Pharmacol Res 2021 Apr 16:105616. Epub 2021 Apr 16.
Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China; Cancer Center of Zhejiang University, Hangzhou, 310058, China. Electronic address:
Targeted therapy has become increasingly important and indispensable in cancer therapy. Cullin3-RING ligases (CRL3) serve as essential executors for regulating protein homeostasis in cancer development, highlighting that CRL3 might be promising targets in various cancer treatments. However, how to design new targeted therapies by disrupting the function of CRL3 are poorly understood. Read More