99 results match your criteria drug-induced thyrotoxicosis


Usefulness of plasmapheresis in patients with severe complicated thyrotoxicosis.

Proc (Bayl Univ Med Cent) 2020 Dec 14;34(2):279-282. Epub 2020 Dec 14.

Division of Internal Medicine/Endocrinology, Texas Tech University Health Science Center, Lubbock, Texas.

The standard treatment of complicated thyrotoxicosis and thyroid storm with the concomitant use of antithyroid medication, iodine, beta-blockers, and corticosteroids is successful in most cases. However, treatment options are limited when antithyroidal drugs cannot be used or in cases that are refractory to standard treatment. Plasmapheresis provides a safe and effective strategy when initial treatment fails, facilitating the transition to definitive treatments such as thyroidectomy. Read More

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December 2020

[Radioiodine therapy outcome in toxic multinodular goiter patient with concomitant hereditary Hasharon hemoglobinopathy].

Probl Endokrinol (Mosk) 2020 Sep 16;66(3):27-32. Epub 2020 Sep 16.

Endocrinology Research Centre.

This research describes a clinical case of treatment of a patient with thyrotoxicosis with concomitant hematological pathology – carriage of unstable hemoglobin Hasharon. A patient diagnosed with «Diffuse toxic nodular goiter. Thyrotoxicosis of medium severity. Read More

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September 2020

PANCYTOPENIA SECONDARY TO AUTOIMMUNE VITAMIN B DEFICIENCY IN GRAVES DISEASE.

AACE Clin Case Rep 2020 Nov-Dec;6(6):e282-e285. Epub 2020 Jun 23.

Objective: To describe a case of Graves disease (GD) and coexistent pancytopenia associated with autoimmune vitamin B deficiency. While thyrotoxicosis and antithyroid drugs can cause pancytopenia, other autoimmune conditions such as vitamin B deficiency can occur, leading to severe anemia and pancytopenia.

Methods: A 19-year-old female with GD treated with methimazole presented with thyrotoxicosis and evidence of pancytopenia. Read More

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Preoperative plasmapheresis experience in Graves' disease patients with anti-thyroid drug-induced hepatotoxicity.

Transfus Apher Sci 2020 Oct 2;59(5):102826. Epub 2020 Jun 2.

Marmara University School of Medicine, Department of Endocrinology and Metabolism, Istanbul, Turkey. Electronic address:

Hepatotoxicity is a rare but serious side effect of antithyroid drug (ATI) therapy in Graves' disease patients. Cessation of ATI drug is needed in most of the patients if liver enzymes highly elevated or in case of agranulocytosis. Permanent therapy, surgery or radioactive iodine ablation are the treatment choices to ensure euthyroidism in active Graves' disease patients. Read More

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October 2020

Effect of high-dose intravenous glucocorticoid therapy on serum thyroid hormone concentrations in type 2 amiodarone-induced thyrotoxicosis: an exploratory study.

J Endocrinol Invest 2020 Nov 16;43(11):1637-1643. Epub 2020 Apr 16.

Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Ospedale Cisanello, via Paradisa 2, 56124, Pisa, Italy.

Purpose: Type 2 amiodarone-induced thyrotoxicosis (AIT2) is a form of drug-induced destructive thyroiditis, usually treated with oral glucocorticoids (oGCs). Our objective was to investigate the short-term effects of intravenous glucocorticoids (ivGCs) on serum thyroid hormone concentrations in patients with AIT2.

Methods: Exploratory study of three naive AIT2 patients treated with iv methylprednisolone (two pulses of 400 mg with no interpulse oGCs), followed by oGCs, matched 1:3 with AIT2 patients treated with oGCs alone. Read More

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November 2020

The interplay between thyroid and liver: implications for clinical practice.

J Endocrinol Invest 2020 Jul 12;43(7):885-899. Epub 2020 Mar 12.

Endocrine Unit, Department of Medicine and Surgery, Ospedale Di Circolo, ASST Dei Sette Laghi, University of Insubria, Viale Borri, 57, Varese, Italy.

A complex relationship exists between thyroid and liver in health and disease. Liver plays an essential physiological role in thyroid hormone activation and inactivation, transport, and metabolism. Conversely, thyroid hormones affect activities of hepatocytes and hepatic metabolism. Read More

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Immunoassay Interference on Thyroid Function Tests During Treatment with Nivolumab.

Thyroid 2020 07 3;30(7):1091-1094. Epub 2020 Apr 3.

Department of Chemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore-Fondazione Policlinico "Gemelli" IRCCS, Rome, Italy.

Immune checkpoint inhibitors (ICIs) are associated with several endocrine side effects. In particular, the use of programmed cell death protein-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) inhibitors is related to a higher incidence of thyroid dysfunction. An 85 years-old patient, diagnosed with a metastatic melanoma treated with nivolumab, presented to our hospital with severe ICI-related thyrotoxicosis. Read More

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[HEPATOCELLULAR TOXICITY IN THE BACKGROUND OF AMIODARON-INDUCED THYROID DYSFUNCTION IN PATIENTS WITH ATRIAL FIBRILLATION].

Georgian Med News 2019 Dec(297):84-87

Ivano-Frankivsk National Medical University, Ukraine.

The purpose of the work was to establish the frequency and conditions in which structural and functional changes of the liver might occur in case of long-term amiodarone use, depending on thyroid dysfunction. The study included 80 patients with cardiosclerosis with atrial fibrillation (AF). The patients were assigned to: group I (n=60) - received amiodarone at a maintenance dose for one year (on background of basic therapy); control group (CG) - patients (n=20) who received on the background of basic therapy digoxin and bisoprolol. Read More

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December 2019

Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis and agranulocytosis in a patient with Graves' disease.

Endocrinol Diabetes Metab Case Rep 2020 Jan 8;2020. Epub 2020 Jan 8.

Department of Endocrinology and Diabetes, Beaumont Hospital Dublin, Dublin, Ireland.

Summary: This case is the first to describe a patient who experienced concomitant agranulocytosis and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis as an adverse effect of propylthiouracil treatment for Graves' disease. A 42-year-old female with Graves' disease presented to the emergency department (ED) with a 2-week history of fevers, night sweats, transient lower limb rash, arthralgia, myalgia and fatigue. She had been taking propylthiouracil for 18 months prior to presentation. Read More

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January 2020

Methimazole-Induced Leukocytoclastic Vasculitis: A Case Report.

Case Rep Dermatol 2019 Sep-Dec;11(3):303-309. Epub 2019 Nov 1.

Division of Dermatology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Major identifiable causes of leukocytoclastic vasculitis include certain infections and medications. Amongst antithyroid drugs, methimazole (MMI) is rarely implicated as a culprit drug. We report the first case, in Thailand, of MMI-induced leukocytoclastic vasculitis in a 41-year-old Thai female who had received MMI for relapsed Graves' disease. Read More

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November 2019

Liver dysfunction induced by Levothyroxine Sodium Tablets (Euthyrox®) in a hypothyroid patient with Hashimoto's thyroiditis: case report and literature review.

Endocr J 2019 Sep 18;66(9):769-775. Epub 2019 Jun 18.

Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.

A 49-year-old woman with hypothyroidism developed liver dysfunction after increasing dose of levothyroxine (L-T4) (Euthyrox) from 25 μg to 50 μg. Viral hepatitis, autoimmune hepatitis and non-alcoholic steatohepatitis (NASH) were ruled out with examinations. She had no concurrent medication and had no history of infectious, chronic or any other autoimmune diseases. Read More

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September 2019

A case report of 131I therapy for Graves' disease patient with hemiagenesis.

Medicine (Baltimore) 2019 Feb;98(8):e14606

Department of Nuclear Medicine, Third Central Hospital of Tianjin, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry.

Rationale: Thyroid hemiagenesis is a rare congenital dysplasia, whereas a variety of pathological changes may occur in residual thyroid lobe. The most frequently described pathology in residual thyroid lobe is Graves' hyperthyroidism. Although I therapy has been generally recommended as the preferred treatment for Graves' disease (GD), subjects relating to hemiagenesis are very limited, especially in China. Read More

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February 2019

Clinical Characteristics of Febrile Outpatients : Possible Involvement of Thyroid Dysfunction in Febrile Tachycardia.

Acta Med Okayama 2018 Oct;72(5):447-456

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

We retrospectively analyzed the cases of 148 febrile patients whose body temperature (BT) was ≥ 37.5°C at our hospital. We categorized them into seven groups; those with bacterial and viral infection, nonspecific inflammation, neoplasm, connective tissue disease (CTD), drug-induced disease, and unidentified causes. Read More

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October 2018

Evaluation and Management of Children with Thyrotoxicosis.

Recent Pat Endocr Metab Immune Drug Discov 2017 ;11(1):22-31

Departments of Medicine, Community Health Sciences, and Oncology, The University of Calgary, Calgary, Alberta, Canada.

Background: Uncontrolled thyrotoxicosis, especially in early infancy, may cause irreversible damage to the central nervous system as well as profound effects on the function of many organs. Thyrotoxicosis has multiple etiologies and treatment depends on the underlying etiology. An accurate diagnosis is essential so that appropriate treatment can be initiated without undue delay. Read More

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October 2018

Rescue of Graves Thyrotoxicosis-Induced Cholestatic Liver Disease Without Antithyroid Drugs: A Case Report.

J Endocr Soc 2017 Mar 15;1(3):231-236. Epub 2017 Feb 15.

Endocrinology, and.

Graves thyrotoxicosis rarely presents with painless jaundice resulting from hyperthyroidism-associated hepatotoxicity, without preexisting liver disease. Management in patients with this presentation is challenging, given that the thionamides, methimazole and propylthiouracil, have both been associated with drug-induced liver injury. Radioactive iodine ablation and thyroidectomy are well-established alternatives, but each have their associated risks and contraindications. Read More

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Methimazole-induced liver injury overshadowed by methylprednisolone pulse therapy: Case report.

Medicine (Baltimore) 2017 Sep;96(39):e8159

Institute of Physiology and Pharmacology, Lithuanian University of Health Sciences Institute of Endocrinology, Lithuanian University of Health Sciences Institute of Physiology and Pharmacology, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Rationale: Treatment choices are limited, when deciding how to manage thyrotoxicosis and moderate to severe Graves ophthalmopathy (GO) with suspected optic nerve damage in patients with elevated liver transaminase levels. The situation become even more complicated, if methimazole induced hepatotoxicity is suspected and intravenous methylprednisolone is co-administrated.

Patient Concerns: A 74-year-old woman presented with spontaneous retro-bulbar pain, eyelid swelling and inconstant diplopia. Read More

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September 2017

Case of painless thyroiditis that developed during adjuvant chemotherapy for breast cancer.

Int Cancer Conf J 2017 Oct 10;6(4):184-187. Epub 2017 Jul 10.

Division of Breast, Endocrine and Respiratory Surgery, Department of Surgery (II), Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621 Japan.

We report a case of painless thyroiditis that occurred during adjuvant chemotherapy for breast cancer. A 41-year-old woman was diagnosed with right breast cancer and underwent surgery followed by adjuvant chemotherapy, given the tumor size and relatively high ratio of Ki-67-positive cells. Three weeks after the first intravenous administration of fluorouracil (500 mg/m), epirubicin (100 mg/m), cyclophosphamide (500 mg/m), and dexamethasone (6. Read More

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October 2017

Drug-induced hypersensitivity reaction: A case of simultaneous thyroiditis and fulminant type 1 diabetes.

Avicenna J Med 2017 Apr-Jun;7(2):67-70

Division of Endocrinology, Albany Medical Center, Albany, NY, USA.

A 43-year-old incarcerated man with AIDS was hospitalized for 30 pounds weight loss and diffuse pruritic rash. Three months prior, he was started on dapsone for pneumonia prevention. Biochemical evaluation was remarkable for eosinophilia, thrombocytopenia, acute renal insufficiency, transaminitis, thyrotoxicosis, and significant hyperglycemia (450 mg/dl; nl, 65-99). Read More

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[Amiodarone-induced thyrotoxicosis].

G Ital Cardiol (Rome) 2017 Mar;18(3):219-229

Unità di Endocrinologia, Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi, Pisa.

Amiodarone-induced thyroid dysfunction occurs in about 15-20% of patients under amiodarone therapy. Amiodarone-induced hypothyroidism (AIH) can develop in patients with an apparently normal thyroid gland or in those with an underlying chronic autoimmune thyroiditis. On a clinical ground, AIH is not challenging and can be easily treated with L-thyroxine therapy. Read More

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Novel melanoma therapies and their side effects.

Cutis 2016 Jun;97(6):426-8

Icahn School of Medicine at Mount Sinai and Mount Sinai Beth Israel, New York, New York, USA.

In the last few years, melanoma treatment has been revolutionized by the development of immune checkpoint-blocking antibodies or immune checkpoint inhibitors including ipilimumab, vemurafenib, dabrafenib, trametinib, nivolumab, and pembrolizumab. Although they have shown promising results, they also have caused multiple adverse events (AEs), particularly immune-related AEs (irAEs). Specialists should be familiar with these AEs. Read More

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[Hyperthyroid and acute tonsillitis in a 23-year-old woman].

Internist (Berl) 2016 Jul;57(7):717-23

Klinik und Poliklinik für Innere Medizin A, Universitätsmedizin Greifswald, Ferdinand-Sauerbruch-Str., 17475, Greifswald, Deutschland.

A 23-year-old woman with preexisting Graves' disease who received thiamazole treatment presented with fever, dysphagia, hyperthyroidism and leukopenia. With suspicion of thyreotoxicosis accompanied by drug-induced agranulocytosis she was successfully managed by plasmapheresis, G‑CSF administration and inhibition of periphereal conversion of thyroid hormones. In due course she underwent thyroidectomy. Read More

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Hyperthyroidism.

Lancet 2016 Aug 30;388(10047):906-918. Epub 2016 Mar 30.

Endocrine Unit, Fondazione IRCCS Cà Granda, Milan, Italy (S De Leo MD); Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy (S De Leo); and Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA, USA (S De Leo, S Y Lee MD, Prof L E Braverman MD).

Hyperthyroidism is characterised by increased thyroid hormone synthesis and secretion from the thyroid gland, whereas thyrotoxicosis refers to the clinical syndrome of excess circulating thyroid hormones, irrespective of the source. The most common cause of hyperthyroidism is Graves' disease, followed by toxic nodular goitre. Other important causes of thyrotoxicosis include thyroiditis, iodine-induced and drug-induced thyroid dysfunction, and factitious ingestion of excess thyroid hormones. Read More

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Nivolumab causing painless thyroiditis in a patient with adenocarcinoma of the lung.

BMJ Case Rep 2016 Jan 5;2016. Epub 2016 Jan 5.

Department of Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.

Thyroiditis is characterised by transient hyperthyroidism, followed sometimes by hypothyroidism, and then recovery. We report a case of painless drug-induced thyroiditis-in a patient with no history of any thyroid disorder-treated with Nivolumab (an IgG4 monoclonal antibody against Programmed Death Receptor 1). The purpose of this case report is to increase awareness among clinicians regarding this possible adverse effect from Nivolumab, and discuss the possible pathophysiology and management strategies in such patients. Read More

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January 2016

Amiodarone and the thyroid.

Endokrynol Pol 2015 ;66(2):176-86

Department of Endocrinology, Jagiellonian University, Medical College, Krakow, Poland.

Amiodarone, a benzofuranic iodine-rich antiarrhythmic drug, causes thyroid dysfunction in 15-20% of cases. Amiodarone can cause both hypothyroidism (AIH, amiodarone-induced hypothyroidism) and thyrotoxicosis (AIT, amiodarone-induced thyrotoxicosis). AIH is treated by L-thyroxin replacement and does not need amiodarone discontinuation. Read More

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February 2017

Patient knowledge of antithyroid drug-induced agranulocytosis.

Eur Thyroid J 2014 Dec 15;3(4):245-51. Epub 2014 Oct 15.

Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, Harrogate, UK.

Background: Agranulocytosis is a serious side effect of antithyroid drugs.

Objective: To ascertain the knowledge of patients and review the quality of information available on the internet.

Methods: A questionnaire survey was performed for patients receiving antithyroid drugs. Read More

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December 2014

Gestational thyrotoxicosis, antithyroid drug use and neonatal outcomes within an integrated healthcare delivery system.

Thyroid 2015 Jun 14;25(6):698-705. Epub 2015 Apr 14.

1Division of Research, Kaiser Permanente Northern California, Oakland, California.

Background: Increasing attention has focused on the prevalence and outcomes of hyperthyroidism in pregnancy, given concerns for hepatotoxicity and embryopathy associated with antithyroid drugs (ATDs).

Methods: In an integrated health care delivery system, we examined the prevalence of thyrotoxicosis and gestational ATD use (propylthiouracil [PTU] or methimazole [MMI]) in women with delivered pregnancies from 1996 to 2010. Birth outcomes were compared among all infants and those born to mothers with diagnosed thyrotoxicosis or ATD therapy during gestation, with examination of ATD-associated hepatotoxicity and congenital malformations in the latter subgroups. Read More

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Internet slimming, thyrotoxicosis and the liver.

Med J Aust 2014 Apr;200(7):419-20

Mater Pathology, Mater Adult Hospital, Brisbane, QLD, Australia.

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Inducing thyrotoxicosis in the liver to treat raised cholesterol.

Lancet Diabetes Endocrinol 2014 Jun 18;2(6):438-9. Epub 2014 Feb 18.

Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5B7, Canada. Electronic address:

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