277,358 results match your criteria drug delivery

Nano drug delivery system reconstruct tumor vasculature for the tumor vascular normalization.

J Drug Target 2021 May 7:1-46. Epub 2021 May 7.

Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160, Shengli Street, Yinchuan, 750004, China.

The specific tumor microenvironment plays a crucial role in the occurrence and development of tumors. Among them, the abnormal structure and function of blood vessels in the tumor microenvironment are obvious characteristics of the tumor. Abnormal blood vessels with high leakage can lead to impaired blood perfusion and non-specific leakage of blood components into the surrounding interstitial spaces. Read More

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Facile synthesis of PEI-based crystalline templated mesoporous silica with molecular chirality for improved oral delivery of the poorly water-soluble drug.

Drug Deliv 2021 Dec;28(1):894-905

School of Pharmacy, China Medical University, Shenyang, China.

The aim of this study was to build up a novel chiral mesoporous silica called PEIs@TA-CMS through a facile biomimetic strategy and to explore its potential to serve as a drug carrier for improving the delivery efficiency of poorly water-soluble drug. PEIs@TA-CMS was synthesized by using a chiral crystalline complex associated of tartaric acid and polyethyleneimine (PEIs) as templates, scaffolds and catalysts. The structural features including morphology, size, pore structure and texture properties were systematacially studied. Read More

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December 2021

Optimization, and and evaluation of etomidate intravenous lipid emulsion.

Drug Deliv 2021 Dec;28(1):873-883

School of Pharmacy, North China University of Science and Technology, Tangshan, China.

The aim of this investigation was to develop an etomidate intravenous lipid emulsion (ETM-ILE) and evaluate its properties and . Etomidate (ETM) is a hydrophobic drug, and organic solvents must be added to an etomidate injectable solution (ETM-SOL) to aid dissolution, that causes various adverse reactions on injection. Lipid emulsions are a novel drug formulation that can improve drug loading and reduce adverse reactions. Read More

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December 2021

The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats.

Drug Deliv 2021 Dec;28(1):865-872

Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, School of Pharmacy, Nano Medical Technology Research Institute, Fujian Medical University, Fuzhou, China.

The calcitonin gene-related peptide (CGRP) has been demonstrated relating to vascular and inflammatory regulations not only the nerve systems. As the anti-inflammation factor and the most potent vasodilator, the CGRP holds therapeutic potentials for the treatment of cardiovascular diseases which was, however, limited by its peptide nature and short half-life. With advantages in improving the stability, circulation time and protection from degradation, the nanoparticles were promising as delivery carriers for the peptide. Read More

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December 2021

Enhancing the and activity of itraconazole against breast cancer using miltefosine-modified lipid nanocapsules.

Drug Deliv 2021 Dec;28(1):906-919

Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Itraconazole (ITC), a well-tolerated antifungal drug, exerts multiple anticancer effects which justified its preclinical and clinical investigation as potential anti-cancer agent with reduced side effects. Enhancement of ITC anti-cancer efficacy would bring valuable benefits to patients. We propose herein lipid nanocapsules (LNCs) modified with a subtherapeutic dose of miltefosine (MFS) as a membrane bioactive amphiphilic additive (M-ITC-LNC) for the development of an ITC nanoformulation with enhanced anticancer activity compared with ITC solution (ITC-sol) and unmodified ITC-LNC. Read More

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December 2021

Biodegradability of Micro/Nanomotors: Challenges and Opportunities.

Adv Healthc Mater 2021 May 6:e2100335. Epub 2021 May 6.

School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, 510515, China.

Micro/nanomotors (MNMs) are miniature machines that can convert chemical or external energy into their own mechanical motions. In previous decades, significant efforts have been made to improve the performance of MNMs. For practical applications, the biodegradability of MNMs is an important aspect that must be considered, particularly in the biomedical field. Read More

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The comprehensive landscape of miR-34a in cancer research.

Cancer Metastasis Rev 2021 May 6. Epub 2021 May 6.

New Drug Screening Center, China Pharmaceutical University, Nanjing, 210009, China.

MicroRNA-34 (miR-34) plays central roles in human diseases, especially cancers. Inactivation of miR-34 is detected in cancer cell lines and tumor tissues versus normal controls, implying its potential tumor-suppressive effect. Clinically, miR-34 has been identified as promising prognostic indicators for various cancers. Read More

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A GLUT1 inhibitor-based probe significantly ameliorates the sensitivity of tumor detection and diagnostic imaging.

Chem Commun (Camb) 2021 May 7. Epub 2021 May 7.

Institute of Molecular Plus, Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Rd, Nankai, Tianjin 300072, P. R. China.

We report a non-antibody GLUT1 inhibitor probe NBDQ that is 30 times more sensitive than the traditional GLUT1 transportable tracer for cancer cell imaging and Warburg effect-based tumor detection. NBDQ reveals significant advantages in terms of tumor selectivity, fluorescence stability and in vivo biocompatibility in xenograft tumor imaging, including triple-negative breast cancer. Read More

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Aerosol drug delivery to tracheotomized patients with COVID-19: Pragmatic suggestions for clinicians.

Can J Respir Ther 2021 30;57:49-52. Epub 2021 Apr 30.

Department of Respiratory Care, Texas State University, College of Health Professions, Round Rock, TX, USA.

Because of the wide and rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the number of hospitalized patients with coronavirus disease 2019 (COVID-19) has rapidly increased medically complex and resource-intensive treatment requirements in health care settings. Although tracheostomy is frequently needed for critically ill patients requiring extended mechanical ventilation, it has been described as an aerosol-generating procedure that puts health care professionals at an increased risk of viral transmission. In addition, the delivery of aerosolized medications to this patient population has become controversial because of concerns on the transmission of SARS-CoV-2 via droplets. Read More

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Enhanced siRNA Delivery and Selective Apoptosis Induction in H1299 Cancer Cells by Layer-by-Layer-Assembled Se Nanocomplexes: Toward More Efficient Cancer Therapy.

Front Mol Biosci 2021 20;8:639184. Epub 2021 Apr 20.

Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmacy, Ghent University, Ghent, Belgium.

Nanotechnology has made an important contribution to oncology in recent years, especially for drug delivery. While many different nano-delivery systems have been suggested for cancer therapy, selenium nanoparticles (SeNPs) are particularly promising anticancer drug carriers as their core material offers interesting synergistic effects to cancer cells. Se compounds can exert cytotoxic effects by acting as pro-oxidants that alter cellular redox homeostasis, eventually leading to apoptosis induction in many kinds of cancer cells. Read More

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Editorial: Advanced Silica Nanomaterials for Drug Delivery.

Front Chem 2021 20;9:677647. Epub 2021 Apr 20.

School of Chemistry, Xi'an Jiaotong University, Xi'an, China.

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Microbial Fabricated Nanosystems: Applications in Drug Delivery and Targeting.

Front Chem 2021 20;9:617353. Epub 2021 Apr 20.

Department of Biochemistry and Biotechnology, Sardar Bhagwan Singh University, Dehradun, India.

The emergence of nanosystems for different biomedical and drug delivery applications has drawn the attention of researchers worldwide. The likeness of microorganisms including bacteria, yeast, algae, fungi, and even viruses toward metals is well-known. Higher tolerance to toxic metals has opened up new avenues of designing microbial fabricated nanomaterials. Read More

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Investigation of EDTA concentration on the size of carbonated flowerlike hydroxyapatite microspheres.

R Soc Open Sci 2021 Mar 10;8(3):202148. Epub 2021 Mar 10.

School of Transportation and Civil Engineering, Shandong Jiaotong University, Ji'nan 250357, People's Republic of China.

Ethylenediamine tetraacetic acid (EDTA) is considered an effective crystal growth modifier for template-assisted hydrothermal synthesis of hydroxyapatite (HA) materials. In this work, flowerlike-carbonated HA (CHA) microspheres were synthesized using EDTA via a one-step hydrothermal route. The phase, functional groups, morphology and particle size distribution of the products were examined by X-ray diffraction, Fourier transform infrared spectrometer, field emission scanning electron microscopy as well as laser diffraction particle size analysis. Read More

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Development of paclitaxel-loaded poly(lactic acid)/hydroxyapatite core-shell nanoparticles as a stimuli-responsive drug delivery system.

R Soc Open Sci 2021 Mar 24;8(3):202030. Epub 2021 Mar 24.

National Institute of Advanced Industrial Science and Technology (AIST), 2266-98 Anagahora, Shimoshidami, Moriyama-ku, Nagoya 463-8560, Japan.

Biodegradable nanoparticles have been well studied as biocompatible delivery systems. Nanoparticles of less than 200 nm in size can facilitate the passive targeting of drugs to tumour tissues and their accumulation therein via the enhanced permeability and retention (EPR) effect. Recent studies have focused on stimuli-responsive drug delivery systems (DDS) for improving the effectiveness of chemotherapy; for example, pH-sensitive DDS depend on the weakly acidic and neutral extracellular pH of tumour and normal tissues, respectively. Read More

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Multicomponent crystalline solid forms of aripiprazole produced via hot melt extrusion techniques: An exploratory study.

J Drug Deliv Sci Technol 2021 Jun 20;63. Epub 2021 Apr 20.

Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.

Multicomponent crystalline solid forms (salts, cocrystals and eutectics) are a promising means of enhancing the dissolution behavior of poorly soluble drugs. The present study demonstrates the development of multicomponent solid forms of aripiprazole (ARP) prepared with succinic acid (SA) and nicotinamide (NA) as coformers using the hot melt extrusion (HME) technique. The HME-processed samples were characterized and analyzed using differential scanning calorimetry (DSC), hot stage microscopy (HSM), Fourier transform infrared (FTIR) spectroscopy, powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM). Read More

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Berberine-Loaded Carboxylmethyl Chitosan Nanoparticles Ameliorate DSS-Induced Colitis and Remodel Gut Microbiota in Mice.

Front Pharmacol 2021 20;12:644387. Epub 2021 Apr 20.

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China.

Inflammatory bowel disease (IBD) is a refractory disorder characterized by chronic and recurrent inflammation. The progression and pathogenesis of IBD is closely related to oxidative stress and irregularly high concentrations of reactive oxygen species (ROS). A new oxidation-responsive nano prodrug was constructed from a phenylboronic esters-modified carboxylmethyl chitosan (OC-B) conjugated with berberine (BBR) that degrades selectively in response to ROS. Read More

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Electrospray Mediated Localized and Targeted Chemotherapy in a Mouse Model of Lung Cancer.

Front Pharmacol 2021 20;12:643492. Epub 2021 Apr 20.

Department of Pulmonary Medicine, University Hospital Bern, Bern, Switzerland.

An advanced stage, centrally localized invasive tumor is a major cause of sudden death in lung cancer patients. Currently, chemotherapy, radiotherapy, laser ablation, or surgical resection if possible are the available state-of-the-art treatments but none of these guarantee remedy or long-term relief and are often associated with fatal complications. Allowing localized chemotherapy, by direct and confined drug delivery only at the tumor site, could be a promising option for preoperative down staging or palliative therapy. Read More

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Inspiratory Flow Parameters Through Dry Powder Inhalers in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease (COPD): Device Resistance Does Not Limit Use in COPD.

Int J Chron Obstruct Pulmon Dis 2021 30;16:1193-1201. Epub 2021 Apr 30.

Biostatistics and Data Analytics, Orion Corporation, Espoo, Finland.

Introduction: Achieving correct inhalation technique through an inhaler to ensure effective drug delivery is key to managing symptoms in patients with chronic obstructive pulmonary disease (COPD). However, many patients struggle to use their inhalers correctly, with the resultant reduction in therapeutic benefit. Consequently, appropriate inhaler choice is important to maximize clinical benefit. Read More

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Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer.

Nat Nanotechnol 2021 May 6. Epub 2021 May 6.

Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.

Nanoparticulate albumin bound paclitaxel (nab-paclitaxel, nab-PTX) is among the most widely prescribed nanomedicines in clinical use, yet it remains unclear how nanoformulation affects nab-PTX behaviour in the tumour microenvironment. Here, we quantified the biodistribution of the albumin carrier and its chemotherapeutic payload in optically cleared tumours of genetically engineered mouse models, and compared the behaviour of nab-PTX with other clinically relevant nanoparticles. We found that nab-PTX uptake is profoundly and distinctly affected by cancer-cell autonomous RAS signalling, and RAS/RAF/MEK/ERK inhibition blocked its selective delivery and efficacy. Read More

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Overcoming physiological barriers by nanoparticles for intravenous drug delivery to the lymph nodes.

Exp Biol Med (Maywood) 2021 May 6:15353702211010762. Epub 2021 May 6.

Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.

The lymph nodes are major sites of cancer metastasis and immune activity, and thus represent important clinical targets. Although not as well-studied compared to subcutaneous administration, intravenous drug delivery is advantageous for lymph node delivery as it is commonly practiced in the clinic and has the potential to deliver therapeutics systemically to all lymph nodes. However, rapid clearance by the mononuclear phagocyte system, tight junctions of the blood vascular endothelium, and the collagenous matrix of the interstitium can limit the efficiency of lymph node drug delivery, which has prompted research into the design of nanoparticle-based drug delivery systems. Read More

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Optical Coherence Tomography and Microdialysis for Microneedle-Mediated Penetration Enhancement Study of Paeoniflorin-Loaded Ethosomes.

Skin Pharmacol Physiol 2021 May 6:1-11. Epub 2021 May 6.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

Background: To understand the cumulative effect of topical formulations after medication, evaluate the therapeutic effect of microneedle-assisted (MN-assisted) paeoniflorin-loaded ethosomes (TGP-E), and explore the potential for deep penetration of drugs, this paper uses microdialysis to systematically study the percutaneous pharmacokinetics of TGP-E.

Methods: First, optical coherence tomography (OCT) was used to study the effectiveness of microneedle puncture. Second, a microdialysis method and a UPLC-MS method for determining the amount of paeoniflorin (Pae) in dialysate were established. Read More

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Polychlorinated biphenyls (PCBs) in the colostrum samples from the Yangtze River Region: Exposure profile and risk assessment.

Environ Pollut 2021 Apr 29;285:117253. Epub 2021 Apr 29.

Interdisciplinary Research Academy (IRA), Zhejiang Shuren University, Hangzhou, 310015, China.

Polychlorinated biphenyls (PCBs) may transfer into the neonates through the placental transfer and via breastfeeding after the delivery, thus might be harmful to the infant. Sixty colostrum samples in the Yangtze River Region were collected to investigate the concentration, distribution pattern, and enantiomer characteristic of the PCB exposure. Among all samples, over 90% of pollutants were tetra-to hepta-chlorinated PCBs. Read More

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Modulating surface charge of dexamethasone non-spherical microcrystals for improved inner ear delivery.

Colloids Surf B Biointerfaces 2021 Apr 29;204:111806. Epub 2021 Apr 29.

Biomedical Barriers Research Center, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Biomedical Materials, Tianjin, 300192, China. Electronic address:

It is important to achieve precise surface charge manipulation of non-spherical drug microcrystals using facile and time-efficient methods for local drug delivery. In this study, silk-coated dexamethasone (DEX) non-spherical microcrystals were synthesized by precipitation technique followed by alternate deposition of poly(allylamine hydrochloride) (PAH) (or PAH-coated FeO) and silk fibroin (SF) via layer-by-layer assembly. EDC and glutaraldehyde were employed to manipulate positive or negative charge of particles by simple chemical cross-linking reactions, respectively. Read More

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pH-tunable nanoparticles composed of copolymers of lactide and allyl-glycidyl ether with various functionalities for the efficient delivery of anti-cancer drugs.

Colloids Surf B Biointerfaces 2021 Apr 29;204:111801. Epub 2021 Apr 29.

Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363, Łódź, Poland. Electronic address:

The designing of biocompatible nanocarriers for the efficient delivery of their cargos to the desired targets remains a challenge. In this regard, the most promising strategy relies on the construction of pH- or thermo-responsive nanoparticles (NPs). However, it is also important to preserve the balance between the responsiveness of the carrier and their stability in physiological conditions. Read More

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DPD simulations and experimental study on reduction-sensitive polymeric micelles self-assembled from PCL-SS-PPEGMA for doxorubicin controlled release.

Colloids Surf B Biointerfaces 2021 Apr 28;204:111797. Epub 2021 Apr 28.

School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006, PR China. Electronic address:

Delivery of anticancer drugs by amphiphilic polymeric micelles with disulfide bonds as the reduction-responsive groups has potential application in the field of drug-controlled release. In this study, three disulfide-linked polycaprolactone-b-polyethylene glycol methyl ether methacrylate (PCL-SS-PPEGMA) were synthesized and confirmed by H NMR and GPC, and then used for doxorubicin (DOX) delivery. The CMC values of the three PCL-SS-PPEGMA micelles were low (0. Read More

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Ceiba pentandra cellulose crosslinked with citric acid for drug release systems.

Carbohydr Res 2021 Apr 28;504:108334. Epub 2021 Apr 28.

Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Calle 43 No. 130 X 32 y 34, Chuburná de Hidalgo, CP 97205, Merida, Yucatán, Mexico. Electronic address:

An alternative for the production of drug delivery system is proposed based on the Ceiba pentandra milkweed. The kapok cellulose was chemically crosslinked with citric acid (CA) at different CA proportions, and loaded with chlorhexidine diacetate (CHX) at different concentrations. Cellulose crosslinking was followed with FTIR and XPS analysis, and the CHX loading was determined using elemental analysis. Read More

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Promotion of the anticancer activity of curcumin based on a metal-polyphenol networks delivery system.

Int J Pharm 2021 May 3:120650. Epub 2021 May 3.

College of Food Science, Southwest University, Chongqing, 400715, People's Republic of China; Research Center of Food Storage & Logistics, Southwest University, Chongqing 400715, People's Republic of China. Electronic address:

Curcumin (Cur), a hydrophobic active pharmaceutical ingredient with high anticancer activity, has poor water solubility and low bioavailability. Although many delivery systems have been developed to improve their bioavailability, some limitation such as low drug loading efficiency and poor stability are still remained. The metal-polyphenol networks (MPNs) delivery system designed in this subject solved above problems and effectively improved the anticancer activity of Cur. Read More

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The Cell-impermeable Ru(II) Polypyridyl Complex as a Potent Intracellular Photosensitizer under Visible Light Irradiation via Ion-Pairing with Suitable Lipophilic Counter-Anions.

Free Radic Biol Med 2021 May 3. Epub 2021 May 3.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, And University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, 100085, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China; Joint Institute for Environmental Science, Research Center for Eco-Environmental Sciences and Hong Kong Baptist University, Hong Kong PR China. Electronic address:

Developing the cell-impermeable Ru(II) polypyridyl cationic complexes as effective photosensitizers (PS) which have high cellular uptake and photo-toxicity, but low dark toxicity, is quite challenging. Here we found that the highly reactive singlet oxygen (O) can be generated by the irradiation of a typical Ru(II) polypyridyl complex Ru(II)tris(tetramethylphenanthroline) ([Ru(TMP)]) under visible light irradiation by ESR with TEMPO (2,2,6,6-tetramethyl-4-piperidone-N-oxyl) as O probe. Effective cellular and nuclear delivery of cationic [Ru(TMP)] was achieved through our recently developed ion-pairing method, and 2,3,4,5-tetrachlorophenol (2,3,4,5-TeCP) was found to be the most effective among all chlorophenols tested. Read More

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Preparation and in-vitro evaluation of mesoporous biogenic silica nanoparticles obtained from rice and wheat husk as a biocompatible carrier for anti-cancer drug delivery.

Eur J Pharm Sci 2021 May 3:105866. Epub 2021 May 3.

Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.

In this study, mesoporous silica nanocarriers were synthesized from natural sources such as rice and wheat husk for drug delivery application. First, the biogenic silica in cereals husk was extracted by acid leaching and then converted to sodium silicate as a silica precursor. Mesoporous silica nanoparticles were then synthesized by adding sodium silicate to the template mixture by continuous and discrete modes during the sol-gel process. Read More

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Anti-inflammatory Effects of Three Withanolides Isolated from Physalis angulata L. in LPS-activated RAW 264.7 Cells through Blocking NF-κB Signaling Pathway.

J Ethnopharmacol 2021 May 3:114186. Epub 2021 May 3.

Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, School of Pharmacy, Yantai University, Yantai, 264005, PR China. Electronic address:

Ethnopharmacological Relevance: Physalis angulata L. is commonly used in many countries as popular medicine for the treatment of a variety of diseases such as malaria, hepatitis, dermatitis and rheumatism. But the anti-inflammatory active constituents of this medicinal plant and their molecular mechanism are still not elucidated clearly. Read More

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