol (Kae) is an anti-inflammatory and antioxidant flavonoid derived from a variety of medicinal plants. Read More

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Combination of GP88 Expression in Tumor Cells and Tumor-Infiltrating Immune Cells Is an Independent Prognostic Factor for Bladder Cancer Patients.

Cells 2021 Jul 15;10(7). Epub 2021 Jul 15.

Bridge Consortium, 68135 Mannheim, Germany.

Urothelial bladder cancer (BCa) is the ninth most commonly diagnosed cancer worldwide and accounts for approximately 3% of global cancer diagnoses. We are interested in prognostic markers that may characterize tumor cells (TCs) and immune cells (ICs) and their relationship in BCa. A potential candidate marker that meets these criteria is progranulin (GP88), which is expressed separately in TCs and ICs. Read More

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NLRP3 Inflammasome Inhibitor OLT1177 Suppresses Onset of Inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis.

Dig Dis Sci 2021 Aug 3. Epub 2021 Aug 3.

Department of Neuroscience, Institute of Biomedical Sciences, Iwate Medical University, Yahaba, Japan.

Background And Aims: NLRP3 inflammasomes have been reported to have a key role in the initiation and perpetuation of inflammatory bowel diseases (IBD). Here we investigated the effects of OLT1177, a selective inhibitor of NLRP3 inflammasomes, in mice with dextran sulfate sodium (DSS)-induced colitis.

Methods: C57BL/6J mice were given drinking water containing 3% DSS for 5 days. Read More

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Immunomodulatory role of Parkinson's disease 7 in inflammatory bowel disease.

Sci Rep 2021 Jul 16;11(1):14582. Epub 2021 Jul 16.

1st Department of Pediatrics, Semmelweis University, 54, Bókay Street, Budapest, 1083, Hungary.

Recently the role of Parkinson's disease 7 (PARK7) was studied in gastrointestinal diseases, however, the complex role of PARK7 in the intestinal inflammation is still not completely clear. Expression and localization of PARK7 were determined in the colon biopsies of children with inflammatory bowel disease (IBD), in the colon of dextran sodium sulphate (DSS) treated mice and in HT-29 colonic epithelial cells treated with interleukin (IL)-17, hydrogen peroxide (HO), tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β or lipopolysaccharide (LPS). Effect of PARK7 on the synthesis of IBD related cytokines was determined using PARK7 gene silenced HT-29 cells and 3,4,5-trimethoxy-N-(4-(8-methylimidazo(1,2-a)pyridine-2-yl)phenyl)benzamide (Comp23)-compound increasing PARK7 activity-treated mice with DSS-colitis. Read More

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Single-cell RNA sequencing reveals distinct cellular factors for response to immunotherapy targeting CD73 and PD-1 in colorectal cancer.

J Immunother Cancer 2021 Jul;9(7)

Therapeutics & Biotechnology Division, Drug Discovery Platform Research Center, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea

Background: Although cancer immunotherapy is one of the most effective advanced-stage cancer therapies, no clinically approved cancer immunotherapies currently exist for colorectal cancer (CRC). Recently, programmed cell death protein 1 (PD-1) blockade has exhibited clinical benefits according to ongoing clinical trials. However, ongoing clinical trials for cancer immunotherapies are focused on PD-1 signaling inhibitors such as pembrolizumab, nivolumab, and atezolizumab. Read More

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Dihydroberberine, an isoquinoline alkaloid, exhibits protective effect against dextran sulfate sodium-induced ulcerative colitis in mice.

Phytomedicine 2021 Sep 25;90:153631. Epub 2021 Jun 25.

Department of Pharmaceutical Sciences, Zunyi Medical University, Zhuhai Campus, Zhuhai 519041, China. Electronic address:

Background: As a chronic inflammatory disease, ulcerative colitis (UC) is relevant to a rising risk of colorectal cancer. Dihydroberberine (DHBB), a natural occurring isoquinoline alkaloid with various bioactivities, was found in many plants including Coptis chinensis Franch. (Ranunculaceae), Phellodendron chinense Schneid. Read More

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September 2021

Changes in Microbial Community Composition Related to Sex and Colon Cancer by Nrf2 Knockout.

Front Cell Infect Microbiol 2021 23;11:636808. Epub 2021 Jun 23.

Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea.

The frequency of azoxymethane/dextran sulfate sodium (AOM/DSS)-induced carcinogenesis in male mice is higher than that in female mice. Previous studies have reported that 17β-estradiol inhibits tumorigenesis in males by modulating nuclear factor-erythroid 2-related factor 2 (Nrf2). This study aimed to investigate the changes in mouse gut microbiome composition based on sex, AOM/DSS-induced colorectal cancer (CRC), and Nrf2 genotype. Read More

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Flower extract of . ameliorates DSS-induced ulcerative colitis by affecting TLR4/NF-B and TLR4/MAPK signaling pathway in a mouse model.

Iran J Basic Med Sci 2021 May;24(5):595-603

College of Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, 650500, People's Republic of China.

Objectives: This study aimed to find out the protective effects and preliminary mechanisms of the flower extract of (FEC) on dextran sulfate sodium salt (DSS)-induced colitis.

Materials And Methods: The ulcerative colitis models of mice induced by 3% DSS were established and treated with FEC. Body weight changes, disease activity index (DAI), colon histopathological score, anti-oxidant ability, and the level of inflammatory cytokines were determined. Read More

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Zanthoxylum alatum Roxb. seed extract ameliorates stress aggravated DSS-induced ulcerative colitis in mice: Plausible role on NF-κB signaling axis.

J Ethnopharmacol 2021 Oct 1;279:114385. Epub 2021 Jul 1.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Assam, 781101, India. Electronic address:

Ethnopharmacological Relevance: Zanthoxylum alatum (ZA) Roxb (family: Rutaceae) plant has been traditionally used for multiple indications by local healers among different communities of South Asian countries mainly in India and Bangladesh. The extracts of ZA have reported strong anti-inflammatory and anti-oxidant activities, but no scientific report is available on its efficacy in intestinal inflammatory disorders like ulcerative colitis.

Aim Of The Study: The overall objective of our study was to evaluate the anti-inflammatory potency of hydro-ethanolic extract of Zanthoxylum alatum seed (ZAHA) using both in-vitro NF-κB-luciferase translocation assay and in-vivo stress aggravated dextran sodium sulfate (DSS)-induced ulcerative colitis model. Read More

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October 2021

Dietary 5-demethylnobiletin modulates xenobiotic-metabolizing enzymes and ameliorates colon carcinogenesis in benzo[a]pyrene-induced mice.

Food Chem Toxicol 2021 Sep 30;155:112380. Epub 2021 Jun 30.

Institute of Food Science and Technology, National Taiwan University, Taipei, 10617, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung, 41354, Taiwan. Electronic address:

The intake of common polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (BaP), is strongly correlated to the initiation of colon cancer. BaP is a well-known pro-carcinogen that is metabolically activated by xenobiotic-metabolizing enzymes. Studies indicate that polymethoxyflavones, including 5-demethylnobiletin (5-DMNB), exhibit anti-inflammatory and anti-carcinogenic properties. Read More

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September 2021

Honokiol Affects Stem Cell Viability by Suppressing Oncogenic YAP1 Function to Inhibit Colon Tumorigenesis.

Cells 2021 Jun 26;10(7). Epub 2021 Jun 26.

Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA.

Honokiol (HNK) is a biphenolic compound that has been used in traditional medicine for treating various ailments, including cancers. In this study, we determined the effect of HNK on colon cancer cells in culture and in a colitis-associated cancer model. HNK treatment inhibited proliferation and colony formation while inducing apoptosis. Read More

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Synergistic Activity of New Diclofenac and Essential Oils Combinations against Different spp.

Antibiotics (Basel) 2021 Jun 8;10(6). Epub 2021 Jun 8.

Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.

According to recent studies, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) have shown a good antimicrobial and antifungal activity. Their association with essential oils (EOs) could be useful for the treatment of infections caused by . The aim of this studyis to evaluate the synergistic antifungal activity of new combinations between Diclofenac Sodium Salt (DSS), a widely used NSAID, with EOs of , and . Read More

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Tumor-Associated Trypsin Inhibitor (TATI) as a Biomarker of Poor Prognosis in Oropharyngeal Squamous Cell Carcinoma Irrespective of HPV Status.

Cancers (Basel) 2021 Jun 4;13(11). Epub 2021 Jun 4.

Department of Pathology, University of Helsinki and HUS Helsinki University Hospital, P.O. Box 21, FI-00014 Helsinki, Finland.

Background: We studied the role of tumor-associated trypsin inhibitor (TATI) in serum and in tumor tissues among human papillomavirus (HPV)-positive and HPV-negative OPSCC patients.

Materials And Methods: The study cohort included 90 OPSCC patients treated at the Helsinki University Hospital (HUS), Helsinki, Finland, in 2012-2016. TATI serum concentrations (S-TATIs) were determined by an immunofluorometric assay. Read More

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The novel piperazino-enaminone JOAB-40 reduced colitis severity in mice via inhibition tumor necrosis factor-α and interleukin-1β.

Biomed Pharmacother 2021 Sep 29;141:111852. Epub 2021 Jun 29.

Department of Pharmaceutical Sciences, University of Saint Joseph School of Pharmacy, Hartford, CT 06103, USA.

Brief Introduction: The synthetic compound enaminone E121 has an established role as a potent anti-tussive, bronchodilator and anti-inflammatory agent in asthma, cough, and colitis induced animal models. The addition of an N-alkylated piperazine motif to the terminal end of E121 lead to the generation of various analogues such as JOAB-40. JOAB-40 was shown to be more potent than the lead compound E121 in inhibiting the expression of the chemokine receptor CCR2, ERK1/2 phosphorylation, and the release of pro-inflammatory cytokines in vitro. Read More

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September 2021

Optimal use of radiotherapy in the definitive treatment of non-bulky IB-IIA cervical cancer: A population-based long-term survival analysis.

PLoS One 2021 24;16(6):e0253649. Epub 2021 Jun 24.

Department of Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, South Korea.

Purpose: Although current clinical guidelines recommend surgery or radiotherapy for non-bulky IB-IIA cervical cancer, clinical data supporting the curative role of radiotherapy in the early-stage disease are insufficient. We evaluated the prognostic implications of definitive radiotherapy and determined its optimal use in clinical practice.

Methods: Patients with non-bulky (<4 cm) IB-IIA cervical cancer who underwent hysterectomy or primary radiotherapy between 1988 and 2015 were identified from the Surveillance, Epidemiology, and End Results database. Read More

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Conditioned secretome of adipose-derived stem cells improves dextran sulfate sodium-induced colitis in mice.

World J Gastroenterol 2021 Jun;27(23):3342-3356

Department of Gastroenterology, Kosin University College of Medicine, Busan 49267, South Korea.

Background: Inflammatory bowel diseases (IBD) is related to uncontrolled immune response. Currently, there is no successful treatment for significant improvement in IBD. Stem cells display their therapeutic effects through their repopulating capacity or secreting factors. Read More

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[rCsHscB derived from has therapeutic effect on dextran sodium sulfate-induced chronic ulcerative colitis in mice].

Nan Fang Yi Ke Da Xue Xue Bao 2021 May;41(5):664-670

Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Key Laboratory of Infection and Immunity, Department of Pathogen and Immunology, Xuzhou Medical University, Xuzhou 221004, China.

Objective: To investigate the therapeutic effect of rCsHscB derived from on dextran sodium sulfate (DSS)-induced chronic ulcerative colitis in mice.

Objective: C57BL/6 mice were randomized into negative control (NC) group (= 10), rCsHscB group (=10), DSS group (=15), and DSS+rCsHscB group (=15), and in the latter two groups, chronic ulcerative colitis was induced in the mice using 2% DSS. In rCsHscB and DSS+ rCsHscB groups, the mice received intraperitoneal injections of 125 μg/mL rCsHscB on the 4th and 7th day following DSS administration, and PBS was injected in the other two groups. Read More

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