2,071 results match your criteria drugs figures

High Prevalence of Depressive Symptoms in Patients With Type 1 and Type 2 Diabetes in Developing Countries: Results From the International Diabetes Management Practices Study.

Diabetes Care 2021 May 7;44(5):1100-1107. Epub 2021 May 7.

Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, China.

Objective: Depression is common in people with diabetes, but data from developing countries are scarce. We evaluated the prevalence and risk factors for depressive symptoms in patients with diabetes using data from the International Diabetes Management Practices Study (IDMPS).

Research Design And Methods: IDMPS is an ongoing multinational, cross-sectional study investigating quality of care in patients with diabetes in real-world settings. Read More

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Micro-droplet-based calibration for quantitative elemental bioimaging by LA-ICPMS.

Anal Bioanal Chem 2021 May 5. Epub 2021 May 5.

Institute of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 38, 1090, Vienna, Austria.

In this work, a novel standardization strategy for quantitative elemental bioimaging is evaluated. More specifically, multi-element quantification by laser ablation-inductively coupled plasma-time-of-flight mass spectrometry (LA-ICP-TOFMS) is performed by multi-point calibration using gelatin-based micro-droplet standards and validated using in-house produced reference materials. Fully automated deposition of micro-droplets by micro-spotting ensured precise standard volumes of 400 ± 5 pL resulting in droplet sizes of around 200 μm in diameter. Read More

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Trends and patterns in EU(7)-PIM prescribing to elderly patients in Germany.

Eur J Clin Pharmacol 2021 May 3. Epub 2021 May 3.

Department of Clinical Pharmacology, University of Witten/Herdecke, Witten, North Rhine-Westphalia, Germany.

Purpose: The aim of this study was to explore patterns and long-term development in prescribing potentially inappropriate medication (PIM) according to the EU(7)-PIM list to elderly patients in Germany.

Methods: We analysed anonymized German claims data. The study population comprised 6. Read More

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Gaps in hypertension care and control: a population-based study in low-income urban Medellin, Colombia.

Trop Med Int Health 2021 May 3. Epub 2021 May 3.

Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Objectives: To assess hypertension prevalence and the extent and associated factors of hypertension diagnosis, follow-up, treatment and control gaps in low-income urban Medellin, Colombia.

Methods: We randomly sampled 1873 adults aged 35 or older. Unaware hypertensive individuals were defined as those without previous diagnosis whose average blood pressure was equal to or above 140/90 mmHg. Read More

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Drug-Related Problems in Prescribing for Pediatric Outpatients in Vietnam.

Healthcare (Basel) 2021 Mar 14;9(3). Epub 2021 Mar 14.

Department of Pediatrics, Can Tho University of Medicine and Pharmacy, Can Tho City 900000, Vietnam.

Background: Our study was conducted to determine the prevalence of drug-related problems (DRPs) in outpatient prescriptions, the impact of DRPs on treatment efficacy, safety, and cost, and the determinants of DRPs in prescribing for pediatric outpatients in Vietnam.

Methods: A retrospective cross-sectional study was conducted on pediatric outpatients at a pediatric hospital in Can Tho, Vietnam. DRPs were classified according to the Pharmaceutical Care Network Europe classification (PCNE) of 2020. Read More

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[Foreign medicinal materials in ].

H S Peng L Q Huang

Zhonghua Yi Shi Za Zhi 2021 Jan;51(1):15-23

State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

(, ) presents the exchange and application of foreign medicine in the middle period of the Northern Song Dynasty. The description records foreign medicinal materials from 29 extraterritorial countries, and also recorded some foreign medicinal materials from wide areas such as the Silk Road, the Maritime Silk Road and minority areas. systematically recorded foreign varieties before the Song Dynasty which used domestic resources in the Song Dynasty; it also recorded a large number of varieties of domestic and foreign resources, including genuine medicinal materials from abroad. Read More

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January 2021

Hepatitis C care cascades for three populations at high risk: low-income trans women, young people who inject drugs, and men who have sex with men and inject drugs.

Clin Infect Dis 2021 Mar 26. Epub 2021 Mar 26.

Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.

Background: To achieve elimination of hepatitis C virus (HCV) infection, limited resources can be best allocated through estimation of "care cascades" among groups disproportionately affected. In San Francisco and elsewhere, these groups include young (age ≤30 years) people who inject drugs (YPWID), men who have sex with men who inject drugs (MSM-IDU), and low-income trans women.

Methods: We developed cross-sectional HCV care cascades for YPWID, MSM-IDU, and trans women using diverse data sources. Read More

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The Importance of Sphingosine Kinase in Breast Cancer: A Potential for Breast Cancer Management.

Cureus 2021 Feb 18;13(2):e13413. Epub 2021 Feb 18.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Breast cancer management includes a combination of surgery, radiation therapy, and chemotherapy. While this management has proven effective, it is not perfect. To expand the umbrella of management to resistant breast cancer tumors, researchers have explored the idea of sphingosine kinase (SphK) and sphingosine-1-phosphate (S1P) as a potential target for treatment. Read More

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February 2021

Medication errors in hospitalised patients.

Tidsskr Nor Laegeforen 2021 03 16;141(5). Epub 2021 Mar 16.

Background: Errors in the use and administration of medicinal drugs are not uncommon. There is little up-to-date information available on medication errors in Norwegian hospitals.

Material And Method: It is compulsory to report all adverse events internally at St Olav's Hospital via an electronic form. Read More

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Antiadhesive activity of hydroethanolic extract from bean pods of Phaseolus vulgaris (common bean) against uropathogenic E. coli and permeability of its constituents through Caco-2 cells monolayer.

J Ethnopharmacol 2021 Jun 19;274:114053. Epub 2021 Mar 19.

Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Ul. Banacha 1, 02-097 Warsaw, Poland; Microbiota Lab, Centre for Preclinical Studies, Medical University of Warsaw, Ul. Banacha 1b, 02-097 Warsaw, Poland. Electronic address:

Ethnopharmacological Relevance: Phaseaoli pericarpium (bean pods) is a pharmacopeial plant material traditionally used as a diuretic and antidiabetic agents. Diuretic activity of pod extracts was reported first in 1608. Since then Phaseoli pericarpium tea figures in many textbooks as medicinal plant material used by patients. Read More

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Racing for COVID-19 Vaccine and Cure: Lessons and Tragedies in Human Subject Research.

Heart Views 2020 Jul-Sep;21(3):229-234. Epub 2020 Oct 13.

College of Medicine, QU Health, Qatar University, Doha, Qatar.

Pressured by the enormous human and economic costs of the COVID-19 pandemic, certain countries and political figures have advocated the use of drugs and vaccines that did not go through the required regulatory stages of the development. Although the reason for bypassing these stages in a race to produce a treatment and vaccine for the COVID-19 patients could have been caused by good intentions to stop the human suffering from the pandemic, nonetheless, history has taught us that the results of this action could be catastrophic. In this article, we briefly review the lessons and tragedies in the evolution of human subject research regulations emphasizing the need for the proper evaluation of drugs and vaccines for COVID-19. Read More

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October 2020

Exploring existing drugs: proposing potential compounds in the treatment of COVID-19.

Heliyon 2021 Feb 25;7(2):e06284. Epub 2021 Feb 25.

Department of Pharmacy, Brac University, Bangladesh.

The COVID-19 situation had escalated into an unprecedented global crisis in just a few weeks. On the 30 of January 2020, World Health Organization officially declared the COVID-19 epidemic as a public health emergency of international concern. The confirmed cases were reported to exceed 105,856,046 globally, with the death toll of above 2,311,048, according to the dashboard from Johns Hopkins University on the 7 of February, 2021, though the actual figures may be much higher. Read More

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February 2021

Prevalence and determinants of chronic kidney disease in urban adults' populations of northern Cameroon.

Clin Exp Nephrol 2021 Mar 2. Epub 2021 Mar 2.

South African Medical Research Council &, University of Cape Town, Cape Town, South Africa.

Background: Chronic kidney disease (CKD) is a major health problem with growing prevalence in sub-Saharan Africa.

Aim: Assess the prevalence and determinants of CKD in Garoua and Figuil cities of the North region of Cameroon.

Methods: A cross-sectional survey was conducted from January to June 2018 in the two cities, using a multi-level cluster sampling. Read More

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Cutaneous eruption with reactive endothelial atypia due to emerging targeted cancer therapies: Report of two cases with clinico-pathologic correlation.

J Cutan Pathol 2021 Jun 1;48(6):789-794. Epub 2021 Mar 1.

Department of Dermatology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.

Targeted anticancer therapy is being used with greater frequency and dermatologic toxicities are among the most frequent adverse events of these drugs. However, histopathological features of these adverse events are not yet well characterized. We present two cases of clinically different cutaneous toxicities on two patients with hematologic neoplasia. Read More

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Antidepressants for functional abdominal pain disorders in children and adolescents.

Cochrane Database Syst Rev 2021 02 9;2:CD008013. Epub 2021 Feb 9.

Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Background: Functional Abdominal Pain Disorders (FAPDs) present a considerable burden to paediatric patients, impacting quality of life, school attendance and causing higher rates of anxiety and depression disorders. There are no international guidelines for the management of this condition. A previous Cochrane Review in 2011 found no evidence to support the use of antidepressants in this context. Read More

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February 2021

Identification and semi-relative quantification of intact glycoforms of human chorionic gonadotropin alpha and beta subunits by nano liquid chromatography-Orbitrap mass spectrometry.

J Chromatogr A 2021 Mar 28;1640:461945. Epub 2021 Jan 28.

Laboratory of Analytical, Bioanalytical Sciences and Miniaturization, Chemistry, Biology and Innovation (CBI) UMR 8231, ESPCI Paris PSL, CNRS, PSL Research University, Paris, France. Electronic address:

The human chorionic gonadotropin (hCG) protein belongs to a family of glycoprotein hormones called gonadotropins. It is a heterodimer made of two non-covalently linked subunits. The α-subunit structure, hCGα, has 2 N-glycosylation sites, while the beta subunit, hCGβ, has 2 N- and 4 O-glycosylation sites. Read More

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Higher concordance of PD-L1 expression between biopsies and effusions in epithelioid than in nonepithelioid pleural mesothelioma.

Cancer Cytopathol 2021 Jan 25. Epub 2021 Jan 25.

Department of Translational Medicine in Malmö, Lund University, Malmö, Sweden.

Background: Malignant mesothelioma (MM) is a therapy-resistant tumor, often causing an effusion. Drugs targeting the programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway have shown promising results, but assessment of PD-L1 expression to select patients for therapy has mainly been performed on histologic tissue samples. In a previous study, we showed that MM effusions are suitable for PD-L1 assessment with results comparable to those reported in histologic studies, but no studies have compared PD-L1 expression in histologic and cytologic samples. Read More

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January 2021

Does treatment with bisphosphonates protect against fractures in real life? The HUNT study, Norway.

Osteoporos Int 2021 Jan 21. Epub 2021 Jan 21.

Department of Public Health and Nursing, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.

Bisphosphonates reduce fractures in randomized controlled trials (RCT); however, there is less information from real life. In our population including 14,990 women and 13,239 men, use of bisphosphonates reduced risk of fractures in hip and forearm in women. The magnitude of the effect was comparable to results from RCT. Read More

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January 2021

An Overview of Medullary Thyroid Cancer Cases Treated at Kuwait Cancer Control Center.

Gulf J Oncolog 2020 Sep;1(34):39-47

Department of Medical Oncology Kuwait Cancer Control Center.

Introduction: Medullary thyroid cancers (MTC) constitute about 5% of all thyroid cancers. The 10-year overall survival (OS) rate of patients with localized disease in thyroid for this pathology is 80% to 90% which is comparable with differentiated thyroid cancers, figures drop to 75% for cases with nodal metastases. Only 20% of patients with distant metastases at diagnosis survive for 10 years. Read More

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September 2020

Efficacy of a joint didactic intervention using the Junta De Andalucía School for Patients method to control prothrombin time in patients taking anticoagulants: protocol for a randomized controlled trial.

Trials 2021 Jan 11;22(1):45. Epub 2021 Jan 11.

Andalusian Health Service, District of Málaga-Guadalhorce, Málaga, Spain.

Background: Oral anticoagulant drugs represent an essential tool in the prevention of thromboembolic events. The ones in widespread use are vitamin K antagonists, whose plasma level is monitored by measuring prothrombin time using the international normalized ratio. If its values are out of the recommended range, the patient will have a higher risk of suffering from thromboembolic or hemorrhagic complications. Read More

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January 2021

Use of Cardiovascular Drugs for Primary and Secondary Prevention of Cardiovascular Disease Among Rural-Dwelling Older Chinese Adults.

Front Pharmacol 2020 18;11:608136. Epub 2020 Dec 18.

Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Cardiovascular risk factors and related disorders are common among older adults, and use of various classes of cardiovascular (CV) drugs could reduce the risk of cardiovascular disease (CVD). However, data are sparse with regard to the use of CV drugs among rural-dwelling older adults in China. Therefore, this population-based study aimed to describe use of CV drugs among older adults living in the rural communities in China, while taking into account the use of CV drugs for primary and secondary prevention of CVDs. Read More

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December 2020

Three-Dimensional (3D)-Printed Zero-Order Released Platform: a Novel Method of Personalized Dosage Form Design and Manufacturing.

AAPS PharmSciTech 2021 Jan 6;22(1):37. Epub 2021 Jan 6.

School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.

In 2017, there are 451 million people with diabetes worldwide. These figures were expected to increase to 693 million by 2045. The research and development of hypoglycemic drugs has become a top priority. Read More

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January 2021

Remdesivir and Hydroxychloroquine: A Compassionate Use in Covid-19.

Curr Drug Targets 2020 Dec 28. Epub 2020 Dec 28.

Chitkara College of Pharmacy, Chitkara University, Punjab,. India.

Objective: Early in December 2019, a mass of sufferers with Novel Coronavirus Pneumonia (SAS-CoV-19) in Wuhan (China) roused worldwide concern. Hardly any drugs showed the light of hope concerning the depletion in the period of treatment and virological suppression is troubled. Furthermore, numerous sufferers have undergone off-label use or compassionate use treatments as well as antiretroviral, antiparasitic agents, anti-inflammatory compounds, and convales-cent plasma in either oral/parenteral route. Read More

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December 2020

Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part III: Sheep and goat.

J Vet Pharmacol Ther 2020 Dec 22. Epub 2020 Dec 22.

Institute of Computational Comparative Medicine (ICCM), Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.

This report is the third in a series of studies that aimed to compile physiological parameters related to develop physiologically based pharmacokinetic (PBPK) models for drugs and environmental chemicals in food-producing animals including swine and cattle (Part I), chickens and turkeys (Part II), and finally sheep and goats (the focus of this manuscript). Literature searches were conducted in multiple databases (PubMed, Google Scholar, ScienceDirect, and ProQuest), with data on relevant parameters including body weight, relative organ weight (% of body weight), cardiac output, relative organ blood flow (% of cardiac output), residual blood volume (% of organ weight), and hematocrit reviewed and statistically summarized. The mean and standard deviation of each parameter are presented in tables. Read More

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December 2020

The Experience of Violence Against Women Who Use Injection Drugs: An Exploratory Qualitative Study.

Can J Nurs Res 2020 Dec 21:844562120979577. Epub 2020 Dec 21.

School of Nursing, University of Ottawa, Ottawa, Ontario, Canada.

Background: While literature exists about persons who use injection drugs, few studies explore the experience of women who use these substances. Furthermore, even less research specifically focuses on the lives and experiences of homeless women who use injection drugs. What literature does exist, moreover, is often dated and primarily addresses concerns about infectious disease transmission among these women; and some highlight that these women have lives fraught with violence. Read More

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December 2020

Development and validation of analytical method for identification of new psychoactive substances using linear retention indexes and gas chromatography-mass spectrometry.

J Chromatogr A 2021 Jan 6;1636:461783. Epub 2020 Dec 6.

Institute of Chemistry, University of Brasília (IQ/UnB), P.O. Box 4478, 70904-970 Brasília, Distrito Federal, Brazil.

New Psychoactive Substances (NPS) are quickly developing to evade legislation, posing unprecedented challenges to public health and law enforcement authorities around the world. The aim of this work was to develop and validate a simple and reliable non-target gas chromatography/mass spectrometry (GC/MS) analytical method based on linear retention indexes for the expeditious identification of NPS without the need of analytical standards. The method was optimized and validated for 22 different drugs covering ten categories: phenethylamines (amphetamine, MDMA, methamphetamine, 25CNBOMe, 2-FA, 5-MAPB), "classic" drugs (cocaine, ephedrine, THC, heroine), synthetic cannabinoids (JWH-081, AM-2201, JWH-210, MAM-2201), piperazines (o-CPP, p-CPP), tryptamines (5-MeO-MiPT), synthetic cathinones (N-ethylpentylone), synthetic opioids (U-47700), aminoindanes (5-IAI), plant-based substances (Salvinorin-A) and "other" (methiopropamine). Read More

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January 2021

Imidazole Derivatives and their Antibacterial Activity - a Mini-Review.

Mini Rev Med Chem 2020 Dec 9. Epub 2020 Dec 9.

Department of Organic Chemistry, Faculty of Pharmacy, University of Medicine, Pharmacy, Science and Technology "George Emil Palade" of Târgu Mureș, Târgu Mureș,. Romania.

Background: The development of drug resistance by bacterial strains is a public health issue, being the main cause for the decrease in effectiveness of numerous antibiotics. In this context, it is essential to find new drugs with better antibacterial activity.

Objective: The authors proposed to cover relevant literature, published following the review article written by Rani et al. Read More

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December 2020

Comparison of community illicit drug use in 11 cities of Turkey through wastewater-based epidemiology.

Environ Sci Pollut Res Int 2021 Mar 23;28(12):15076-15089. Epub 2020 Nov 23.

Department of Forensic Medicine, School of Medicine, Cukurova University, 01330, Adana, Turkey.

Wastewater-based epidemiology (WBE) is an ever-increasing discipline that enables researchers to track near-real-time data concerning the recreational use of illicit drugs. Community illicit drug use was estimated in eleven Turkish cities, using eighteen wastewater treatment plants, representing the metropolitan cities and rural areas with different socio-demographic characteristics. In this study, 24-h composite influent wastewater samples were collected for 1 week per season between March 2019 and December 2019. Read More

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Design, implementation, and monitoring of HIV service packages for people who inject drugs: An assessment of programs supported by the Global Fund in 46 countries.

Int J Drug Policy 2021 Feb 17;88:103036. Epub 2020 Nov 17.

The Global Fund to fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland.

Background: People who inject drugs (PWID) are at higher risk of acquiring and transmitting HIV, accounting for an estimated 10% of HIV new infections globally. The World Health Organization (WHO) and other international agencies have clearly outlined the comprehensive package of services that should be available for PWID.

Methods: This paper summarizes the data and findings from the PWID service packages assessed in 15 countries across different regions. Read More

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February 2021

Antiproliferative and antitumour activity of saponins from Astragalus glycyphyllos on myeloid Graffi tumour.

J Ethnopharmacol 2021 Mar 1;267:113519. Epub 2020 Nov 1.

Department of Internal Non-communicable Diseases, Pathology and Pharmacology, Faculty of Veterinary Medicine, University of Forestry, 10 St. Kliment Ohridski Blvd., 1797, Sofia, Bulgaria. Electronic address:

Ethnopharmacological Relevance: Astragalus glycyphyllos L. has been extensively used in Bulgarian folk medicine as an antihypertensive, diuretic, anti-inflammatory, anti-tumour, in cases of cardiac insufficiency, renal inflammation, calculosis, etc. AIM OF THE STUDY: To evaluate the possible in vitro/in vivo anti-proliferative/anti-tumour activity of a purified saponins' mixture (PSM) obtained from the plant. Read More

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