26,632 results match your criteria drug eruptions

No antibody response in cutaneous manifestations associated with COVID-19: an observational study of 64 cases with microbiological and clinical characterization.

Dermatol Ther 2021 Sep 21:e15142. Epub 2021 Sep 21.

Department of Dermatology, Lozano Blesa University Clinical Hospital, Zaragoza, Spain.

Background: The microbiological diagnosis of skin lesions related to COVID-19 is not well known.

Objective: Perform a microbiological diagnosis in COVID19-related cutaneous manifestations.

Methods: A cross-sectional study was performed with 64 patients with cutaneous manifestations associated with COVID-19 who underwent serological and nasopharyngeal RT-PCR for SARS-CoV-2. Read More

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September 2021

Sorafenib-related generalized eruptive keratoacanthomas (Grzybowski syndrome): a case report.

J Med Case Rep 2021 Sep 21;15(1):481. Epub 2021 Sep 21.

Flinders Centre for Innovation in Cancer, Flinders Medical Centre, Adelaide, South Australia, Australia.

Background: Sorafenib is an oral multikinase inhibitor that targets Raf serine/threonine receptor tyrosine kinases and inhibits tumor cell growth and angiogenesis. Cutaneous toxicities of sorafenib are common, including cutaneous eruptions (such as truncal erythema and seborrheic-dermatitis-like changes) and hand-foot syndrome. Keratoacanthomas and squamous cell carcinomas have been reported previously; however, we report a case of multiple eruptive keratoacanthomas in the form of Grzybowski syndrome after initiation of sorafenib. Read More

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September 2021

Maculopapular Drug Eruption Caused by Apalutamide: Case Report and Review of the Literature.

J Nippon Med Sch 2021 Sep 14. Epub 2021 Sep 14.

Department of Dermatology, Nippon Medical School Tama Nagayama Hospital.

Apalutamide, an oral androgen receptor signaling inhibitor, is approved for the treatment of non-metastatic castration-resistant prostate cancer and metastatic prostate cancer. In the international randomized placebo-controlled clinical trials, apalutamide was associated with a higher rate of rash than placebo. However, given that reports from a dermatological perspective are limited, the skin manifestations and histopathology of the skin lesions caused by apalutamide are largely unknown. Read More

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September 2021

Carbamazepine-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Treated Successfully with Oral Cyclosporin: Case report and literature review.

Sultan Qaboos Univ Med J 2021 Aug 29;21(3):491-494. Epub 2021 Aug 29.

Department of Medicine, Rustaq Hospital, Rustaq, Oman.

Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute life-threatening mucocutaneous drug reactions. Several therapies have been used in the treatment of SJS/TEN but none of them have yet been established as the gold standard treatment. Studies have shown that cyclosporine (CsA) can be used off-label in TEN/SJS, which has shown promising therapeutic effectiveness in such diseases. Read More

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Maculopapular-type drug eruptions caused by apalutamide: case series and a review of the literature.

J Eur Acad Dermatol Venereol 2021 Sep 12. Epub 2021 Sep 12.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Apalutamide, a novel selective inhibitor of the androgen receptor, is approved for the treatment of metastatic castration-sensitive and nonmetastatic castration-resistant prostate cancer (PC). According to global SPARTAN and TITAN studies, the incidence of skin rash in the apalutamide group was as high as 23.8% and 27. Read More

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September 2021

Orofacial Herpes Zoster Infection in Dental practice: A Case Report.

JNMA J Nepal Med Assoc 2020 Nov 22;58(231):941-944. Epub 2020 Nov 22.

Department of Oral and Maxillofacial Surgery, Kathmandu Medical College and Teaching Hospital, Duwakot, Bhaktapur, Nepal.

Herpes zoster infection, commonly known as Shingles, is caused by reactivation of the Varicella-Zoster virus which may have remained latent in the dorsal root ganglia. HZI is characterized by prodromal symptoms of unilateral deep aching, burning pain followed by a maculopapular rash, vesicular eruptions, ulcers, and scab formations over the affected nerve distribution. The ophthalmic branch of the trigeminal nerve is more commonly involved in HZI than maxillary and mandibular branches; in particular, the maxillary involvement is rare. Read More

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November 2020

Dual Antiepileptics Induced Stevens-Johnson Syndrome: A Case Report.

JNMA J Nepal Med Assoc 2020 Oct 15;58(230):801-804. Epub 2020 Oct 15.

Chirayu National Hospital and Medical Institute, Basundhara, Kathmandu, Nepal.

Stevens-Johnson syndrome and Toxic Epidermal Necrolysis are acute mucocutaneous reactions hallmark of which is widespread necrosis and detachment of epidermis. SJS/TEN fall under the single disease spectrum with an incidence rate of 1.0 to 6. Read More

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October 2020

[Arrested root development related to Stevens-Johnson syndrome: a case report].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 Sep;56(9):900-903

Department of Pediatric Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.

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September 2021

Amoxicillin Rash in Infectious Mononucleosis.

N Engl J Med 2021 Sep;385(11):1033

University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND

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September 2021

Recurrent Cellulitis-Like Episodes of the Lower Limbs and Acute Diarrhea in a 30-Year-Old Woman: A Case Report.

Am J Case Rep 2021 Aug 31;22:e932732. Epub 2021 Aug 31.

Department of Surgery, Evangelismos Hospital, Paphos, Cyprus.

BACKGROUND Wells syndrome is an uncommon inflammatory dermatosis that presents as tender or mildly pruritic cellulitis-like eruptions. The clinical presentation can include papular and nodular eruptions, annular plaques, vesicles, bullae, and urticaria. This syndrome can be promoted by inappropriate eosinophilic stimulation by factors that affect normal eosinophil cellular systems. Read More

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Serum Sickness-Like Reaction in an Adolescent Taking Minocycline for Acne.

S D Med 2021 Jul;74(7):310-313

Avera Medical Group Dermatology, Sioux Falls, South Dakota.

We report a case of serum sickness-like reaction (SSLR) in a 14-year-old male taking minocycline for acne. The patient presented with urticarial rash, arthralgia/arthritis, and tender lymphadenopathy. Symptoms resolved with discontinuation of minocycline and treatment with prednisone, cetirizine, and ibuprofen. Read More

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Virology and Etiopathogenesis of COVID-19 with Special Reference to Cutaneous Implications.

Indian J Dermatol 2021 May-Jun;66(3):231-236

Department of Dermatology, Lady Hardinge Medical College and Associated KSCH and SSK Hospital, New Delhi, India.

Severe Acute Respiratory Virus Corona Virus 2 (SARS-CoV-2) has got its name Corona from Latin meaning "crown." It has crown-like spikes present on the surface, which encloses the RNA, genetic material of this deadly virus. The virus attacks pneumocytes after binding with the angiotensin-converting enzyme 2 (ACE2) of the cell surface, which ultimately leads to chemotaxis followed by leukocyte infiltration, increased permeability of blood vessels and alveolar walls, and decreased surfactant in the lung leading to various symptoms. Read More

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Erythema Multiforme and COVID-19: What Do We Know?

Medicina (Kaunas) 2021 Aug 16;57(8). Epub 2021 Aug 16.

Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.

: Erythema multiforme (EM) is an acute cutaneous eruption often associated with infections and more rarely with drugs. This review aimed to evaluate the association between erythema multiforme and coronavirus disease 2019 (COVID-19). : A systematic search of PubMed/MEDLINE, Scimago Scopus, and ISI/Web of Science was performed. Read More

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A Comparison of Diagnosed Skin Diseases between the Years with and without COVID-19 Pandemic.

Medicina (Kaunas) 2021 Jul 29;57(8). Epub 2021 Jul 29.

Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

: The COVID-19 pandemic has a considerable influence on public health, either directly or indirectly. We investigated outpatient skin disease diagnoses at the dermatology clinic to determine the effect of the COVID-19 pandemic on these patients. : We conducted a retrospective study using the International Codes of Diseases data from the outpatient department of Dermatology clinic, Vajira hospital, Navamindradhiraj University, Bangkok, Thailand from January 2019 to June 2021. Read More

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Persistent cutaneous lesion in a child with tyrosinemia: Esomeprazole-induced lichenoid drug eruptions.

Clin Case Rep 2021 Aug 16;9(8):e04610. Epub 2021 Aug 16.

School of Medicine Isfahan University of Medical Sciences Isfahan Iran.

Lichenoid drug eruptions (LDEs) are among well-recognized adverse reactions that different drugs including Proton-pump inhibitors (PPIs) are associated with. LDEs are rare adverse reaction of PPIs but they should be considered as appropriate management can lead to full resolution. Herein, we report a case of Esomeprazole-induced LDE in a child with tyrosinemia. Read More

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DRESS syndrome induced by imatinib.

J Postgrad Med 2021 Jul-Sep;67(3):158-163

Department of Dermatology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) is a severe, potentially life-threatening drug-induced hypersensitivity reaction characterized by cutaneous eruptions, fever, diffuse lymphadenopathy, along with eosinophilia and elevated liver enzymes. The severity and potential organ damage associated with DRESS mandates withdrawing the offending drug and provide a suitable replacement. We report a 55-year-old man who developed prolonged fever, generalized maculopapular rash and facial edema after 3 weeks of starting imatinib for chronic myeloid leukemia (CML). Read More

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Bullous fixed drug eruption following administration of the recombinant adjuvant Shingrix vaccine.

BMJ Case Rep 2021 Aug 19;14(8). Epub 2021 Aug 19.

Sanford Health North, Fargo, North Dakota, USA.

A 51-year-old woman with Crohn's disease presented with a bullous rash on her left arm and axilla 2 days after receiving her second dose of the recombinant adjuvant Shingrix vaccine. PCR for herpes simplex virus (HSV) 1, HSV 2 and varicella zoster virus was negative. Punch biopsy revealed changes that were consistent with a bullous fixed drug eruption. Read More

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Severe and life-threatening COVID-19-related mucocutaneous eruptions: A systematic review.

Int J Clin Pract 2021 Aug 19:e14720. Epub 2021 Aug 19.

Department of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences (IUMS), Tehran, Iran.

Objectives: Earlier diagnosis and the best management of virus-related, drug-related or mixed severe potentially life-threatening mucocutaneous reactions of COVID-19 patients are of great concern. These patients, especially hospitalized cases, are usually in a complicated situation (due to multi-organ failures), which makes their management more challenging. In such consultant cases, achieving by the definite beneficial management strategies that therapeutically address all concurrent comorbidities are really hard to reach or even frequently impossible. Read More

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Clinical background of patients with psoriasiform skin lesions due to tumor necrosis factor antagonist administration at a single center.

J Dermatol 2021 Aug 19. Epub 2021 Aug 19.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

Paradoxical reaction (PR) occurs when a drug elicits a reaction contrary to what was expected. To clarify the clinical features and genetic background of individuals susceptible to PR, we analyzed the clinical course of patients in whom psoriatic eruptions worsened or newly developed during tumor necrosis factor (TNF) antagonist administration and the role of focal infections and genetic variations. Of 125 patients who received TNF antagonist therapy for psoriasis, acrodermatitis continua of Hallopeau (ACH), generalized pustular psoriasis (GPP), or palmoplantar pustular psoriasis (PPP), eight patients with PR were surveyed at our hospital Dermatology Department between 2010 and 2021. Read More

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[Analysis of the clinical features and prognostic influencing factors of toxic epidermal necrolysis].

Zhonghua Shao Shang Za Zhi 2021 Aug;37(8):738-746

Department of Burns and Wound Repair, Guangdong Provincial People's Hospital, Guangzhou 510080, China.

To investigate the clinical features and prognostic influencing factors of toxic epidermal necrolysis (TEN). A retrospective observational study was conducted. From January 2008 to March 2019, a total of 46 TEN patients who met the inclusion criteria were admitted to Guangdong Provincial People's Hospital. Read More

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Successful treatment of corticosteroid-dependent drug reaction with eosinophilia and systemic symptoms with cyclosporine.

Ann Allergy Asthma Immunol 2021 Aug 13. Epub 2021 Aug 13.

Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou and Keelung, Taiwan; College of Medicine, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan; Department of Dermatology, Xiamen Chang Gung Hospital, Fujian, People's Republic of China; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan; Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan; Department of Dermatology, Beijing Tsinghua Chang Gung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People's Republic of China; Department of Dermatology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China; Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan. Electronic address:

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is an intractable drug hypersensitivity disease with high mortality. The current standard treatment requires high-dose and long-term systemic corticosteroids, which may lead to adverse effects and intolerability of patients.

Objective: To evaluate the efficacy and safety of cyclosporine in patients with corticosteroid-dependent DRESS or intolerance to systemic corticosteroids. Read More

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Sulfasalazine-Induced Toxic Epidermal Necrolysis: A Challenging Case During the COVID-19 Pandemic.

Adv Emerg Nurs J 2021 Jul-Sep 01;43(3):194-197

Skin Research Center (Drs Shahidi-Dadras and Dadkhahfar), Men's Health and Reproductive Health Research Center (Dr Fatemi), Department of Radiology (Dr Mahboubi-Fooladi), Department of Internal Medicine, Clinical Research Development Unit of Shohada-e-Tahrish Hospital (Dr Yazdi), Shahid Beheshti University of Medical Sciences, Tehran, Iran; and Faculty of Medicine, Université Laval, Quebec City, Quebec, Canada (Ms Shahrigharahkoshan).

COVID-19 is a major health issue, and patients with underlying conditions are more susceptible to catastrophic outcomes. Toxic epidermal necrolysis (TEN) is a severe systemic disease caused by an immune system hypersensitive reaction. We present a case of TEN induced following sulfasalazine administration that later on complicated with COVID-19, deep vein thrombosis, pulmonary emboli, and eventually death. Read More

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Tylenol or acetaminophen: a recurrent fixed drug eruption perpetuated through the use of inconsistent drug terminology.

BMJ Case Rep 2021 Aug 3;14(8). Epub 2021 Aug 3.

Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA

An 87-year-old man with a history of osteoarthritis presented with worsening knee pain. He was prescribed acetaminophen with codeine. A few days later, he developed a rash on his right buttock and proximal thigh, similar to a rash he experienced in the past when he took over-the-counter (OTC) acetamenophen and an unknown lozenge to treat a presumed viral illness. Read More

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Zoster-associated limb paralysis mimicking acute stroke: a case report.

J Med Case Rep 2021 Jul 30;15(1):380. Epub 2021 Jul 30.

Department of Medicine, University of Peradeniya, Kandy, Sri Lanka.

Background: Varicella zoster virus is a Deoxyribonucleic acid (DNA) virus exclusively affecting humans. Reactivation of varicella zoster virus causes herpes zoster with vesicular eruptions in a restricted dermatomal distribution. Peripheral motor neuropathy is a very rare complication of varicella zoster virus. Read More

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Carbamazepine-associated Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome.

J Pediatr Neurosci 2021 Jan-Mar;16(1):55-57. Epub 2021 Jun 25.

Department of Anaesthesiology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana (Ambala), Haryana, India.

Drug reaction with eosinophilia and systemic symptoms syndrome is a severe type IV (delayed T-cell-dependent reaction) hypersensitivity reaction, characterized by fever, mucocutaneous eruptions, eosinophilia, and systemic inflammatory involvement. It usually begins a few weeks after the exposure to offending drug. Commonly implicated drugs are aromatic anticonvulsants (phenytoin, phenobarbitone, and carbamazepine) and sulfa drugs (sulfonamides, sulfasalazine, and dapsone). Read More

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COVID-19 Vaccine Reactions in Dermatology: "Filling" in the Gaps.

Cutis 2021 06;107(6):288-290

Ms. Rice and Dr. Kourosh are from the Department of Dermatology, Massachusetts General Hospital, Boston. Dr. Kourosh also is from the Department of Dermatology, Harvard Medical School, Boston. Dr. Ferree is from the Department of Medicine, Cambridge Health Alliance, Massachusetts.

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Warfarin-induced Stevens-Johnson syndrome with severe liver injury.

J Int Med Res 2021 Jul;49(7):3000605211033196

Department of Dermatology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a life-threatening mucocutaneous disease that is predominantly drug-induced. Warfarin is the most commonly used drug for long-term anti-coagulant therapy; however, warfarin-induced SJS/TEN is seldom reported. In this study, we presented the case of a 61-year-old man who developed SJS after receiving multiple-drug therapy following aortic valve replacement surgery. Read More

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Two linear progressive blistering eruptions in an immunocompromised patient.

JAAD Case Rep 2021 Aug 19;14:43-45. Epub 2021 Jun 19.

Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.

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Response to: Momen et al's "Discriminating minor and major forms of drug reaction with eosinophilia and systemic symptoms: Facial edema aligns to the severe phenotype".

J Am Acad Dermatol 2021 Jul 21. Epub 2021 Jul 21.

Department of Dermatology, National Skin Centre, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

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