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Maternal Serum Placental Protein-13 Levels in the Prediction of Pregnancies with Abnormal Invasive Placentation.

Z Geburtshilfe Neonatol 2021 May 5. Epub 2021 May 5.

Department of Obstetrics and Gynecology, Veris delli Ponti Hospital, Scorrano, Lecce, Italy, Lecce, Italy.

Objective: To evaluate whether placental protein-13 (PP-13) measured in the serum of pregnant women could predict abnormal invasive placentation (AIP) detected by color Doppler ultrasound (US) and magnetic resonance imaging scan in addition to the routine US scan during the third trimester.

Materials And Methods: The prospective case-control study included patients subdivided in 2 groups: 42 pregnant women with a singleton pregnancy at 28-32 weeks of gestation with only suspected AIP, and 32 healthy pregnant women. The serum PP-13 levels were measured in both groups using an enzyme-linked immunosorbent assay (ELISA) method and statistically compared. Read More

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Musculoskeletal ultrasound for ankylosing spondylitis: A systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(18):e25822

Department of Rheumatology, Xuzhou City Hospital of Traditional Chinese Medicine, Xuzhou, China.

Objective: To clarify if musculoskeletal ultrasound (US) would give additional information for the clinical examination to diagnose and evaluate the activity of ankylosing spondylitis (AS).

Methods: A literature search was performed in PubMed, Embase, Web of Science, the Cochrane Library, Sinomed, Chinese National Knowledge Infrastructure (CINK), and Wanfang databases from their inceptions to May 15, 2020. Studies that examined the musculoskeletal US, which detected sacroiliac joints in people with AS were included. Read More

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Pulse wave imaging coupled with vector flow mapping: A phantom, simulation and in vivo study.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 May 5;PP. Epub 2021 May 5.

Pulse wave imaging (PWI) is an ultrasound imaging modality that estimates the wall stiffness of an imaged arterial segment by tracking the pulse wave propagation. The aim of the present study is to integrate PWI with vector flow imaging, enabling simultaneous and co-localized mapping of vessel wall mechanical properties and 2-D flow patterns. Two vector flow imaging techniques were implemented using the PWI acquisition sequence: 1) multi-angle vector Doppler, and 2) a cross correlation based vector flow imaging (CC VFI) method. Read More

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Medium to Long Term Follow-Up of Treated Hypertensive Mediated Heart Disease.

High Blood Press Cardiovasc Prev 2021 May 5. Epub 2021 May 5.

Cardiology Institute of the Sanatorio Britanico de Rosario, Jujuy 1540, Floor 5th, 2000, Rosario, Argentina.

Introduction: Hypertensive mediated heart disease is the consequence of anatomical and functional changes in cardiovascular system. The benefits on left ventricular (LV) diastolic impairment and remodeling of hypertension treatment are well established.

Aim: To evaluate LV structure, systolic and diastolic function of treated hypertensive patients on a medium to long term follow-up. Read More

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The pentose phosphate pathway in industrially relevant fungi: crucial insights for bioprocessing.

Appl Microbiol Biotechnol 2021 May 5. Epub 2021 May 5.

Christian Doppler Laboratory for Optimized Expression of Carbohydrate-Active Enzymes, Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, A-1060, Vienna, Austria.

The pentose phosphate pathway (PPP) is one of the most targeted pathways in metabolic engineering. This pathway is the primary source of NADPH, and it contributes in fungi to the production of many compounds of interest such as polyols, biofuels, carotenoids, or antibiotics. However, the regulatory mechanisms of the PPP are still not fully known. Read More

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Induction of labor in late-FGR.

Minerva Obstet Gynecol 2021 May 5. Epub 2021 May 5.

Centre for Fetal Care and High-risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Chieti, Italy -

Late-onset FGR is a peculiar condition characterized by the inability for the fetus to reach its growth potential diagnosed from 32 weeks of gestation. Placental insufficiency is among the leading causes of late FGR and is commonly due to a primary maternal cardiovascular non-adaptation potentially leading to fetal decompensation during labor especially once exposed to uterine hyperstimulation. Abnormalities that usually characterize late FGR include reduced fetal growth, decreased amniotic fluid index, and loss of fetal heart rate variability at CTG. Read More

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Neurodevelopment of infant with late fetal growth restriction.

Minerva Obstet Gynecol 2021 May 5. Epub 2021 May 5.

Neonatology Division, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.

Introduction: Late fetal growth restriction has increasingly gain interest. Differently from early fetal growth restriction, the severity of this condition and the impact on perinatal mortality and morbidity is less severe. Nevertheless, there is some evidence to suggest that fetuses exposed to growth restriction late in pregnancy are at increased risk of neurological dysfunction and behavioural impairment. Read More

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Changes of cerebral oxygenation indices measured by near infrared time-resolved spectroscopy during spinal anesthesia for cesarean section: Simultaneous measurement with cerebral blood flow.

J Obstet Gynaecol Res 2021 May 4. Epub 2021 May 4.

Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Aim: To measure the changes in cerebral oxygenation indices by near infrared time-resolved spectroscopy and the cerebral blood flow simultaneously after spinal anesthesia for cesarean section.

Methods: This prospective observational study was conducted for 25 pregnant women scheduled for elective cesarean section under spinal anesthesia. During a period of 15 min after spinal anesthesia, cerebral oxygenation (ScO ), and the total cerebral hemoglobin concentration (tHb) were measured using near infrared time-resolved spectroscopy and mean cerebral blood flow velocity (Vm) was measured using transcranial Doppler ultrasonography. Read More

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Echocardiographic assessment of coronary microvascular dysfunction: Basic concepts, technical aspects, and clinical settings.

Echocardiography 2021 May 5. Epub 2021 May 5.

Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.

Coronary flow reserve is the capacity of the coronary circulation to augment the blood flow in response an increase in myocardial metabolic demands and has a powerful prognostic significance in different clinical situations. It might assess with invasive and noninvasive technique. Transthoracic echocardiography Doppler is an emerging diagnostic technique, noninvasive, highly feasible, safe for patient and physician, without radiation, and able to detect macrovascular and microvascular anomalies in the coronary circulation. Read More

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Association of bone biomarkers with advanced atherosclerotic disease in people with overweight/obesity.

Endocrine 2021 May 4. Epub 2021 May 4.

Experimental Medicine Department, Sapienza University of Rome, Rome, Italy.

Background: A growing body of evidence suggests a potential link between bone metabolism and cardiovascular disease. Aim of this study was to investigate the relationship between levels of circulating bone turnover biomarkers and advanced atherosclerosis.

Methods: Klotho (KL), sclerostin (SOST), osteopontin (OPN) and osteoprotegerin (OPG) were measured in patients undergoing elective coronary angiography and carotid Doppler ultrasound. Read More

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Effects of circulatory arrest and cardiopulmonary bypass on cerebral autoregulation in neonatal swine.

Pediatr Res 2021 May 4. Epub 2021 May 4.

Department of Pediatrics, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Background: Cerebral autoregulation mechanisms help maintain adequate cerebral blood flow (CBF) despite changes in cerebral perfusion pressure. Impairment of cerebral autoregulation, during and after cardiopulmonary bypass (CPB), may increase risk of neurologic injury in neonates undergoing surgery. In this study, alterations of cerebral autoregulation were assessed in a neonatal swine model probing four perfusion strategies. Read More

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"Knobology" in Doppler Ultrasound.

Med Ultrason 2021 May 4. Epub 2021 May 4.

Department Allgemeine Innere Medizin (DAIM) Kliniken Hirslanden Beau Site, Salem und Permanence, Bern, Switzerland.

Ultrasonography is a ubiquitous and indispensable diagnostic and therapeutic tool in medicine. Due to modern equipment and automatic image optimization, nowadays the introduction of ultrasound imaging requires only little technical and physical knowledge. However, profound knowledge of the device function repertoire and underlying mechanisms are essential foroptimal image adjustment and documentation. Read More

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Mimicking the Human Tympanic Membrane: The Significance of Scaffold Geometry.

Adv Healthc Mater 2021 May 4:e2002082. Epub 2021 May 4.

Department of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.

The human tympanic membrane (TM) captures sound waves from the environment and transforms them into mechanical motion. The successful transmission of these acoustic vibrations is attributed to the unique architecture of the TM. However, a limited knowledge is available on the contribution of its discrete anatomical features, which is important for fabricating functional TM replacements. Read More

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Assessment of the Rigidity Changes of Corpus Cavernosum Penis in Vasculary Erectile Dysfunction (ED) Subtypes by Shear Wave Elastography (SWE).

J Ultrasound Med 2021 May 4. Epub 2021 May 4.

Radiology Department, Mehmet Akif Ersoy Training and Research Hospital, Istanbul, Turkey.

Introduction: Erectile dysfunction (ED) is a condition that is very common all over the world, concerns about men and causes very important social problems. The aim of this study is to perform quantitative penile corpus cavernosum (CC) stiffness measurements by using SWE for patients with both types of vascular ED.

Methods: In our study, we handled the data of 101 participants in total. Read More

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Pigmented onychomatricoma: A clinical simulator that could not mislead ultrasound.

Acta Biomed 2021 Apr 30;92(S1):e2021158. Epub 2021 Apr 30.

Department of Dermatology, Faculty of Medicine, University of Chile, Santiago.

Introduction: Onychomatricoma is a rare subungual tumor composed of stroma and nail matrix-like epithelium. Only seven cases of the pigmented variant have been reported in the literature.

Case Report: We present a 62-year-old male patient with a 2-years history of a single fingernail thickening, deformation, and hyperpigmentation. Read More

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Intracranial dolichoectasia in patients with symptomatic intracranial atherosclerotic disease: Results from the MYRIAD study.

J Neuroimaging 2021 May 4. Epub 2021 May 4.

Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.

Background And Purpose: It is unknown whether intracranial atherosclerotic disease (ICAD), in addition to causing stenosis, also associates with abnormal arterial enlargement, a condition known as intracranial dolichoectasia (IDE). Across symptomatic ICAD patients, we aim to determine IDE prevalence and IDE impact on cerebral hemodynamics and recurrent cerebral ischemia.

Methods: We analyzed 98 participants (mean age 63. Read More

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Emergency amputation necessitated within 24 hours by a human bite: a case report.

J Int Med Res 2021 May;49(5):3000605211012201

Department of Foot and Ankle Surgery, Center for Orthopaedic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou 510610, China.

We herein review and analyze the diagnosis, treatment, and outcome of a severe infection caused by a human bite. A 68-year-old man was bitten on the forearm by a 3-year-old child. Rapid progression of infection, severe local and systemic poisoning, and diverse clinical manifestations were observed at presentation. Read More

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Quantitative Assessment of Ensemble Coherency in Contrast-free Ultrasound Microvasculature Imaging.

Med Phys 2021 May 3. Epub 2021 May 3.

Department of Radiology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, 55902, United States.

Purpose: Contrast-free visualization of microvascular blood flow (MBF) using ultrasound can play a valuable role in diagnosis and detection of diseases. In this study, we demonstrate the importance of quantifying ensemble coherence for robust MBF imaging. We propose a novel approach to quantify ensemble coherence by estimating the local spatiotemporal correlation (LSTC) image, and evaluate its efficacy through simulation and in vivo studies. Read More

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Current Status of Ultrasound in Acute Rejection After Renal Transplantation: A Review with a Focus on Contrast-Enhanced Ultrasound.

Ann Transplant 2021 May 4;26:e929729. Epub 2021 May 4.

Department of Nephrology, Chongqing Southwest Hospital, Chongqing, China (mainland).

Renal transplantation has developed into the best treatment for end-stage renal disease, but severe cases can even lead to loss of renal allograft function due to rejection and complications caused by surgical procedures. If a series of postoperative complications can be reduced or even avoided, the quality of life of recipients will be significantly improved. Acute rejection in a transplanted kidney is one of the main complications after renal transplantation. Read More

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Thrombolysis of Pulmonary Emboli via Endobronchial Ultrasound-Guided Transbronchial Needle Injection.

Ann Thorac Surg 2020 Oct 24. Epub 2020 Oct 24.

Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Ontario, Canada. Electronic address:

Background: Endobronchial ultrasound-guided transbronchial needle injection (EBUS-TBNI) is a novel technique for treating peribronchial targets. The aim of this study was to evaluate preliminary feasibility of thrombolysis of pulmonary emboli via EBUS-TBNI.

Methods: Yorkshire pigs (30-48 kg) were anesthetized and mechanically ventilated. Read More

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October 2020

Detection of Large Vessel Occlusion Stroke in the Prehospital Setting: Electroencephalography as a Potential Triage Instrument.

Stroke 2021 May 4:STROKEAHA120033053. Epub 2021 May 4.

Department of Neurology, Amsterdam UMC, University of Amsterdam, the Netherlands. (L.C.C.v.M., Y.B.W.E.M.R., W.V.P., J.M.C.).

A reliable and fast instrument for prehospital detection of large vessel occlusion (LVO) stroke would be a game-changer in stroke care, because it would enable direct transportation of LVO stroke patients to the nearest comprehensive stroke center for endovascular treatment. This strategy would substantially improve treatment times and thus clinical outcomes of patients. Here, we outline our view on the requirements of an effective prehospital LVO detection method, namely: high diagnostic accuracy; fast application and interpretation; user-friendliness; compactness; and low costs. Read More

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Preliminary assessment of ship detection and trajectory evaluation using distributed acoustic sensing on an optical fiber telecom cable.

J Acoust Soc Am 2021 Apr;149(4):2615

FEBUS-Optics, Technopole Helioparc, 2 Avenue Président Pierre Angot, 64 000 Pau, France.

Distributed acoustic sensing (DAS) is a recent instrumental approach allowing the conversion of fiber-optic cables into dense arrays of acoustic sensors. This technology is attractive in marine environments where instrumentation is difficult to implement. A promising application is the monitoring of environmental and anthropic noise, leveraging existing telecommunication cables on the seafloor. Read More

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Synergistic aircraft and ground observations of transported wildfire smoke and its impact on air quality in New York City during the summer 2018 LISTOS campaign.

Sci Total Environ 2021 Jun 3;773:145030. Epub 2021 Feb 3.

City College of New York, New York, NY 10031, USA; NOAA - Cooperative Science Center for Earth System Sciences and Remote Sensing Technologies, New York, NY 10031, USA.

Air pollution associated with wildfire smoke transport during the summer can significantly affect ozone (O) and particulate matter (PM) concentrations, even in heavily populated areas like New York City (NYC). Here, we use observations from aircraft, ground-based lidar, in-situ analyzers and satellite to study and assess wildfire smoke transport, vertical distribution, optical properties, and potential impact on air quality in the NYC urban and coastal areas during the summer 2018 Long Island Sound Tropospheric Ozone Study (LISTOS). We investigate an episode of dense smoke transported and mixed into the planetary boundary layer (PBL) on August 15-17, 2018. Read More

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Vasa previa: when antenatal diagnosis can change fetal prognosis.

J Perinat Med 2021 May 3. Epub 2021 May 3.

Gynecology and Obstetrics Unit, Prenatal Diagnosis Ultrasound Center, Sant'Anna Hospital, Città della Salute e della Scienza, University of Turin, Turin, Italy.

Objectives: Evaluate ultrasound diagnostic accuracy, maternal-fetal characteristics and outcomes in case of vasa previa diagnosed antenatally, postnatally or with spontaneous resolution before delivery.

Methods: Monocentric retrospective study enrolling women with antenatal or postnatal diagnosis of vasa previa at Sant'Anna Hospital in Turin from 2007 to 2018. Vasa previa were defined as fetal vessels that lay 2 cm within the uterine internal os using 2D and Color Doppler transvaginal ultrasound. Read More

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Laser Doppler Perfusion Imaging in the Mouse Hindlimb.

J Vis Exp 2021 Apr 18(170). Epub 2021 Apr 18.

VA Puget Sound Health Care System.

Blood flow recovery is a critical outcome measure after experimental hindlimb ischemia or ischemia-reperfusion. Laser Doppler perfusion imaging (LDPI) is a common, noninvasive, repeatable method for assessing blood flow recovery. The technique calculates overall blood flow in the sampled tissue from the Doppler shift in frequency caused when a laser hits moving red blood cells. Read More

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Association of alpha-thalassemia and Glucose-6-Phosphate Dehydrogenase deficiency with transcranial Doppler ultrasonography in Nigerian children with sickle cell anemia.

J Clin Lab Anal 2021 May 3:e23802. Epub 2021 May 3.

Department of Molecular Biology and Biotechnology, Nigerian Institute of Medical Research, Lagos, Nigeria.

Background: Stroke is a devastating complication of sickle cell anemia (SCA) and can be predicted through abnormally high cerebral blood flow velocity using transcranial Doppler Ultrasonography (TCD). The evidence on the role of alpha-thalassemia and glucose-6-phosphate dehydrogenase (G6PD) deficiency in the development of stroke in children with SCA is conflicting. Thus, this study investigated the association of alpha-thalassemia and G6PD(A ) variant with abnormal TCD velocities among Nigerian children with SCA. Read More

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Evaluation of right side foetal myocardial performance index in pregestational and gestational diabetes mellitus.

J Obstet Gynaecol 2021 May 2:1-6. Epub 2021 May 2.

Department of Obstetrics and Gynecology, Beykent University, Istanbul, Turkey.

The aim of our study is to investigate the myocardial performance index (MPI) of the right side of the foetal heart in pregestational and gestational diabetes mellitus and to compare it with non-diabetic pregnancies. This prospective cross-sectional study was conducted between August 2018 and March 2019 at Kanuni Sultan Suleyman Research and Training Hospital. Women with pregestational or gestational diabetes mellitus at 24-34 weeks of gestation were included in the study and non-diabetic pregnant women were included as the control group. Read More

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Foetal cardiac function in third trimester pregnancies with reduced fetal movements.

J Obstet Gynaecol 2021 May 2:1-7. Epub 2021 May 2.

Department of Obstetrics and Gynecology, Uskudar Yunus Emre Hospital, Istanbul, Turkey.

The objective of our study was to investigate the possible relationship between poor perinatal outcome and foetal cardiac functions in pregnant women with reduced foetal movements (RFM). This cross-sectional study included 126 pregnant women with normal foetal movements (Group 1, Controls) and 42 pregnant women over 32 weeks gestation with RFM (Group 2). Group 2 was further divided into two subgroups according to their perinatal outcome: normal perinatal outcome (Group 2a) and poor perinatal outcome (Group 2b). Read More

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Combined associations of obesity and metabolic health with subclinical left ventricular dysfunctions: Danyang study.

ESC Heart Fail 2021 May 2. Epub 2021 May 2.

Institute of Hypertension, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.

Aims: The association of strictly defined metabolic healthy obese (MHO) with subclinical cardiac function was unclear. Our study aims to examine the role of MHO in subclinical cardiac dysfunction in a Chinese population.

Methods And Results: The study subjects were recruited from Danyang from 2017 to 2019. Read More

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Impact of acute changes in blood pressure and arterial stiffness on cerebral pulsatile hemodynamics in young and middle-aged adults.

Exp Physiol 2021 May 2. Epub 2021 May 2.

Department of Kinesiology & Nutrition, University of Illinois at Chicago.

New Findings: What is the central question of this study? Examine whether cerebrovascular pulsatility responds differently to acute increases in arterial stiffness in middle-aged compared to young adults. What is the main finding and its importance? Compared to young adults, middle-aged adults exhibited similar changes in cerebral pulsatile damping despite attenuated changes in carotid diameter and cerebrovascular pulsatility during blood pressure-dependent, but not blood pressure-independent, increases in large artery stiffness.

Abstract: Acutely manipulating arterial stiffness through interventions that increase sympathetic activity may provoke cerebral pulsatility and damping, and reveal whether cerebrovascular hemodynamics respond differently in middle-age adults to transient elevations in arterial stiffness. Read More

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