3,923 results match your criteria dme

American Society of Retina Specialists Clinical Practice Guidelines on the Management of Nonproliferative and Proliferative Diabetic Retinopathy without Diabetic Macular Edema.

J Vitreoretin Dis 2020 Mar 6;4(2):125-135. Epub 2020 Jan 6.

Retina Consultants of Houston, Blanton Eye Institute, Houston Methodist Hospital, Weill Cornell Medical College, Houston, TX.

Purpose: Nonproliferative (NPDR) and proliferative diabetic retinopathy (PDR) without diabetic macular edema (DME) affect millions of individuals living with diabetes throughout the world. There is increasing data on various management strategies for such patients, but there is limited consensus on how the data should be adopted into clinical practice.

Methods: This literature review and editorial presents and synthesizes the current evidence for various management paradigms for NPDR and PDR without DME. Read More

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Systemic exposure following intravitreal administration of therapeutic agents: an integrated pharmacokinetic approach. 2. THR-687.

J Pharmacokinet Pharmacodyn 2021 Jul 23. Epub 2021 Jul 23.

Oxurion N.V, Gaston Geenslaan 1, 3001, leuven, Belgium.

Intravitreal (IVT) injection remains the preferred administration route of pharmacological agents intended for the treatment of back of the eye diseases such as diabetic macular edema (DME) and neovascular age-related macular degeneration (nvAMD). The procedure enables drugs to be delivered locally at high concentrations whilst limiting whole body exposure and associated risk of systemic adverse events. Nevertheless, intravitreally-delivered drugs do enter the general circulation and achieving an accurate understanding of systemic exposure is pivotal for the evaluation and development of drugs administered in the eye. Read More

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KSI-301: antibody biopolymer conjugate in retinal disorders.

Ther Adv Ophthalmol 2021 Jan-Dec;13:25158414211027708. Epub 2021 Jul 12.

Retina Services, JB Eye Care & Retina Centre, Salem, India.

KSI-301 is a new intravitreal anti-vascular endothelial growth factor (VEGF) antibody biopolymer conjugate under investigation for the treatment of age-related macular degeneration (AMD), diabetic macular oedema (DME) and retinal vein occlusion (RVO). Preclinical and early clinical trials so far have shown promising results in retinal vascular diseases. When using anti-VEGF agents for treatment of retinal disorders, the frequency of injections and follow-up visits has increased the treatment burden, greatly affecting the treatment outcome. Read More

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Aflibercept versus Ranibizumab as a Second Line Therapy After Bevacizumab for Diabetic Macular Edema.

Clin Ophthalmol 2021 13;15:2975-2980. Epub 2021 Jul 13.

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To compare the visual and anatomic outcomes of aflibercept versus ranibizumab as a second line treatment for persistent diabetic macular edema (DME) after initial bevacizumab injections.

Methods: In this retrospective cohort study, patients with center-involved DME of ≥ 300 μm thickness after bevacizumab intravitreal injections in 2015-2019 were included. Those treated with ranibizumab (R) and aflibercept (A) were grouped as group R and group A, respectively. Read More

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Costs comparison of treating diabetic macular edema with aflibercept, ranibizumab or dexamethasone at 1 year in France (INVICOST study).

Eur J Ophthalmol 2021 Jul 20:11206721211033480. Epub 2021 Jul 20.

Allergan, an AbbVie company, Courbevoie, France.

Purpose: INVICOST, a medico-economic analysis, compared costs of managing treatment-naive patients with diabetic macular edema (DME) receiving intravitreal injections (IVIs) of aflibercept (AFL), dexamethasone implant (DXI) or ranibizumab (RAN) over 1 year.

Methods: Healthcare resource use and associated costs were estimated using individual patient data from INVICTUS, a prospective, open-label, monocentric study. Healthcare costs comprised direct medical costs such as drug acquisition and administration, consultations and ophthalmological procedures. Read More

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Fluctuations in central subfield thickness associated with worse visual outcomes in patients with diabetic macular edema in clinical trial setting.

Am J Ophthalmol 2021 Jul 17. Epub 2021 Jul 17.

Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA. Electronic address:

Purpose: This study examines the relationship between fluctuations in central subfield thickness (CST) and visual acuity in patients with diabetic macular edema (DME) using data from two large clinical trials.

Design: Clinical cohort study using post hoc analysis of clinical trial databases.

Methods: Standard deviation (SD) of all recorded CSTs for each patient during the study period were used to quantify the fluctuations in CST. Read More

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Outcomes of Eyes with Diabetic Macular Edema that are Lost to Follow-up after Anti-Vascular Endothelial Growth Factor Therapy.

Am J Ophthalmol 2021 Jul 17. Epub 2021 Jul 17.

The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, PA. Electronic address:

Purpose: To evaluate the effect of loss to follow up (LTFU) on outcomes in eyes with diabetic macular edema (DME) treated with anti-vascular endothelial growth factor (VEGF).

Design: Retrospective cohort study METHODS: : Single-center study of 90 eyes of 73 patients with non-proliferative diabetic retinopathy (NPDR) and DME treated with anti-VEGF injections who were LTFU for >6 months. Main outcomes were the change in mean visual acuity (VA) and central foveal thickness (CFT) at the return and final visits compared to the visit before LTFU. Read More

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Changes in choroidal thickness after anti-vascular endothelial growth factor treatment of diabetic macular edema, real-life data, 2-year results.

Cutan Ocul Toxicol 2021 Jul 19:1-6. Epub 2021 Jul 19.

Ophthalmology Department, Basaksehir Cam ve Sakura City Hospital, Istanbul, Turkey.

Purpose: To evaluate the effect of intravitreal anti-vascular endothelial growth factor (anti-VEGF) injection on central choroidal thickness (CCT), central macular thickness (CMT) and best-corrected visual acuity (BCVA) in diabetic macular edema (DME).

Methods: Retrospective, cohort analysis of 90 eyes of 90 patients receiving anti-VEGF therapy for DME. In patients' records, measurements of CCT, CMT, and BCVA before treatment and at 2 years after treatment were recorded. Read More

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Ontogeny of Drug-Metabolizing Enzymes.

Methods Mol Biol 2021 ;2342:551-593

Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.

Almost 50% of prescription drugs lack age-appropriate dosing guidelines and therefore are used "off-label." Only ~10% drugs prescribed to neonates and infants have been studied for safety or efficacy. Immaturity of drug metabolism in children is often associated with drug toxicity. Read More

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January 2021

The DME demethylase regulates sporophyte gene expression, cell proliferation, differentiation, and meristem resurrection.

Proc Natl Acad Sci U S A 2021 Jul;118(29)

Department of Biological Sciences, Seoul National University, Seoul 08826, Korea;

The flowering plant life cycle consists of alternating haploid (gametophyte) and diploid (sporophyte) generations, where the sporophytic generation begins with fertilization of haploid gametes. In , genome-wide DNA demethylation is required for normal development, catalyzed by the DEMETER (DME) DNA demethylase in the gamete companion cells of male and female gametophytes. In the sporophyte, postembryonic growth and development are largely dependent on the activity of numerous stem cell niches, or meristems. Read More

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Structural and functional findings in patients with moderate diabetic retinopathy.

Graefes Arch Clin Exp Ophthalmol 2021 Jul 15. Epub 2021 Jul 15.

Department of Ophthalmology, Lozano Blesa University Hospital, 50009, Zaragoza, Spain.

Purpose: To evaluate structural and functional ocular changes in patients with type 2 diabetes mellitus (DM2) and moderate diabetic retinopathy (DR) without apparent diabetic macular edema (DME) assessed by optical coherence tomography (OCT) and microperimetry.

Methods: This was a single-center cross-sectional descriptive study for which 75 healthy controls and 48 DM2 patients with moderate DR were included after applying exclusion criteria (one eye per patient was included). All eyes underwent a complete ophthalmic examination (axial length, macular imaging with swept-source OCT, and MAIA microperimetry). Read More

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Real-World Outcomes in Diabetic Macular Edema for the 0.2 µg/Day Fluocinolone Acetonide Implant: Case Series from the Midlands, UK.

Clin Ophthalmol 2021 7;15:2935-2943. Epub 2021 Jul 7.

Ophthalmology Department, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Aim: To investigate real-world effectiveness and safety of fluocinolone acetonide (FAc) implant over three years of treatment in eyes with diabetic macular edema (DME) in a population with large ethnic diversity.

Methods: This audit of three large treatment centres in the UK involved retrospective collection of outcome data (best recorded visual acuity [BRVA] by Early Treatment Diabetic Retinopathy Study [ETDRS] letters, central retinal thickness [CRT], intraocular pressure [IOP] and use of supplementary treatments) from patients with DME treated with 0.2 µg/day FAc intravitreal implant with three-year follow-up expected. Read More

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[Differential diagnosis and prevention of diabetic macular edema after cataract surgery in patients with nonproliferative diabetic retinopathy].

S Guo J Wang

Zhonghua Yan Ke Za Zhi 2021 Jul;57(7):546-551

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China.

Cataract surgery can increase the risk of diabetic macular edema (DME) and Irvine-Gass syndrome postoperatively in nonproliferative diabetic retinopathy (NPDR) patients. An accurate distinction between DME and Irvine-Gass syndrome in NPDR patients after cataract surgery is significantly important for the selection of subsequent treatment plans and guarantee of long-term vision quality. This article elaborates the differential diagnosis and prevention of DME, in order to provide a theoretical basis for the timely prevention, accurate diagnosis and standardized treatment of DME in NPDR patients after cataract surgery. Read More

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[The Eye in Internal Medicine: Diabetic retinopathy].

Michael Ulbig

Dtsch Med Wochenschr 2021 Jul 13;146(13-14):874-881. Epub 2021 Jul 13.

Diabetic retinopathy has seen tremendous progress in diagnostic tools and treatment in recent 15 years. Sight threatening stages like proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME) can be treated much more effectively now. The recognition of vascular endothelial growth factor (VEGF) as a driver of proliferation and macular edema has led to the development of VEGF inhibiting drugs such as antibodies (Bevacizumab), fragments of an antibody (Ranibizumab), or a so called VEGF trap (Aflibercept). Read More

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Treatment patterns in patients with age-related macular degeneration and diabetic macular edema: A real-world claims analysis in Dubai.

PLoS One 2021 13;16(7):e0254569. Epub 2021 Jul 13.

Novartis Pharma AG, Basel, Switzerland.

Objectives: To characterize the pattern of approved anti-vascular endothelial growth factor (VEGF) treatments among patients with neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) in the United Arab Emirates (UAE).

Method: This was a retrospective, nonrandomized, observational cohort analysis of the Dubai Real-world Claims Database with a 360-day follow-up period. Adult patients diagnosed with nAMD or DME treated with ranibizumab or aflibercept for the first time were included. Read More

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Synthesis and Characterization of Divalent Samarium and Thulium ,-Dimethylaminodiboranates.

Inorg Chem 2021 Jul 13. Epub 2021 Jul 13.

School of Chemical Sciences, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave., Urbana, Illinois 61801, United States.

The syntheses and molecular structures of new Sm and Tm ,-dimethylaminodiboranate (DMADB) complexes are described. Treating SmI(THF) with Na(HBNMeBH) in THF results in the formation of Sm(HBNMeBH)(THF) (), which can be readily converted to Sm(HBNMeBH)(DME) (DME = 1,2-dimethoxyethane) or Sm(HBNMeBH)(diglyme) by exchange with the corresponding ether. We also show that Sm(HBNMeBH)(THF) can be prepared by reduction of the Sm compound Sm(HBNMeBH)(THF) with KC and that addition of 18-crown-6 to this reaction mixture results in the formation of the Sm compound Sm(HBNMeBH)(18-crown-6). Read More

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Non-Damaging Retinal Laser Therapy in Recurrent Diabetic Macular Edema after Anti-VEGF injections.

Mehmet Çitirik

Turk J Med Sci 2021 Jul 12. Epub 2021 Jul 12.

Background/aim: Subthreshold yellow non-damaging retinal laser therapy (NRT) could provide a greater safety profile when compared to conventional laser methods. NRT may also improve diabetic macular edema (DME). This study aims to assess whether the severity of DME affects the efficacy of subthreshold yellow NRT. Read More

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Mfsd2a overexpression alleviates vascular dysfunction in diabetic retinopathy.

Pharmacol Res 2021 Jul 3;171:105755. Epub 2021 Jul 3.

Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

Diabetic retinopathy (DR) is one of the common complications in diabetic patients. Nowadays, VEGF pathway is subject to extensive research. However, about 27% of the patients have a poor visual outcome, with 50% still having edema after two years' treatment of diabetic macular edema (DME) with ranibizumab. Read More

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Establishing a Stable Anode-Electrolyte Interface in Mg Batteries by Electrolyte Additive.

ACS Appl Mater Interfaces 2021 Jul 6;13(28):33123-33132. Epub 2021 Jul 6.

Helmholtz Institute Ulm (HIU) Electrochemical Energy Storage, Helmholtzstraße 11, D-89081 Ulm, Germany.

Simple magnesium salts with high electrochemical and chemical stability and adequate ionic conductivity represent a new-generation electrolyte for magnesium (Mg) batteries. Similar to other Mg electrolytes, the simple-salt electrolyte also suffers from high charge-transfer resistance on the Mg surface due to the adsorbed species in the solution. In the current study, we built a model Mg cell system with the Mg[B(hfip)]/DME electrolyte and Chevrel phase MoS cathode, to demonstrate the effect of such anode-electrolyte interfacial properties on the full-cell performance. Read More

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Evaluation of retinal inflammatory biomarkers after intravitreal steroid implant and Ranibizumab injection in diabetic macular edema.

Eur J Ophthalmol 2021 Jul 5:11206721211029465. Epub 2021 Jul 5.

Kocaeli University School of Medicine, Department of Ophthalmology, Kocaeli, Turkey.

Purpose: To compare the efficacy of intravitreal (IV) ranibizumab (IVR) injection with IV dexamethasone implant (IVDEX) in treatment naive diabetic macular edema (DME) patients with inflammatory component.

Materials And Methods: Treatment naive DME eyes with subfoveal neurosensorial detachment (SND) and hyperreflective spots (HRS) were treated either three loading doses of IVR (18 eyes) or one dose of IVDEX (19 eyes). Central macular thickness (CMT), height of SND, the number of HRSs scattered on the individual retinal layers and photoreceptor integrity were assessed using spectral domain- optical coherence tomography scans over 3-months follow-up. Read More

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Prescription and acceptance of durable medical equipment in FORTITUDE-ALS, a study of in ALS: post hoc analyses of a randomized, double-blind, placebo-controlled clinical trial.

Amyotroph Lateral Scler Frontotemporal Degener 2021 Jul 5:1-8. Epub 2021 Jul 5.

Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.

: To evaluate the possible effect of , a fast skeletal muscle troponin activator, on prescription and acceptance of durable medical equipment (DME) in the FORTITUDE-ALS trial. Health economic outcome information was collected in FORTITUDE-ALS (NCT03160898); sites recorded if and when DME, specifically manual or power wheelchairs, gastrostomy tubes, noninvasive ventilators, or augmentative language devices, was prescribed by a physician and accepted by the patient (DME-PAP) during the trial. Acceptance was defined as the patient agreeing the item was needed. Read More

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Drug Delivery via the Suprachoroidal Space for the Treatment of Retinal Diseases.

Pharmaceutics 2021 Jun 26;13(7). Epub 2021 Jun 26.

Department of Ophthalmology, Meir Medical Center, Kfar Saba, 59 Tshernichovsky St., Kfar Saba 4428164, Israel.

The suprachoroidal space (SCS), a potential space between the sclera and choroid, is becoming an applicable method to deliver therapeutics to the back of the eye. In recent years, a vast amount of research in the field has been carried out, with new discoveries in different areas of interest, such as imaging, drug delivery methods, pharmacokinetics, pharmacotherapies in preclinical and clinical trials and advanced therapies. The SCS can be visualized via advanced techniques of optical coherence tomography (OCT) in eyes with different pathologies, and even in healthy eyes. Read More

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Sub- and Supercritical Extraction of Slovenian Hops ( L.) Aurora Variety Using Different Solvents.

Plants (Basel) 2021 Jun 3;10(6). Epub 2021 Jun 3.

Laboratory for Separation Processes and Product Design, Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia.

This work investigates the efficiency of supercritical fluid extraction of hops with a variety of solvents including carbon dioxide (CO), propane, sulfur hexafluoride (SF), and dimethyl ether (DME) at various densities (low-density and high-density). Operating parameters were 50 bar, 100 bar and 150 bar and 20 °C, 40 °C, 60 °C and 80 °C for all solvents, respectively. The influence of process parameters on the total yield of extraction and content of bitter acids in the extracts has been investigated. Read More

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ResNet Based Deep Features and Random Forest Classifier for Diabetic Retinopathy Detection.

Sensors (Basel) 2021 Jun 4;21(11). Epub 2021 Jun 4.

Center of Excellence in Intelligent Engineering Systems, Department of Electrical and Computer Engineering, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Diabetic retinopathy, an eye disease commonly afflicting diabetic patients, can result in loss of vision if prompt detection and treatment are not done in the early stages. Once the symptoms are identified, the severity level of the disease needs to be classified for prescribing the right medicine. This study proposes a deep learning-based approach, for the classification and grading of diabetic retinopathy images. Read More

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Assessment of knowledge, attitude, and practice regarding Deep Margin Elevation (DME) among dental practitioners in Riyadh, Saudi Arabia.

J Family Med Prim Care 2021 May 31;10(5):1931-1937. Epub 2021 May 31.

Dental Student, Riyadh Elm University, Riyadh, Saudi Arabia.

Objectives: To evaluate Knowledge, Attitude, and Practice (KAP) regarding deep margin elevation (DME) among dental practitioners in Riyadh city.

Materials And Methodology: A cross-sectional study that comprised a total number of 535 dental practitioners: 255 (47.7%) were males and 280 (52. Read More

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Mean macular intercapillary area in eyes with diabetic macular oedema after anti-VEGF therapy and its association with treatment response.

Clin Exp Ophthalmol 2021 Jun 29. Epub 2021 Jun 29.

New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA.

Background: To evaluate the changes in the mean macular intercapillary area (ICA) from sequential enface optical coherence tomography angiography (OCTA) images following intravitreal anti-VEGF therapy in initially treatment-naïve eyes with diabetic macular oedema (DME).

Methods: In this multicenter retrospective study, 6x6 and 3x3 mm customized, total retinal projection enface OCTA images were collected and processed for quantitative assessment of ICA by a customized MATLAB software. Measurements were done in concentric regions centered on the fovea -with the exclusion of foveal avascular zone (FAZ)- in 0. Read More

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Pars Plana Vitrectomy with Internal Limiting Membrane Peeling for Treatment-Naïve Diabetic Macular Edema: A Prospective, Uncontrolled Pilot Study.

Clin Ophthalmol 2021 21;15:2619-2624. Epub 2021 Jun 21.

Panhandle Eye Group, Amarillo, TX, 79106, USA.

Purpose: To report the outcomes in subjects undergoing pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling for the management of treatment-naïve diabetic macular edema (DME).

Methods: Ten treatment-naïve subjects with non-proliferative diabetic retinopathy prospectively underwent PPV with ILM peeling for the treatment of DME at a single university-affiliated institution. The preoperative features, intraoperative details and postoperative outcomes were collected and analyzed. Read More

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Effects of Applied Interfacial Pressure on Li-Metal Cycling Performance and Morphology in 4 M LiFSI in DME.

ACS Appl Mater Interfaces 2021 Jul 28;13(27):31668-31679. Epub 2021 Jun 28.

Lithium-metal anodes can theoretically enable 10× higher gravimetric capacity than conventional graphite anodes. However, Li-metal anode cycling has proven difficult due to porous and dendritic morphologies, extensive parasitic solid electrolyte interphase reactions, and formation of dead Li. We systematically investigate the effects of applied interfacial pressure on Li-metal anode cycling performance and morphology in the recently developed and highly efficient 4 M lithium bis(fluorosulfonyl)imide in 1,2-dimethoxyethane electrolyte. Read More

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Does conventional laser photocoagulation still have a place in the treatment of diabetic macular edema?

Rom J Ophthalmol 2021 Apr-Jun;65(2):130-135

Department of Ophthalmology, Osmanoglu Hospital, Istanbul, Turkey.

The study aimed to investigate the long-term efficacy of conventional laser photocoagulation in the treatment of diabetic macular edema. In this retrospective study, the records of patients presented with diabetic macular edema (DME) and non-proliferative diabetic retinopathy were reviewed. DME defined as clinically significant macular edema was treated by using argon green or yellow dye laser with focal, grid, and modified grid techniques according to Early Treatment Diabetic Retinopathy Study parameters. Read More

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Evaluation of Explainable Deep Learning Methods for Ophthalmic Diagnosis.

Clin Ophthalmol 2021 18;15:2573-2581. Epub 2021 Jun 18.

Theoretical and Experimental Epistemology Laboratory (TEEL), School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada.

Background: The lack of explanations for the decisions made by deep learning algorithms has hampered their acceptance by the clinical community despite highly accurate results on multiple problems. Attribution methods explaining deep learning models have been tested on medical imaging problems. The performance of various attribution methods has been compared for models trained on standard machine learning datasets but not on medical images. Read More

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