4,233 results match your criteria donor candidates

Virtual noncontrast images derived from dual-energy CT for assessment of hepatic steatosis in living liver donors.

Eur J Radiol 2021 Mar 27;139:109687. Epub 2021 Mar 27.

Department of Radiology, Seoul National University Hospital, Seoul, South Korea; Department of Radiology, Seoul National University College of Medicine, Seoul, South Korea; Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, South Korea.

Purpose: This study aimed to investigate the correlation of attenuation between virtual noncontrast (VNC) and true noncontrast (TNC) CT images and compare the diagnostic performance for hepatic steatosis using MR spectroscopy (MRS) as the reference standard.

Methods: A total of 131 consecutive hepatic donor candidates who underwent dual-source dual-energy CT and MRS within one month from January 2018 to April 2019 were included. An MRS value > 5. Read More

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Breaking the Age Barrier: Physicians' Perceptions on Candidacy for Allogeneic Hematopoietic Cell Transplantation in Older Adults.

Transplant Cell Ther 2021 Apr 6. Epub 2021 Apr 6.

City of Hope, Duarte, CA.

Background: Despite continued increases in use of allogeneic hematopoietic cell transplantation (alloHCT) among older adults, no standardized geriatric assessment (GA) has been established to risk-stratify for transplant-related morbidity. We conducted a survey of transplant physicians to determine perceptions of the impact of older age (≥60 years) on alloHCT candidacy, and utilization of tools to gauge candidacy.

Methods: We conducted a 23-item, online cross-sectional survey of HCT physicians caring for adults in the United States between May and July 2019. Read More

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Novel High-Efficiency Polymer Acceptors via Random Ternary Copolymerization Engineering Enables All-Polymer Solar Cells with Excellent Performance and Stability.

ACS Appl Mater Interfaces 2021 Apr 9. Epub 2021 Apr 9.

College of Chemistry/Institute of Polymers and Energy Chemistry (IPEC), Nanchang University, Nanchang 330031, P. R. China.

Continuous breakthroughs have been achieved in improving the efficiency of all-polymer solar cells (all-PSCs) using diimide-based polymer acceptors, and their easy-to-synthesize, low-cost, and high stability attributes make them potential candidates for use in commercial all-PSCs. However, their low light absorption coefficient, strong aggregation, and poor adaptability with high-efficient polymer donors still limit further improvements in the device performance. Here, we combine the advantages of fluorinated bithiophene and rhodanine dye molecules to create low-cost diimide-based polymer acceptors, PNDI-2FT-TR10 and PNDI-2FT-TR20, by random copolymerization for achieving highly efficient and stable all-PSCs. Read More

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The Exploration of Novel Pharmacophore Characteristics and Multidirectional Elucidation of Structure-Activity Relationship and Mechanism of Sesquiterpene Pyridine Alkaloids from Based on Computational Approaches.

Evid Based Complement Alternat Med 2021 24;2021:6676470. Epub 2021 Mar 24.

Chongqing Academy of Chinese Materia Medica, No. 34 Nanshan Road, Nan'an District, Chongqing 400065, China.

Sesquiterpene pyridine alkaloids are a large group of highly oxygenated sesquiterpenoids, which are characterized by a macrocyclic dilactone skeleton containing 2-(carboxyalkyl) nicotinic acid and dihydro--agarofuran sesquiterpenoid, and are believed to be the active and less toxic components of . In this study, 55 sesquiterpene pyridine alkaloids from were subjected to identification of pharmacophore characteristics and potential targets analysis. Our results revealed that the greatest structural difference of these compounds was in the pyridine ring and the pharmacophore model-5 (Pm-05) was the best model that consisted of three features including hydrogen bond acceptor (HBA), hydrogen bond donor (HBD), and hydrophobic (HY), especially hydrophobic group located in the pyridine ring. Read More

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Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold.

Eur J Med Chem 2021 Mar 15;218:113385. Epub 2021 Mar 15.

Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA; Center of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address:

An expanded series of alkyl 2-arylhydrazinylidene-3-oxo-3-polyfluoroalkylpropionates (HOPs) 3 was obtained via Cu(OAc)-catalyzed azo coupling. All were nanomolar inhibitors of carboxylesterase (CES), while moderate or weak inhibitors of acetylcholinesterase and butyrylcholinesterase. Steady-state kinetics studies showed that HOPs 3 are mixed type inhibitors of the three esterases. Read More

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Evaluation of a Multimodal Analgesic Regimen on Outcomes Following Laparoscopic Living Donor Nephrectomy.

Clin Transplant 2021 Apr 8:e14311. Epub 2021 Apr 8.

Department of Pharmacy Services, Hartford Hospital, Hartford, CT, USA.

Postoperative pain is a significant source of morbidity in patients undergoing living donor nephrectomy (LDN) and a deterrent for candidates. We implemented a standardized multimodal analgesic regimen, which consists of pharmacist-led pre-procedure pain management education, a combination transversus abdominis plane and rectus sheath block performed by the regional anesthesia team, scheduled acetaminophen and gabapentin, and as-needed opioids. This single-center retrospective study evaluated outcomes between patients undergoing LDN who received a multimodal analgesic regimen and a historical cohort. Read More

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Cardiac imaging for the assessment of patients being evaluated for liver transplantation.

J Nucl Cardiol 2021 Apr 6. Epub 2021 Apr 6.

Division of Cardiology, Cook County Health, Chicago, IL, USA.

Cardiac risk assessment prior to liver transplantation has become widely accepted. With the emergence of nonalcoholic steatohepatitis among the leading causes of end-stage liver disease and the steady rise of the age of liver transplant recipients, the burden of cardiovascular diseases has markedly increased in this population. Selecting appropriate liver transplant candidates is crucial due to the increasing demand for scarce donor organs. Read More

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Semen quality and windows of susceptibility: A case study during COVID-19 outbreak in China.

Environ Res 2021 Apr 1:111085. Epub 2021 Apr 1.

Department of Environmental Sciences and Engineering, College of Architecture and Environment, Sichuan University. Electronic address:

Background: To evaluate the impact of ambient air pollutant exposures on semen quality parameters during COVID-19 outbreak in China, and to identify susceptible windows for associations between air pollution and semen quality.

Methods: A case study was carried out, including 781 sperm donor candidates (1991 semen samples) collected between November 23, 2019 and July 23, 2020 (a period covering COVID-19 lock-down in China) in University-affiliated Sichuan provincial Human Sperm Bank.

Result(s): Our results suggested that sperm motility is susceptible to ambient pollution exposure. Read More

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Cytocompatibility and Suitability of Protein-Based Biomaterials as Potential Candidates for Corneal Tissue Engineering.

Int J Mol Sci 2021 Mar 31;22(7). Epub 2021 Mar 31.

Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/ EHU), Barrio Sarriena S/N, 48940 Leioa, Spain.

The vision impairments suffered by millions of people worldwide and the shortage of corneal donors show the need of substitutes that mimic native tissue to promote cell growth and subsequent tissue regeneration. The current study focused on the in vitro assessment of protein-based biomaterials that could be a potential source for corneal scaffolds. Collagen, soy protein isolate (SPI), and gelatin films cross-linked with lactose or citric acid were prepared and physicochemical, transmittance, and degradation measurements were carried out. Read More

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Should the BCRA1/2-mutations healthy carriers be valid candidates for hematopoietic stem cell donation?

Hered Cancer Clin Pract 2021 Apr 1;19(1):22. Epub 2021 Apr 1.

Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Roma, Largo A. Gemelli 8, 00168, Rome, Italy.

It's still not clear whether the mutational status of BRCA-mutated healthy hematopoietic stem cells (HSCs) donors could have an impact on the engraftment. Comparing the studies present in literature, we focused on the correlation between BRCA mutations and the development of hematological malignancies and Fanconi anemia (FA); then, we explored HSCs types, frequencies, and functions in the presence of BRCA mutations, as well as the reconstitution of hematopoiesis after chemotherapy and radiation treatments. The role of BRCA mutations in the FA showed a possible involvement in the onset of the disease; the mutation carriers, indeed, did not show any sign of the typical phenotype of the FA. Read More

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Impact of mechanical circulatory support on donor heart allocation: past, present, and future.

Rev Cardiovasc Med 2021 Mar;22(1):25-32

Division of Cardiac Surgery, Department of Surgery, Thomas Jefferson University, 19107 Philadelphia, USA.

The United Network for Organ Sharing (UNOS) recently revised its heart allocation policy to address numerous shortcomings of the previous system. Implemented in 2018, the changes sought to reduce waiting list mortality, clearly define urgency status based on objective physiologic variables, decrease exemption requests, and introduce geographic modifications to ensure organ distribution favors the highest urgency candidates. In large part, UNOS policy revisions were driven by the growing use of continuous flow left ventricular assist devices (CF-LVADs) and the relevant device complications that led to an unacceptably high number of status exemptions. Read More

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Stratifying the humoral risk of candidates to a solid organ transplantation: a proposal of the ENGAGE working group.

Transpl Int 2021 Mar 31. Epub 2021 Mar 31.

Service de Transplantation, Néphrologie et Immunologie Clinique, Hôpital Edouard Herriot, Lyon, France.

Detection of circulating antibodies directed against human leukocyte antigen (HLA) molecules, which corresponds to the current definition of "sensitized patient", has been shown to have a severe impact on both access to transplantation and, if the anti-HLA antibodies are specific to the selected donor, survival of the graft. However, not all donor-specific antibodies (DSA) are equally harmful to the graft, and progress in the understanding of humoral memory has led to the conclusion that absence of DSA at transplantation does not rule out the possibility that the patient has a preformed cellular humoral memory against the graft (thereby defining a category of DSA-negative sensitized recipients). Technological progress has led to the generation of new assays that offer unprecedented precision in exploring the different layers (serological and cellular) of alloimmune humoral memory. Read More

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Impact of carfilzomib-based desensitization on heart transplantation of sensitized candidates.

J Heart Lung Transplant 2021 Mar 5. Epub 2021 Mar 5.

Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Background: Allosensitization in heart transplant candidates is associated with longer transplant wait times and post-transplant complications. We summarize our experience with desensitization using carfilzomib, an irreversible proteasome inhibitor that causes plasma cell apoptosis.

Methods: One cycle of desensitization consisted of plasmapheresis and carfilzomib 20 mg/m on days 1, 2, 8, 9, 15, and 16 with intravenous immune globulin 2 g/kg after carfilzomib on day 16. Read More

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Performance Changes Following the Revision of Organ Allocation System of Lung Transplant: Analysis of Korean Network for Organ Sharing Data.

J Korean Med Sci 2021 Mar 29;36(12):e79. Epub 2021 Mar 29.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.

Background: There is currently a lack of data on the impact of the recent revision of the domestic lung allocation system on transplant performance.

Methods: We conducted a retrospective analysis of transplant candidates and transplant patients registered in Korean Network for Organ Sharing between July 2015 and July 2019. Study periods were classified according to the introduction of the revised lung allocation system as follows: period 1 from July 2015 to June 2017 and period 2 from August 2017 to July 2019. Read More

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Investigation of erythrocyte antigen frequencies in draft horse populations in Japan to assess blood donor suitability.

J Equine Sci 2021 Mar 16;32(1):17-19. Epub 2021 Mar 16.

Ban'ei Horse Racing Promotion Section, Agricultural Affairs Department, Hokkaido 080-0023, Japan.

Erythrocyte alloantigen frequencies of draft horses in Japan were investigated to assess blood donor suitability for transfusion. Here, 148 Japanese draft, 69 Percheron, and 65 Breton horses were blood-typed and subjected to an indirect antiglobulin test. Regarding the major immunogenic factors, the rates of Aa- and Qa-negative horses ranged from 0. Read More

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Living kidney donor evaluation for all candidates with normal estimated GFR for age.

Transpl Int 2021 Mar 27. Epub 2021 Mar 27.

Nephrology, Dialysis and Renal Transplantation Department, Hôpital Nord, CHU de Saint-Etienne, Jean Monnet University, COMUE Université de Lyon, France.

Background: Multiple-days-assessments is frequent for the evaluation of candidates to living kidney donation, combined with an early GFR estimation (eGFR). Living kidney donation is questionable when eGFR is <90mL/min/1.73m (KDIGO guidelines) or 80mL/min/1. Read More

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Change in hepatic volume profile in potential live liver donors after lifestyle modification for reduction of hepatic steatosis.

Abdom Radiol (NY) 2021 Mar 25. Epub 2021 Mar 25.

Division of Liver Transplantation and Hepatobiliary Surgery, Departments of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Purpose: We aimed to evaluate changes in hepatic volume and hemiliver volume percentage in potential liver donors after hepatic steatosis (HS) reduction through lifestyle modification.

Methods: Fifty liver donor candidates with HS (macrovesicular fat [MaF] ≥ 20%) underwent abdominal computed tomography (CT) and liver biopsy before (baseline) and after (follow-up) lifestyle modification. According to the change in MaF, subjects were classified as group A (MaF reduction ≥ 20%, n = 25), and group B (MaF reduction < 20%, n = 25). Read More

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Reducing the wait: TCV can expand the donor pool for heart transplant candidates.

Pediatr Transplant 2021 Mar 23:e14012. Epub 2021 Mar 23.

The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

A 16-year-old with new-onset dilated cardiomyopathy underwent VAD placement, later complicated by low flow from outflow graft kinking. To expedite heart transplantation, TCV was calculated and compared with 141 normal patients pinpointing the upper weight threshold. He was transplanted 2 days later within the expanded weight range with no post-transplant complications. Read More

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Identifying Needs and Barriers to Engage Family Members in Transplant Candidate Care.

Prog Transplant 2021 Mar 23:15269248211002794. Epub 2021 Mar 23.

Nephrology Department, 5532Hennepin Healthcare, Minneapolis, MN, USA.

Introduction: Friends and family members provide critical support to patients on the waitlist for deceased donor kidney transplantation. However, little is known about how best to support and engage them effectively to improve patient outcomes.

Methods: We conducted 5 focus groups with the family members of patients on the waitlist for a deceased donor kidney (n=23) to identify individual- and group-level targets for an intervention. Read More

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Generation of high yield insulin-producing cells (IPCs) from various sources of stem cells.

Vitam Horm 2021 9;116:235-268. Epub 2021 Mar 9.

Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Molecular and Cell biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

Type 1 diabetes mellitus occurs when beta cell mass is reduced to less than 20% of the normal level due to immune system destruction of beta cell resulting in an inability to secrete enough insulin. The prevalence of diabetes is expanding according to the American Diabetes Association and the World Health Organization (WHO), foretold to exceed 350 million by 2030. The current treatment does not cure many of the serious complications associated with the disease such as neuropathy, nephropathy, dyslipidemia, retinopathy and cardiovascular disease. Read More

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Estimated Impact of Novel Coronavirus-19 and Transplant Center Inactivity on ESRD-related Patient Mortality in the United States.

Clin Transplant 2021 Mar 22:e14292. Epub 2021 Mar 22.

Department of Medicine - Med/Nephrology, Stanford University, Stanford, CA.

To predict if the COVID-19 pandemic and transplant center responses could have resulted in preventable deaths, we analyzed registry information of the U.S. ESRD patient population awaiting kidney transplantation. Read More

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Destination Transplant: Protocol for a Parallel-group Randomized Trial of an Educational Intervention to Increase Kidney Transplant Among Black People on the Transplant Waiting List.

Transplant Direct 2021 Apr 16;7(4):e683. Epub 2021 Mar 16.

Division of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.

For most patients with kidney failure, living donor kidney transplant (LDKT) is their best treatment option. Compared with White people, Black people are more likely to have kidney failure but less likely to receive LDKTs. In this study, the investigators will test an educational intervention, Destination Transplant, designed to reduce this disparity, among Black people already listed for kidney transplant. Read More

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Evaluation and Transplantation of a SARS-CoV-2 Seropositive Kidney Candidate.

Case Rep Nephrol 2021 8;2021:6613023. Epub 2021 Mar 8.

New York University Grossman School of Medicine, New York, NY, USA.

The COVID-19 pandemic affected transplant center activity in areas with high number of cases such as New York City and prompted reevaluation of patients awaiting organ transplant diagnosed with SARS-CoV-2 infection. To resume safe transplantation at our center, we found it necessary to (1) identify transplant candidates with possible exposure to or history of COVID-19 infection, (2) outline a clinical and laboratory assessment to determine adequate clinical recovery from COVID-19 for transplantation, and (3) determine whether the possibility of perioperative COVID-19 transmission from the patient to staff would pose unacceptable risk. Here, we describe our center's approach to proceeding with transplantation in a SARS-CoV-2 seropositive living donor kidney transplant recipient and describe early posttransplant outcomes. Read More

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Role and application of stem cells in dental regeneration: A comprehensive overview.

EXCLI J 2021 22;20:454-489. Epub 2021 Feb 22.

Nanotechnology and Regenerative Medicine Commercialization Centre (Ltd), The London Bioscience Innovation Centre, London, UK.

Recently, a growing attention has been observed toward potential advantages of stem cell (SC)-based therapies in regenerative treatments. Mesenchymal stem/stromal cells (MSCs) are now considered excellent candidates for tissue replacement therapies and tissue engineering. Autologous MSCs importantly contribute to the state-of-the-art clinical strategies for SC-based alveolar bone regeneration. Read More

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February 2021

Renal Cell Carcinoma and Kidney Transplantation: A Narrative Review.

Transplantation 2021 Mar 19. Epub 2021 Mar 19.

Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway. Department of Oncology, Oslo University Hospital, Oslo, Norway Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway Department of Urology, Oslo University Hospital, Oslo, Norway.

Kidney transplant recipients (KTRs) are at increased risk of developing renal cell carcinoma (RCC). The cancer can be encountered at different steps in the transplant process. RCC found during work-up of a transplant candidate needs treatment and to limit the risk of recurrence usually a mandatory observation period before transplantation is recommended. Read More

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Anatomic Variation of the Superficial Temporal Artery and Posterior Auricular Artery in a Pediatric Moyamoya Disease Population.

S Lee S-K Kim J H Phi

AJNR Am J Neuroradiol 2021 Mar 18. Epub 2021 Mar 18.

From the Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea

Background And Purpose: In certain cases of pediatric patients with Moyamoya disease undergoing encephaloduroarteriosynangiosis (EDAS) treatment, the posterior auricular artery can be used as an alternative when the parietal branch of the superficial temporal artery is unavailable. In this study, anatomic variations of the superficial temporal and posterior auricular arteries in pediatric patients with Moyamoya disease and postoperative outcomes of posterior auricular artery-EDAS are explored.

Materials And Methods: Medical records of 572 patients with Moyamoya disease who underwent surgical procedures from 2007 to 2017 at the Seoul National University Children's Hospital were reviewed. Read More

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The impact of the 2017 kidney allocation policy change on simultaneous liver kidney utilization and outcomes.

Liver Transpl 2021 Mar 18. Epub 2021 Mar 18.

Duke University Hospital, Department of Surgery.

Background & Aims: Historically in the United States, kidneys for simultaneous liver kidney (SLK) candidates were allocated with livers, prioritizing SLK recipients over much of the kidney waiting list. A 2017 change in policy delineated renal function criteria for SLK and implemented a Safety Net for kidney-after-liver transplantation. We aimed to compare utilization and outcomes of SLK and kidney-after-liver transplant around the 2017 policy. Read More

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Factors Influencing Long-Term Patient and Allograft Outcomes in Elderly Kidney Transplant Recipients.

Kidney Int Rep 2021 Mar 13;6(3):727-736. Epub 2020 Dec 13.

Department of Renal Medicine, Westmead Hospital, Sydney, Australia.

Introduction: Individuals aged ≥65 years are increasingly prevalent on the waitlist for kidney transplantation, yet evidence on recipient and donor factors that define optimal outcomes in elderly patients after kidney transplantation is scarce.

Methods: We used multivariable Cox regression modeling to determine the factors associated with all-cause death, death with a functioning graft, and overall and death-censored graft survival, using data from the Australia and New Zealand Dialysis and Transplant (ANZDATA) registry.

Results: A total of 802 kidney transplant recipients aged ≥65 years underwent their first transplantation between June 2006 and December 2016. Read More

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Improving the predictability of time to death in controlled donation after circulatory death lung donors.

Transpl Int 2021 Mar 16. Epub 2021 Mar 16.

Lung Transplant Service, The Alfred Hospital and Monash University, Melbourne, Vic., Australia.

Although the use of donation after circulatory death (DCD) donors has increased lung transplant activity, 25-40% of intended DCD donors do not convert to actual donation because of no progression to asystole in the required time frame after withdrawal of cardiorespiratory support (WCRS). No studies have specifically focussed on DCD lung donor progression. This retrospective study reviewed intended DCD lung donors to make a prediction model of the likelihood of progression to death using logistic regression and classification and regression tree (CART). Read More

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Can Beaver Tail Liver be the Cause of Preference in Living Liver Transplantation Donors?

Eurasian J Med 2021 Feb;53(1):53-56

Department of Radiology, Ataturk University School of Medicine, Erzurum, Turkey.

Objective: This study aims to investigate whether there was a difference between the levels of safety in terms of the postoperative residual liver volume in living transplant donors with normal liver anatomy and beaver tail liver.

Materials And Methods: Contrast-enhanced abdominal computed tomography (CT) images of 158 volunteers were retrospectively scanned. They were divided into 2 groups; with and without beaver tail liver. Read More

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February 2021