J Control Release 2021 Apr 12. Epub 2021 Apr 12.
Therapeutics Research Group, The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia; Therapeutics Research Centre, University of South Australia Division of Clinical and Health Sciences, Basil Hetzel Institute for Translational Medical Research, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia.
Increasing emphasis is being placed on using in vitro permeation test (IVPT) results for topical products as a surrogate for their in vivo behaviour. This study sought to relate in vivo plasma concentration - time pharmacokinetic (PK) profiles after topical application of drug products to IVPT findings with mechanistic diffusion and compartment models that are now widely used to describe permeation of solutes across the main skin transport barrier, the stratum corneum. Novel in vivo forms of the diffusion and compartment-in-series models were developed by combining their IVPT model forms with appropriate in vivo disposition functions. Read More