394,462 results match your criteria dosage form


Evidence of immunogenic cancer cell death induced by honey-processed Astragalus polysaccharides in vitro and in vivo.

Exp Cell Res 2021 Nov 23:112948. Epub 2021 Nov 23.

Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong Province, PR China; .GDPU-HKU Zhongshan Biomedical Innovation Plaform, Zhongshan, 528437, Guangdong Province, PR China; Guangdong Engineering & Technology Research Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong Province, PR China; Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, Guangzhou, 510006, Guangdong Province, PR China; Guangdong Cosmetics Engineering & Technology Research Center, Guangzhou, 510006, Guangdong Province, PR China. Electronic address:

Honey-processed Astragalus is a dosage form of Radix Astragalus mixed with honey by a traditional Chinese medicine processing method which improves immune activity. This pharmacological activity of honey-processed Astragalus polysaccharide (HP-APS) might be due to structural changes during the honey roasting process. Previously, we have prepared and characterized HP-APS and preliminarily found its anti-inflammatory effects. Read More

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November 2021

Quality of FDM 3D Printed Medicines for Pediatrics: Considerations for Formulation Development, Filament Extrusion, Printing Process and Printer Design.

Ther Innov Regul Sci 2021 Nov 26. Epub 2021 Nov 26.

Laboratory for Manufacturing Systems, University of Applied Sciences Cologne, Betzdorfer Str. 2, 50679, Cologne, Germany.

3d printing is capable of providing dose individualization for pediatric medicines and translating the precision medicine approach into practical application. In pediatrics, dose individualization and preparation of small dosage forms is a requirement for successful therapy, which is frequently not possible due to the lack of suitable dosage forms. For precision medicine, individual characteristics of patients are considered for the selection of the best possible API in the most suitable dose with the most effective release profile to improve therapeutic outcome. Read More

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November 2021

Tyrosine kinase inhibitors as next generation oncological therapeutics: Current strategies, limitations and future perspectives.

Therapie 2021 Nov 2. Epub 2021 Nov 2.

Translational Pharmaceutics Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science, Pilani Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District, Telangana 500078, India. Electronic address:

Protein kinases, a class of enzymes that govern various biological phenomena at a cellular level, are responsible for signal transduction in cells that regulate cellular proliferation, differentiation, and growth. Protein kinase enzyme mutation results in abnormal cell division leading to a pathological condition like cancer. Tyrosine kinase (TK) inhibitors, which helps as a potential drug candidate for the treatment of cancer, are continuously being developed. Read More

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November 2021

Prediction of the CYP2D6 enzymatic activity based on investigating of the CYP2D6 genotypes around the vivax malaria patients in Yunnan Province, China.

Malar J 2021 Nov 25;20(1):448. Epub 2021 Nov 25.

Yunnan Institute of Parasitic Diseases Control, Yunnan Provincial Key Laboratory of Vector-Borne Diseases Control and Research, Yunnan Centre of Malaria Research, Pu'er, 665000, China.

Background: In recent years, the incidence rate of vivax malaria recurrence still had 3.1% in Yunnan Province population after eradication therapy using primaquine (PQ). In order to understand the specific failure reasons for preventing vivax malaria relapses, a preliminary exploration on the CYP2D6 enzyme activity was carried out in the vivax malaria patients in Yunnan Province population by analysing mutational polymorphism in the coding region of CYP2D6 gene. Read More

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November 2021

Orodispersible tablets for pediatric drug delivery: current challenges and recent advances.

Expert Opin Drug Deliv 2021 Nov 25. Epub 2021 Nov 25.

Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University Düsseldorf, Universitätsstr, 1, 40225 Düsseldorf, Germany.

Introduction: Child appropriate dosage forms are indispensable in modern medicine and are a prerequisite for successful pediatric drug therapy. For years experts call for a paradigm shift, from liquid dosage forms to novel oral solid dosage forms. This review aims to shed light on recent developments on Orodispersible tablets (ODTs) and mini-tablets (ODMTs). Read More

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November 2021

Stress relaxation in tunable gels.

Soft Matter 2021 Nov 24;17(45):10254-10262. Epub 2021 Nov 24.

Department of Applied Physics, Eindhoven University of Technology, P. O. Box 513, NL-5600 MB Eindhoven, The Netherlands.

Hydrogels are a staple of biomaterials development. Optimizing their use in drug delivery or tissue engineering requires a solid understanding of how to adjust their mechanical properties. Here, we present a numerical study of a class of hydrogels made of 4-arm star polymers with a combination of covalent and reversible crosslinks. Read More

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November 2021

Does skin permeation kinetics influence efficacy of topical dermal drug delivery system?: Assessment, prediction, utilization, and integration of chitosan biomacromolecule for augmenting topical dermal drug delivery in skin.

J Adv Pharm Technol Res 2021 Oct-Dec;12(4):345-355. Epub 2021 Oct 20.

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India.

Skin permeation is an integral part of penetration of topical therapeutics. Zero order in addition to Higuchi permeation kinetic is usually preferred in topical drug delivery cargo. Penetration of therapeutic entities through epidermal barrier is a major challenge for scientific fraternity. Read More

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October 2021

Use of Ketamine Infusions for Treatment of Complex Regional Pain Syndrome: A Systematic Review.

Cureus 2021 Oct 19;13(10):e18910. Epub 2021 Oct 19.

Internal Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, USA.

This systematic review aims to review clinical studies on the use of ketamine infusion for patients with treatment-resistant complex regional pain syndrome (CRPS). The following systematic review was registered on the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42021228470). Studies for the systematic review were identified through three databases: PubMed, Cumulative Index of Nursing and Allied Health Literature (CINAHL), and Cochrane Reviews. Read More

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October 2021

Nanoemulsion and Solid Nanoemulsion for Improving Oral Delivery of a Breast Cancer Drug: Formulation, Evaluation, and a Comparison Study.

Saudi Pharm J 2021 Nov 8;29(11):1278-1288. Epub 2021 Oct 8.

Department of Pharmaceutics, College of Pharmacy, University of Kerbala, Kerbala, Iraq.

Letrozole (LZ) is an aromatase inhibitor, which inhibits the formation of estrogens from androgens. Nanoemulsion is a liquid emulsion formulation utilized to increase solubility, bioavailability, and drug delivery to cancer cells. This study aims to improve LZ oral delivery through formulating solid nanoemulsion (SNE). Read More

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November 2021

Paediatric poisoning in Kuwait-Al Adan joint hospital: The need for functional poisoning control centre in Kuwait.

Saudi Pharm J 2021 Nov 19;29(11):1267-1271. Epub 2021 Oct 19.

Kuwait-Al Adan Joint Paediatric Hospital, Al-Adan Paediatric Pharmacy, Department of Pharmacy, Mohammad Tahous Nasser bin Tahous street, Sabah Alsalem 44001, Kuwait.

Poisoning is a major global health concern. Every year, unintentional poisoning contributes to 106,683 deaths globally. In Kuwait, paediatric poisoning cases comprise approximately 50% of total poisoning cases. Read More

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November 2021

Role of lipopolysaccharides in potential applications of nanocarrier systems.

Curr Pharm Des 2021 Nov 23. Epub 2021 Nov 23.

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai. India.

Background: Lipopolysaccharides (LPS) are considered the main molecular component in the outer membrane of gram-negative bacteria. The LPS molecule in the bacterial cell wall acts as a primary physical barrier and protects gram-negative bacteria from the surrounding environment. LPS (endotoxins) show immunomodulatory therapeutic properties as well as toxicity to the host cell, whereas potential applications encompass. Read More

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November 2021

Comparative observation of aerosol vertical profiles in urban and suburban areas: Impacts of local and regional transport.

Sci Total Environ 2022 Jan 16;805:150363. Epub 2021 Sep 16.

Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China; Institute of Eco-Chongming (IEC), No. 20 Cuiniao Road, Shanghai 202162, China; Institute of Atmospheric Sciences, Fudan University, Shanghai 200433, China. Electronic address:

Ground-based Multi-Axis Differential Optical Absorption Spectroscopy (MAX-DOAS) instruments were used to carry out observation of aerosol in the urban and suburban areas of Shanghai from October 17 to November 21, 2019. Fudan University (FDU) site is a typical urban environment, surrounded by residential areas, commercial areas and arterial roads, while Dianshan Lake (DSL) site is a suburban environment with high vegetation coverage and no pollutant emission sources. The aerosol retrieved by MAX-DOAS was in good correlation with the observation of sun photometer and the PM concentration of the corresponding site, which demonstrates that the aerosol retrieved by MAX-DOAS is reliable and feasible. Read More

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January 2022

High internal phase oil-in-water emulsions stabilized by supercritical carbon dioxide extruded whey protein concentrate.

Food Chem 2022 Mar 7;372:131362. Epub 2021 Oct 7.

Department of Food Science, Cornell University, Ithaca, NY, USA.

High Internal Phase Emulsions (HIPEs) were stabilized by functionalized whey protein concentrate (WPC-80). Functionalization of WPC-80 was done by supercritical CO assisted extrusion technology. HIPEs were formed by 80% oil and 1-4 wt% of control (untreated) whey protein concentrate, extruded/functionalized whey protein concentrates (f-WPC-80) at pH 3. Read More

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Improvement of gel properties and digestibility of the water-soluble polymer of tea polyphenol-egg white under thermal treatment.

Food Chem 2022 Mar 6;372:131319. Epub 2021 Oct 6.

Jiangxi Key Laboratory of Natural Products and Functional Food, Jiangxi Agricultural University, Nanchang 330045, China. Electronic address:

In this study, the improvement of gel properties and digestibility of the water-soluble polymer of tea polyphenol (TP)-egg white protein (TEP) under heat induction (HTEP), was studied. Results indicated that the particle size and turbidity of TEP increased with TP concentration, and the absolute value of ζ-potential decreased. After heat induction, the surface hydrophobicity of HTEP decreased with TP concentration, and the degree of protein aggregation increased. Read More

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Physiologically based pharmacokinetic modeling of candesartan related to CYP2C9 genetic polymorphism in adult and pediatric patients.

Arch Pharm Res 2021 Nov 24. Epub 2021 Nov 24.

School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Candesartan cilexetil is an angiotensin II receptor blocker and it is widely used to treat hypertension and heart failure. This drug is a prodrug that rapidly converts to candesartan after oral administration. Candesartan is metabolized by cytochrome P450 2C9 (CYP2C9) enzyme or uridine diphosphate glucurinosyltransferase 1A3, or excreted in an unchanged form through urine, biliary tract and feces. Read More

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November 2021

Fibrinspecific liposomes as a potential method of delivery of the thrombolytic preparation streptokinase.

J Thromb Thrombolysis 2021 Nov 23. Epub 2021 Nov 23.

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine.

The use of streptokinase (SK) in the clinic is limited by the lack of fibrin-specificity and the short half-life of the drug. We have developed a new dosage form of streptokinase (immunoliposome), which consists of "free" native streptokinase and "bound" encapsulated in liposomes conjugated through carboxylated dextran with fibrin-specific monoclonal antibodies FnI-3C (IgG2 class), in a ratio of 60 and 40%, respectively, and studied their physicochemical properties, pharmacokinetic parameters, and the ability of fibrin-specific liposomes with SK for targeted delivery to fibrin in an in vivo experiment. The obtained immunoliposomes had a hydrodynamic diameter of ~ 140 nm, a zeta potential of - 19. Read More

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November 2021

The Advances of Neutrophil-Derived Effective Drug Delivery Systems: A Key Review of Managing Tumors and Inflammation.

Int J Nanomedicine 2021 16;16:7663-7681. Epub 2021 Nov 16.

Department of Nephrology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.

The chimeric trait of recruitment by inflammatory signals endows neutrophils with the functionality of migrating to inflamed tissues, which can be utilized to tailor novel drug delivery systems. In this review, we introduce a mechanism of neutrophil-derived drug delivery systems recruited into inflamed sites and provide insight into tumors and inflammation therapy. In particular, the advantages of neutrophils-their endogenous-derived neutrophil membrane, exosomes as drug carriers for augmented targeting, prolonged circulation, and improved biostability-were concluded. Read More

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November 2021

Pseudophase microextraction for in-line sample concentration in micellar electrokinetic chromatography.

Anal Chim Acta 2022 Jan 27;1189:339219. Epub 2021 Oct 27.

Australian Centre for Research on Separation Science (ACROSS), School of Natural Sciences-Chemistry, University of Tasmania, Hobart, Tasmania, 7001, Australia. Electronic address:

Pseudophase microextraction (PPME) as a simple in-line sample concentration technique in micellar electrokinetic chromatography (MEKC) is presented. In contrast to popular electric-field driven stacking techniques in MEKC such as sweeping, PPME is pressure-driven. The technique afforded up to 403-2968x improvements in peak heights for fenoprop, dichlorprop, 1- and 2-naphthol compared to typical injection. Read More

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January 2022

Nanocrystal-based 3D-printed tablets: Semi-solid extrusion using Melting solidification printing process (MESO-PP) for Oral Administration of poorly soluble drugs.

Int J Pharm 2021 Nov 20:121311. Epub 2021 Nov 20.

Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET; Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, X5000XHUA Córdoba, Argentina. Electronic address:

This is the first report on the inclusion of nanocrystals (NCs) within 3D-printed oral solid dosage forms -3D-printed tablets or printlets- produced by the Melting Solidification Printing Process (MESO-PP) 3D printing technique. This method allowed the incorporation of albendazole (ABZ) nanocrystals in a concentration of up to 50% w/w, something not achieved in conventional tablets. An ink of PEG 1500/propylenegycol was used as a carrier and no physicochemical interactions or crystallinity modifications were observed due to the inclusion of ABZ-NCs into the ink, as demonstrated by TGA, DSC, XRD and FT-IR. Read More

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November 2021

Cryogel-based Injectable 3D Microcarrier Co-culture for Support of Hematopoietic Progenitor Niches.

Curr Protoc 2021 Nov;1(11):e275

Laboratory of Regenerative Hematopoiesis, Swiss Institute for Experimental Cancer Research & Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Although hematopoietic stem cell (HSC) transplantation can restore functional hematopoiesis upon immune or chemotherapy-induced bone marrow failure, complications often arise during recovery, leading to up to 25% transplant-related mortality in treated patients. In hematopoietic homeostasis and regeneration, HSCs in the bone marrow give rise to the entirety of cellular blood components. One of the challenges in studying hematopoiesis is the ability to successfully mimic the relationship between the stroma and hematopoietic stem and progenitor cells (HSPCs). Read More

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November 2021

Alginate-Based Smart Materials and Their Application: Recent Advances and Perspectives.

Top Curr Chem (Cham) 2021 Nov 23;380(1). Epub 2021 Nov 23.

Department of Chemistry, School of Advanced Science (SAS), Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, India.

Nature produces materials using available molecular building blocks following a bottom-up approach. These materials are formed with great precision and flexibility in a controlled manner. This approach offers the inspiration for manufacturing new artificial materials and devices. Read More

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November 2021

[Determination of the enantiomers of salmeterol xinafoate in salmeterol fluticasone powder inhalant by chiral nonaqueous capillary electrophoresis].

Se Pu 2021 Dec;39(12):1355-1361

Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Institute of Life Science and Green Development, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.

Salmeterol xinafoate (SalX) is one of the ideal drugs used for the treatment of nocturnal asthma attacks and daily maintenance. The molecular structure of SalX contains a chiral carbon atom, and thus, SalX has two enantiomers, viz. ()-SalX and ()-SalX. Read More

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December 2021

Can silver diamine fluoride be an alternative to aerosol-based dentistry during the COVID scenario? A retrospective analysis.

J Indian Soc Pedod Prev Dent 2021 Jul-Sep;39(3):316-320

Department of Pedodontics, PGIDS, Rohtak, Haryana, India.

Background: Restrictions on routine dental procedures involving aerosols during COVID-19 have resulted in a significant increase in the suffering of pediatric patients.

Aim: The study reported the alternative measures followed in our department using SDF during the COVID era when routine elective dental procedures were prohibited.

Materials And Methods: The retrospective data of patients aged 2-13 years with carious molar teeth who were treated with silver diamine fluoride without (Group 1) or with (Group 2) caries excavation were collected. Read More

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November 2021

Investigating colloid-associated transport of cadmium and lead in a clayey soil under preferential flow conditions.

Water Sci Technol 2021 Nov;84(9):2486-2498

Department of Civil and Energy Engineering, College of Environmental Science and Engineering, Donghua University, Shanghai 201620, China E-mail:

Colloids have a high adsorption capacity and can be mobile under preferential flow, and so may facilitate heavy metal migration. Heavy metal migration with soil colloids in a clayey soil under preferential flow conditions was investigated through experiments. Adsorption tests were carried out to determine the adsorption of Cd and Pb to the clay and colloids. Read More

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November 2021

Innovative derivative/zero ratio spectrophotometric method for simultaneous determination of sofosbuvir and ledipasvir: Application to average content and uniformity of dosage units.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Nov 14:120623. Epub 2021 Nov 14.

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

An innovative simple, rapid and sensitive spectrophotometric method was developed for the simultaneous analysis of sofosbuvir (SOF) and ledipasvir (LED) in their combined dosage forms. Sofosbuvir with ledipasvir (SOF/LED) as a combined dosage form was tried at the pandemic COVID 19 crisis. This technique has the advantages of both zero order and first order spectrophotometry. Read More

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November 2021

Evaluation of alginate-biopolymers (protein, hydrocolloid, starch) composite microgels prepared by the spray aerosol technique as a carrier for green tea polyphenols.

Food Chem 2022 Mar 11;371:131382. Epub 2021 Oct 11.

School of Agriculture and Food Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address:

Effects of low methoxyl pectin, milk protein concentrate (MPC), and waxy starch on the encapsulation of green tea-polyphenols in alginate gels produced using spray aerosol technique were evaluated. MPC and waxy starch treated first by cold-renneted induced gelation method and gelatinization method, respectively. DSC thermal analysis and FTIR spectroscopy were used to prove the presence of polyphenols in gel matrixes. Read More

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Baicalin-liposomes loaded polyvinyl alcohol-chitosan electrospinning nanofibrous films: Characterization, antibacterial properties and preservation effects on mushrooms.

Food Chem 2022 Mar 9;371:131372. Epub 2021 Oct 9.

College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China. Electronic address:

To investigate antibacterial properties and application in food preservation of nanofibrous films (NFs), baicalin-liposomes (BCL-LPs) were loaded into polyvinyl alcohol-chitosan (PVA-CS) substrates to form NFs using electrospinning technology. The microstructure and phase identification of the NFs were characterized. The antibacterial properties and cytotoxicity of NFs were determined. Read More

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Fabrication of flavour oil high internal phase emulsions by casein/pectin hybrid particles: 3D printing performance.

Food Chem 2022 Mar 7;371:131349. Epub 2021 Oct 7.

National Engineering Research Center of Seafood, Collaborative Innovation Center of Provincial and Ministerial Co-construction for Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China.

In this study, three-dimensional (3D) printable oil/water (O/W) high-internal-phase emulsions (HIPEs) (internal phase fraction = 75%) were fabricated using casein (3% w/v)/pectin (1-5% w/v) hybrid particles with flavour oil. The morphologies of the HIPEs, revealed by confocal laser scanning microscopy (CLSM) and cryo-scanning electron microscopy (cryo-SEM), indicated that the casein/pectin hybrid particles were mainly distributed on the interface of oil droplets. Additionally, the results of rheological and gel-strength measurements indicated that the viscosity (ranging from 1316. Read More

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A new crystalline ketoprofen sodium salt: solid-state characterization, solubility, and stability.

J Pharm Sci 2021 Nov 19. Epub 2021 Nov 19.

Faculty of Pharmaceutical Sciences, Federal University of Alfenas (UNIFAL-MG), Alfenas, Minas Gerais 37130-001, Brazil. Electronic address:

Ketoprofen (KTP) is an Active Pharmaceutical Ingredient (API) that has low solubility in aqueous solvents. The use of KTP salts has attracted attention due to its improvements in terms of solubility, tolerability, higher rate and extent of absorption, and faster onset of the therapeutic effect. In this work, a crystalline KTP sodium salt (coded as KTP-Na) was successfully obtained and widely characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), solubility and accelerated stability studies. Read More

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November 2021

Formulation, Physical Stability, and the Clinical Effectiveness of Extemporaneous Ivermectin Oral Solution.

Int J Pharm Compd 2021 Nov-Dec;25(6):523-527

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.

Ivermectin is a gamma amino butyric acid (GABA)-gated-Cl-channels modulator, which has been used orally in the treatment of numerous parasitic infections. The study target was to set up a stable, efficient 0.2% w/v ivermectin solution, which would be achieved from pure ivermectin powder as a source of the active pharmaceutical ingredient. Read More

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November 2021