523 results match your criteria doxylamine


Cardiac arrest following unsuspected self-poisoning with doxylamine.

Ther Drug Monit 2022 Jan 11. Epub 2022 Jan 11.

Clinical Toxicology Unit, Clinical Analysis Department. Hospital Universitari Son Llàtzer. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Intensive Care Department. Hospital Universitari Son Llàtzer. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Intensive Care Department. Hospital Universitari Son Llàtzer. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Intensive Care Department. Hospital Universitari Son Llàtzer. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Cardiology Department. Hospital Universitari Son Llàtzer. Department of Medicine, Faculty of Medicine, University of the Balearic Islands. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Institute of Legal Medicine of the Balearic Islands. Ministry of Justice. Department of Medicine, Faculty of Medicine, University of the Balearic Islands. Palma de Mallorca, Spain. Institute of Legal Medicine of the Balearic Islands. Ministry of Justice. Department of Medicine, Faculty of Medicine, University of the Balearic Islands. Palma de Mallorca, Spain.

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January 2022

Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study.

Biol Psychiatry 2021 Oct 6. Epub 2021 Oct 6.

Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut; Department of Social and Behavioral Sciences, Yale School of Public Health, New Haven, Connecticut; Clinical Neurosciences Division, National Center for PTSD, West Haven, Connecticut.

Background: Posttraumatic stress disorder (PTSD) develops consequent to complex gene-by-environment interactions beyond the precipitating trauma. To date, however, no known study has used a prospective design to examine how polygenic risk scores (PRSs) interact with social-environmental factors such as attachment style to predict PTSD development.

Methods: PRSs were derived from a genome-wide association study of PTSD symptoms (N = 186,689; Million Veteran Program cohort). Read More

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October 2021

Ocular Flutter in Acute Doxylamine Intoxication.

Neurol Clin Pract 2021 Oct;11(5):e740-e741

Department of Neurology (DZL, ZRW, KJL), Department of Ophthalmology (ZRW), Department of Neurosurgery (ZRW), and Department of Emergency Medicine (NN), University of Rochester Medical Center; Upstate Poison Center, Syracuse; and Motor Physiology and Neuromodulation Program (KJL), Division of Movement Disorders, and Center for Health + Technology (CHeT), Department of Neurology, University of Rochester Medical Center, Rochester, NY.

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October 2021

Harnessing of Doxylamine Succinate/Pyridoxine Hydrochloride-Dual Laden Bilosomes as a Novel Combinatorial Nanoparadigm for Intranasal Delivery: In Vitro Optimization and In Vivo Pharmacokinetic Appraisal.

J Pharm Sci 2021 Nov 20. Epub 2021 Nov 20.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt. Electronic address:

The present work is concerned with tailoring and appraisal of a novel nano-cargo; bilosomes (BLS) dual laded with doxylamine succinate (DAS) and pyridoxine hydrochloride (PDH), the first treatment option against gestational nausea and vomiting, for intranasal delivery. This bifunctional horizon could surmount constraints of orally-commercialized platforms both in dosage regimen and pharmacokinetic profile. For accomplishing this purpose, DAS/PDH-BLS were elaborated integrating phospholipid, sodium cholate and cholesterol applying thin-film hydration method based on Box-Behnken design. Read More

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November 2021

[Nausea and vomiting in pregnancy: A place for ondansetron?]

Authors:
B Coulm

Gynecol Obstet Fertil Senol 2021 Dec 23;49(12):947-950. Epub 2021 Oct 23.

DMU ESPRIT (épidémiologie et biostatistique, santé publique, pharmacie, pharmacologie, recherche, information médicale, thérapeutique et médicaments), centre de référence sur les agents tératogènes (CRAT), GHU, Sorbonne université, AP-HP, site Trousseau, 26, avenue Docteur-Netter, 75571 Paris cedex 12, France. Electronic address:

Although there is no recommendation in France relating to the treatment of nausea and vomiting of pregnancy, there are some in other countries, where ondansetron, widely used, appears to be an effective second-line treatment option behind doxylamine/vitamin B6 association and metoclopramide. However, based on some recent publication suggesting an increased risk of orofacial clefts and congenital heart defects in fetuses exposed in utero to ondansetron in the 1st trimester of pregnancy, the European Medicines Agency now states that this drug should not longer be used during this period. This 2019 decision is controversial and whether ondansetron can be used in pregnant women with severe vomiting during pregnancy is still in question. Read More

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December 2021

Pediatric Fatalities Associated With Over-the-Counter Cough and Cold Medications.

Pediatrics 2021 11 4;148(5). Epub 2021 Oct 4.

Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, Denver, Colorado.

Background And Objectives: In 2008, over-the-counter cough and cold medications (CCMs) underwent labeling changes in response to safety concerns, including fatalities, reported in children exposed to CCMs. The objective of this study is to describe fatalities associated with exposures to CCMs in children <12 years old that were detected by a safety surveillance system from 2008 to 2016.

Methods: Fatalities in children <12 years old that occurred between 2008 and 2016 associated with oral exposure to one or more CCMs were identified by the Pediatric Cough and Cold Safety Surveillance System. Read More

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November 2021

Comprehensive analysis of lncRNA-miRNA-mRNA regulatory networks for microbiota-mediated colorectal cancer associated with immune cell infiltration.

Bioengineered 2021 12;12(1):3410-3425

Hunan Key Laboratory of Precise Diagnosis and Treatment of Gastrointestinal Tumor, Xiangya Hospital Central South University, Changsha, Hunan Province, China.

Recent findings have identified microbiota as crucial participants in many disease conditions, including cancers. Competing endogenous RNA (ceRNA) is regarded as a candidate mechanism involving relevant biological processes. We therefore constructed a ceRNA network using the TCGA and GEO database, to determine the potential mechanisms of microbiota-mediated colorectal carcinogenesis and progression. Read More

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December 2021

Prescription medications for use in pregnancy-perspective from the US Food and Drug Administration.

Am J Obstet Gynecol 2021 07;225(1):21-32

Division of Urology, Obstetrics & Gynecology, US Food and Drug Administration, Silver Spring, MD.

Obstetrical healthcare providers frequently field questions about the safety of medications recommended or prescribed to their pregnant patients. Most women use as least 1 medication during pregnancy; however, there is little information about the safety or appropriate dosing of many medications during this phase of life. In addition, the development of drugs for use in pregnant women trails behind the development of drugs intended for other sectors of the population. Read More

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Insights on the role of periphytic biofilm in synergism with Iris pseudacorus for removing mixture of pharmaceutical contaminants from wastewater.

J Hazard Mater 2021 09 8;418:126349. Epub 2021 Jun 8.

Department of Earth Resources and Environmental Engineering, Hanyang University, Seoul 04763, Republic of Korea. Electronic address:

The potential of Iris pseudacorus and the associated periphytic biofilm for biodegradation of two common pharmaceutical contaminants (PCs) in urban wastewater was assessed individually and in consortium. An enhanced removal for sulfamethoxazole (SMX) was achieved in consortium (59%) compared to individual sets of I. pseudacorus (50%) and periphytic biofilm (7%) at concentration of 5 mg L. Read More

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September 2021

Pregnant women report being denied medications to treat severe nausea and vomiting of pregnancy or hyperemesis gravidarum - findings from an Australian online survey.

Aust N Z J Obstet Gynaecol 2021 08 13;61(4):616-620. Epub 2021 May 13.

SA Pharmacy, Flinders Medical Centre, SA Health, Adelaide, South Australia, Australia.

We conducted an online survey of 249 Australian women who currently or previously experienced severe nausea and vomiting of pregnancy (NVP) or hyperemesis gravidarum (HG) and examined their experiences in being denied medications during pregnancy. One in four women reported being denied medications for NVP/HG, which most commonly involved doxylamine and encounters with community pharmacists. Women's experiences reflected that lack of awareness of guidelines and unfavourable risk-benefit assessments appeared to be key barriers to facilitating medication access. Read More

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Confusion about doxylamine safety in pregnancy.

Med J Aust 2021 04 24;214(6):286-286.e1. Epub 2021 Feb 24.

Melbourne, VIC.

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Evaluation of Medicine Exposure During Pregnancy at a Tertiary Center of an Indian State.

Maedica (Bucur) 2020 Dec;15(4):503-512

Department of Pharmacology, AIIMS, Deoghar, India.

Prescribing drugs in pregnancy is a challenging approach for doctors. To evaluate drugs used in pregnancy. A prospective, cross-sectional, descriptive study was carried out by collecting and evaluating prescriptions on various parameters. Read More

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December 2020

Biodegradation of Doxylamine From Wastewater by a Green Microalga, .

Front Microbiol 2020 3;11:584020. Epub 2020 Nov 3.

College of Marine Life Sciences, Ocean University of China, Qingdao, China.

Pharmaceutical contaminants (PCs) have been recognized as emerging contaminants causing unexpected consequences to environment and humans. There is an urgent need for development of efficient technologies to treat these PCs from water. The current study has investigated the removal capacity of a green microalgal species, , for doxylamine, chemical oxygen demand (COD), and nutrients from real wastewater. Read More

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November 2020

In vitro analytical dissolution profiling of antiemetic delayed release tablets in two different dissolution media: Validated spectrophotometric methods versus reported HPLC.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Feb 30;246:119013. Epub 2020 Sep 30.

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt.

The combination of pyridoxine HCl (PYR) and doxylamine succinate (DOX) was proved to be effective and safe acting as the first line of pregnancy medication for vomiting and nausea under a trade name; Vomibreak® delayed release tablets. This combination has been available in the Egyptian market since 2016. Dissolution study is a meaningful tool that represents a predictor of output because the rate controlling steps in any drug's absorption is the rate of discharging from its medicinal formulation. Read More

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February 2021

Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy.

Pharmacol Res 2021 01 5;163:105229. Epub 2020 Oct 5.

National Centre of Healthcare Research and Pharmacoepidemiology, University of Milano-Bicocca, Milan, Italy; Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy.

Objectives: Because observational studies often use imperfect measurements, results are prone to misclassification errors. We used as a motivating example the possible teratogenic risks of antiemetic agents in pregnancy since a large observational study recently showed that first-trimester exposure to doxylamine-pyridoxine was associated with significantly increased risk of congenital malformations as a whole, as well as central nervous system defects, and previous observational studies did not show such associations. A meta-analysis on this issue was carried out with the aim to illustrate how differential exposure and outcome misclassifications may lead to uncertain conclusions. Read More

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January 2021

Transition-Metal Free Chemoselective Hydroxylation and Hydroxylation-Deuteration of Heterobenzylic Methylenes.

Org Lett 2020 10 7;22(20):8127-8131. Epub 2020 Oct 7.

State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, and School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

We developed an approach for direct selective hydroxylation of heterobenzylic methylenes to secondary alcohols avoiding overoxidation to ketones by using a KOBu-t/DMSO/air system. Most reactions could reach completion in several minutes to give hydroxylated products in 41-76% yields. Using DMSO-, this protocol resulted in difunctionalization of heterobenzylic methylenes to afford α-deuterated secondary alcohols (>93% incorporation). Read More

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October 2020

[Interest of vitamin b6 for treatment of nausea and/or vomiting during pregnancy].

Authors:
C Pecriaux

Gynecol Obstet Fertil Senol 2020 11 19;48(11):840-843. Epub 2020 Sep 19.

Centre de référence sur les agents tératogènes (CRAT), DMU ESPRIT (Épidémiologie et biostatistique, santé publique, pharmacie, pharmacologie, recherche, information médicale, thérapeutique et médicaments), GHU AP-HP Sorbonne université, Site Trousseau 26 avenue Dr Netter, 75571 Paris cedex 12, France. Electronic address:

In France there is no official recommendation for the drug management of nausea and vomiting during pregnancy. In the USA, Canada and Australia, vitamin B6 is officially recommended in the treatment of mild to moderate pregnancy sickness and vomiting. Indeed, some studies have shown some effectiveness of oral vitamin B6, most often in combination with doxylamine, in comparison with a placebo. Read More

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November 2020

Genome-wide RNA-sequencing dataset reveals the prognostic value and potential molecular mechanisms of lncRNA in non-homologous end joining pathway 1 in early stage Pancreatic Ductal Adenocarcinoma.

J Cancer 2020 20;11(19):5556-5567. Epub 2020 Jul 20.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People's Republic of China.

Our current study is to explore the prognostic value and molecular mechanisms underlying the role of lncRNA in non-homologous end joining pathway 1 (LINP1) in early stage pancreatic ductal adenocarcinoma (PDAC). Genome-wide RNA-seq datasets of 112 early stage PDAC patients were got from The Cancer Genome Atlas and analyzed using multiple online tools. Overall survival in high LINP1 expression patients was shorter than those with low expression (high-LINP1 vs. Read More

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Protection Versus Progress: The Challenge of Research on Cannabis Use During Pregnancy.

Pediatrics 2020 08;146(Suppl 1):S93-S98

Seattle Children's Hospital, Treuman Katz Center for Pediatric Bioethics, Seattle, Washington; and.

A central tension in pediatric research ethics arises from our desire to protect children from harm while also allowing progress toward discoveries that could improve child health. A prime example of this tension is research on a controversial yet increasingly common practice: the use of cannabis by women to treat nausea and vomiting of pregnancy. Studies of cannabis use in pregnancy face a combination of ethical hurdles because of the inclusion of pregnant women and involvement of a schedule I controlled substance. Read More

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Assessment of Pharmacologic Ingredients in Common Over-the-Counter Sinonasal Medications.

Authors:
Edward D McCoul

JAMA Otolaryngol Head Neck Surg 2020 09;146(9):810-815

Department of Otorhinolaryngology, Ochsner Clinic Foundation, New Orleans, Louisiana.

Importance: Sinonasal remedies are the most frequently purchased category of over-the-counter (OTC) drugs in the United States. A variety of options for relief are available under proprietary names, although the actual number of available options may not be readily appreciated by the consumer or the clinician.

Objective: To determine the prevalence of specific ingredients in OTC sinonasal products. Read More

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September 2020

Unravelling metabolism and microbial community of a phytobed co-planted with Typha angustifolia and Ipomoea aquatica for biodegradation of doxylamine from wastewater.

J Hazard Mater 2021 01 6;401:123404. Epub 2020 Jul 6.

Department of Earth Resources and Environmental Engineering, Hanyang University, Seoul, 04763, South Korea. Electronic address:

Pharmaceutical contaminants in environment induce unexpected effects on ecological systems and human; thus, development of efficient technologies for their removal is immensely necessary. In this study, biodegradation and metabolic fate of a frequently found pharmaceutical contaminant, doxylamine by Typha angustifolia and Ipomoea aquatica was investigated. Microbial community of the plant rhizosphere has been identified to understand the important roles of the functional microbes. Read More

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January 2021

Trends in first-trimester nausea and vomiting of pregnancy and use of select treatments: Findings from the National Birth Defects Prevention Study.

Paediatr Perinat Epidemiol 2021 01 4;35(1):57-64. Epub 2020 Jul 4.

Slone Epidemiology Center, Boston University, Boston, MA, USA.

Background: Although nausea and vomiting of pregnancy (NVP) is common, the secular and demographic trends of NVP and its treatments are not well-studied.

Objectives: To describe the prevalence and patterns of first-trimester NVP and selected treatments among controls in the National Birth Defects Prevention Study (NBDPS).

Methods: National Birth Defects Prevention Study is a population-based case-control study of birth defects in the United States (1997-2011). Read More

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January 2021

Spectral resolution of quaternary components in a sinus and congestion mixture; Multivariate algorithms to approach extremes of concentration levels.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Oct 16;239:118489. Epub 2020 May 16.

Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, El-Kasr El-Aini Street, 11562 Cairo, Egypt.

Sinus and congestion mixture of three drugs and an impurity was studied for their spectral resolution using four multivariate algorithms. The studied drugs present in extremes of low and high concentrations. Low concentration levels of phenylephrine HCl and doxylamine succinate with high concentration of paracetamol along with its official impurity was a challenging mixture for pharmaceutical analysis. Read More

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October 2020

The CD45dim/CD123bright/HLADRneg BAT in the Anti-histamine Drug Allergy.

Iran J Allergy Asthma Immunol 2020 Apr 16;19(2):203-205. Epub 2020 Apr 16.

Council for Nutritional and Environmental Science (CONEM), Mo i Rana, Norway.

No Abstract. Read More

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Magnetic Solid-Phase Extraction of Drugs and Pesticides from Human Plasma Using COOH-mMWCNTs.

J Anal Toxicol 2021 Jan;44(9):968-975

Graduate School of Analytical Science and Technology, Chungnam National University, 99-Daehak-ro, Yuseongk-gu, Daejeon 305-764, Korea.

Carbon nanotubes (CNTs) are useful for extracting chemical compounds due to their properties, such as surface area and the potential for chemical modification. Especially the formation of CNTs with carboxylic acid functional group makes them disperse in water-based samples and have strong interaction forces with cationizable analytes. Based on these features, carboxylic acid functionalized multi-walled CNTs (COOH-MWCNTs) have been used as extraction sorbents. Read More

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January 2021

Using recreational cannabis to treat insomnia: Evidence from over-the-counter sleep aid sales in Colorado.

Complement Ther Med 2019 Dec 12;47:102207. Epub 2019 Oct 12.

University of New Mexico, Department of Psychology, United States. Electronic address:

This study seeks to understand whether people substitute between recreational cannabis and conventional over-the-counter (OTC) sleep medications. UPC-level grocery store scanner data in a multivariable panel regression design were used to compare the change in the monthly market share of sleep aids with varying dispensary-based recreational cannabis access (existence, sales, and count) in Colorado counties between 12/2013 and 12/2014. We measured annually-differenced market shares for sleep aids as a portion of the overall OTC medication market, thus accounting for store-level demand shifts in OTC medication markets and seasonality, and used the monthly changes in stores' sleep aid market share to control for short-term trends. Read More

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December 2019

Nausea and vomiting of pregnancy and hyperemesis gravidarum.

Nat Rev Dis Primers 2019 09 12;5(1):62. Epub 2019 Sep 12.

Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Nausea and vomiting of pregnancy (NVP) is a common condition that affects as many as 70% of pregnant women. Although no consensus definition is available for hyperemesis gravidarum (HG), it is typically viewed as the severe form of NVP and has been reported to occur in 0.3-10. Read More

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September 2019