Gynecol Obstet Fertil Senol 2021 Dec 23;49(12):947-950. Epub 2021 Oct 23.
DMU ESPRIT (épidémiologie et biostatistique, santé publique, pharmacie, pharmacologie, recherche, information médicale, thérapeutique et médicaments), centre de référence sur les agents tératogènes (CRAT), GHU, Sorbonne université, AP-HP, site Trousseau, 26, avenue Docteur-Netter, 75571 Paris cedex 12, France. Electronic address:
Although there is no recommendation in France relating to the treatment of nausea and vomiting of pregnancy, there are some in other countries, where ondansetron, widely used, appears to be an effective second-line treatment option behind doxylamine/vitamin B6 association and metoclopramide. However, based on some recent publication suggesting an increased risk of orofacial clefts and congenital heart defects in fetuses exposed in utero to ondansetron in the 1st trimester of pregnancy, the European Medicines Agency now states that this drug should not longer be used during this period. This 2019 decision is controversial and whether ondansetron can be used in pregnant women with severe vomiting during pregnancy is still in question. Read More